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CA-30, an oligosaccharide fraction derived from Liuwei Dihuang decoction, ameliorates cognitive deterioration via the intestinal microbiome in the senescence-accelerated mouse prone 8 strain
- Source :
- Aging (Albany NY)
- Publication Year :
- 2019
-
Abstract
- Mounting evidence points to alterations in the gut microbiota-neuroendocrine immunomodulation (NIM) network that might drive Alzheimer's Disease (AD) pathology. In previous studies, we found that Liuwei Dihuang decoction (LW) had beneficial effects on the cognitive impairments and gastrointestinal microbiota dysbiosis in an AD mouse model. In particular, CA-30 is an oligosaccharide fraction derived from LW. We sought to determine the effects of CA-30 on the composition and function of the intestinal microbiome in the senescence-accelerated mouse prone 8 (SAMP8) mouse strain, an AD mouse model. Treatment with CA-30 delayed aging processes, ameliorated cognition in SAMP8 mice. Moreover, CA-30 ameliorated abnormal NIM network in SAMP8 mice. In addition, we found that CA-30 mainly altered the abundance of four genera and 10 newborn genera. Advantageous changes in carbohydrate-active enzymes of SAMP8 mice following CA-30 treatment, especially GH85, were also noted. We further found that seven genera were significantly correlated with the NIM network and cognitive performance. CA-30 influenced the relative abundance of these intestinal microbiomes in SAMP8 mice and restored them to SAMR1 mouse levels. CA-30 ameliorated the intestinal microbiome, rebalanced the NIM network, improved the AD-like cognitive impairments in SAMP8 mice, and can thus be a potential therapeutic agent for AD.
- Subjects :
- Senescence
Male
medicine.medical_specialty
Aging
senescence-accelerated mouse prone 8 strain
Biology
Mice
Cognition
Internal medicine
medicine
Animals
oligosaccharide
Cognitive Dysfunction
Microbiome
chemistry.chemical_classification
Strain (chemistry)
Cell Biology
Oligosaccharide
medicine.disease
intestinal microbiome
Gastrointestinal Microbiome
Disease Models, Animal
Enzyme
Endocrinology
chemistry
Intestinal Microbiome
Dysbiosis
Alzheimer’s disease
Function (biology)
Drugs, Chinese Herbal
Research Paper
CA-30
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 11
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....cb5bf5da0da658825e5dc880ff3498bd