Pre‐existing inflammation reduces the response to contact allergens in Tmem79‐deficient mice.

The study investigated whether patients with atopic dermatitis (AD) have an altered response to contact allergens compared to those without AD. The researchers compared the response to a contact allergen in mice with different skin conditions. They found that mice with impaired skin barrier and pre-existing skin inflammation had a reduced inflammatory response to the allergen compared to mice with healthy skin or impaired skin barrier without inflammation. The study suggests that pre-existing skin inflammation can suppress immune responses to new allergens, which may have implications for future research in contact allergy and dermal vaccine development. [Extracted from the article]