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Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor: A Case Report.

Authors :
Kongsbak-Wismann, Martin
Al-Jaberi, Fatima A. H.
Schmidt, Jonas Damgård
Ghanizada, Mustafa
Hansen, Cecilie Bo
Lopez, Daniel Villalba
Woetmann, Anders
Ødum, Niels
Bonefeld, Charlotte Menné
Stryhn, Anette
Garred, Peter
Buus, Søren
Geisler, Carsten
Source :
Frontiers in Immunology; 9/30/2021, Vol. 12, p1-7, 7p
Publication Year :
2021

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has severely impacted daily life all over the world. Any measures to slow down the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to decrease disease severity are highly requested. Recent studies have reported inverse correlations between plasma levels of vitamin D and susceptibility to SARS-CoV-2 infection and COVID-19 severity. Therefore, it has been proposed to supplement the general population with vitamin D to reduce the impact of COVID-19. However, by studying the course of COVID-19 and the immune response against SARS-CoV-2 in a family with a mutated, non-functional vitamin D receptor, we here demonstrate that vitamin D signaling was dispensable for mounting an efficient adaptive immune response against SARS-CoV-2 in this family. Although these observations might not directly be transferred to the general population, they question a central role of vitamin D in the generation of adaptive immunity against SARS-CoV-2. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16643224
Volume :
12
Database :
Complementary Index
Journal :
Frontiers in Immunology
Publication Type :
Academic Journal
Accession number :
152742851
Full Text :
https://doi.org/10.3389/fimmu.2021.758154