1. Pre‐existing inflammation reduces the response to contact allergens in Tmem79‐deficient mice.
- Author
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Jee, Mia Hamilton, Funch, Anders Boutrup, Weber, Julie Friis, Yeung, Kelvin, Mraz, Veronika, Gadsbøll, Anne‐Sofie Østergaard, Song, Tinghuan, Woetmann, Anders, Ødum, Niels, Johansen, Jeanne Duus, Geisler, Carsten, and Bonefeld, Charlotte Menné
- Subjects
ALLERGENS ,MICE - Abstract
The study investigated whether patients with atopic dermatitis (AD) have an altered response to contact allergens compared to those without AD. The researchers compared the response to a contact allergen in mice with different skin conditions. They found that mice with impaired skin barrier and pre-existing skin inflammation had a reduced inflammatory response to the allergen compared to mice with healthy skin or impaired skin barrier without inflammation. The study suggests that pre-existing skin inflammation can suppress immune responses to new allergens, which may have implications for future research in contact allergy and dermal vaccine development. [Extracted from the article]
- Published
- 2024
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