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Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus.

Authors :
Buus, Terkild Brink
Ødum, Niels
Geisler, Carsten
Holst Lauritsen, Jens Peter
Source :
Nature Communications; 12/4/2017, Vol. 8 Issue 1, p1-13, 13p, 1 Diagram, 6 Graphs
Publication Year :
2017

Abstract

Murine γδ T cells include subsets that are programmed for distinct effector functions during their development in the thymus. Under pathological conditions, different γδ T cell subsets can be protective or can exacerbate a disease. Here we show that CD117, CD200 and CD371, together with other markers, identify seven developmental stages of γδ T cells. These seven stages can be divided into three distinct developmental pathways that are enriched for different TCRδ repertoires and exhibit characteristic expression patterns associated with adaptive (γδTn), IFN-γ-producing (γδT1) and IFN-γ/IL-4-co-producing γδ T cells (γδNKT). Developmental progression towards both IFN-γ-producing subsets can be induced by TCR signalling, and each pathway results in thymic emigration at a different stage. Finally, we show that γδT1 cells are the predominating IFN-γ-producing subset developing in the adult thymus. Thus, this study maps out three distinct development pathways that result in the programming of γδTn, γδT1 and γδNKT cells. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Complementary Index
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
144690529
Full Text :
https://doi.org/10.1038/s41467-017-01963-w