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2024 APR 18 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- A new study on cervical screening is now available. According to news reporting originating [...]

2024 JAN 25 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Investigators publish new report on cervical screening. According to news originating from Mashhad, Iran, [...]

A recent report from the Department of Pathology discusses the prognostic value of IMP3 expression in squamous cervical cancer. IMP3 is a protein associated with invasiveness and aggressive tumor characteristics. The study examined IMP3 expression in 80 patients with early-stage squamous cell cervical cancer but did not find a statistically significant association with disease outcomes. The research suggests that analyzing IMP3 protein expression in early-stage cervical cancer may have limited utility. [Extracted from the article]

A recent study conducted in Mashhad, Iran, explored the prevalence of Human Papillomavirus (HPV) infection and its association with Pap smear findings among women undergoing gynecological screening. The study found that the overall HPV prevalence was 37.5%, with high-risk genotypes identified in one-fourth of the study population. The research highlights the importance of HPV prevention programs in this population and found no direct link between bacterial vaginosis or candida infection and HPV positivity. [Extracted from the article]

A systematic review was conducted to summarize the use of automated technology systems in cervical cancer screening. The review found that researchers have been developing low-cost portable devices and automating image analysis to address the barriers of implementation in low- and middle-income countries (LMICs). The study identified 17 studies that reported algorithms developed with source images from mobile devices and 56 studies that reported algorithms with source images from conventional/commercial acquisition devices. The review concluded that computer aided diagnostics (CAD) showed superior prediction performance compared to manual analysis, and highlighted the need for adequate clinical validation of novel devices with CAD in LMICs. [Extracted from the article]

A recent study conducted at the Post Graduate Institute of Medical Sciences in Haryana, India, examined the knowledge, attitude, and practice of healthcare professionals regarding Pap smear screening for cervical cancer. The study found that while there was a moderate level of knowledge among the participants, there was a significant gap between their attitudes and actual practices related to Pap smear and cervical cancer screening. The study involved 424 married female healthcare workers of varying experience levels and utilized a questionnaire to gather data. This research provides valuable insights into the need for improved awareness and implementation of cervical screening practices among healthcare professionals. [Extracted from the article]

A new report discusses research findings on cervical cancer, specifically focusing on vulvar intraepithelial neoplasia (VIN), a dysplastic condition of the vulva. The report highlights the management options for VIN, including excision, laser ablation, and topical therapy. The case study presented in the report describes a woman in her 60s who had previously been treated for cervical adenocarcinoma and subsequently developed recurrent vulvar dysplasia. The report concludes with the histological examination of the specimen, which showed human papillomavirus-associated classic VIN II. For more information, readers can refer to the Philippine Journal of Obstetrics and Gynecology. [Extracted from the article]

Cinesteam(R) is a medical device developed by Clemence Desjardin and his team at Cemag Care to help women manage the malodors generated by fungating breast wounds (FBW) during breast cancer treatment. FBW can create unpleasant smells, adding stress and discomfort to an already difficult situation. Cinesteam(R) is a secondary dressing that includes an absorbent core and an adsorbent sachet filled with cinnamon powder, effectively removing the odors and replacing them with a pleasant smell. This accessible solution aims to help patients maintain peace and quality of life during the healing process. [Extracted from the article]

A new report discusses research conducted by Guilan University of Medical Sciences on the prevalence and risk factors of cervical inflammations among low-income women in Rasht, Iran. The study found that cervical inflammation was detected in 94.3% of participants, with 1% showing precancerous lesions. The research emphasizes the importance of early detection and intervention through screening tests like Pap smears for the pre-diagnosis of cervical cancer. The study provides valuable insights into the health challenges faced by low-income women in Iran and highlights the need for accessible and affordable healthcare services. [Extracted from the article]

A study conducted by Qingdao University in China investigated the impact of surgical treatment on the survival prognosis of patients with locally advanced cervical cancer (LACC). The study utilized data from the SEER database and a hospital, and analyzed the effects of surgical intervention on overall survival (OS) and disease-specific survival (DSS) in LACC patients. The results showed that the surgical group had significantly better OS and DSS compared to the non-surgical group, particularly for patients with tumor diameters less than 6 cm. Surgery combined with radiotherapy also yielded better outcomes than chemoradiotherapy alone. These findings suggest that surgical treatment, especially when combined with radiotherapy, may be more beneficial for LACC patients with smaller tumors. [Extracted from the article]

This document provides information about a clinical trial conducted by the National Cancer Institute on Human Papillomavirus (HPV) and cervical cancer prevention. The trial, called the Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial, aims to evaluate the use of self-collected vaginal samples for HPV testing in patients referred for colposcopy and/or cervical excisional procedures. The trial will compare the clinical accuracy of HPV testing on self-collected vaginal samples versus cervical samples collected by a clinician. It will also assess human factors such as usability, acceptability, and preferences for self-collection. The trial is currently recruiting participants and is expected to be completed by May 2025. [Extracted from the article]

A patent application has been submitted for a computer-based system that uses machine learning algorithms to identify subjects for clinical procedures in healthcare. The system retrieves subject records from a database, processes them using the algorithms, and outputs a subset of subjects who are prioritized for the procedure. The algorithms analyze demographic characteristics and clinical history to determine the likelihood of compliance with the procedure. The system aims to improve the efficiency and effectiveness of medical screenings and follow-up care by streamlining the outreach process and potentially sending reminders or notifications to subjects. [Extracted from the article]

A recent study conducted by researchers at Lanzhou University in Gansu, China explored the impact of frailty on chemotherapy toxicity in patients with cervical cancer. The study followed 259 postoperative cervical cancer patients for four chemotherapy cycles after surgery. The researchers found that frailty was an independent risk factor for total chemotherapy toxicity, as well as nausea and vomiting. Additionally, the study found that frailty was associated with lower white blood cell and hemoglobin values in patients. These findings may help healthcare providers take effective measures to reduce the toxicity of chemotherapy in cervical cancer patients. [Extracted from the article]

A systematic review conducted by researchers at Mayo Clinic examined the breast cancer screening rates among transgender and gender diverse (TGD) individuals. The review found that there is limited research on this topic, but the studies that do exist show mixed results. Some studies found lower rates of screening in TGD individuals compared to cisgender women, while others found no differences. The researchers concluded that more research is needed to develop protocols that ensure equitable access to preventative care for TGD individuals. This information is important for clinicians and national guidelines to better inform their recommendations. [Extracted from the article]

A recent study conducted by the University of Pennsylvania Perelman School of Medicine examined racial disparities in the receipt of radiation and brachytherapy in Medicare patients with cervical cancer. The study found that Black patients were more likely to undergo radiation therapy (RT) than White patients, but had similar rates of brachytherapy (BT). There were no significant differences in RT, BT, or RT duration by race, and there were no differences in overall survival (OS) or cancer-specific survival (CSS) between White and Black patients. These findings suggest that there are no racial disparities in the receipt of radiation and brachytherapy for cervical cancer patients. [Extracted from the article]

A study conducted in Ethiopia examined the success rate of ureteral stenting in patients with locally advanced cervical cancer. The research found that the overall success rate of stenting was 54.2%, with a higher success rate in the prophylactic group (94%) compared to the therapeutic group (42.6%). Factors such as bilateral hydronephrosis and increased serum creatinine were identified as indicators of significant ureteral obstruction and predictors of stent placement failure. The study suggests that for patients with these risk factors, alternative options such as percutaneous nephrostomy should be considered. [Extracted from the article]

A study conducted at the First Affiliated Hospital of the University of Science and Technology China aimed to investigate the impact of postsurgical vaginal microbiome (VM) on high-risk human papillomavirus (hrHPV) infection and the risk of disease recurrence in patients with cervical cancer (CC) or intraepithelial neoplasia (CIN). The study included 207 women who underwent surgical treatment for CC or CIN, and their clinical data was analyzed. The findings showed that postsurgical VM imbalance, particularly abnormal indices such as a pH above 4.5, a lactobacilli proportion below 50%, and the presence of aerobic vaginitis (AV), were associated with an increased risk of postsurgical recurrence. The study suggests that monitoring and potentially intervening in the VM may improve the prognosis of these patients. [Extracted from the article]

A new report published by investigators at Imelda Hospital in Bonheiden, Belgium describes a new approach to performing a radical hysterectomy for cervical cancer using vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES). The technique, demonstrated in 10 steps with original video footage, involves performing most of the procedure retroperitoneally. The researchers emphasize that this is a new approach that requires further validation and should only be performed in a research setting. The study concludes that vNOTES offers a potentially less invasive approach to radical hysterectomy, leaving no visible scars and providing excellent visualization of the anatomy. [Extracted from the article]

A study conducted by researchers at the Medical University of Innsbruck compared the vaginal microbiome of transgender men receiving gender-affirming hormonal therapy to that of cisgender women. The study found that the vaginal microbiome of trans men and menopausal women showed a higher alpha diversity than that of premenopausal women. The composition of the vaginal microbiome differed between trans men and premenopausal and menopausal women, with trans men showing a loss of Lactobacillus and an increase in bacteria associated with the intestinal flora. The duration of hormonal therapy in trans men may have important impacts on the vaginal microbiome and the risk for sexually transmitted infections. [Extracted from the article]

Researchers at Northeastern University in Shenyang, China have developed a DL-based method called VTCNet for classifying cervical Pap cells. The method combines CNN-SPPF and ViT components to extract local and global features and enhance classification performance. The researchers achieved high accuracy rates on the SIPaKMeD and Herlev datasets, outperforming previous methods. This research provides a promising approach to improving the accuracy of cervical cancer detection through computer-aided diagnosis systems. [Extracted from the article]

A recent systematic review conducted by researchers at Hospital Britanico in Montevideo, Uruguay, aimed to evaluate the impact of different doses of indocyanine green (ICG) on sentinel lymph node (SLN) mapping in early-stage cervical cancer. The review included twelve studies and found that an ICG concentration of 1.25 mg/mL with a 4 mL injection volume yielded the most consistent results, achieving high detection rates with minimal variability. The researchers recommend standardizing this dose in clinical practice to improve reproducibility and outcomes. This information is valuable for those interested in cervical cancer surgery and SLN mapping. [Extracted from the article]

A report from the University of Massachusetts Memorial Medical Center discusses the history and advancements in cervical cytopathology. The report highlights the success of cervical screening in reducing the incidence of cervical cancer but acknowledges its limitations. The research focuses on the transition from "evidence-based" to "risk-stratified" algorithms in clinical guidelines, with primary high-risk human papillomavirus (hrHPV) testing considered the preferred screening test. The report also discusses the use of dual stain biomarkers and the impact of new guidelines on cervical cytopathology. [Extracted from the article]

Researchers from Wroclaw University of Science and Technology in Poland have conducted a systematic review on the segmentation and classification of Pap smear images for cervical cancer detection. The review focused on articles published between 2016 and 2023 and explored the use of deep learning techniques in this area. The researchers found that advanced image processing approaches, feature extraction methods, and classification algorithms have been developed to detect cervical cancer using Pap smear images. The most widely used techniques for segmenting the images were Unet and Mask RCNN, while SVM and CNN were used for classification. The algorithms achieved high levels of accuracy, with some reaching over 90%. The researchers concluded that the effective use of deep learning techniques has the potential to enhance the accuracy and efficiency of cervical cancer detection in early diagnosis. [Extracted from the article]

A recent study conducted at Xi'an Jiaotong University in Shaanxi, China, aimed to evaluate the impact of family synchronized empowerment education on the sense of shame and quality of life in patients discharged with catheters following radical surgery for cervical cancer. The study included 92 patients who underwent surgery and were divided into two groups: a control group and an observation group. The observation group received family synchronized empowerment education, while the control group received conventional health education. The results showed that the observation group had significant improvements in sense of shame, family function, quality of life, self-urination, catheter reset, and urinary tract infection compared to the control group. The study suggests that family synchronized empowerment education can effectively reduce shame, enhance quality of life, and facilitate early catheter removal and resumption of self-urination for patients with cervical cancer. [Extracted from the article]

A study conducted by the Liaoning Cancer Hospital and Institute examined the treatment of secondary uterine malignancy following radiotherapy for cervical cancer. The study analyzed data from the Surveillance, Epidemiology, and End Results (SEER) database and included 142 patients with a secondary uterine malignancy after cervical cancer treatment. The results showed that surgery combined with chemotherapy had better survival outcomes compared to other treatments. The study highlights the importance of treatment modality in improving survival for patients with secondary uterine malignancy after radiotherapy for cervical cancer. [Extracted from the article]

A recent study conducted at Fujian Medical University in China aimed to identify the lymph node drainage route and the first station of lymph node metastasis (LNM) in patients with stage IB1 to IIA2 cervical cancer. The study analyzed the clinicopathological data of patients who underwent radical surgery between 2018 and 2022. The researchers found that the most common first stations of LNM were the internal iliac, obturator, and external iliac lymph nodes in sequence. Complete removal of these lymph nodes is crucial for patients without satisfactory or failed sentinel lymph node mapping. This research provides valuable insights into the lymph node drainage route in cervical cancer. [Extracted from the article]

A recent study conducted by researchers at KIIT University in India explores the relationship between cervical inflammation, Pap smear changes, and infertility in women. The study found that reproductive tract infections can lead to marked cervical inflammation, which can be detected through Pap smears. The researchers observed that almost 50% of women with inflammatory smears had infections, with candidiasis and bacterial vaginosis being the most common. Additionally, the study found that women with Pap smear changes had a significantly lower conception rate, even with assisted reproductive technology. The researchers recommend that Pap smears be conducted in all cases of infertility to identify infections and inflammation, and follow-up high vaginal swab cultures should be done when inflammation is detected. [Extracted from the article]

A recent study conducted in Zhejiang, China, examined the use of vaginal dilators in cervical cancer patients after radiotherapy. The study found that using a vaginal dilator is safe and can effectively promote the recovery of patients' sexual activity and quality of life. The research involved 128 patients with cervical cancer who underwent radical hysterectomy and vaginal lengthening surgery. The study measured vaginal diameter and length during the follow-up period and assessed changes in quality of life using a questionnaire. The findings suggest that vaginal dilators may be a beneficial treatment option for cervical cancer patients post-radiotherapy. [Extracted from the article]

A recent study conducted by researchers at Shanghai Jiao Tong University has shed light on the mechanisms of perineural invasion (PNI) in cervical cancer. PNI involves the interaction between tumors and nerves and plays a role in the invasion and metastasis of cervical cancer. The study found that Schwann cells, a type of neuroglia, are the cells that initiate PNI in advanced cervical cancer. The researchers also identified the neuropeptide neuromedin B (NMB) produced by cervical cancer cells as the signal that reprograms Schwann cells and induces PNI. The findings suggest that measuring serum levels of NMB and CCL2, another molecule involved in PNI, could be useful in predicting PNI and guiding treatment decisions for cervical cancer patients. [Extracted from the article]

The document outlines a clinical trial, NCT06572800, that is investigating the use of a test developed by DiviTum to determine the optimal levels of CDK 4/6 inhibitor medications in the blood for patients with ER/PR positive metastatic breast cancer. The trial aims to improve medication compliance and reduce potential drug interactions by assessing medical compliance and drug-drug interactions. CDK4/6 inhibitors, in combination with endocrine therapy, are the first-line treatment for this type of breast cancer. The study will analyze the response of patients to CDK4/6 inhibitor therapy by evaluating progression-free survival rates, TKa levels, response profiles across different inhibitors, and correlating TKa levels with tumor marker levels. Blood samples will be collected from participants using the DiviTum-TKa device. The study is currently recruiting participants and is expected to be completed by May 2027. [Extracted from the article]

A recent study conducted in Mississippi aimed to understand the follow-up procedures for individuals with abnormal cervical screening results. The study found that out of 1,458 individuals requiring a colposcopy, 43% had the procedure within 4 months, 16.4% had a delayed procedure, and 39.5% had no documented follow-up. Age and cytology diagnosis were identified as significant predictors of follow-up, with individuals over 30 more likely to have a colposcopy. The study highlights the need for further research to address incomplete follow-up and improve health outcomes for cervical cancer prevention. [Extracted from the article]

A recent report from researchers at Ajou University in Suwon, South Korea discusses the use of robotic radical hysterectomy (RRH) as a treatment for early-stage cervical cancer. The report highlights that while minimally invasive radical hysterectomy (MIRH) has been widely performed, a randomized controlled trial in 2018 showed that MIRH had poorer oncologic outcomes compared to laparotomy. However, the researchers argue that RRH is a safe and effective alternative to the abdominal approach, offering perioperative benefits such as reduced blood loss and shorter hospital stays without compromising overall survival and progression-free survival. Ongoing clinical trials will provide further insight into the use of RRH in cervical cancer treatment. [Extracted from the article]

A study conducted by researchers at Qingdao University in China explored the feasibility of using local excision as an alternative to hysterectomy for fertility preservation in young patients with early-stage cervical cancer. The study analyzed data from the Surveillance, Epidemiology, and End Results (SEER) database and found that local excision showed favorable outcomes compared to hysterectomy for patients with cervical squamous cell carcinoma and adenosquamous cell carcinoma. However, there was no significant difference in prognosis for patients with cervical adenocarcinoma. The researchers concluded that local excision may be a viable option for fertility preservation in early-stage cervical cancer patients, particularly those with well- or moderately-differentiated squamous cell carcinoma. [Extracted from the article]

A study conducted by researchers at Delhi Technological University in India has explored the use of Digital Twin (DT) technology in the diagnosis of cervical cancer. The researchers developed an automated cervical cancer detection framework using machine learning and image classification techniques. The framework achieved a high accuracy rate of 98.91% in classifying cervical cancer cases, particularly with support vector machines (SVM). The study suggests that integrating DT with the healthcare industry can enhance healthcare procedures and improve patient outcomes. [Extracted from the article]

A recent report from investigators at National Taiwan University Hospital discusses the current state and latest updates in the treatment of cervical cancer. Cervical cancer is a significant global health issue and the fourth most common cancer in women worldwide. The standard management of cervical cancer involves a combination of treatment approaches, including surgery, radiotherapy, chemotherapy, and novel systemic therapies. The introduction of immune checkpoint inhibitors has had a significant impact on the treatment of cervical cancer, leading to improved survival rates. The report aims to provide a comprehensive discussion of the evolving landscape of cervical cancer therapies. [Extracted from the article]

2023 JAN 5 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Researchers detail new data in cervical intraepithelial neoplasia. According to news reporting from Lumbini [...]

A report from Medical University Pleven in Bulgaria discusses the Querleu-Morrow (Q-M) classification of radical hysterectomy, which provides a standardized surgical and anatomical terminology for cervical cancer surgery. The report highlights the importance of anatomical landmarks and resection margins in the Q-M classification and proposes an update that includes additional procedures. The research aims to achieve surgical harmonization and standardization among oncogynecologists, leading to more accurate and comparable results in clinical trials. The report concludes that the proposed update may facilitate improved patient management and outcomes. [Extracted from the article]

A recent study conducted in Debre Berhan City, Ethiopia, found that male support plays a significant role in women's decision to undergo cervical cancer screening. Women of low socioeconomic status are particularly affected by cervical cancer, and resistance from male partners is common in low- and middle-income countries. The survey, which involved 614 male participants, revealed that 58.5% of men supported their partners for cervical cancer screening. While awareness, knowledge, and perceptions of cervical cancer screening were low among men, they generally had a positive attitude and encouraged their wives to get screened if they noticed symptoms. The study suggests that strategies and action plans should be developed to promote and support male participation in cervical cancer screening in Ethiopia, including public campaigns, raising awareness among community leaders, involving non-governmental organizations, and community education. [Extracted from the article]

A clinical trial, NCT06536881, is being conducted to investigate the feasibility of using water-only fasting for 24-48 hours to improve the effectiveness of chemotherapy in patients with early-stage breast cancer. The trial aims to determine if fasting can help reduce the negative effects of chemotherapy and maintain the intended dosage and schedule. The study will assess the proportion of participants who adhere to the fasting regimen and evaluate the occurrence of severe side effects, blood-related toxicities, and dose adjustments or delays. Additionally, the trial will examine changes in quality of life, fatigue, inflammatory markers, tumor cells, and the composition of the gut microbiome. The researchers hope to determine if fasting can be used as an intervention to enhance chemotherapy delivery in early-stage breast cancer patients, while also improving survival outcomes and reducing disparities in survival rates. The study is not yet recruiting participants and is expected to be completed by May 2029. [Extracted from the article]

A recent study conducted by researchers from Hacettepe University in Ankara, Turkey, focused on evaluating the risk factors for cervical intraepithelial neoplasia (CIN2+) lesions in endocervical curettage (ECC) and the relationship between ECC and punch biopsy in detecting these lesions. The study analyzed data from 11,944 patients who underwent colposcopy between February 2018 and 2019. The findings revealed that ASC-H/HSIL cytology and HPV-16/18 infection were identified as risk factors for CIN2+ lesions. ECC was found to have a diagnostic yield of 1.2% in all patients, and a higher yield was observed with increasing age and in cases of incomplete visualization of the squamocolumnar junction (SCJ). The researchers concluded that ECC should be considered in older patients and in cases where the SCJ is not routinely visualized, particularly in HPV-positive cases and those with cytological abnormalities. [Extracted from the article]

A recent study conducted in Estonia aimed to evaluate the impact of opt-in and opt-out options for human papillomavirus (HPV) self-sampling on participation in organized cervical cancer screening. The study found that providing women with a choice between self-sampling and clinician sampling significantly increased participation in cervical cancer screening. The effectiveness of the opt-in and opt-out options varied across different age groups, suggesting the need for tailored strategies. Overall, the study highlights the potential benefits of HPV self-sampling in improving screening attendance for cervical cancer. [Extracted from the article]

A recent study conducted at the Islamic University of Gaza has developed a new surface plasmon resonance sensor (SPRS) for the early detection of cervical cancer. The SPRS is constructed using layers of silver, BaTiO3, and graphene, along with a coupling prism. The researchers found that the optimal thicknesses of the materials used in the SPRS resulted in a sensitivity of 300 degrees RIU-1, which is higher than previously published SPRS structures. The study concludes that this SPRS shows promise for use in various biosensing applications. [Extracted from the article]

A clinical trial has been launched to study the prevalence and anatomical variations of uterine veins in endometrial and cervical cancer patients. The study aims to deepen our understanding of the anatomy, prevalence, and relationship of superficial and deep uterine veins with neighboring structures. This knowledge could be helpful in uterine transplantation and radical hysterectomy operations. The trial is currently recruiting participants and is expected to be completed by March 2026. [Extracted from the article]

A recent study conducted at the University Hospital of Wuerzburg evaluated the use of 3D printed models for examination, diagnosis, and treatment planning of cervical cancer. The study found that the models were well-received by medical professionals, particularly radiation oncologists, who rated them highly for understanding patient-specific characteristics and improving treatment planning. Surgeons also found the models useful during surgery and for patient communication. The study suggests that addressing the specific needs of each medical specialty will be crucial for maximizing the potential of 3D printed models in clinical practice. [Extracted from the article]

A study conducted at the University Hospital Son Espases aimed to determine the rate of atypical lymphatic drainage in patients with early-stage cervical cancer using a hybrid tracer. The study included 39 cases of cervical cancer, and the overall sentinel lymph node (SLN) detection rate was 97.4%. Atypical lymphatic drainage was present in 21.1% of patients, and SLNs in the atypical area had a higher proportion of metastasis compared to the usual area. The researchers concluded that SLN biopsy using a standardized technique with a hybrid tracer could help improve staging and tailor therapy for cervical cancer patients. [Extracted from the article]

A recent study conducted by Fujian Medical University Union Hospital examined the immediate risk of cervical intraepithelial neoplasia (CIN) among patients who tested negative for cytology but positive for high-risk human papillomavirus (HR-HPV). The study found that patients who were not HR-HPV16/18-positive had comparable rates of CIN2+ lesions to those who were HPV16/18-positive. Additionally, the study concluded that colposcopy, while moderately accurate, can be influenced by factors such as age and the type of cervical transformation zone. The researchers recommend immediate colposcopy referral for cytology-negative but HR-HPV-positive patients, as well as cervical cancer screening for women under 30 years old. [Extracted from the article]

A recent report from the University of Campania "Luigi Vanvitelli" in Naples, Italy, discusses the treatment options for locally advanced cervical cancer (LACC). The study compares the benefits of surgery after neoadjuvant treatments with standard treatment. The meta-analysis found that patients who underwent surgery after concurrent radio chemotherapy (CCRT) or neoadjuvant chemotherapy (NACT) had significantly improved disease-free survival (DFS) and overall survival (OS) compared to those who received standard treatment. These findings provide updated information on the efficacy of neoadjuvant treatments for LACC. [Extracted from the article]

A recent study published in BMJ Open examined the association between Pap test utilization and comorbidity and functional impairment among middle-aged non-Hispanic black women in the USA. The study found that middle-aged non-Hispanic black women with comorbidity or functional impairment had a lower rate of Pap test utilization compared to healthier counterparts, regardless of histories of hysterectomy and prior cancer. The researchers suggest that targeted intervention programs and prioritized health resource allocation are important for promoting Pap test utilization among this population. Further cohort studies are needed to better understand this association. [Extracted from the article]

A recent study conducted by researchers at Nanjing Medical University aimed to identify risk factors for postoperative infectious complications following laparoscopic hysterectomy for cervical cancer and develop a prediction model based on these factors. The study included 301 patients, of whom 38 (12.6%) experienced infectious complications within one month after surgery. The researchers identified six independent risk factors for these complications: age 60, body mass index (BMI) 24.0, diabetes, systemic immune-inflammation index (SII) 830, albumin-to-fibrinogen ratio (AFR) < 9.25, and neutrophil-to-lymphocyte ratio (NLR) 3.45. The nomogram model developed using these factors demonstrated strong predictive capabilities for postoperative infectious complications. [Extracted from the article]

A recent study conducted at the University of Nevada explored the feasibility and early oncologic outcomes of a new surgical technique called Total Intracorporeal Robotic Radical Hysterectomy with Vaginal Cerclage (TIRRHVC) for the treatment of early-stage cervical cancer. The study included 26 patients who underwent the TIRRHVC procedure and their demographics, clinical, surgical, and oncologic outcomes were reviewed retrospectively. The results showed promising early oncologic outcomes, with a 3-year disease-free survival rate of 95.5%. The researchers concluded that TIRRHVC may be a treatment option that offers the benefits of minimally invasive surgery without compromising oncologic outcomes. [Extracted from the article]