107 results on '"Xiaorui Cheng"'
Search Results
2. The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease
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He Li, Tianyuan Ye, Xingyang Liu, Rui Guo, Xiuzhao Yang, Yangyi Li, Dongmei Qi, Yihua Wei, Yifan Zhu, Lei Wen, and Xiaorui Cheng
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Alzheimer's disease ,Microglia ,Immune ,Crosstalk ,Chemokine ,Colony-stimulating factor ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Based on single-cell sequencing of the hippocampi of 5× familiar Alzheimer's disease (5× FAD) and wild type mice at 2-, 12-, and 24-month of age, we found an increased percentage of microglia in aging and Alzheimer's disease (AD) mice. Blood brain barrier injury may also have contributed to this increase. Immune regulation by microglia plays a major role in the progression of aging and AD, according to the functions of 41 intersecting differentially expressed genes in microglia. Signaling crosstalk between C−C motif chemokine ligand (CCL) and major histocompatibility complex-1 bridges intercellular communication in the hippocampus during aging and AD. The amyloid precursor protein (APP) and colony stimulating factor (CSF) signals drive 5× FAD to deviate from aging track to AD occurrence among intercellular communication in hippocampus. Microglia are involved in the progression of aging and AD can be divided into 10 functional types. The strength of the interaction among microglial subtypes weakened with aging, and the CCL and CSF signaling pathways were the fundamental bridge of communication among microglial subtypes.
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- 2023
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3. Causal Relationship Between Basal Metabolic Rate and Alzheimer’s Disease: A Bidirectional Two-sample Mendelian Randomization Study
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Yuexiao Zou, Qingxian Wang, and Xiaorui Cheng
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Basal metabolic rate ,Alzheimer’s disease ,Mendelian randomization ,Causal relationship ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Introduction Objective observational studies have shown that basal metabolic rate (BMR) decreases in patients with Alzheimer’s disease (AD), but the causal relationship between BMR and AD has not been established. We determined the causal relationship between BMR and AD by two-way Mendelian randomization (MR) and investigated the impact of factors associated with BMR on AD. Methods We obtained BMR (n = 454,874) and AD from a large genome-wide association study (GWAS) database (21,982 patients with AD, 41,944 controls). The causal relationship between AD and BMR was investigated using two-way MR. Additionally, we identified the causal relationship between AD and factors related with BMR, hyperthyroidism (hy/thy) and type 2 diabetes (T2D), height and weight. Results BMR had a causal relationship with AD [451 single nucleotide polymorphisms (SNPs), odds ratio (OR) 0.749, 95% confidence intervals (CIs) 0.663–0.858, P = 2.40E-03]. There was no causal relationship between hy/thy or T2D and AD (P > 0.05). The bidirectional MR showed that there was also a causal relationship between AD and BMR (OR 0.992, Cls 0.987–0.997, N SNPs18, P = 1.50E−03). BMR, height and weight have a protective effect on AD. Based on MVMR analysis, we found that genetically determined height and weight may be adjusted by BMR to have a causal effect on AD, not height and weight themselves. Conclusion Our study showed that higher BMR reduced the risk of AD, and patients with AD had a lower BMR. Because of a positive correlation with BMR, height and weight may have a protective effect on AD. The two metabolism-related diseases, hy/thy and T2D, had no causal relationship with AD.
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- 2023
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4. Qi-fu-yin attenuated cognitive disorders in 5xFAD mice of Alzheimer's disease animal model by regulating immunity
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Xiuzhao Yang, Tianyuan Ye, Yun He, Lei Wen, and Xiaorui Cheng
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Qi-fu-yin ,Alzheimer's disease ,learning and memory ,cytokine ,5xFAD mice ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
IntroductionCognitive impairment is the main symptom of Alzheimer's disease (AD). Accumulating evidence implicate that immunity plays an important role in AD. Here, we investigated the effect of Qi-fu-yin (QFY) on cognitive impairment and cytokine secretion of 5xFAD mice.MethodsWe used 2.5-month-old 5xFAD transgenic mice for behavioral tests to observe the changes in cognitive function after QFY treatment. After the behavioral experiment, the whole brain, cortex and plasma of each mouse were collected for soluble Aβ analysis, immunohistochemical experiment and cytokine analysis.ResultsHere we found that the treatment of QFY ameliorated the ability of object recognition, passive avoidance responses and the ability of spatial learning and memory in 5xFAD mice. The deposits of β1 − 42 and Aβ1 − 40 were alleviated and the ration of Aβ1 − 42/Aβ1 − 40 was decrease in the plasma and brain of 5xFAD mice administrated with QFY. The administration of QFY promoted the secretion of anti-inflammatory cytokines, IL-5, IL-10 and G-CSF, and reduced the content of proinflammatory cytokines IFN-γ in plasma of 5xFAD mice. Notably, we found that the treatment of QFY decreased the concentration of CCL11 in the brain and plasma of 5xFAD mice.ConclusionThis suggested that QFY improved cognition and reduced Aβ deposits in 5xFAD mice by regulating abnormal immunity in 5xFAD mice. QFY may be as a potential therapeutic agent for AD.
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- 2023
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5. A Tuberculosis Detection Method Using Attention and Sparse R-CNN.
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Xuebin Xu, Jiada Zhang, Xiaorui Cheng, Longbin Lu, Yuqing Zhao, Zongyu Xu, and Zhuangzhuang Gu
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- 2022
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6. Identification of the molecular subgroups in Alzheimer's disease by transcriptomic data
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He Li, Meiqi Wei, Tianyuan Ye, Yiduan Liu, Dongmei Qi, and Xiaorui Cheng
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Alzheimer's disease ,heterogeneity ,molecular subtype ,transcriptomics ,diagnosis ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
BackgroundAlzheimer's disease (AD) is a heterogeneous pathological disease with genetic background accompanied by aging. This inconsistency is present among molecular subtypes, which has led to diagnostic ambiguity and failure in drug development. We precisely distinguished patients of AD at the transcriptome level.MethodsWe collected 1,240 AD brain tissue samples collected from the GEO dataset. Consensus clustering was used to identify molecular subtypes, and the clinical characteristics were focused on. To reveal transcriptome differences among subgroups, we certificated specific upregulated genes and annotated the biological function. According to RANK METRIC SCORE in GSEA, TOP10 was defined as the hub gene. In addition, the systematic correlation between the hub gene and “A/T/N” was analyzed. Finally, we used external data sets to verify the diagnostic value of hub genes.ResultsWe identified three molecular subtypes of AD from 743 AD samples, among which subtypes I and III had high-risk factors, and subtype II had protective factors. All three subgroups had higher neuritis plaque density, and subgroups I and III had higher clinical dementia scores and neurofibrillary tangles than subgroup II. Our results confirmed a positive association between neurofibrillary tangles and dementia, but not neuritis plaques. Subgroup I genes clustered in viral infection, hypoxia injury, and angiogenesis. Subgroup II showed heterogeneity in synaptic pathology, and we found several essential beneficial synaptic proteins. Due to presenilin one amplification, Subgroup III was a risk subgroup suspected of familial AD, involving abnormal neurogenic signals, glial cell differentiation, and proliferation. Among the three subgroups, the highest combined diagnostic value of the hub genes were 0.95, 0.92, and 0.83, respectively, indicating that the hub genes had sound typing and diagnostic ability.ConclusionThe transcriptome classification of AD cases played out the pathological heterogeneity of different subgroups. It throws daylight on the personalized diagnosis and treatment of AD.
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- 2022
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7. NAMRTNet: Automatic Classification of Sleep Stages Based on Improved ResNet-TCN Network and Attention Mechanism
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Xuebin Xu, Chen Chen, Kan Meng, Longbin Lu, Xiaorui Cheng, and Haichao Fan
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sleep stage classification ,sleep quality assessment ,single-channel EEG signals ,deep learning ,long time series ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Sleep, as the basis for regular body functioning, can affect human health. Poor sleep conditions can lead to various physical ailments, such as poor immunity, memory loss, slow cognitive development, and cardiovascular diseases. Along the increasing stress in society comes with a growing surge in conditions associated with sleep disorders. Studies have shown that sleep stages are essential for the body’s memory, immune system, and brain functioning. Therefore, automatic sleep stage classification is of great medical practice importance as a basis for monitoring sleep conditions. Although previous research into the classification of sleep stages has been promising, several challenges remain to be addressed: (1) The EEG signal is a non-smooth signal with harrowing feature extraction and high requirements for model accuracy. (2) Some existing network models suffer from overfitting and gradient descent. (3) Correlation between long time sequences is challenging to capture. This paper proposes NAMRTNet, a deep model architecture based on the original single-channel EEG signal to address these challenges. The model uses a modified ResNet network to extract features from sub-epochs of individual epochs, a lightweight attention mechanism normalization-based attention module (NAM) to suppress insignificant features, and a temporal convolutional network (TCN) network to capture dependencies between features of long time series. The recognition rate of 20-fold cross-validation with the NAMRTNet model for Fpz-cz channel data in the public sleep dataset Sleep-EDF was 86.2%. The experimental results demonstrate the network’s superiority in this paper, surpassing some state-of-the-art techniques in different evaluation metrics. Furthermore, the total time to train the network was 5.1 h, which was much less than the training time of other models.
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- 2023
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8. Genomic Analysis of Amphioxus Reveals a Wide Range of Fragments Homologous to Viral Sequences
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Qiao Du, Fang Peng, Qing Xiong, Kejin Xu, Kevin Yi Yang, Mingqiang Wang, Zhitian Wu, Shanying Li, Xiaorui Cheng, Xinjie Rao, Yuyouye Wang, Stephen Kwok-Wing Tsui, and Xi Zeng
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amphioxus ,virus ,homologous fragment ,evolution ,Microbiology ,QR1-502 - Abstract
Amphioxus species are considered living fossils and are important in the evolutionary study of chordates and vertebrates. To explore viral homologous sequences, a high-quality annotated genome of the Beihai amphioxus (Branchiostoma belcheri beihai) was examined using virus sequence queries. In this study, 347 homologous fragments (HFs) of viruses were identified in the genome of B. belcheri beihai, of which most were observed on 21 genome assembly scaffolds. HFs were preferentially located within protein-coding genes, particularly in their CDS regions and promoters. A range of amphioxus genes with a high frequency of HFs is proposed, including histone-related genes that are homologous to the Histone or Histone H2B domains of viruses. Together, this comprehensive analysis of viral HFs provides insights into the neglected role of viral integration in the evolution of amphioxus.
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- 2023
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9. Decoction on Major Depressive Disorder based on Network Pharmacology and Molecular Docking
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Xiaorui Cheng, Liyuan Chen, Tianyuan Ye, Xiaolong Wang, Lu Han, Tongxing Wang, and Dongmei Qi
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Organic Chemistry ,Drug Discovery ,General Medicine ,Computer Science Applications - Abstract
Background and Aim: Major Depressive Disorder (MDD) is a common affective disorder. GuiPi decoction (GPD) is used to treat depression in China, Japan, and Korea. However, its effective ingredients and antidepressant mechanisms remain unclear. We attempted to reveal the potential mechanisms of GPD in the treatment of MDD by network pharmacology and molecular docking. In addition, we conducted an enzymatic activity assay to validate the results of molecular docking. Methods: GPD-related compounds and targets, and MDD-related targets were retrieved from databases and literature. The herb-compound-target network was constructed by Cytoscape. The protein- protein interaction network was built using the STRING database to find key targets of GPD on MDD. Enrichment analysis of shared targets was analyzed by MetaCore database to obtain the potential pathway and biological process of GPD on MDD. The main active compounds treating MDD were screened by molecular docking. The PDE4s inhibitors were screened and verified by an enzyme activity assay. Results: GPD contained 1222 ingredients and 190 potential targets for anti-MDD. Possible biological processes regulated by GPD were neurophysiological processes, blood vessel morphogenesis, Camp Responsive Element Modulator (CREM) pathway, and Androgen Receptor (AR) signaling crosstalk in MDD. Potential pathways in MDD associated with GPD include neurotransmission, cell differentiation, androgen signaling, and estrogen signaling. Fumarine, m-cresol, quercetin, betasitosterol, fumarine, taraxasterol, and lupeol in GPD may be the targets of SLC6A4, monoamine oxidase A (MAOA), DRD2, OPRM1, HTR3A, Albumin (ALB), and NTRK1, respectively. The IC50 values of trifolin targeting Phosphodiesterase (PDE) 4A and girinimbine targeting PDE4B1 were 73.79 μM and 31.86 μM, respectively. The IC50 values of girinimbine and benzo[a]carbazole on PDE4B2 were 51.62 μM and 94.61 μM, respectively. Conclusion: Different compounds in GPD may target the same protein, and the same component in GPD can target multiple targets. These results suggest that the effects of GPD on MDD are holistic and systematic, unlike the pattern of one drug-one target.
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- 2023
10. Effect of inlet sweepback angle on the cavitation performance of an inducer
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Xiaorui Cheng, Yibin Li, and Shuyan Zhang
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inducer ,sweepback angle ,cavitation ,simulation ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
In order to study the effects of inlet sweepback angle on the cavitation performance of inducers based on the Reynolds N-S equation, RNG k-ε turbulent model, and Schnerr and Sauer cavitation model, a three-dimensional numerical calculation is employed to study the flow characteristics of a certain LNG pump. Laws of the variation of cavitation performance, head, and efficiency with the change of sweepback were studied. Numerical analysis of the eight inducer projects with a sweepback angle from 120° to 290° was carried out. The results show that the cavitation bubbles first appear at the suction surface near the inlet side. With the decrease of net positive suction head (NPSHa), the bubbles spread to the outlet side of the inducer and the pressure surface. Finally, they fill the entire channel. When the inducer sweepback angle increases from 120° to 270°, the NPSHr of the pump reduces gradually, that is to say that the anti-cavitation performance of the pump has been improved. However, the NPSHr of the pump increases gradually when the inducer sweepback angle increases from 270° to 290°. In other words, there is an optimal sweepback from 120° to 290°, and efficiency and head of pump tend to be stable near the optimal sweepback.
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- 2019
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11. Study on the influence of blade outlet cutting on hydraulic noise of centrifugal pump with low specific speed
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Xiaorui Cheng, Tianpeng Li, and Peng Wang
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Mechanical engineering and machinery ,TJ1-1570 - Abstract
In order to study the influence of blade outlet cutting width on hydrodynamic excitation noise of the centrifugal pump with low specific speed, five schemes are used to perform V-shaped cutting on the outlet of the impeller blade are studied in this study. Based on Lighthill acoustic analogy, combining computational fluid dynamics and computational acoustics, RNG k-ε turbulence model is used to calculate internal unsteady flow field of the centrifugal pump, and the acoustic solution is based on the flow field calculation. The results show that the pressure pulsation can reflect the sound pressure level to a certain extent; proper cutting of the blade outlet can improve the flow state of the rear cavity of the centrifugal pump and make the flow uniform; the V-shaped cutting of the blade outlet also can reduce the dynamic and static interference between the impeller outlet and the volute tongue, effectively reducing the sound pressure level of the internal sound field, when the blade outlet cutting width is a / b 2 = 33.33%, the inlet sound pressure level and the outlet sound pressure level are decreased by 4.8% and 7.2%, respectively. In terms of internal sound field, the sound pressure level at the outlet of the pump is obviously higher than that at the inlet.
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- 2020
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12. Comparison of Donepezil, Memantine, Melatonin, and Liuwei Dihuang Decoction on Behavioral and Immune Endocrine Responses of Aged Senescence-Accelerated Mouse Resistant 1 Mice
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Ju Zeng, Xiaorui Zhang, Jianhui Wang, Xiaorui Cheng, Yongxiang Zhang, and Wenxia Zhou
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aging ,Liuwei Dihuang decoction ,cognition ,immune response ,inflammation ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Aging is a natural biological process associated with cognitive decline and neuroendocrine–immune system changes; the neuroendocrine–immune system plays crucial role in brain aging and neurodegeneration, and it is essential to discern beneficial attempts to delay the aging progress based on immunological aging. In this study, we have investigated the effects of Traditional Chinese Medicine (TCM)—Liuwei Dihuang decoction (LW)—and donepezil, memantine, and melatonin on cognitive decline in aging mice. The aged SAMR1 mice received oral administration of donepezil (1mg/kg), memantine (10 mg/kg), melatonin (10 mg/kg), and LW (10 g/kg) for 3 months. A shuttle box, Morris water maze, and elevated-zero maze were performed to assess cognitive function, and flowcytometry, Luminex, and radioimmunoassay were performed to measure the lymphocyte subsets, inflammatory factors, and hormones. We observed that survival days of mice was increased with melatonin and LW, the anxiety behavior was significantly improved by memantine, melatonin, and LW treatment, active avoidance responses significantly improved by LW, donepezil, and memantine, the spatial learning ability was significantly improved by donepezil, and LW and melatonin were beneficial to the spatial memory of old mice. For immune function, LW increased CD4+ and CD4+CD28+ cells and reduced TNF-α, IL-1β, and G-CSF in plasma, and it also promoted the secretion of anti-inflammatory factors IL-4, IL-5, and IL-10 by regulating the active of Th2 cells in spleen. Donepezil and memantine exerted protective effects against CD4+CD28+ cell decrease caused by aging and reduced the pro-inflammatory factors TNF-α, IL-1β, and G-CSF in plasma. Melatonin could reverse CD8+CD28+ cell imbalances and increased B cells. For endocrine factors, LW increased TSH levels in the pituitary, and melatonin increased the GH level in blood. Our findings indicated that LW improved the cognitive decline in aging mice, and this might be associated with modulation of the active T cells and HPG axis hormones as well as increasing anti-inflammatory factors. Meanwhile, donepezil and memantine have advantages in regulating adaptive immunity, melatonin has advantages in the regulation of B cells and pituitary hormones, and LW exhibits a better effect on neuroendocrine immune function compared with the others from a holistic point of view. LW might be a potential therapeutic strategy for anti-aging-related syndromes, and it can also provide a value on medication guidance about drug combinations or treatment in clinic.
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- 2020
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13. LINCS Dataset-Based Repositioning of Dutasteride as an Anti-Neuroinflammation Agent
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Dan Luo, Lu Han, Shengqiao Gao, Zhiyong Xiao, Qingru Zhou, Xiaorui Cheng, Yongxiang Zhang, and Wenxia Zhou
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neuroinflammation ,cognitive impairment ,drug repurposing ,LINCS ,dutasteride ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Neuroinflammation is often accompanied by central nervous system (CNS) injury seen in various CNS diseases, with no specific treatment. Drug repurposing is a strategy of finding new uses for approved or investigational drugs, and can be enabled by the Library of Integrated Network-based Cellular Signatures (LINCS), a large drug perturbation database. In this study, the signatures of Lipopolysaccharide (LPS) were compared with the signatures of compounds contained in the LINCS dataset. To the top 100 compounds obtained, the Quantitative Structure-Activity Relationship (QSAR)-based tool admetSAR was used to identify the top 10 candidate compounds with relatively high blood–brain barrier (BBB) penetration. Furthermore, the seventh-ranked compound, dutasteride, a 5-α-reductase inhibitor, was selected for in vitro and in vivo validation of its anti-neuroinflammation activity. The results showed that dutasteride significantly reduced the levels of IL-6 and TNF-α in the supernatants of LPS-stimulated BV2 cells, and decreased the levels of IL-6 in the hippocampus and plasma, and the number of activated microglia in the brain of LPS administration mice. Furthermore, dutasteride also attenuated the cognitive impairment caused by LPS stimulation in mice. Taken together, this study demonstrates that the LINCS dataset-based drug repurposing strategy is an effective approach, and the predicted candidate, dutasteride, has the potential to ameliorate LPS-induced neuroinflammation and cognitive impairment.
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- 2021
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14. NAMRTNet: Automatic Classification of Sleep Stages Based on Improved ResNet-TCN Network and Attention Mechanism
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Fan, Xuebin Xu, Chen Chen, Kan Meng, Longbin Lu, Xiaorui Cheng, and Haichao
- Subjects
sleep stage classification ,sleep quality assessment ,single-channel EEG signals ,deep learning ,long time series - Abstract
Sleep, as the basis for regular body functioning, can affect human health. Poor sleep conditions can lead to various physical ailments, such as poor immunity, memory loss, slow cognitive development, and cardiovascular diseases. Along the increasing stress in society comes with a growing surge in conditions associated with sleep disorders. Studies have shown that sleep stages are essential for the body’s memory, immune system, and brain functioning. Therefore, automatic sleep stage classification is of great medical practice importance as a basis for monitoring sleep conditions. Although previous research into the classification of sleep stages has been promising, several challenges remain to be addressed: (1) The EEG signal is a non-smooth signal with harrowing feature extraction and high requirements for model accuracy. (2) Some existing network models suffer from overfitting and gradient descent. (3) Correlation between long time sequences is challenging to capture. This paper proposes NAMRTNet, a deep model architecture based on the original single-channel EEG signal to address these challenges. The model uses a modified ResNet network to extract features from sub-epochs of individual epochs, a lightweight attention mechanism normalization-based attention module (NAM) to suppress insignificant features, and a temporal convolutional network (TCN) network to capture dependencies between features of long time series. The recognition rate of 20-fold cross-validation with the NAMRTNet model for Fpz-cz channel data in the public sleep dataset Sleep-EDF was 86.2%. The experimental results demonstrate the network’s superiority in this paper, surpassing some state-of-the-art techniques in different evaluation metrics. Furthermore, the total time to train the network was 5.1 h, which was much less than the training time of other models.
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- 2023
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15. Influence of the Impeller/Guide Vane Clearance Ratio on the Performances of a Nuclear Reactor Coolant Pump
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Xiang Liu, Xiaorui Cheng, and Boru Lv
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Impeller ,Materials science ,Nuclear reactor coolant ,Nuclear engineering ,General Materials Science - Published
- 2022
16. FERTNet: Automatic Sleep Stage Scoring Method Based on Frame Level and Epoch Level
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Xuebin Xu, Chen Chen, Kan Meng, Xiaorui Cheng, and Haichao Fan
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- 2023
17. Sternal Fracture Recognition Based on EfficientNetV2 Fusion Spatial and Channel Features
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Xuebin Xu, Muyu Wang, Dehua Liu, Meng Lei, and Xiaorui Cheng
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- 2023
18. Emotion Recognition from Multi-channel EEG via an Attention-Based CNN Model
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Xuebin Xu, Xiaorui Cheng, Chen Chen, Haichao Fan, and Muyu Wang
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- 2023
19. A Method for Classification of Skin Cancer Based on VisionTransformer
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Xuebin Xu, Haichao Fan, Muyu Wang, Xiaorui Cheng, and Chen Chen
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- 2023
20. Influence of the Balance Hole Circumferential Position on the Cavitation Performance of the Semiopen Impeller Centrifugal Pump
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Xiaorui Cheng, Bo Xiong, Jiaheng Luo, and Yimeng Jiang
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Leading edge ,Jet (fluid) ,Materials science ,Article Subject ,Turbulence ,General Mathematics ,Specific speed ,General Engineering ,02 engineering and technology ,Mechanics ,Engineering (General). Civil engineering (General) ,Centrifugal pump ,Rotation ,Impeller ,020303 mechanical engineering & transports ,020401 chemical engineering ,0203 mechanical engineering ,Cavitation ,QA1-939 ,TA1-2040 ,0204 chemical engineering ,Mathematics - Abstract
In order to study the influence of the circumferential position of the balance hole on the cavitation performance of the semiopen impeller centrifugal pump, a low specific speed semiopen impeller centrifugal pump is taken as the object, and 4 kinds of circumferential positions of balance holes are designed. The SST k-ω turbulence model and the Rayleigh–Plesset cavitation bubble dynamics equation are used to calculate the full flow field of the centrifugal pump. Research shows that, under cavitation conditions, as the circumferential position of the balance hole is farther away from the blade working surface, the cavitation performance of the pump is reduced, and the larger θ (the angle of the balance hole and the leading edge of the blade in the direction of rotation) is, the easier the jet cavitation occurs near the balance hole. On the other hand, with the development of cavitation, the axial force of the impeller has also changed greatly. In contrast, the farther the balance hole is arranged in the circumferential direction (i.e., the greater θ), the more limited is the ability of the balance hole to balance the axial force.
- Published
- 2021
21. Sensitivity analysis of nuclear main pump annular casing tongue blend
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Xiaorui Cheng, Wenrui Bao, Li Fu, and Xiaoting Ye
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Mechanical engineering and machinery ,TJ1-1570 - Abstract
Based on the Reynolds-averaged Navier–Stokes equations of relative coordinates and the RNG k-ε turbulence model, using our SIMPLE algorithm, we performed numerical simulations for an AP1000 nuclear main pump model with water as the medium. By changing the size of the tongue blend in the annular casing, seven different schemes were designed. Three-dimensional numerical simulations were conducted for the flow within the pump under various settings, and the flow characteristics of the annular casing using different tongue blends were obtained. The results show that for different operating conditions, there is a specific tongue blend that optimizes pump performance. Based on the calculation results, a larger tongue blend leads to a larger flow rate. Off-design conditions caused flow instability, which in turn caused the tongue blend to have a certain impact on the performance of the impeller. However, the performance of the pump was not primarily affected by changes in the impeller performance, but was instead affected by the performance of the annular casing, which was itself affected by tongue blend. When changing the tongue blend, the change in static pressure and total pressure of the annular casing was larger under the condition of 0.6 Q d and was smaller under the conditions of 1.0 Q d and 1.4 Q d . The turbulent kinetic energy in the annular casing changed mainly in the tongue impact zone and outlet diffuser under the condition of 1.0 Q d ; furthermore, the turbulent kinetic energy in the whole of the annular casing demonstrated significant changes under the conditions of 0.6 Q d and 1.4 Q d .
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- 2017
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22. A Systematic Review on Chemical Constituents of Suanzaoren Decoction, a Traditional Chinese Medicine Prescription
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Dongmei Qi, Xiaorui Cheng, Yang Yong, Tianyuan Ye, Wenchao Gu, Liangkun Zhang, and Xin Wang
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Chemical research ,food.ingredient ,Phytochemistry ,Traditional medicine ,business.industry ,Decoction ,Traditional Chinese medicine ,Triterpenoid ,food ,Herb ,Chemical constituents ,Medicine ,Medical prescription ,business - Abstract
Traditional Chinese Medicine prescription Suanzaoren decoction (SZRD) is composed of Ziziphi Spinosae Semen, Chuanxiong Rhizoma, Anemarrhenae rhizoma, Poria and Licorice. It was used to treat central nervous system diseases such as insomnia and anxiety for thousands of years. This paper aims to systematically understand varieties and quantities of compounds and clarify chemical components of SZRD, subsequently to further provide the reference for phytochemistry and pharmacology researches of SZRD. Our results showed that SZRD contained 145 components, including flavonoids, triterpenoids, steroids, coumarins, phthalides, and volatile oils, etc., while five-single herbs contain 1104 components. Only in terms of compound number, there were 80 common components in SZRD and its five herbs, which accounted for 6.8% of total compounds in all 5 herbs and 55.2% of compounds in SZRD. The components of SZRD were not simply the sum of one in every single herb. It is necessary to perform parallel studies among SZRD and its herbs. This review discussed the problems that existed in the chemical research of SZRD and pointed out the direction for its further research.
- Published
- 2021
23. The mechanisms underlying the pharmacological effects of GuiPi decoction on major depressive disorder based on network pharmacology and molecular docking
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Liyuan, Chen, Tianyuan, Ye, Xiaolong, Wang, Lu, Han, Tongxing, Wang, Dongmei, Qi, and Xiaorui, Cheng
- Abstract
Major depressive disorder (MDD) is a common affective disorder. GuiPi decoction (GPD) is used to treat depression in China, Japan, and Korea. However, its effective ingredients and antidepressant mechanisms remain unclear. We attempted to reveal the potential mechanisms of GPD in the treatment of MDD by network pharmacology and molecular docking. In addition, we conducted an enzymatic activity assay to validate the results of molecular docking.GPD-related compounds and targets, MDD-related targets were retrieved from databases and literature. The herb-compound-target network was constructed by Cytoscape. The protein-protein interaction network was built using STRING database to find key targets of GPD on MDD. Enrichment analysis of shared targets were analyzed by MetaCore database to obtain the potential pathway and biological process of GPD on MDD. The main active compounds treating for MDD were screened by molecular docking. The PDE4s inhibitors were screened and verified by an enzyme activity assay.GPD contained 1222 ingredients and 190 potential targets for anti-MDD. Possible biological processes regulated by GPD were neurophysiological processes, blood vessel morphogenesis, cAMP responsive element modulator (CREM) pathway, and androgen receptor (AR) signaling crosstalk in MDD. Potential pathways in MDD associated with GPD include neurotransmission, cell differentiation, androgen signaling, and estrogen signaling. Fumarine, m-cresol, quercetin, beta-sitosterol, fumarine, taraxasterol, and lupeol in GPD may be the targets of SLC6A4, monoamine oxidase A (MAOA), DRD2, OPRM1, HTR3A, albumin (ALB), and NTRK1, respectively. The IC50 values of trifolin targeting phosphodiesterase (PDE)4A and girinimbine targeting PDE4B1 were 73.79 μM and 31.86 μM, respectively. The IC50 values of girinimbine and benzo[a]carbazole on PDE4B2 were 51.62 μM and 94.61 μM, respectively.Different compounds in GPD may target the same protein, and the same component in GPD can target multiple targets. These results suggest that the effects of GPD on MDD are holistic and systematic, unlike the pattern of one drug-one target.
- Published
- 2022
24. Study on the influence of the specific area of balance hole on cavitation performance of high- speed centrifugal pump
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Zhengbai Chang, Yimeng Jiang, and Xiaorui Cheng
- Subjects
0209 industrial biotechnology ,geography ,geography.geographical_feature_category ,Materials science ,Rotor (electric) ,Mechanical Engineering ,Flow (psychology) ,02 engineering and technology ,Mechanics ,Inlet ,Centrifugal pump ,Vortex ,law.invention ,Impeller ,020303 mechanical engineering & transports ,020901 industrial engineering & automation ,0203 mechanical engineering ,Mechanics of Materials ,law ,Cavitation ,Head (vessel) - Abstract
In this paper, the influence of the specific area of balancing hole on the cavitation performance of high-speed centrifugal pump is studied by numerical method. The results show that in the initial cavitation stage, with the increase of the specific area, the head and efficiency of the pump decreases, and the shaft power increases in a small range. The specific area of the balance hole can change the magnitude and direction of the rotor axial force. With the increase of the specific area, the anti-cavitation performance of the pump is weakened, especially when the specific area reaches a certain value, the vortex flow appears in the balance hole, which causes serious distortion of the flow condition at the inlet of the centrifugal impeller. Meanwhile, cavitation also occurs in the balance chamber and is mainly concentrated near the hub of the centrifugal impeller.
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- 2020
25. Correlation Research between Turbulent Pressure Pulsation and Internal Sound Field Characteristics of Centrifugal Pump
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Xiaorui Cheng, Peng Wang, and Shuyan Zhang
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Physics ,Frequency response ,Turbulence ,Internal flow ,020209 energy ,02 engineering and technology ,Volute ,Mechanics ,Condensed Matter Physics ,Centrifugal pump ,Physics::Fluid Dynamics ,Dipole ,Noise ,020303 mechanical engineering & transports ,0203 mechanical engineering ,0202 electrical engineering, electronic engineering, information engineering ,Sound pressure - Abstract
In order to study the correlation between the internal flow noise of the centrifugal pump and the turbulent pressure pulsation, a single-stage single-suction centrifugal pump was used as the research object by the combination of numerical calculation and experiment. Based on the RNG k-e model and the N-S equation, the model pump was simulated numerically by CFD. A dipole sound source was extracted by the turbulent pulse action of the volute wall surface according to the FW-H equation. The acoustic field of the model pump was solved on the basis of the boundary element method, and the sound pressure distribution of the internal flow field under the action of the dipole sound source of the volute wall and the frequency response of the inlet and outlet fields were obtained. The results show that the distribution of hydrodynamic noise inside the centrifugal pump is related to the pressure pulsation, presenting obvious dipole distribution and disturbance at the tongue. The sound pressure value of the field is mainly concentrated in the blade passing frequency and double frequency, in which the blade passing frequency is the strongest, and the sound pressure value decreases obviously under other double frequency. The main frequency of hydrodynamic noise is the blade passing frequency.
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- 2020
26. Influence of Circumferential Placement Position of Guide Vanes on Performance and Dynamic Characteristics of Nuclear Reactor Coolant Pump
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Dorah N, Xiaorui Cheng, Ningning Jia, Chenying Ji, and Boru Lv
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Materials science ,Article Subject ,General Mathematics ,05 social sciences ,General Engineering ,050301 education ,Mechanics ,Edge (geometry) ,Engineering (General). Civil engineering (General) ,Diffuser (thermodynamics) ,Shock absorber ,Nuclear reactor coolant ,Position (vector) ,0502 economics and business ,QA1-939 ,Head (vessel) ,Coupling (piping) ,Shroud ,TA1-2040 ,0503 education ,Mathematics ,050203 business & management - Abstract
In order to study the influence of the circumferential placement position of the guide vane on the flow field and stress-strain of a nuclear reactor coolant pump, the CAP1400 nuclear reactor coolant pump is taken as the research object. Based on numerical calculation and test results, the influence of circumferential placement position of the guide vane on the performance of the nuclear reactor coolant pump and stress-strain of guide vanes are analyzed by the unidirectional fluid-solid coupling method. The results show that the physical model and calculation method used in the study can accurately reflect the influence of the circumferential placement position of the guide vane on the nuclear reactor coolant pump. In the design condition, guide vane position has a great influence on the nuclear reactor coolant pump efficiency value, suction surface of the guide vane blade, and the maximum equivalent stress on the hub. However, it has a weak effect on the head value, pressure surface of the guide vane blade, and the maximum equivalent stress on the shroud. When the center line of the outlet diffuser channel of the case is located at the center of the outlet of flow channel of the guide vane, it is an optimal guide vane circumferential placement position, which can reduce the hydraulic loss of half of the case. Finally, it is found that the high stress concentration area is at the intersection of the exit edge of the vane blade and the front and rear cover, and the exit edge of the guide vane blade and its intersection with the front cover are areas where the strength damage is most likely to occur. This study provides a reference for nuclear reactor coolant pump installation, shock absorption design, and structural optimization.
- Published
- 2020
27. Effect of axial matching between inducer and centrifugal pump suction chamber on cavitation performance
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Xiaorui Cheng and Aimin Zhang
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Materials science ,Booster (rocketry) ,Turbulence ,Mechanical Engineering ,Energy Engineering and Power Technology ,02 engineering and technology ,Mechanics ,Centrifugal pump ,01 natural sciences ,010305 fluids & plasmas ,020303 mechanical engineering & transports ,0203 mechanical engineering ,Cavitation ,0103 physical sciences ,Inducer - Abstract
According to the design requirements of a booster centrifugal pump, the full three-dimensional numerical calculation of the model pump is carried out based on the RNG k-ɛ turbulence model and the Rayleigh–Plesset cavitation model to analyze the influence of the axial matching of the inducer and the suction chamber (i.e. the degree of the axial extension of the inducer into the suction chamber) on the cavitation performance of the centrifugal pump. Five sets of centrifugal pump design schemes were selected respectively with the ratio of the axial direction of the inducer into the suction chamber and the axial distance of the inducer hub were 0 (original scheme), 1.6%, 3.2%, 4.8%, and 6.4% to compare the distribution of axial static pressure of the inducer and the suction chamber, the variation of cavitation characteristics, head (energy of a fluid per unit weight obtained by working with a pump expressed in the form of height) and efficiency of the centrifugal pump, the distribution of bubbles in the inducer and the impeller, and the static pressure distribution law of the inducer in the runner. According to the results, what are illustrated are that the cavitation performance of the centrifugal pump can be improved by inserting the inducer into the suction chamber to a certain extent, and the cavitation performance is better with the increase of the axial indentation degree, but it tends to be stable after reaching a certain degree. At the same time, it was found that the vapor bubbles in the inducer and the impeller first appeared in the low pressure region at the inlet rim of the blade.
- Published
- 2019
28. Identification of Chemical Components of Qi-Fu-Yin and Its Prototype Components and Metabolites in Rat Plasma and Cerebrospinal Fluid via UPLC-Q-TOF-MS
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Hengyu Li, Hongwei Zhao, Yong Yang, Dongmei Qi, Xiaorui Cheng, and Jiafeng Wang
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Other systems of medicine ,Complementary and alternative medicine ,Article Subject ,RZ201-999 ,Research Article - Abstract
Qi-Fu-Yin, a traditional Chinese medicine formula, has been used to treat Alzheimer’s disease (AD, a neurodegenerative disorder) in clinical setting. In this study, the chemical components of Qi-Fu-Yin and its prototype components and metabolites in rat plasma and cerebrospinal fluid, after oral administration, were preliminarily characterized via ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS). A total of 180 compounds, including saponins, flavonoids, organic acids, sucrose esters, oligosaccharide esters, phthalides, phenylethanoid glycosides, alkaloids, xanthones, terpene lactones, ionones, and iridoid glycoside, were tentatively characterized. For the first time, 51 prototypical components and 26 metabolites, including saponins, phthalides, flavonoids, sucrose esters, organic acids, alkaloids, ionones, terpene lactones, iridoid glycoside, and their derivatives, have been tentatively identified in the plasma. Furthermore, 10 prototypical components (including butylidenephthalide, butylphthalide, 20(S)-ginsenoside Rh1, 20(R)-ginsenoside Rh1, and zingibroside R1) and 6 metabolites were preliminarily characterized in cerebrospinal fluid. These results were beneficial to the discovery of the active components of Qi-Fu-Yin anti-AD.
- Published
- 2021
29. Knowledge-Based Neuroendocrine Immunomodulation (NIM) Molecular Network Construction and Its Application
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Tongxing Wang, Lu Han, Xiaorui Zhang, Rongrong Wu, Xiaorui Cheng, Wenxia Zhou, and Yongxiang Zhang
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neuroendocrine immunomodulation network ,disease network ,rheumatoid arthritis ,Alzheimer’s disease ,drug target ,pathogenesis ,Organic chemistry ,QD241-441 - Abstract
Growing evidence shows that the neuroendocrine immunomodulation (NIM) network plays an important role in maintaining and modulating body function and the homeostasis of the internal environment. The disequilibrium of NIM in the body is closely associated with many diseases. In the present study, we first collected a core dataset of NIM signaling molecules based on our knowledge and obtained 611 NIM signaling molecules. Then, we built a NIM molecular network based on the MetaCore database and analyzed the signaling transduction characteristics of the core network. We found that the endocrine system played a pivotal role in the bridge between the nervous and immune systems and the signaling transduction between the three systems was not homogeneous. Finally, employing the forest algorithm, we identified the molecular hub playing an important role in the pathogenesis of rheumatoid arthritis (RA) and Alzheimer’s disease (AD), based on the NIM molecular network constructed by us. The results showed that GSK3B, SMARCA4, PSMD7, HNF4A, PGR, RXRA, and ESRRA might be the key molecules for RA, while RARA, STAT3, STAT1, and PSMD14 might be the key molecules for AD. The molecular hub may be a potentially druggable target for these two complex diseases based on the literature. This study suggests that the NIM molecular network in this paper combined with the forest algorithm might provide a useful tool for predicting drug targets and understanding the pathogenesis of diseases. Therefore, the NIM molecular network and the corresponding online tool will not only enhance research on complex diseases and system biology, but also promote the communication of valuable clinical experience between modern medicine and Traditional Chinese Medicine (TCM).
- Published
- 2018
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30. The Molecular Mechanisms of Suanzaoren Prescription for Anti-Anxiety Were Investigated Based on Network Pharmacology
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Tianyuan Ye, Lu Han, Xin Wang, Xiaorui Cheng, Tong-xing Wang, Dongmei Qi, Xiaohong Bao, and Xiaolong Wang
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Anti anxiety ,business.industry ,Network pharmacology ,Medicine ,Pharmacology ,Medical prescription ,business - Abstract
Anxiety is a common, universal disease caused by psychological and environmental factors. There are medications available to treat anxiety disorders, but these are accompanied by problems such as addiction and withdrawal difficulties. Suanzaoren Prescription (SZRP) is often used to treat anxiety disorders in traditional Chinese medicine clinical practice. However, its therapeutic mechanism remains unclear. This work aims to identify potential core therapeutic targets and predict major bioactive compounds by means of network pharmacology, screen compounds that may bind to anxiety targets by molecular docking methods, and validate and evaluate possible therapeutic mechanisms of compounds for anxiety in vitro cell experiments. Datebase TCMSP, BATMAN-TCM, ETCM, TCMGeneDIT and TCMID was used to obtain SZRP compounds, while TCMSP, BATMAN-TCM and ETCM were used to obtain target of compounds. The targets of anxiety disorders were obtained through database TTD, OMIM, PharmgKB, CTD, DrugBank and Metacore. The network diagram is drawn by Cytoscape 3.7.2 software and STRING. Biological process and KEGG pathway analysis were conducted by MetaCore and NIMNT. AutoDock Vina software was used to conduct molecular docking. The calcium Flux assay was employed to detect the activation of compounds on CNR1 in cell line CHO-K1/CNR1/Gα15. The 545 compounds in SZRP were collected. We found there were 1050 potential targets of these compounds in SZRP which involved in brain disease, mood disorder, endocrine system disease, bipolar disorder, etc. There were 117 potential targets of SZRP against anxiety (such as DRD2, BDNF, COMT, SLC6A4, HTR1A, etc.), which played the roles in regulation of membrane potential and synaptic transmission, nicotine addiction, retinol metabolism, GABAergic and serotonergic synapse, etc. The results of molecular docking indicated there were the biggest affinity between Jujuboside B and DRD2, BDNF, COMT, SLC6A4, Anemarsaponin B_qt and HTR1A, n-methylasimilobine and MAPK3. Based on cell CHO-K1/CNR1/Gα15 and calcium flux technique, we found Chrysophanol, Kaempferol and Emodin have activation effects on CNR1 with EC50 138.3µM, 52.28µM and 56.86µM respectively. These results indicated that the effects of SZRP against anxiety were correlated with synaptic transmission, substance addiction and retinol metabolism, especially targeted on CNR1. It suggested that the therapeutic mechanism of SZRP treating anxiety might be due to the weak action of multiple compounds on multiple pathways and biological processes.
- Published
- 2021
31. Studying on the influence of the annular groove position on the cavitation performance of high-speed inducer
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Dengfeng Yang, Xinggang Lu, and Xiaorui Cheng
- Subjects
0209 industrial biotechnology ,Leading edge ,Materials science ,Mechanical Engineering ,Applied Mathematics ,General Engineering ,Aerospace Engineering ,02 engineering and technology ,Mechanics ,Centrifugal pump ,Industrial and Manufacturing Engineering ,Vortex ,Tip clearance ,020901 industrial engineering & automation ,Cavitation ,Automotive Engineering ,Inducer ,Shroud ,Groove (music) - Abstract
To suppress the cavitation instability caused by the leakage vortex at the tip clearance of the high-speed inducer, this study establishes a structure (i.e., annular groove) at the upstream boundary of the high-speed inducer that can absorb the leakage vortex, and 6 sets of design projects are determined, including the initial plan and the axial distance of 0 mm, 2.5 mm, 5 mm, 7.5 mm, and 10 mm, respectively. The effects of annular grooves on cavitation performance under different schemes are studied through a combination of experiment and numerical calculation. The results show that cavitation tends to occur at the position where the leading edge of the suction surface of the inducer intersects the shroud and the bubbles volume is distributed in gradient. Vortex belt is formed at the inlet of the inducer. The axial position of the annular groove relative to the inducer is an important parameter suppressing the occurrence of clearance leakage vortex cavitation, asymmetric vortex cavitation and rotating vortex cavitation. In the proper position, annular groove can significantly suppress the bubbles incipient and improve the cavitation performance of the inducer. It can improve the head of the centrifugal pump effectively under the condition of little effect on centrifugal pump efficiency. However, at other positions, the annular groove cannot improve the cavitation performance of the centrifugal pump, indicating the annular groove has an axial optimal position in inhibiting cavitation and improving cavitation performance of the inducer, at this time $${\mathrm{L}}_{1}=0$$ mm.
- Published
- 2021
32. A combination of indomethacin and atorvastatin ameliorates cognitive and pathological deterioration in PrP-hAβPPswe/PS1ΔE9 transgenic mice
- Author
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Liu Gang, Wen-Xia Zhou, Yongxiang Zhang, Jianhui Wang, Yongan Wang, Xiaorui Cheng, and Xiaorui Zhang
- Subjects
0301 basic medicine ,Genetically modified mouse ,Exacerbation ,business.industry ,Atorvastatin ,Transgene ,Immunology ,Hippocampus ,Inflammation ,Pharmacology ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Immune system ,Neurology ,mental disorders ,medicine ,Immunology and Allergy ,Cytokine secretion ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Mounting evidence has shown that inflammation might drive Alzheimer's disease (AD) pathology and contribute to its exacerbation. Previous studies have indicated that indomethacin or atorvastatin are beneficial in treating AD; however, no significant clinical effects have been shown. Furthermore, no study has investigated the efficacy of combining these agents for treating AD. This study sought to determine the effect of a combination of indomethacin and atorvastatin in the PrP-hAβPPswe/PS1ΔE9 (APP/PS1) transgenic AD mouse model. Treatment with indomethacin and atorvastatin ameliorated impairments in spatial learning and memory, and the active avoidance response in APP/PS1 mice. Moreover, we found a suppression of Aβ plaques and decreased concentration of Aβ1-42 in the hippocampus of APP/PS1 mice following treatment. In addition, indomethacin and atorvastatin ameliorated abnormal cytokine secretion, lymphocyte subset disorder, and hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axis imbalances in APP/PS1 mice. The combination of indomethacin and atorvastatin restored immune and neuroendocrine processes, attenuated pathologic changes and cognitive impairments in APP/PS1 transgenic mice, and could thus be a potential therapeutic agent for AD.
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- 2019
33. Analysis of the Impact of the Space Guide Vane Wrap Angle on the Performance of a Submersible Well Pump
- Author
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Xiaorui Cheng, Hongxing Chen, and Xiaoquan Wang
- Subjects
General Materials Science ,Space (mathematics) ,Geology ,Marine engineering - Published
- 2019
34. Effect of inlet sweepback angle on the cavitation performance of an inducer
- Author
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Shuyan Zhang, Xiaorui Cheng, and Yibin Li
- Subjects
geography ,geography.geographical_feature_category ,Materials science ,General Computer Science ,Turbulence ,02 engineering and technology ,Mechanics ,simulation ,Inlet ,01 natural sciences ,010305 fluids & plasmas ,sweepback angle ,020303 mechanical engineering & transports ,cavitation ,0203 mechanical engineering ,lcsh:TA1-2040 ,Modeling and Simulation ,Cavitation ,0103 physical sciences ,Inducer ,inducer ,lcsh:Engineering (General). Civil engineering (General) - Abstract
In order to study the effects of inlet sweepback angle on the cavitation performance of inducers based on the Reynolds N-S equation, RNG k-ε turbulent model, and Schnerr and Sauer cavitation model, a three-dimensional numerical calculation is employed to study the flow characteristics of a certain LNG pump. Laws of the variation of cavitation performance, head, and efficiency with the change of sweepback were studied. Numerical analysis of the eight inducer projects with a sweepback angle from 120° to 290° was carried out. The results show that the cavitation bubbles first appear at the suction surface near the inlet side. With the decrease of net positive suction head (NPSHa), the bubbles spread to the outlet side of the inducer and the pressure surface. Finally, they fill the entire channel. When the inducer sweepback angle increases from 120° to 270°, the NPSHr of the pump reduces gradually, that is to say that the anti-cavitation performance of the pump has been improved. However, the NPSHr of the pump increases gradually when the inducer sweepback angle increases from 270° to 290°. In other words, there is an optimal sweepback from 120° to 290°, and efficiency and head of pump tend to be stable near the optimal sweepback.
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- 2019
35. A network pharmacology-based study on key pharmacological pathways and targets of Qi Fu Yin acting on Alzheimer's disease
- Author
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Dongmei Qi, Xiaolong Wang, Tianyuan Ye, Lu Han, Shengqi Wang, Qiuyue Xiao, Tong-xing Wang, and Xiaorui Cheng
- Subjects
0301 basic medicine ,Aging ,Disease ,Pharmacology ,medicine.disease_cause ,Biochemistry ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,Alzheimer Disease ,Genetics ,Medicine ,Humans ,Molecular Biology ,IC50 ,business.industry ,Kinase ,Cyclin-dependent kinase 5 ,Cell Biology ,humanities ,Molecular Docking Simulation ,030104 developmental biology ,chemistry ,Docking (molecular) ,business ,Kaempferol ,030217 neurology & neurosurgery ,Nepetin ,Oxidative stress - Abstract
Background Alzheimer's disease (AD) is a central nervous system (CNS) disease characterized by progressive cognitive dysfunction and memory loss. Qi Fu Yin is mainly used to treat dementia, particularly AD, in the clinic, but its comprehensive mechanisms are not known. Objective In this research, we aimed to investigate the mechanisms of Qi Fu Yin in AD by network pharmacology and molecular docking. Methods First, the chemical constituents in Qi Fu Yin were obtained from five databases and classified according to their structure. Targets of chemical constituents and AD-related targets were also collected from the databases. Then, overlapping genes between Qi Fu Yin and AD were identified by intersection analysis. MetaCore was used to gather enrichment information. Combination synergy analysis was performed by Cytoscape. After ligand-receptor docking, the binding affinity was verified by ADP-Glo™ kinase assay and fluorescence resonance energy transfer (FRET) assay. Results We found 12 classes with 977 components in Qi Fu Yin. A total of 511 compounds and 577 potential target proteins in Qi Fu Yin were found to be related to AD. The pathways of Qi Fu Yin in AD included oxidative stress and immune response. There was the best binding affinity between 11 pairs of genes and compounds. Furthermore, CDK5 was inhibited by nepetin with an IC50 of 3.172 μM and kaempferol with an IC50 of 2.659 μM. Ceanothic acid and 18 beta-glycyrrhetinic acid inhibited GSK3β, and the IC50 values were 8.732 μM and 8.06 μM, respectively. Conclusion Qi Fu Yin might alleviate Tau hyperphosphorylation by nepetin, kaempferol, ceanothic acid and 18 beta-glycyrrhetinic acid.
- Published
- 2020
36. Effect of meridian plane dip angle of the variable pitch inducer blade on cavitation performance of high-speed centrifugal pump
- Author
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Ningning Jia, Boru Lv, Hongxing Chen, and Xiaorui Cheng
- Subjects
0209 industrial biotechnology ,Leading edge ,Materials science ,Blade (geometry) ,Computer simulation ,Turbulence ,Mechanical Engineering ,Applied Mathematics ,General Engineering ,Aerospace Engineering ,Magnetic dip ,02 engineering and technology ,Mechanics ,Centrifugal pump ,Industrial and Manufacturing Engineering ,020901 industrial engineering & automation ,Cavitation ,Automotive Engineering ,Shroud - Abstract
To study the effect of the dip angle of the inducer blade section in the meridian plane on the cavitation performance of the high-speed centrifugal pump, four schemes of the inducer have been considered only by changing the dip angle of the blade section in the meridian plane while keeping the other geometrical parameters unchanged. Based on the RNG k–ɛ turbulence model and Zwart-Gerber-Belamri cavitation model, three-dimensional numerical simulation of a high-speed centrifugal pump is carried out. The results show that the cavitation performance of high-speed centrifugal pump will be improved when the dip angle of the blade section in the meridian plane increases within a certain range, but the cavitation performance will deteriorate when the dip angle exceeds a certain extent. A moderate raise of the blade section dip angle will change the blade inlet angle and blade outlet angle of the shroud and hub of the inducer, improve the matching of the liquid flow angle with the blade inlet angle and restrain the cavitation at the blade leading edge. The change in the dip angle has a weak influence on the external performance of the high-speed centrifugal pump, indicating that there is almost no effect on the capacity of the inducer.
- Published
- 2020
37. LW-AFC, a new formula from the traditional Chinese medicine Liuwei Dihuang decoction, as a promising therapy for Alzheimer's disease: Pharmacological effects and mechanisms
- Author
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Xiaorui, Cheng, Yan, Huang, Yongxiang, Zhang, and Wenxia, Zhou
- Subjects
Cognition ,Glycosylation ,Alzheimer Disease ,Animals ,Humans ,Medicine, Chinese Traditional ,Drugs, Chinese Herbal ,Gastrointestinal Microbiome - Abstract
LW-AFC is a new formula derived from the Liuwei Dihuang decoction, a classical traditional Chinese medicine prescription. Based on our research, LW-AFC is a promising drug for Alzheimer's disease (AD). The studies were conducted primarily in two typical AD mouse models: SAMP8 and APP/PS1 mice. The results showed that LW-AFC could improve many cognitive behaviors, such as spatial learning and memory ability, passive and active avoidance response, and object recognition memory capability. In addition, LW-AFC could also alleviate the AD-like pathology in animal models, such as neuron loss and Aβ deposition. Subsequent studies found that LW-AFC could rebalance hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-gonadal (HPG) axis, and modulate the disturbance of immune system and gut flora. These data suggested that the anti-AD effects of LW-AFC might be mainly via modulating the neuroendocrine immunomodulation (NIM) network. As inhibiting the immune function by immunosuppressant could abolish the protective effects of LW-AFC against long-term potentiation (LTP) impairment model, it is likely that LW-AFC balancing the NIM network is initiated by modulating the immune system.
- Published
- 2020
38. LW-AFC, a new formula derived from Liuwei Dihuang decoction, ameliorates cognitive deterioration via modulating the hippocampus transcriptome in senescence-accelerated mouse prone 8 strain, a mouse model of Alzheimer's disease
- Author
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Yongxiang Zhang, Wenxia Zhou, Yang Liu, Fei Li, Jianhui Wang, and Xiaorui Cheng
- Subjects
Transcriptome ,Senescence ,Strain (chemistry) ,Applied Mathematics ,General Mathematics ,Hippocampus ,Cognitive deterioration ,Disease ,Biology ,Liuwei Dihuang Decoction ,Cell biology - Published
- 2018
39. Investigation on matching characteristics of nuclear main pump guide vanes and annular casing
- Author
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Peng Wang, Xiaorui Cheng, and Shuyan Zhang
- Subjects
0209 industrial biotechnology ,Turbulence ,Mechanical Engineering ,Applied Mathematics ,Flow (psychology) ,General Engineering ,Aerospace Engineering ,02 engineering and technology ,Mechanics ,Pressure field ,Industrial and Manufacturing Engineering ,Impeller ,020901 industrial engineering & automation ,Coincident ,Automotive Engineering ,Line (geometry) ,cardiovascular system ,Vector field ,cardiovascular diseases ,human activities ,Casing ,Geology - Abstract
Based on the RNG k–ɛ turbulence model, the multi-coordinate system is used to simulate the three-dimensional unsteady constant value of the nuclear main pump model under different axial and circumferential positions of the guide vane and the annular casing. By analyzing the external characteristics, pressure field and velocity field of different schemes and comparing the pressure pulsation at the impeller outlet, the flow of guide vane and the annular casing is studied through the axial and circumferential position changes in the vane and the annular casing. The results show that the axial distance between the center line of the guide vane and the center line of the outlet extension will increase the uneven distribution of pressure in the impeller outlet and the annular casing and the circumferential position of the guide vane will increase as well. When the center lines of the two are coincident, the pressure distribution in the impeller outlet and the casing is relatively uniform. The change in the axial and circumferential positions of the guide vane of the nuclear main pump has little effect on the vector distribution of the impeller outlet flow, and the influence of liquid flow in the interior of casing is large. The impeller outlet pressure pulsation increases as the axial distance between the guide vane outlet center line and the annular casing outlet center line increases. When the two center lines coincide, the impeller outlet pressure pulsation peak is the lowest.
- Published
- 2019
40. CA-30, an oligosaccharide fraction derived from Liuwei Dihuang decoction, ameliorates cognitive deterioration via the intestinal microbiome in the senescence-accelerated mouse prone 8 strain
- Author
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Wenxia Zhou, Xiaorui Zhang, Xiaorui Cheng, Yongxiang Zhang, Zongjie Xie, Xi Lei, and Jianhui Wang
- Subjects
Senescence ,Male ,medicine.medical_specialty ,Aging ,senescence-accelerated mouse prone 8 strain ,Biology ,Mice ,Cognition ,Internal medicine ,medicine ,Animals ,oligosaccharide ,Cognitive Dysfunction ,Microbiome ,chemistry.chemical_classification ,Strain (chemistry) ,Cell Biology ,Oligosaccharide ,medicine.disease ,intestinal microbiome ,Gastrointestinal Microbiome ,Disease Models, Animal ,Enzyme ,Endocrinology ,chemistry ,Intestinal Microbiome ,Dysbiosis ,Alzheimer’s disease ,Function (biology) ,Drugs, Chinese Herbal ,Research Paper ,CA-30 - Abstract
Mounting evidence points to alterations in the gut microbiota-neuroendocrine immunomodulation (NIM) network that might drive Alzheimer's Disease (AD) pathology. In previous studies, we found that Liuwei Dihuang decoction (LW) had beneficial effects on the cognitive impairments and gastrointestinal microbiota dysbiosis in an AD mouse model. In particular, CA-30 is an oligosaccharide fraction derived from LW. We sought to determine the effects of CA-30 on the composition and function of the intestinal microbiome in the senescence-accelerated mouse prone 8 (SAMP8) mouse strain, an AD mouse model. Treatment with CA-30 delayed aging processes, ameliorated cognition in SAMP8 mice. Moreover, CA-30 ameliorated abnormal NIM network in SAMP8 mice. In addition, we found that CA-30 mainly altered the abundance of four genera and 10 newborn genera. Advantageous changes in carbohydrate-active enzymes of SAMP8 mice following CA-30 treatment, especially GH85, were also noted. We further found that seven genera were significantly correlated with the NIM network and cognitive performance. CA-30 influenced the relative abundance of these intestinal microbiomes in SAMP8 mice and restored them to SAMR1 mouse levels. CA-30 ameliorated the intestinal microbiome, rebalanced the NIM network, improved the AD-like cognitive impairments in SAMP8 mice, and can thus be a potential therapeutic agent for AD.
- Published
- 2019
41. Effect of Velocity Slip on Head Prediction for Centrifugal Pumps as Turbines
- Author
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Yan Hao, Zhengting Xia, Xiaohui Wang, Xiaorui Cheng, and Junhu Yang
- Subjects
Article Subject ,business.industry ,020209 energy ,General Mathematics ,lcsh:Mathematics ,Specific speed ,General Engineering ,Mode (statistics) ,02 engineering and technology ,Mechanics ,Slip (materials science) ,Computational fluid dynamics ,Centrifugal pump ,lcsh:QA1-939 ,Slip factor ,Turbine ,020303 mechanical engineering & transports ,0203 mechanical engineering ,lcsh:TA1-2040 ,0202 electrical engineering, electronic engineering, information engineering ,Head (vessel) ,business ,lcsh:Engineering (General). Civil engineering (General) ,Mathematics - Abstract
The application of pumps as turbines (PAT) has been developed in several applications for energy recovery schemes. Therefore, establishing a performance correlation between pump mode and turbine mode is essential for selecting the proper machine. However, slip phenomenon is the challenges of head prediction for PAT. In this paper, the slip phenomenon of pump and PAT was revealed, and the slip factor was studied using CFD. The effect of slip on head prediction for PAT was analyzed, and a theoretical prediction model was presented considering slip factors. In order to validate the head prediction model, six centrifugal pumps with specific speed (ns) from 9 to 54.8 were tested as turbines. Results showed that the predicted head by the proposed method was in good agreement with the experimental data, and it is more accurate than Stepanoff, Alatorre-Frenk, Sharma, and Derakhshan models. This method can be applied in head prediction for low specific speed PAT ( ns
- Published
- 2019
- Full Text
- View/download PDF
42. A combination of indomethacin and atorvastatin ameliorates cognitive and pathological deterioration in PrP-hAβPPswe/PS1
- Author
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Jianhui, Wang, Xiaorui, Cheng, Xiaorui, Zhang, Gang, Liu, Yongan, Wang, Wenxia, Zhou, and Yongxiang, Zhang
- Subjects
Male ,Anti-Inflammatory Agents, Non-Steroidal ,Indomethacin ,Mice, Transgenic ,Prion Proteins ,Amyloid beta-Protein Precursor ,Mice ,Random Allocation ,Alzheimer Disease ,Atorvastatin ,Presenilin-1 ,Animals ,Humans ,Cognitive Dysfunction ,Drug Therapy, Combination ,Hydroxymethylglutaryl-CoA Reductase Inhibitors - Abstract
Mounting evidence has shown that inflammation might drive Alzheimer's disease (AD) pathology and contribute to its exacerbation. Previous studies have indicated that indomethacin or atorvastatin are beneficial in treating AD; however, no significant clinical effects have been shown. Furthermore, no study has investigated the efficacy of combining these agents for treating AD. This study sought to determine the effect of a combination of indomethacin and atorvastatin in the PrP-hAβPPswe/PS1
- Published
- 2018
43. Effect of Cavitation Flow on Energy Conversion Characteristics of Nuclear Main Pump
- Author
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Xiaorui Cheng
- Subjects
Materials science ,Cavitation flow ,Cavitation ,Energy transformation ,Mechanics - Abstract
In order to study the relationship between the cavitation flow and energy conversion, based on the continuity equation, Renault N-S equation and RNG k-ε turbulence model, the whole flow field cavitation numerical simulation on unclear main pump model under design condition is carried out. Through the variation of pressure and velocity on the streamlines, combined with the basic equation of the pump, the dynamic and hydrostatic head of the nuclear main pump under different cavitation conditions are studied. The results show that the energy of fluid of nuclear main pump is provided by posterior segment of impeller, and the energy of the fluid decreases gradually from the shroud to the hub. Cavitation interferes with the flow of liquid in the impeller, which leads to the relative velocity increases and the pressure decreases in cavitation region, and the work capacity of blades is almost zero in bubble areas. At the same time, in non-cavitation region along with streamlines the dynamic head increases and the hydrostatic head decreases with the development of cavitation, and the decrease of the hydrostatic head is greater than the increase of the dynamic head, which results in the decrease of pump head and efficiency. In addition, in the cavitation region, with the development of cavitation, the sudden change of the dynamic and hydrostatic head increases, which increase the flow loss in the impeller and results in the decrease of pump head and efficiency moreover.
- Published
- 2018
44. Meta-microRNAs as potential noninvasive markers for early diagnosis of Alzheimer’s disease
- Author
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Wei-Shan Wang, Ji-Ping Tan, Can-jun Ruan, Wenxia Zhou, Lu-Ning Wang, Xiaorui Cheng, Yongxiang Zhang, Ning Jiang, and Fang Liu
- Subjects
Oncology ,medicine.medical_specialty ,Mini–Mental State Examination ,Microarray ,medicine.diagnostic_test ,business.industry ,Diagnostic marker ,Disease ,Logistic regression ,Internal medicine ,Cohort ,microRNA ,Medicine ,business ,Cognitive impairment - Abstract
IntroductionThe aim of this study was to investigate the potential role of a microRNA panel as early diagnostic markers for Alzheimer’s disease (AD).MethodsThe differentially expressed serum microRNAs were screened with microarray among cognitively normal controls (CNC), mild cognitive impairment (MCI), and AD. QRT-PCR assay was applied to evaluate differentially expressed microRNAs with two independent cohorts including 202 participants. Logistic regression model based on microRNA panel was constructed using a training cohort and then validated using an independent cohort.ResultsFirst, four differentially expressed serum microRNAs (let-7g, miR-197, miR-126 and miR-29a) were found, which expressions were positively correlated with mini mental state examination (MMSE) score. Second, a microRNA panel with the four microRNAs demonstrated good diagnostic performance for MCI and AD with 84% and 92% accuracy. Third, when combined with MMSE score, the diagnostic performance of the microRNA panel was further improved.DiscussionBlood microRNAs are potential AD biomarkers that may lead to new diagnostic strategies.
- Published
- 2018
- Full Text
- View/download PDF
45. LW-AFC Effects on
- Author
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Jianhui, Wang, Xiaorui, Cheng, Ju, Zeng, Jiangbei, Yuan, Zhongfu, Wang, Wenxia, Zhou, and Yongxiang, Zhang
- Subjects
traditional Chinese medicine ,LW-AFC ,senescence-accelerated mouse prone 8 strain ,glycome ,Original Article ,Alzheimer’s disease - Abstract
Glycosylation is one of the most common eukaryotic post-translational modifications, and aberrant glycosylation has been linked to many diseases. However, glycosylation and glycome analysis is a significantly challenging task. Although several lines of evidence have indicated that protein glycosylation is defective in Alzheimer’s disease (AD), only a few studies have focused on AD glycomics. The etiology of AD is unclear and there are no effective disease-modifying treatments for AD. In this study, we found that the object recognition memory, passive avoidance, and spatial learning and memory of senescence-accelerated mouse prone 8 (SAMP8) strain, an AD animal model, were deficient, and LW-AFC, which was prepared from the traditional Chinese medicine prescription Liuwei Dihuang decoction, showed beneficial effects on the deterioration of cognitive capability in SAMP8 mice. Forty-three and 56 N-glycan were identified in the cerebral cortex and serum of SAMP8 mice, respectively. The N-glycan profile in SAMP8 mice was significantly different from that of senescence accelerated mouse resistant 1 (SAMR1) strains, the control of SAMP8 mice. Treatment with LW-AFC modulated the abundance of 21 and 6 N-glycan in the cerebral cortex and serum of SAMP8 mice, respectively. The abundance of (Hex)3(HexNAc)5(Fuc)1(Neu5Ac)1 and (Hex)2(HexNAc)4 decreased in the cerebral cortex and serum of SAMP8 mice compared with SAMR1 mice, decreases that were significantly correlated with learning and memory measures. The administration of LW-AFC could reverse or increase these levels in SAMP8 mice. These results indicated that the effects of LW-AFC on cognitive impairments in SAMP8 mice might be through modulation of N-glycan patterns, and LW-AFC may be a potential anti-AD agent.
- Published
- 2016
46. Parameter equation study for screw centrifugal pump
- Author
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Rennian Li and Xiaorui Cheng
- Subjects
Engineering ,Axial-flow pump ,business.industry ,Radial piston pump ,Axial piston pump ,Screw centrifugal pump ,Mechanical engineering ,Physics::Optics ,General Medicine ,Progressive cavity pump ,Centrifugal pump ,Computer Science::Robotics ,Physics::Fluid Dynamics ,Impeller profile parameter equation ,Rotodynamic pump ,Change regularity of pitch ,business ,Screw pump ,Variable displacement pump ,Engineering(all) - Abstract
Compared with the general centrifugal pump, the screw centrifugal pump has a spiral radial impeller and opening flow passage. The impeller inlet is a spiral blade and outlet of blade looks like to mixing-flow pump blade. Its special structure made the screw pump not only having spiral propelling effect but also having centrifugal effect, therefore the screw centrifugal pump has both the merits of screw pump and centrifugal pump. According to the structure characteristics of screw centrifugal pump, character of flow-field inside the pump and projection drawing on foundation with one-dimension, the regularity for change of pitch in the variable-pitch parametric equation group is given in this paper. And the variable-pitch parameter equation group of the screw centrifugal pump is perfected. Using the parametric equation, to segment streamline dots on axial plane for designing screw centrifugal pump blade is facilitated, which has important meaning to the CAD, numerical simulation of three-dimension flow-field and improve performances of screw centrifugal pump
- Published
- 2012
- Full Text
- View/download PDF
47. Pharmacological action and mechanism of traditional Chinese medicine
- Author
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Wenxia Zhou, Xiaorui Cheng, Yongxiang Zhang, and Ning Jiang
- Subjects
Traditional medicine ,business.industry ,Mechanism (biology) ,Applied Mathematics ,General Mathematics ,Medicine ,Traditional Chinese medicine ,business ,Liuwei Dihuang Decoction ,Pharmacological action - Published
- 2018
48. Network pharmacology based study of LW-AFC, a new formula from a traditional Chinese medicinal prescription, on neuroendocrine immunomodulation network
- Author
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Wenxia Zhou, Yongxiang Zhang, Xiaorui Cheng, Jianhui Wang, Yan Huang, and Lu Han
- Subjects
Traditional medicine ,business.industry ,Applied Mathematics ,General Mathematics ,Network pharmacology ,Medicine ,Medical prescription ,business - Published
- 2018
49. The Effects of LW-AFC on the Hippocampal Transcriptome in Senescence-Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer's Disease.
- Author
-
Jianhui Wang, Yang Liu, Xiaorui Cheng, Xiaorui Zhang, Feng Liu, Gang Liu, Shanyi Qiao, Ming Ni, Wenxia Zhou, Yongxiang Zhang, Fei Lic, Wang, Jianhui, Liu, Yang, Cheng, Xiaorui, Zhang, Xiaorui, Liu, Feng, Liu, Gang, Qiao, Shanyi, Ni, Ming, and Zhou, Wenxia
- Subjects
ALZHEIMER'S disease treatment ,BASAL ganglia diseases ,NEURODEGENERATION ,LABORATORY mice ,TRANSGENIC mice ,ALZHEIMER'S disease ,ANIMAL experimentation ,BIOLOGICAL models ,HERBAL medicine ,HIPPOCAMPUS (Brain) ,LEARNING ,CHINESE medicine ,MEMORY ,MICE ,NOOTROPIC agents ,STATISTICAL sampling ,GENE expression profiling ,PHARMACODYNAMICS - Abstract
The senescence-accelerated mouse prone 8 (SAMP8) strain is considered a robust experimental model for developing preventative and therapeutic treatments for Alzheimer's disease (AD), a neurodegenerative disease which cannot be effectively prevented, halted, or cured. Our previous studies showed that LW-AFC, a new formula derived from the classical traditional Chinese medicinal prescription Liuwei Dihuang decoction, ameliorates cognitive deterioration in PrP-hAβPPswe/PS1ΔE9 transgenic mice and SAMP8 mice. This study aims to investigate the mechanism that mediates how LW-AFC improves cognitive deficit on the basis of the transcriptome. We conducted a genome-wide survey of gene expression in the hippocampus in mice from the senescence accelerated mouse resistant 1 (SAMR1) strain, from SAMP8 and from LW-AFC treated SAMP8. The results showed that LW-AFC reversed the transcriptome in the hippocampus of SAMP8 mice. The specific investigation of altered gene expression in subtypes defined by cognitive profiles indicated that the systemic lupus erythematosus pathway, spliceosomes, amyotrophic lateral sclerosis, and the insulin signaling were involved in the improvement of cognitive ability by LW-AFC. The expression of genes Enpp2, Etnk1, Epdr1, and Gm5900 in the hippocampus were correlated with that of LW-AFC's ameliorating cognitive impairment in SAMP8 mice. Because LW-AFC is composed of polysaccharides, glycosides, and oligosaccharides, we infer that LW-AFC has direct or indirect effects on altering gene expressions and regulating pathways in the hippocampus of SAMP8 mice. These data are helpful for the enhanced identification of LW-AFC as new therapeutic modalities to AD. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
50. LW-AFC Effects on N-glycan Profile in Senescence- Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer's Disease.
- Author
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Jianhui Wang, Xiaorui Cheng, Ju Zeng, Jiangbei Yuan, Zhongfu Wang, Wenxia Zhou, and Yongxiang Zhang
- Subjects
ALZHEIMER'S disease ,GLYCOSYLATION ,GLYCOMICS - Abstract
Glycosylation is one of the most common eukaryotic post-translational modifications, and aberrant glycosylation has been linked to many diseases. However, glycosylation and glycome analysis is a significantly challenging task. Although several lines of evidence have indicated that protein glycosylation is defective in Alzheimer's disease (AD), only a few studies have focused on AD glycomics. The etiology of AD is unclear and there are no effective disease-modifying treatments for AD. In this study, we found that the object recognition memory, passive avoidance, and spatial learning and memory of senescence-accelerated mouse prone 8 (SAMP8) strain, an AD animal model, were deficient, and LW-AFC, which was prepared from the traditional Chinese medicine prescription Liuwei Dihuang decoction, showed beneficial effects on the deterioration of cognitive capability in SAMP8 mice. Forty-three and 56 N-glycan were identified in the cerebral cortex and serum of SAMP8 mice, respectively. The N-glycan profile in SAMP8 mice was significantly different from that of senescence accelerated mouse resistant 1 (SAMR1) strains, the control of SAMP8 mice. Treatment with LW-AFC modulated the abundance of 21 and 6 N-glycan in the cerebral cortex and serum of SAMP8 mice, respectively. The abundance of (Hex)3(HexNAc)5(Fuc)1(Neu5Ac)1 and (Hex)2(HexNAc)4 decreased in the cerebral cortex and serum of SAMP8 mice compared with SAMR1 mice, decreases that were significantly correlated with learning and memory measures. The administration of LW-AFC could reverse or increase these levels in SAMP8 mice. These results indicated that the effects of LW-AFC on cognitive impairments in SAMP8 mice might be through modulation of N-glycan patterns, and LW-AFC may be a potential anti-AD agent. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
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