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An 80-year-old man experienced lack of efficacy during treatment with amiodarone, calcium gluconate, magnesium sulfate, and sodium bicarbonate for monomorphic ventricular tachycardia. Prior to seeking medical help, he had consumed Nirmashi (delphinium species) to treat gastric acidity, resulting in poisoning symptoms. Despite receiving various treatments, including lidocaine and phenytoin, he continued to have cardiac issues, eventually requiring vasopressor support before gradually recovering and being discharged after six days of hospitalization. [Extracted from the article]

A 34-year-old woman experienced lack of efficacy when treated with adenosine for atrioventricular nodal reentrant tachycardia (AVNRT). She presented with symptoms of ingesting an unspecified substance, including vomiting, restlessness, palpitations, and shortness of breath. The woman was diagnosed with cartap poisoning and high anion gap metabolic acidosis, and was successfully treated with sodium bicarbonate, acetylcysteine, and magnesium-sulfate. Despite initial treatment with adenosine, her AVNRT did not improve, and she was eventually treated with amiodarone for successful cardioversion. She was discharged in stable condition after a seven-day hospitalization, with a prescription for fluoxetine for depression. [Extracted from the article]

A 56-year-old woman with moderate persistent asthma, obesity, and active tobacco use experienced lack of efficacy during treatment with methylprednisolone and magnesium sulfate for status asthmaticus. Despite receiving these treatments along with a nebulizer, her respiratory status did not improve, leading to intubation and ventilation due to severe respiratory acidosis. After being paralyzed with vecuronium-bromide infusion and receiving other interventions, she was successfully liberated from the ventilator on day 3 with uneventful recovery. [Extracted from the article]

A 39-year-old woman with Ehler-Danlos syndrome experienced lack of efficacy when treated with epinephrine, magnesium sulfate, and morphine for expiratory central airway collapse. She presented to the hospital with wheezing and shortness of breath, having had frequent hospitalizations and intubations in the past year. Despite initial treatment, she required emergent intubation, leading to a diagnosis of expiratory central airway collapse with vocal cord dysfunction. Tracheo-bronchoplasty with tracheostomy was recommended for further management. [Extracted from the article]

A 32-year-old woman with a history of thrombotic thrombocytopenic purpura (TTP) and preeclampsia received treatment during her pregnancy, including methylprednisolone, plasma, magnesium sulfate, and labetalol. Despite the treatment, she experienced a lack of efficacy with methylprednisolone for TTP. The woman delivered a healthy neonate via cesarean section at 26 weeks gestation. After delivery, she continued to receive medication for TTP. [Extracted from the article]

A 16-year-old girl with acute promyelocytic leukaemia developed QT prolongation while undergoing treatment with cytarabine, daunorubicin, mitoxantrone, and pirarubicin. She had a history of congenital long QT syndrome and was previously treated with mexiletine and nadolol. The QT prolongation was attributed to the anthracycline drugs used in her treatment, but her QT interval returned to baseline after three days. Despite this complication, she achieved complete remission and was on intermittent maintenance therapy with tretinoin at the time of discharge. [Extracted from the article]

A 60-year-old woman experienced hypermagnesemia while being treated with magnesium sulfate for hypomagnesemia. She had a history of melena and had previously undergone a subtotal gastrectomy. After receiving an oral solution of magnesium sulfate, she lost consciousness and was diagnosed with magnesium poisoning. She received various treatments in the intensive care unit, including calcium gluconate, sodium chloride, diprophylline, metaraminol bitartrate, and furosemide. Eventually, she underwent continuous renal replacement therapy, which successfully reduced her serum magnesium levels. Her symptoms improved, and she was discharged after conservative treatments. [Extracted from the article]

This article presents two case reports involving a 40-year-old woman and a neonate who experienced lack of efficacy during treatment with methylthioninium-chloride and ascorbic-acid for acquired methemoglobinemia. The woman received these medications, along with sodium-chloride and magnesium-sulfate, during the third trimester of pregnancy. The woman recovered and was discharged without any complications, but unfortunately, the neonate's condition continued to deteriorate and ultimately resulted in death. This suggests that the medications were not effective in treating the neonate's condition. [Extracted from the article]

A 47-year-old woman with asthma experienced a lack of efficacy during treatment with various medications, including epinephrine, magnesium sulfate, ketamine, β-adrenergic-receptor-agonists, and corticosteroids. Despite receiving these treatments, her condition did not improve, and she required intubation. Additional interventions, such as femoral-jugular venovenous extracorporeal membrane oxygenation (VV-ECMO) and radiotherapy, were attempted, but the woman ultimately succumbed to widespread cancer metastasis. The article provides a detailed account of the patient's medical history and treatment, highlighting the challenges faced in managing her condition. [Extracted from the article]

A 28-year-old woman developed hypermagnesaemia while being treated with magnesium sulfate for eclampsia prophylaxis. She also experienced a lack of efficacy with labetalol, nifedipine, and hydralazine for preeclampsia. The woman was diagnosed with preeclampsia at 24 weeks of gestation and received oral labetalol and nifedipine, as well as aspirin. Despite treatment, her blood pressure remained elevated, and IV hydralazine was added. She underwent a caesarean section and delivered a neonate who was transferred to the neonatal ICU. The woman experienced quadriparesis, encephalopathy, acute kidney injury, and HELLP syndrome. She was treated with transfusions, calcium gluconate, and dialysis, which led to improvement in her condition. However, her hypertension persisted, indicating a lack of efficacy with the antihypertensive medications. [Extracted from the article]

A 52-year-old man experienced an episode of syncope, wide complex tachycardia, and a brugada pattern after taking an overdose of nortriptyline while being treated for depression and bipolar disorder. He mistakenly took 5 tablets of nortriptyline 75mg instead of his previous dose of 5 pills of nortriptyline 25mg. Upon arrival at the emergency department, he received treatment with magnesium sulfate, sodium bicarbonate, and amiodarone, which improved his heart rate and normalized his QRS duration. A transthoracic echocardiogram showed normal left ventricular function. [Extracted from the article]

A male foetus experienced bladder rupture after being exposed to remifentanil, fentanyl, and nalbuphine in utero. The mother was hospitalized with lung failure and severe sepsis during pregnancy. The foetus initially had normal monitoring, but an enlarged bladder was later observed. The mother underwent a caesarean delivery, and the neonate received immediate resuscitation and surgery to repair the bladder. The neonate ultimately made a full recovery. [Extracted from the article]

A 3-month-old boy with a history of abdominal distension, jaundice, biliary atresia, and poor feeding was admitted to the hospital for suspected sepsis. He was diagnosed with Pseudomonas infection, Acinetobacter infection, and Candida palmioleophila candidaemia. The boy received multiple treatments including antibacterials, antifungals, and magnesium sulfate, but his symptoms did not improve. He was transferred to the ICU and his treatment was changed, but he ultimately died from bradycardia and hypoxemia. The case highlights a lack of efficacy in the treatments administered. [Extracted from the article]

In a retrospective study of pregnant women, a 27-year-old woman with antepartum eclampsia (APE) exhibited no therapeutic response while being treated with magnesium sulfate and unspecified antiepileptic drugs during pregnancy. Despite receiving treatment, her seizures were intractable and her neurological status deteriorated. She also had hypothyroidism and tested positive for COVID-19. After undergoing a Caesarean section, her condition worsened and she eventually died. The study highlights the lack of therapeutic response in this particular case and the rapid progression of COVID-19 leading to her death. [Extracted from the article]

Author InformationAn event is serious (based on the ICH definition) when the patient outcome is:• * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important eventA woman in her 20s developed severe hypocalcaemia secondary to hypermagnesaemia during treatment with magnesium sulfate for fetal neuroprotection during pregnancy. [Extracted from the article]

Author InformationAn event is serious (based on the ICH definition) when the patient outcome is:• * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important eventA 32-year-old woman developed magnesium sulfate toxicity in the form of progressive weakness, slurred speech, tongue paresis, visual disturbances and bradycardia during treatment with magnesium sulfate for HELLP syndrome [route not stated]. [Extracted from the article]

This document provides a list of drugs associated with non-serious adverse events identified in the scientific literature over the last week. The table includes the drug names, the adverse events reported, and the number of cases. Some of the drugs mentioned include Cannabidiol, Clodronic acid, Doxycycline, Elasomeran, Tozinameran, Furazolidone, Insulin, Lenalidomide, Levodopa/carbidopa, Levofloxacin, Magnesium sulfate, Oxaliplatin, Treprostinil, and Voriconazole. The adverse events range from diaphoresis and tachycardia to injection site pain and delayed hypersensitivity. [Extracted from the article]

In a retrospective study of 229 patients, a case was described of a patient who developed an abnormal heart rate while receiving combination therapy with corticotropin and magnesium sulfate for infantile spasm. The patient had previously been treated for infantile spasm but it was unsuccessful, leading to the use of the combination therapy. However, the patient experienced an abnormal heart rate as a result of the treatment. The study does not provide information on the patient's age, sex, or the outcome of the reaction. [Extracted from the article]

Both neonates were initiated on parenteral nutrition with soya oil emulsion [Intralipid] 20% infusion via an umbilical venous catheter infusion pump. For twin 2, the soya oil emulsion bag was changed on day 2 of life and the infusion pump was reset with an intention to deliver the daily 15.9mL (i.e., 12.5 mL/kg) dose over 24 hours. [Extracted from the article]

The table below provides a list of the drugs associated with non-serious adverse events identified in the scientific literature over the last week. Reactions Weekly 21 Jun 2023. [Extracted from the article]

He underwent colonoscopy with bowel preparation containing potassium chloride tablet along with magnesium sulfate and sodium sulfate. For colonoscopy she received bowel preparation containing potassium chloride tablet along with magnesium sulfate and sodium sulfate. For colonoscopy she received bowel preparation containing potassium chloride tablet along with magnesium sulfate and sodium sulfate. [Extracted from the article]

Hypersensitivity Reaction to Magnesium Sulfate Infusion in Gitelman Syndrome. Type I hypersensitivity reaction in the form of erythematous and pruritic rash was attributed to magnesium sulfate. The woman, who had Gitelman syndrome, started receiving oral magnesium sulfate supplementation and daily IV infusions of magnesium sulfate for repeated episodes of severe hypomagnesaemia. [Extracted from the article]

However, her BP was unmanageable, indicating lack of efficacy to methyldopa, magnesium sulfate and unspecified calcium-channel antagonist. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 38-year-old woman exhibited lack of efficacy to methyldopa, magnesium sulfate and unspecified calcium-channel antagonist during treatment for chronic gestational hypertension during pregnancy [ I dosages, routes and pregnancy outcome not stated i ] The primigravida woman with uterine fibroids was hospitalised due to superimposed preeclampsia at 28 weeks of gestation. [Extracted from the article]

Laboratory work up revealed creatinine of 3.3 mg/dL, calcium of 8 mg/dL, magnesium of 10.8 mg/dL (hypermagnesaemia), PH of 7.12, partial pressure of CO2 28mm Hg, bicarbonate of 9 mmol/L. Urine output was >=2 L/day. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 73-year-old man developed hypermagnesaemia during treatment with magnesium sulfate for constipation [ I dosage and duration of treatment to reaction onset not stated i ]. He was transferred to the intensive care unit and therapy was repeated and sodium chloride was added to the therapy. [Extracted from the article]

One early morning in December 2020, he was brought to the emergency room (ER) with an acute episode of bilateral lower limb weakness. Additionally, he developed hypermagnesaemia during treatment with magnesium sulfate for TPP [ I durations of treatments to reaction onset not stated; not all outcomes stated i ]. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 35-year-old man developed thyrotoxic periodic paralysis (TPP) following administration of contrast agent iodixanol. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: Drug overdose * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 53-year-old woman developed drug toxicity in the form of hypotension, sinus bradycardia, QTc interval prolongation and polymorphic ventricular tachycardia following intentional overdose and misuse of sotalol. Subsequent electrocardiogram (EKG) showed sinus bradycardia without QTc interval prolongation. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 28-year-old man exhibited lack of efficacy with sodium bicarbonate, magnesium sulfate and unspecified vasopressors, while being treated for prolonged QTc and premature ventricular contractions. He received unspecified vasopressors, boluses of sodium bicarbonate and magnesium sulfate [ I dosages not stated i ] along with IV fluids and rapid sequence intubation without improvement (lack of efficacy). [Extracted from the article]

Chest X-ray revealed worsening perihilar infiltrates, indicating acute pulmonary oedema. It was concluded that she developed magnesium sulfate-induced pulmonary oedema, causing acute hypoxic respiratory failure [ I time to reaction onset not clearly stated i ]. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 60-year-old woman developed pulmonary oedema during treatment with magnesium sulfate for low magnesium level. [Extracted from the article]

Later, she was treated with lorazepam, levetiracetam and phenytoin for tonic-clonic seizure control, and labetalol and hydralazine for hypertension. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 30-year-old woman exhibited a lack of efficacy during treatment with magnesium sulfate during delivery and propofol sedation for tonic-clonic seizure [ I not all routes and dosages stated i ]. Regardless of propofol sedation and therapeutic levels of magnesium sulfate, she had ongoing fitting (lack of efficacy) along with hypertension. [Extracted from the article]

Additionally, she developed headache and hypoaesthesia during treatment with epinephrine for allergic asthma [ I not all dosages and routes stated i ]. From admission day 15-53, she presented 50 episodes of bronchospasm and received a total of IV bolus of epinephrine 6.85mg, SC epinephrine 5mg and inhalation epinephrine 21.5mg as inhalation aerosol. [Extracted from the article]