32 results on '"Xiaoxiu Li"'
Search Results
2. Cohort profile: the Chinese Pregnant Women Cohort Study and Offspring Follow-up (CPWCSaOF)
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Xuan Liu, Guangliang Shan, Ping Huang, Yu Jiang, Yimin Qu, Jian Zhao, Tianchen Lyu, Yunli Chen, Yongle Zhan, Yingjie Shi, Hexin Yue, Yaohan Meng, Ao Jing, Haihui Ma, Dongmei Man, Xiaoxiu Li, and Hongguo Wu
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Medicine - Abstract
Purpose A multicentre prospective cohort study, known as the Chinese Pregnant Women Cohort Study (CPWCS), was established in 2017 to collect exposure data during pregnancy (except environmental exposure) and analyse the relationship between lifestyle during pregnancy and obstetric outcomes. Data about mothers and their children’s life and health as well as children’s laboratory testing will be collected during the offspring follow-up of CPWCS, which will enable us to further investigate the longitudinal relationship between exposure in different periods (during pregnancy and childhood) and children’s development.Participants 9193 pregnant women in 24 hospitals in China who were in their first trimester (5–13 weeks gestational age) from 25 July 2017 to 26 November 2018 were included in CPWCS by convenience sampling. Five hospitals in China which participated in CPWCS with good cooperation will be selected as the sample source for the Chinese Pregnant Women Cohort Study (Offspring Follow-up) (CPWCS-OF).Findings to date Some factors affecting pregnancy outcomes and health problems during pregnancy have been discovered through data analysis. The details are discussed in the ‘Findings to date’ section.Future plans Infants and children and their mothers who meet the criteria will be enrolled in the study and will be followed up every 2 years. The longitudinal relationship between exposure (questionnaire data, physical examination and biospecimens, medical records, and objective environmental data collected through geographical information system and remote sensing technology) in different periods (during pregnancy and childhood) and children’s health (such as sleeping problem, oral health, bowel health and allergy-related health problems) will be analysed.Trail registration number CPWCS was registered with ClinicalTrials.gov on 18 January 2018: NCT03403543. CPWCS-OF was registered with ClinicalTrials.gov on 24 June 2020: NCT04444791.
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- 2021
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3. The Role of p-STAT3 as a Prognostic and Clinicopathological Marker in Colorectal Cancer: A Systematic Review and Meta-Analysis.
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Kun Ji, Mingxuan Zhang, Qi Chu, Yong Gan, Hui Ren, Liyan Zhang, Liwei Wang, Xiaoxiu Li, and Wei Wang
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Medicine ,Science - Abstract
High expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) has been detected in a variety of human tumors. However, the association of positive p-STAT3 expression with clinicopathological parameters and the prognosis of colorectal cancer patients remain controversial. To identify the relationship between p-STAT3 expression and clinicopathological parameters and prognosis in patients with colorectal cancer, a systematic review and meta-analysis were performed.We performed a comprehensive literature search from PubMed, EMBASE, and SinoMed through 27 March, 2016. Hazard ratios (HRs) with 95% confidence intervals (CI) were combined to evaluate the association between p-STAT3 expression and overall survival of colorectal cancer patients. Odds ratios (ORs) with 95% CI were combined to evaluate the association between p-STAT3 expression and clinicopathological parameters in patients with colorectal cancer.Seventeen studies including a total of 2,346 colorectal cancer patients were included in this meta-analysis. The combined HR was 1.43 (95% CI: 1.23-1.67, P < 0.001), which suggested a positive relationship between p-STAT3 overexpression and poorer overall survival of colorectal cancer patients. In addition, the results indicated that positive p-STAT3 expression was significantly associated with the presence of lymph node metastasis (OR: 2.43, 95% CI: 1.18-5.01, P = 0.02) but was not associated with TNM stage, tumor differentiation or gender.The meta-analysis results suggest that p-STAT3 overexpression is unfavorable for the prognosis of colorectal cancer patients, and p-STAT3 overexpression is associated with the presence of lymph node metastasis among colorectal cancer patients.
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- 2016
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4. Design and Implementation of Survey and Design Enterprise File Sorting System.
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Xiaoxiu Li, Junyong Wei, Xiaoxia Deng, Xiang Shi, Yanqiao Liang, and Yanling Wei 0004
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- 2022
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5. Design and Implementation of survey and design enterprise file collection system.
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Junyong Wei, Xiaoxiu Li, Xiaoxia Deng, Xiang Shi, Yanqiao Liang, Yanling Wei 0004, and Yu Xu
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- 2021
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6. Application of β-triketone herbicides improves the purity of two-line hybrid rice seed without compromising yield
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Xiuli Zhang, Qing Wang, Guojian Fan, Jianhang Lou, Xiaoxiu Li, Li Tang, Ye Shao, Bigang Mao, Qiming Lv, and Bingran Zhao
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Two-line hybrid rice based on Photoperiod/thermo-sensitive genic male sterile (P/TGMS) lines has been developed and applied widely in agriculture due to the freedom in making hybrid combinations, less difficulty in breeding sterile lines, and simpler procedures for breeding and producing hybrid seed. However, there are certain risks associated with hybrid seed production; if the temperature during the P/TGMS fertility-sensitive period is lower than the critical temperature, seed production will fail due to self-pollination. In a previous study, we found that the issue of insufficient purity of two-line hybrid rice seed could be initially addressed by using the difference in tolerance to β-triketone herbicides (bTHs) between the female parent and the hybrid seeds. In this study, we further investigated the types of applicable herbicides, application methods, application time, and the effects on physiological and biochemical indexes and yield in rice. The results showed that this method could be used for hybrid purification by soaking seeds and spraying plants with the bTH benzobicylon (BBC) at safe concentrations in the range of 37.5-112.5 mg/L, and the seeds could be soaked in BBC at a treatment rate of 75.0 mg/L for 36–55 h without significant negative effects. The safe concentration for spraying in the field is 50.0-400.0 mg/L BBC at the three-leaf stage. The two methods of hybrid seed purification can reach 100% efficiency without compromising the nutritional growth and yield of hybrid rice. Unlike BBC, Mesotrione (MST) can only be sprayed to achieve hybrid purification at concentrations between 10.0 and 70.0 mg/L without affecting yield. bTH stress significantly increases the index of the reactive oxygen species (ROS) hydrogen peroxide (H2O2) in the hybrid LLY942 in the safe concentration range. The peroxidase (POD) enzyme activity showed a significant upward trend with increasing herbicide concentration, which kept the content of the lipid peroxide malondialdehyde (MDA) within a certain range that did not affect the normal growth of the rice hybrids. Our study establishes a foundation for the application of the bTH seed purification strategy and showed that it is the most economical, convenient, and effective way to improve the purity of two-line hybrid rice seeds.
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- 2022
7. Ecological-Based Mining: A Coal–Water–Thermal Collaborative Paradigm in Ecologically Fragile Areas in Western China
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Xiaoxiu Liu, Yifan Zeng, Qiang Wu, Shihao Meng, Jiyue Liang, and Zhuping Hou
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Dual carbon targets ,Coal–water–thermal co-mining ,Ecologically fragile areas ,Mine–water control ,Resource utilization ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
A substantial reduction in groundwater level, exacerbated by coal mining activities, is intensifying water scarcity in western China’s ecologically fragile coal mining areas. China’s national strategic goal of achieving a carbon peak and carbon neutrality has made eco-friendly mining that prioritizes the protection and efficient use of water resources essential. Based on the resource characteristics of mine water and heat hazards, an intensive coal–water–thermal collaborative co-mining paradigm for the duration of the mining process is proposed. An integrated system for the production, supply, and storage of mining companion resources is achieved through technologies such as roof water inrush prevention and control, hydrothermal quality improvement, and deep-injection geological storage. An active preventive and control system achieved by adjusting the mining technology and a passive system centered on multi-objective drainage and grouting treatment are suggested, in accordance with the original geological characteristics and dynamic process of water inrush. By implementing advanced multi-objective drainage, specifically designed to address the “skylight-type” water inrush mode in the Yulin mining area of Shaanxi Province, a substantial reduction of 50% in water drillings and inflow was achieved, leading to stabilized water conditions that effectively ensure subsequent safe coal mining. An integrated-energy complementary model that incorporates the clean production concept of heat utilization is also proposed. The findings indicate a potential saving of 8419 t of standard coal by using water and air heat as an alternative heating source for the Xiaojihan coalmine, resulting in an impressive energy conservation of 50.2% and a notable 24.2% reduction in carbon emissions. The ultra-deep sustained water injection of 100 m3·h−1 in a single well would not rupture the formation or cause water leakage, and 7.87 × 105 t of mine water could be effectively stored in the Liujiagou Formation, presenting a viable method for mine–water management in the Ordos Basin and providing insights for green and low-carbon mining.
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- 2024
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8. Pre-pregnancy body mass index and risk of maternal or infant complications with gestational diabetes mellitus as a mediator: A multicenter, longitudinal cohort study in China
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Jichun Yang, Jie Qian, Yimin Qu, Yongle Zhan, Hexin Yue, Haihui Ma, Xiaoxiu Li, Dongmei Man, Hongguo Wu, Ping Huang, Liangkun Ma, and Yu Jiang
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Endocrinology ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,General Medicine - Published
- 2023
9. Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity
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Yonghui Ma, Xinyue Suo, Xiaoxiu Li, Tingting Zhu, Jin Li, Tengfei Ji, and Bo Liu
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Cyclopropanes ,Molecular Structure ,Plant Science ,General Medicine ,Phloroglucinol ,Horticulture ,Molecular Biology ,Biochemistry ,Hypericum ,Acetaminophen - Abstract
Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them.
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- 2022
10. Prevalence, Characteristics, and Outcome of Cow's Milk Protein Allergy in Chinese Infants: A Population‐Based Survey
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Xiaoxiu Li, Lanlan Geng, Xiaoling Long, Min Yang, Jie-Ling Wu, Sitang Gong, Yong Zhang, Yongmei Zeng, Yuan Wang, Hai-Jin Ke, Huabo Cai, Yulian Xiao, Huiwen Li, Zhuojie Chen, Huan Chen, Kelvin Li, Meizhen Tan, Hongli Wang, Linhui Rong, Peiyu Chen, Jing Xie, Ding-You Li, Simao Fu, Hong Wang, and Ying Liu
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Male ,China ,Allergy ,Pediatrics ,medicine.medical_specialty ,030309 nutrition & dietetics ,Population ,Breastfeeding ,Medicine (miscellaneous) ,Atopy ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Food allergy ,Prevalence ,Animals ,Humans ,Medicine ,Family ,Prospective Studies ,Family history ,education ,Anaphylaxis ,0303 health sciences ,education.field_of_study ,Nutrition and Dietetics ,Cesarean Section ,business.industry ,Oral food challenge ,Infant ,Allergens ,Immunoglobulin E ,Milk Proteins ,medicine.disease ,Health Surveys ,Bottle Feeding ,Telephone interview ,Cattle ,Female ,030211 gastroenterology & hepatology ,Milk Hypersensitivity ,business - Abstract
Background Cow's milk protein allergy (CMPA) is commonly seen in children. There have been no reports of the true prevalence of CMPA in Chinese infants. The aim of this population-based study is to determine the prevalence, clinical characteristics, and outcome of CMPA in Chinese infants. Methods We carried out a prospective survey in 7 participating hospitals throughout southern China. We included infants ≤12 months of age during the survey. For those suspected of CMPA, oral food challenge with cow's milk protein (CMP) was performed. A follow-up telephone interview was conducted at 12 months after the diagnosis to assess the clinical outcome of CMPA. Results A total of 9910 questionnaire surveys were distributed and 7364 (74.3%) were returned. The eligible survey number of surveys was 6768 (91.9%). A total of 182 infants was confirmed with CMPA, including 13 with anaphylactic reactions, 28 with clinical symptoms and serum immunoglobulin E (sIgE) >3.5 IU/mL, and 141 with positive CMP challenge test. The prevalence of CMPA was 2.69%. Infants with confirmed CMPA had significantly stronger family history of either 1 or both parents with food allergy, higher Cesarean section rate, and lower rate of breastfeeding, compared with those without CMPA. At 12-month telephone follow-up of 176 CMPA infants, 136 infants (77.3%) had become tolerant to CMP. Conclusions The prevalence of CMPA was 2.69%. CMPA infants had a strong family history of food allergy and atopy. Both Cesarean delivery and formula feeding were risk factors for CMPA. At 12-month follow-up, the majority of CMPA infants had become tolerant to CMP.
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- 2018
11. A de novo 921 Kb microdeletion at 11q13.1 including neurexin 2 in a boy with developmental delay, deficits in speech and language without autistic behaviors
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Xiaoxiu Li, Jiage Song, Yiping Shen, Qingming Wang, Wei Yang, Xizi Hu, and Haiming Yuan
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Male ,0301 basic medicine ,Language delay ,Developmental Disabilities ,Genetic counseling ,Neurexin ,Nerve Tissue Proteins ,Penetrance ,Language Development ,Short stature ,03 medical and health sciences ,Genetics ,medicine ,Humans ,Autistic Disorder ,Genetics (clinical) ,Exome sequencing ,Sequence Deletion ,business.industry ,Chromosomes, Human, Pair 11 ,General Medicine ,medicine.disease ,Phenotype ,030104 developmental biology ,Child, Preschool ,Autism ,medicine.symptom ,business - Abstract
Microdeletions at 11q13.1 are very rare. At present only two patients with 11q13.1 deletion involving neurexin 2 (NRXN2) have been reported. Both patients exhibited autistic features, which supported the role of NRXN2 in autism pathogenicity. It is currently unknown whether heterozygous deletion of NRXN2 is of high penetrance or if it is sufficient to result in autism behaviors. Here we reported a 2-year-9-month old boy with developmental delay, short stature, significant language delay and other congenital anomalies. In contrast to previously reported cases, the boy did not present with autistic behaviors and did not meet the clinical diagnosis of autism. A de novo 921 kb microdeletion at 11q13.1 was detected by chromosomal microarray analysis (CMA). Whole Exome Sequencing (WES) was also employed for our patient. The deletion was confirmed and no additional pathogenic variants were detected. We compared our patient's genomic information and clinical features with those of two previously reported individuals. Three patients shared similar deleted intervals and had similar clinical features except for autistic behaviors. This study suggested that NRXN2 gene had incomplete penetrance for autistic behavioral phenotype. The finding is of interest for genetic counseling and clinical management to patients with NRXN2 defects.
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- 2018
12. Extended biotic ligand model for predicting combined Cu–Zn toxicity to wheat ( Triticum aestivum L.): Incorporating the effects of concentration ratio, major cations and pH
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Junxing Yang, Xuedong Wang, Xiaolin Chen, Jingxing Ma, Dongxue Ji, Xiaoxiu Li, and Yibing Ma
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Health, Toxicology and Mutagenesis ,0211 other engineering and technologies ,Biological Availability ,chemistry.chemical_element ,Metal toxicity ,02 engineering and technology ,Zinc ,010501 environmental sciences ,Ligands ,Toxicology ,01 natural sciences ,Concentration ratio ,Metal ,Cations ,Toxicity Tests ,Soil Pollutants ,Triticum ,0105 earth and related environmental sciences ,021110 strategic, defence & security studies ,Chemistry ,Biotic Ligand Model ,General Medicine ,Hydrogen-Ion Concentration ,Pollution ,Copper ,Bioavailability ,Metals ,Environmental chemistry ,visual_art ,Toxicity ,visual_art.visual_art_medium - Abstract
Current risk assessment models for metals such as the biotic ligand model (BLM) are usually applied to individual metals, yet toxic metals are rarely found singly in the environment. In the present research, the toxicity of Cu and Zn alone and together were studied in wheat (Triticum aestivum L.) using different Ca2+ and Mg2+ concentrations, pH levels and Zn:Cu concentration ratios. The aim of the study was to better understand the toxicity effects of these two metals using BLMs and toxic units (TUs) from single and combined metal toxicity data. The results of single-metal toxicity tests showed that toxicity of Cu and Zn tended to decrease with increasing Ca2+ or Mg2+ concentrations, and that the effects of pH on Cu and Zn toxicity were related not only to free Cu2+ and Zn2+ activity, respectively, but also to other inorganic metal complex species. For the metal mixture, Cu–Zn interactions based on free ion activities were primarily additive for the different Ca2+ and Mg2+ concentrations and levels of pH. The toxicity data of individual metals derived by the BLM, which incorporated Ca2+ and Mg2+ competition and toxicity of inorganic metal complexes in a single-metal toxicity assessment, could predict the combined toxicity as a function of TU. There was good performance between the predicted and observed effects (root mean square error [RMSE] = 7.15, R2 = 0.97) compared to that using a TU method with a model based on free ion activity (RMSE = 14.29, R2 = 0.86). The overall findings indicated that bioavailability models that include those biochemistry processes may accurately predict the toxicity of metal mixtures.
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- 2017
13. Spatial and temporal variation, source profile of PCDD/Fs in the atmosphere of a municipal waste incinerator in China
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Congcong Zhang, Xiaoxiu Li, and Zhiguang Zhou
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Flue gas ,China ,Municipal solid waste ,Polychlorinated Dibenzodioxins ,Health, Toxicology and Mutagenesis ,0211 other engineering and technologies ,02 engineering and technology ,Incineration ,010501 environmental sciences ,01 natural sciences ,Atmosphere ,Stack (abstract data type) ,medicine ,0105 earth and related environmental sciences ,021110 strategic, defence & security studies ,Air Pollutants ,Public Health, Environmental and Occupational Health ,General Medicine ,Seasonality ,Dibenzofurans, Polychlorinated ,medicine.disease ,Pollution ,Ambient air ,Refuse Disposal ,Congener ,Environmental chemistry ,Environmental science ,Gases ,Seasons ,Environmental Monitoring - Abstract
The mass concentrations, toxic equivalent quantity (TEQ) concentrations and congener profiles of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in the stack flue gas and ambient air of municipal solid waste incinerator (MSWI) were monitored in this study to evaluate the levels, emission characteristics, seasonal variation and emission sources of PCDD/Fs. Thirty-one ambient air samples were collected from four sites around MSWI during 2016–2017, and twelve stack flue gas samples were collected from one MSWI. Results showed that the PCDD/Fs concentrations of the stack flue gas ranged from 0.0077 to 0.021 ng I-TEQ/Nm3, with an average value of 0.016 ng I-TEQ/Nm3. The ambient air samples collected in 2016 and 2017 ranged from 0.017 to 0.27, and 0.035–0.27 pg I-TEQ/Nm3, with an average value of 0.078 and 0.10 pg I-TEQ/Nm3, respectively. The 2, 3, 4, 7, 8-PCDF always contributes most to toxicity both in stack flue gas and ambient air samples. PCDD/Fs in the ambient air of the study area showed significant seasonal differences, and the total concentration of PCDD/Fs was highest in winter, which was about 3.5–7.5 times that of summer. Principal component analysis (PCA) and hierarchical cluster analysis (HCA) were used to determine the correlation between MSWI emissions and PCDD/Fs in ambient air. It is worth mentioning that MSWI is not the main source of PCDD/Fs in ambient air.
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- 2019
14. Characteristics, causes, and prevention measures of coal mine water hazard accidents in China
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Yifan ZENG, Qiang WU, Suqi ZHAO, Yaowu MIAO, Ye ZHANG, Aoshuang MEI, Shihao MENG, and Xiaoxiu LIU
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mine safety ,mine water inrush ,hidden disaster-causing factors ,water exploration and discharge ,water hazard prevention and control. ,Mining engineering. Metallurgy ,TN1-997 - Abstract
As one of the top “five major hazards” in coal mines, water hazards have become the second leading cause of danger for coal mine safety and worker lives, next only to gas accidents. Between 2000 and 2022, a total of 1206 water hazard accidents occurred in coal mines in China, resulting in 5018 deaths, among which 103 larger-scale events resulted in 2039 deaths. In order to identify accident patterns, summarize lessons learned, and promote prevention of water hazard accidents, various aspects were analyzed statistically, including geographical regions, years, seasons, hydrogeological types, water sources, and ownership of coal mines. Analyses revealed that the complexity of hydrogeological conditions highly correlated with the frequency of water-related accidents. Southern China recorded the highest number of incidents and casualties, and the peak incidence periods throughout the year mainly concentrated in March to May and July to August. Goaf water was identified as the primary source of water filling, which presented strong concealment and harm, mainly occurring in township-owned coal mines with weaker technical exploration and management capabilities. As for the causes of accidents, complex mining environments and insufficient attention subjectively, i.e., improper management and illegal mining, were the main reasons for accidents. Hidden water-bearing structures such as point-like collapse columns and linear fault structures, as well as goaf water that were not explored and placed in accordance with regulations, were identified as the main technical causes of accidents. By analyzing bibliometrics, it was found that current research themes focusing on coal mine water disasters align well with the principles of “predicting and forecasting, exploring if in doubt, exploring before mining, treating before mining”. To address the problems of “unclear risk assessment, inaccurate risk identification, and incapability to cope with accidents” in coal mine water disasters, corresponding countermeasures were proposed in three aspects: surveying filling factors and hidden geological factors causing disasters, analyzing three-dimensional hydrogeological conditions of filling water, and implementing an accurate classification source prevention. In response to the trend of informationization and intelligent development of water disaster prevention and control, technical measures such as transparent mines, water disaster monitoring and early warning, and emergency rescue were proposed.
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- 2023
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15. Pollution Level and Health Risk Assessment of PM2.5-Bound Metals in Baoding City Before and After the Heating Period
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Chunyuan Sun, Xue Yu, Yixuan Liu, Wenji Zhao, Xiaoxiu Li, Mengxi Qi, and Shanshan Li
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Inhalation exposure ,Pollution ,010504 meteorology & atmospheric sciences ,Health risk assessment ,Period (periodic table) ,PM2.5 ,Health, Toxicology and Mutagenesis ,media_common.quotation_subject ,lcsh:R ,Public Health, Environmental and Occupational Health ,lcsh:Medicine ,Heavy metals ,010501 environmental sciences ,heavy metal ,01 natural sciences ,Environmental chemistry ,Environmental science ,health risk assessment ,pollution level ,Enrichment factor ,Risk assessment ,0105 earth and related environmental sciences ,Index method ,media_common - Abstract
In order to assess the pollution levels and health risks of PM2.5-bound metals in Baoding City before and after the heating period, samples were collected in 2016 at Hebei University from September 25th to November 14th during the non-heating period, and November 15th to December 26th during the heating period, respectively. ICP-MS was applied to analyze seven heavy metals (Cr, Zn, Cu, Pb, Ni, Cd and Fe). The statistical analysis, enrichment factor (EF), pollution load index method, and Risk Assessment Method proposed by U.S. EPA were used to evaluate the non-carcinogenic risks of six of these heavy metals (Cr, Zn, Cu, Pb, Ni and Cd) and carcinogenic risks of three of these heavy metals (Cr, Ni and Cd). The results showed three main results. First, the average daily PM2.5 concentrations of the national air monitoring stations was 155.66 &mu, g·, m&minus, 3 which was 2.08 times as high as that of the second level criterion in China (75 &mu, 3) during the observation period. Compared with the non-heating period, all heavy metals concentrations increased during heating period. The growth rates of Pb and Ni were the highest and the lowest, which were 88.03 and 5.11 percent, respectively. Second, the results of enrichment factor indicated that the EF values of all heavy metals were higher during the heating period in comparison with during the non-heating period, but the degree of enrichment of all heavy metals remained unchanged. Not only those, Cr and Ni were minimally enriched and were affected by both human and natural factors, Pb, Cu and Zn were significantly enriched and were mainly affected by human factors, the enrichment of Cd was much higher than that of the other heavy metals, exhibiting extremely high enrichment, mainly due to human factors during the whole sampling period. The results of the pollution load index indicated that the proportions of the number of highly and very highly polluted PM2.5-bound metals were the highest during the heating period, while the proportion of moderately polluted PM2.5-bound metals was the highest during the non-heating period. The combined pollution degree of heavy metals was more serious during the heating period. Third, according to the health risk assessment model, we concluded that the non-carcinogenic and carcinogenic risks caused by inhalation exposure were the highest and by dermal exposure were the lowest for all kinds of people. The overall non-carcinogenic risk of heavy metals via inhalation and subsequent ingestion exposure caused significant harm to children during the non-heating and the heating periods, and the risk values were 2.64, 4.47, 1.20 and 1.47, respectively. Pb and Cr exhibited the biggest contributions to the non-carcinogenic risk. All the above non-carcinogenic risks exceeded the standard limits suggested by EPA (HI or HQ <, 1). The carcinogenic risk via inhalation exposure to children, adult men and women were 2.10 ×, 10&minus, 4, 1.80 ×, 4, and 1.03 ×, 4 during the non-heating period, respectively, and 2.52 ×, 4, 2.16 ×, 4 and 1.23 ×, 4 during the heating period, respectively. All the above carcinogenic risks exceeded the threshold ranges (10&minus, 6~10&minus, 4), and Cr posed a carcinogenic risk to all people.
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- 2018
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16. Pollution Level and Health Risk Assessment of PM
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Yixuan, Liu, Shanshan, Li, Chunyuan, Sun, Mengxi, Qi, Xue, Yu, Wenji, Zhao, and Xiaoxiu, Li
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Adult ,Male ,Air Pollutants ,China ,PM2.5 ,heavy metal ,Risk Assessment ,Article ,Heating ,Air Pollution ,Metals, Heavy ,Humans ,health risk assessment ,Female ,Particulate Matter ,pollution level ,Seasons ,Child ,Environmental Monitoring - Abstract
In order to assess the pollution levels and health risks of PM2.5-bound metals in Baoding City before and after the heating period, samples were collected in 2016 at Hebei University from September 25th to November 14th during the non-heating period, and November 15th to December 26th during the heating period, respectively. ICP-MS was applied to analyze seven heavy metals (Cr, Zn, Cu, Pb, Ni, Cd and Fe). The statistical analysis, enrichment factor (EF), pollution load index method, and Risk Assessment Method proposed by U.S. EPA were used to evaluate the non-carcinogenic risks of six of these heavy metals (Cr, Zn, Cu, Pb, Ni and Cd) and carcinogenic risks of three of these heavy metals (Cr, Ni and Cd). The results showed three main results. First, the average daily PM2.5 concentrations of the national air monitoring stations was 155.66 μg·m−3 which was 2.08 times as high as that of the second level criterion in China (75 μg·m−3) during the observation period. Compared with the non-heating period, all heavy metals concentrations increased during heating period. The growth rates of Pb and Ni were the highest and the lowest, which were 88.03 and 5.11 percent, respectively. Second, the results of enrichment factor indicated that the EF values of all heavy metals were higher during the heating period in comparison with during the non-heating period, but the degree of enrichment of all heavy metals remained unchanged. Not only those, Cr and Ni were minimally enriched and were affected by both human and natural factors, Pb, Cu and Zn were significantly enriched and were mainly affected by human factors, the enrichment of Cd was much higher than that of the other heavy metals, exhibiting extremely high enrichment, mainly due to human factors during the whole sampling period. The results of the pollution load index indicated that the proportions of the number of highly and very highly polluted PM2.5-bound metals were the highest during the heating period, while the proportion of moderately polluted PM2.5-bound metals was the highest during the non-heating period. The combined pollution degree of heavy metals was more serious during the heating period. Third, according to the health risk assessment model, we concluded that the non-carcinogenic and carcinogenic risks caused by inhalation exposure were the highest and by dermal exposure were the lowest for all kinds of people. The overall non-carcinogenic risk of heavy metals via inhalation and subsequent ingestion exposure caused significant harm to children during the non-heating and the heating periods, and the risk values were 2.64, 4.47, 1.20 and 1.47, respectively. Pb and Cr exhibited the biggest contributions to the non-carcinogenic risk. All the above non-carcinogenic risks exceeded the standard limits suggested by EPA (HI or HQ < 1). The carcinogenic risk via inhalation exposure to children, adult men and women were 2.10 × 10−4, 1.80 × 10−4, and 1.03 × 10−4 during the non-heating period, respectively, and 2.52 × 10−4, 2.16 × 10−4 and 1.23 × 10−4 during the heating period, respectively. All the above carcinogenic risks exceeded the threshold ranges (10−6~10−4), and Cr posed a carcinogenic risk to all people.
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- 2018
17. Modeling acute toxicity of metal mixtures to wheat (Triticum aestivum L.) using the biotic ligand model-based toxic units method
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Xuedong Wang, Dongxue Ji, Karel A.C. De Schamphelaere, Xiaoxiu Li, Zhiguo Jia, Xiaolin Chen, and Mingyan Wu
- Subjects
Metal ions in aqueous solution ,Daphnia magna ,0211 other engineering and technologies ,lcsh:Medicine ,chemistry.chemical_element ,02 engineering and technology ,magnesium ,010501 environmental sciences ,Ligands ,Models, Biological ,Plant Roots ,01 natural sciences ,Article ,soil ,Toxicology ,Metal ,nickel ,natural waters ,Cations ,Magnesium ,lcsh:Science ,Triticum ,0105 earth and related environmental sciences ,Barley root elongation ,021110 strategic, defence & security studies ,calcium ,Multidisciplinary ,lcsh:R ,Biotic Ligand Model ,Biology and Life Sciences ,Cobalt ,Hydrogen-Ion Concentration ,cobalt ,Copper ,hordeum-vulgare ,Nickel ,Crystallography ,chemistry ,Earth and Environmental Sciences ,visual_art ,acute copper toxicity ,visual_art.visual_art_medium ,lcsh:Q ,Hordeum vulgare ,Edible Grain - Abstract
The combined toxic effects of copper (Cu) and cobalt (Co) were predicted using the biotic ligand model (BLM) for different concentrations of magnesium (Mg2+) and pH levels, with parameters derived from Cu-only and Co-only toxicity data. The BLM-based toxic unit (TU) approach was used for prediction. Higher activities of Mg2+ linearly increased the EC50 of Cu and Co, supporting the concept of competitive binding of Mg2+ and metal ions in toxic action. The effects of pH on Cu and Co toxicity were related not only to free Cu2+ and Co2+ activity, respectively, but also to inorganic metal complexes. Stability constants for the binding of Cu2+, CuHCO3+, CuCO3(aq), CuOH+, Mg2+, Co2+, CoHCO3+ and Mg2+ with biotic ligands were logKCuBL 5.87, $$\mathrm{log}\,{K}_{{{\rm{CuHCO}}}_{3}{\rm{BL}}}$$ log K CuHCO 3 BL 5.67, $$\mathrm{log}\,{K}_{{{\rm{CuCO}}}_{3}{\rm{BL}}}$$ log K CuCO 3 BL 5.44, logKCuOHBL 5.07, logKMgBL 2.93, logKCoBL 4.72, $$\mathrm{log}\,{K}_{{{\rm{CoHCO}}}_{3}{\rm{BL}}}$$ log K CoHCO 3 BL 5.81 and logKMgBL 3.84, respectively. The combinations of Cu and Co showed additive effects under different conditions. When compared with the FIAM-based TU model (root mean square error [RMSE = 16.31, R2 = 0.84]), the BLM-based TU model fitted the observed effects better (RMSE = 6.70, R2 = 0.97). The present study supports the BLM principles, which indicate that metal speciation and major cations competition need to be accounted for when predicting toxicity of both single metals and mixtures of metals.
- Published
- 2017
18. Concentrations and patterns of polychlorinated naphthalenes in urban air in Beijing, China
- Author
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Liang Dong, Lingnan Xue, Lifei Zhang, Yan Yan, Xiaoxiu Li, and Yeru Huang
- Subjects
Polychlorinated naphthalene ,Environmental Engineering ,010504 meteorology & atmospheric sciences ,Halogenation ,Health, Toxicology and Mutagenesis ,Air sampler ,010501 environmental sciences ,Naphthalenes ,01 natural sciences ,chemistry.chemical_compound ,Beijing ,Air pollutants ,Trichloronaphthalene ,medicine ,Environmental Chemistry ,Cities ,0105 earth and related environmental sciences ,Air Pollutants ,Chemistry ,Atmosphere ,Public Health, Environmental and Occupational Health ,General Medicine ,General Chemistry ,Seasonality ,medicine.disease ,Pollution ,Environmental chemistry ,Correlation analysis ,Seasons ,Environmental Monitoring - Abstract
Air samples were collected, using a high-volume air sampler, at an urban site in Beijing from April 2014 to March 2015. The polychlorinated naphthalene (PCN) concentration in the atmosphere in each season was determined. The total PCN (total target tri- to octachloronaphthalene congeners) concentrations were 1.99-19.0 pg/m(3), and the mean was 7.20 pg/m(3). The PCN concentrations were higher in fall than summer, indicating that the concentrations varied significantly over time. The trichloronaphthalene homolog was the predominant PCN homolog in all four seasons. The PCN toxic equivalent (TEQ) concentrations were 0.42-6.89 fg/m(3), and the mean was 1.74 fg/m(3). The CN-66/67 and CN-73 congeners were the predominant contributors to the TEQ concentrations. The mean seasonal TEQ concentration decreased in the order fall (3.18 fg/m(3)) > winter (1.41 fg/m(3)) > summer (1.11 fg/m(3)) > spring (1.03 fg/m(3)). The TEQ concentrations and the PCN concentrations did not follow the same seasonal trends, but the highest TEQ and PCN concentrations were both found in fall. Correlation analysis, ratio analysis, and principal component analysis were used to investigate the sources of PCNs to the Beijing atmosphere. The results suggested that combustion processes may be the main sources of PCNs to the Beijing atmosphere.
- Published
- 2016
19. Effect of valsartan on the pathological progression of hepatic fibrosis in rats with type 2 diabetes
- Author
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Li Zhang, Qi Xuan, Haiguang Yang, Lili Shi, Mian Zu, Jing Guo, Xiuying Yang, Xiaoxiu Li, Guanhua Du, Guifen Qiang, Dan Zhou, Bainian Chen, and Hengai Zhang
- Subjects
Pathology ,medicine.medical_specialty ,Tetrazoles ,Apoptosis ,Mitochondria, Liver ,Liver Cirrhosis, Experimental ,Diabetes Mellitus, Experimental ,Rats, Sprague-Dawley ,Liver disease ,Non-alcoholic Fatty Liver Disease ,Internal medicine ,Nonalcoholic fatty liver disease ,In Situ Nick-End Labeling ,medicine ,Animals ,Respiratory function ,Pharmacology ,TUNEL assay ,business.industry ,Valine ,medicine.disease ,Streptozotocin ,Rats ,Fatty Liver ,Endocrinology ,Diabetes Mellitus, Type 2 ,Gene Expression Regulation ,Valsartan ,Disease Progression ,Hepatocytes ,Steatosis ,business ,Hepatic fibrosis ,Angiotensin II Type 1 Receptor Blockers ,medicine.drug - Abstract
Currently there is no effective treatment for nonalcoholic fatty liver disease (NAFLD), especially hepatic fibrosis induced by type 2 diabetes. Valsartan maybe has beneficial effect on the liver disease. The aim of the present study was to investigate the effect of valsartan on the pathological progression of hepatic fibrosis in rats with type 2 diabetes. An animal model of hepatic fibrosis with type 2 diabetes was developed using a high-sucrose, high-fat diet and low-dose streptozotocin. Valsartan (15 mg/kg/day, i.g.) was orally administered for four months. The livers were removed to make hematoxylin-eosin (HE) staining and Picric acid-Sirius red staining, and immunohistochemistry staining of α-smooth-muscle-actin (α-SMA), transforming growth factor β1 (TGF-β1), tumor necrosis factor (TNF-α) and monocyte chemotactic protein-1 (MCP-1). Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining was performed to detect hepatocyte apoptosis. The liver mitochondria were isolated to measure the mitochondrial respiratory function. The results showed that valsartan significantly alleviated the lesion of hepatic steatosis and hepatic fibrosis by HE staining and Picric acid-Sirius red staining. Immunohistochemical staining suggested that the expression of α-SMA, TGF-β1, TNF-α and MCP-1 in liver tissue of diabetic rats was markedly reduced by valsartan. TUNEL staining showed that there were fewer TUNEL-positive apoptotic hepatocytes in valsartan group. In addition, valsartan restored the injured hepatic mitochondrial respiratory function. The findings demonstrated that valsartan prevented the pathological progression of hepatic fibrosis in type 2 diabetic rats, correlated with reducing α-SMA, TGF-β1, TNF-α and MCP-1 expression, also anti-apoptosis and mitochondria-protective potential.
- Published
- 2012
20. Protective effects of baicalein against rotenone-induced neurotoxicity in PC12 cells and isolated rat brain mitochondria
- Author
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Shuo Tian, Bei Xu, Fanrui Meng, Xin Yu, Zhao-Hong Xuan, Xin Mu, Guanhua Du, Guorong He, and Xiaoxiu Li
- Subjects
Male ,Cell Respiration ,Neurotoxins ,Apoptosis ,Mitochondrion ,Pharmacology ,medicine.disease_cause ,PC12 Cells ,Neuroprotection ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Rotenone ,medicine ,Animals ,Caspase 7 ,Membrane Potential, Mitochondrial ,biology ,Caspase 3 ,business.industry ,Neurotoxicity ,Brain ,medicine.disease ,biology.organism_classification ,Mitochondria ,Rats ,Baicalein ,Oxidative Stress ,Neuroprotective Agents ,chemistry ,Cytoprotection ,Flavanones ,Scutellaria ,Mitochondrial Swelling ,business ,Oxidative stress - Abstract
Baicalein is one of the major flavonoids obtained from the Scutellaria root. Previous pharmacological studies found that baicalein had neuroprotective effects in animal models of Parkinson's disease. The purpose of this paper was to explore the molecular mechanism of the action of baicalein on PC12 cells and isolated rat brain mitochondria. Firstly, we investigated the effects of baicalein on rotenone-induced toxicity in PC12 cells. The results showed that baicalein suppressed rotenone-induced apoptosis, and inhibited the accumulation of reactive oxidant species, ATP deficiency, mitochondrial membrane potential dissipation, and caspase-3/7 activation in a concentration-dependent manner, indicating that baicalein likely improved mitochondrial function. Furthermore, we used isolated rat brain mitochondria to evaluate the effect of baicalein. Treatment with baicalein prevented rotenone-induced reactive oxidant species production, ATP deficiency and mitochondrial swelling in isolated brain mitochondria. Interestingly, exposure of isolated mitochondria to baicalein promoted mitochondrial active respiration. These results suggest that baicalein may be a mitochondria-targeted antioxidant and exerts neuroprotective effects on rotenone-induced neurotoxicity. This study supports our previous research that baicalein possesses neuroprotective activity in vivo and it is worthy of further study.
- Published
- 2012
21. Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice
- Author
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Guorong He, Xiaoxiu Li, Guanhua Du, Xin Mu, and Xia Yuan
- Subjects
Male ,medicine.medical_specialty ,Tyrosine 3-Monooxygenase ,Dopamine ,Clinical Biochemistry ,Substantia nigra ,Toxicology ,Biochemistry ,Neuroprotection ,Antioxidants ,Mice ,Behavioral Neuroscience ,chemistry.chemical_compound ,Malondialdehyde ,Internal medicine ,medicine ,Animals ,Biological Psychiatry ,Neurons ,Pharmacology ,Glutathione Peroxidase ,Behavior, Animal ,Tyrosine hydroxylase ,Superoxide Dismutase ,MPTP ,Dopaminergic ,Brain ,MPTP Poisoning ,Corpus Striatum ,Baicalein ,Mice, Inbred C57BL ,Substantia Nigra ,Oxidative Stress ,Endocrinology ,nervous system ,chemistry ,Flavanones ,medicine.drug - Abstract
Many studies of Parkinson's disease suggest that oxidative stress is involved in the neurodegenerative process. Baicalein has been shown to have antioxidant effects. The present study examines the effect of baicalein on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice. MPTP treatment impaired spontaneous motor activity and rotarod performance, but baicalein improved this deficit. Moreover, baicalein at 280 and 560 mg/kg exhibited a protective effect against the MPTP-induced decrease in tyrosine hydroxylase (TH)-positive fibers in the substantia nigra, demonstrated by the immunohistological, morphological and behavioral outcomes. MPTP treatment also decreased dopamine levels in the striatum. However, treatment with baicalein attenuated these decreases in dopamine levels by changing dopamine catabolism and inhibiting dopamine turnover. The neuroprotective effect of baicalein on dopaminergic neurons may partly be due to its antioxidant properties. Therefore, we speculate that baicalein might be a promising candidate for prevention or treatment of oxidative stress-related neurodegenerative disorders such as Parkinson's disease.
- Published
- 2011
22. Isothermal crystallization behavior of poly(L-lactic acid)/organo-montmorillonite nanocomposites
- Author
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Xiaoxiu Li, Zhenyang Yu, Xuesi Chen, Bin Cao, Shifeng Yan, Xiaochun Lu, Jingbo Yin, and Yinjie Wang
- Subjects
chemistry.chemical_classification ,Nanocomposite ,Materials science ,Polymers and Plastics ,General Chemistry ,Polymer ,Poly(methyl methacrylate) ,law.invention ,chemistry.chemical_compound ,Crystallinity ,Montmorillonite ,chemistry ,law ,visual_art ,Materials Chemistry ,Ceramics and Composites ,Melting point ,visual_art.visual_art_medium ,Organoclay ,Crystallization ,Composite material - Abstract
The isothermal crystallization behavior of poly(L-lactic acid)/organo-montmorillonite nanocomposites (PLLA/OMMT) with different content of OMMT, using a kind of twice-functionalized organoclay (TFC), prepared by melt intercalation process has been investigated by optical depolarizer. In isothermal crystallization from melt, the induction periods (t(i)) and half times for overall PLLA crystallization (100 degrees C
- Published
- 2009
23. Development and validation of a high-performance liquid chromatographic method for determination of pinocembrin in rat plasma: Application to pharmacokinetic study
- Author
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Xiaoxiu Li, Rui Liu, Guanhua Du, Qing-shan Liu, Zhihong Yang, and Shuo Tian
- Subjects
Male ,Quality Control ,Clinical Biochemistry ,Pharmaceutical Science ,Sensitivity and Specificity ,High-performance liquid chromatography ,Analytical Chemistry ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Drug Stability ,Freezing ,Drug Discovery ,Animals ,Protein precipitation ,Chromatography, High Pressure Liquid ,Spectroscopy ,Detection limit ,Chromatography ,Pinocembrin ,Dose-Response Relationship, Drug ,Molecular Structure ,Chemistry ,Temperature ,Reproducibility of Results ,Half-life ,Reversed-phase chromatography ,Reference Standards ,Rats ,Area Under Curve ,Calibration ,Flavanones ,Linear Models ,Powders ,Ammonium acetate ,Quantitative analysis (chemistry) ,Half-Life - Abstract
A sensitive and specific reversed-phase high-performance liquid chromatography with ultraviolet detection (RP-UV-HPLC) method has been developed and validated for the identification and quantification of pinocembrin in rat plasma using chrysin as the internal standard. Following protein precipitation with acetonitrile, the analytes were separated by the mobile phase 0.01 M ammonium acetate (pH 4.0)-methanol (35:65, v/v) with an Agilent TC-C18 column (5 microm, 4.6 mm x 150 mm) at a flow rate of 1 ml/min, column temperature 40 degrees C and detection wavelength 290 nm. A good linear relationship was obtained in the concentration range studied (0.07-133.33 microg/ml, r=0.9995). The lowest limit of quantification (LLOQ) was 66.7 ng/ml and the lowest limit of detection (LLOD) was 25 ng/ml. Average recoveries ranged from 93.9 to 97.8% in plasma at the concentrations of 0.33 and 33.33 microg/ml. Intra- and inter-batch relative standard deviations were 0.15-2.03 and 1.18-9.96%, respectively. This method was successfully applied to the pharmacokinetic studies in rats after intravenous administration of pinocembrin.
- Published
- 2009
24. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro
- Author
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Cheng Yinxia, Xiaoxiu Li, Guorong He, Xin Mu, Guanhua Du, and Bei Xu
- Subjects
Male ,Tyrosine 3-Monooxygenase ,Cell Survival ,Clinical Biochemistry ,Apoptosis ,Substantia nigra ,Pharmacology ,Toxicology ,PC12 Cells ,Biochemistry ,Neuroprotection ,Cell Line ,Rats, Sprague-Dawley ,Behavioral Neuroscience ,chemistry.chemical_compound ,Parkinsonian Disorders ,In vivo ,Glial Fibrillary Acidic Protein ,Animals ,Humans ,Medicine ,Oxidopamine ,Biological Psychiatry ,Hydroxydopamine ,Plants, Medicinal ,biology ,Tyrosine hydroxylase ,business.industry ,Brain ,biology.organism_classification ,Rats ,Baicalein ,Substantia Nigra ,Neuroprotective Agents ,nervous system ,chemistry ,Flavanones ,Nerve Degeneration ,Scutellaria baicalensis ,business ,Phytotherapy - Abstract
Baicalein, a flavonoid obtained from the root of Chinese medicinal herb Scutellaria baicalensis, has been shown to exert a protective effect on neurons against several neuronal insults. The aim of this study was to explore the neuroprotective effect of baicalein in 6-hydroxydopamine (6-OHDA)-induced experimental parkinsonism in vitro and in vivo. In in vitro experiments, we found that baicalein (0.5, 5 μg/mL) could significantly ameliorate the 6-OHDA-induced SH-SY5Y cell apoptosis from 31.56% in the 6-OHDA group to 18.90%, 21.61% respectively, and also promote neurite outgrowth of PC12 cell. In in vivo experiments, baicalein had no effect on apomorphine (APO)-induced rotations, but it could significantly attenuate muscle tremor of 6-OHDA-lesioned rats. The burst frequency and amplitude are 13.43%, 35.18% compared to 6-OHDA group. Moreover, baicalein treatment could also increase tyrosine hydroxylase (TH)-positive neurons to 265.52% of the 6-OHDA group. The neuroprotective action of baicalein was coincident with an attenuated astroglial response within the substantia nigra. Neuroprotective effect of baicalein as demonstrated by the increasing the number of dopaminergic neurons may have been, in part, caused by anti-apoptotic, pro-differentiation and anti-inflammatory mechanisms of baicalein. Therefore, baicalein can be a promising candidate for prevention or treatment of Parkinson's disease, owing to its anti-apoptotic, pro-differentiation and anti-inflammatory action.
- Published
- 2009
25. Baicalein protects rat brain mitochondria against chronic cerebral hypoperfusion-induced oxidative damage
- Author
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Tiantai Zhang, Xiaoxiu Li, Yue-Hua Wang, Xiao-Li He, Guanhua Du, and Mei Gao
- Subjects
Male ,Cytochrome ,Blotting, Western ,Oxidative phosphorylation ,Motor Activity ,Mitochondrion ,Pharmacology ,medicine.disease_cause ,Oxidative Phosphorylation ,chemistry.chemical_compound ,Cognition ,medicine ,Animals ,Rats, Wistar ,Molecular Biology ,bcl-2-Associated X Protein ,Membrane Potential, Mitochondrial ,chemistry.chemical_classification ,Reactive oxygen species ,biology ,General Neuroscience ,Cytochrome c ,Brain ,Cytochromes c ,Mitochondria ,Rats ,Baicalein ,Cerebrovascular Disorders ,Oxidative Stress ,Carotid Arteries ,Proto-Oncogene Proteins c-bcl-2 ,chemistry ,Biochemistry ,Flavanones ,biology.protein ,Neurology (clinical) ,Mitochondrial Swelling ,Reactive Oxygen Species ,Homeostasis ,Oxidative stress ,Developmental Biology - Abstract
This study investigated the effects of baicalein, a natural compound isolated from the root of scutellaria, on cognitive and motor ability impaired by chronic cerebral hypoperfusion in rats, as well as its effects on brain mitochondria. Rats subjected to permanent bilateral common carotid artery occlusion experienced cognitive deficits, oxidative stress and mitochondria dysfunction, which was associated with the elevation of reactive oxygen species level, the decrease of oxidative phosphorylation parameters, the loss of mitochondrial membrane potential, the reduce in Bcl-2/Bax ratio, and the release of cytochrome c. Baicalein alleviated cognitive and motor impairments and decreased mitochondria reactive oxygen species production, in accordance with its improvements on membrane potential level, oxidative phosphorylation process, mitochondrial swelling degree, Bcl-2/Bax ratio and cytochrome c release. These data indicated that baicalein might have therapeutic potential for the treatment of dementia caused by chronic cerebral hypoperfusion, contributed to its protections on brain mitochondrial homeostasis and function.
- Published
- 2009
26. Concentrations and patterns of polychlorinated naphthalenes in surface sediment samples from Wuxi, Suzhou, and Nantong, in East China
- Author
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Liang Dong, Lifei Zhang, Linli Zhang, Yeru Huang, and Xiaoxiu Li
- Subjects
Delta ,China ,Geologic Sediments ,Environmental Engineering ,Halogenation ,Chemistry ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Sediment ,General Medicine ,General Chemistry ,Naphthalenes ,Pollution ,Grand canal ,Environmental chemistry ,Independent samples ,Yangtze river ,Environmental Chemistry ,Environmental Pollutants ,Environmental Monitoring - Abstract
The concentrations and patterns of polychlorinated naphthalenes (PCNs) were determined in surface sediment samples from Wuxi, Suzhou, and Nantong, in the Yangtze River Delta (East China), which has become urbanized rapidly. The total PCN (tri- to octachlorinated naphthalenes) concentrations in the samples from Wuxi, Suzhou, and Nantong were 0.89-40, 2.8-4600, and 0.60-34 ng/gdry weight, respectively. Unexpectedly high PCN concentrations were found in four of the sediment samples. The PCN concentrations were much higher in the samples from the Beijing-Hangzhou Grand Canal than in the samples from the Yangtze River. The toxic equivalent (TEQ) concentrations (determined from the concentrations of the "dioxin-like" PCNs) ranged from 1.45×10(-7) to 2.16 ng TEQ/g, and the congeners CN-66/67 and CN-73 were the predominant contributors to the TEQs. Independent samples t-tests were performed, and no significant differences were found between the PCN concentrations in the samples from the metropolitan area and the development zone when the four development-zone samples that contained very high PCN concentrations were excluded. The PCN profiles were dominated by the hexa- to octachlorinated naphthalene homologs. The CN-66/67 to CN-71/72 and CN-66 to CN-67 concentration ratios were used to identify specific PCN sources. Emissions from chemical and other industrial plants were found to have strongly influenced the PCN concentrations in sediment in the study area.
- Published
- 2015
27. Highly chlorinated unintentionally produced persistent organic pollutants generated during the methanol-based production of chlorinated methanes: A case study in China
- Author
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Lifei Zhang, Linli Zhang, Xiaoxiu Li, and Wenlong Yang
- Subjects
Pollutant ,China ,Environmental Engineering ,Halogenation ,Chemistry ,Health, Toxicology and Mutagenesis ,Methanol ,Public Health, Environmental and Occupational Health ,General Medicine ,General Chemistry ,Hexachlorobenzene ,Hexachlorocyclopentadiene ,Pollution ,Hexachlorobutadiene ,chemistry.chemical_compound ,Pentachlorobenzene ,Environmental Chemistry ,Organic chemistry ,Environmental Pollutants ,Methane ,Polychlorinated dibenzofurans - Abstract
The formation of unintentionally produced persistent organic pollutants (POPs) may occur during various chlorination processes. In this study, emissions of unintentionally produced POPs during the methanol-based production of chlorinated methanes were investigated. High concentrations of highly chlorinated compounds such as decachlorobiphenyl, octachloronaphthalene, octachlorostyrene, hexachlorobutadiene, hexachlorocyclopentadiene, hexachlorobenzene, and pentachlorobenzene were found in the carbon tetrachloride byproduct of the methanol-based production of chlorinated methanes. The total emission amounts of hexachlorocyclopentadiene, hexachlorobutadiene, polychlorinated benzenes, polychlorinated naphthalenes, octachlorostyrene, and polychlorinated biphenyls released during the production of chlorinated methanes in China in 2010 were estimated to be 10 080, 7350, 5210, 427, 212, and 167 kg, respectively. Moreover, polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) were formed unintentionally during chlorinated methanes production, the emission factor for PCDDs/DFs was 364 μg toxic equivalency quotient (TEQ) t−1 product for residues, which should be added into the UNEP toolkit for updating. It was worth noting that a high overall toxic equivalency quotient from polychlorinated naphthalenes and PCDDs/DFs was generated from the chlorinated methanes production in China in 2010. The values reached 563 and 32.8 g TEQ, respectively. The results of the study indicate that more research and improved management systems are needed to ensure that the methanol-based production of chlorinated methanes can be achieved safely.
- Published
- 2014
28. The Role of p-STAT3 as a Prognostic and Clinicopathological Marker in Colorectal Cancer: A Systematic Review and Meta-Analysis
- Author
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Wei Wang, Hui Ren, Liyan Zhang, Liwei Wang, Xiaoxiu Li, Yong Gan, Qi Chu, Mingxuan Zhang, and Kun Ji
- Subjects
0301 basic medicine ,Oncology ,Cytoplasm ,Colorectal cancer ,lcsh:Medicine ,Metastasis ,Mathematical and Statistical Techniques ,0302 clinical medicine ,Basic Cancer Research ,Medicine and Health Sciences ,Morphogenesis ,Stage (cooking) ,lcsh:Science ,Sexual Differentiation ,Multidisciplinary ,Hazard ratio ,Prognosis ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Meta-analysis ,Physical Sciences ,Anatomy ,Cellular Structures and Organelles ,Colorectal Neoplasms ,Statistics (Mathematics) ,Research Article ,STAT3 Transcription Factor ,medicine.medical_specialty ,Research and Analysis Methods ,Lymphatic System ,03 medical and health sciences ,Text mining ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,In patient ,Statistical Methods ,Immunohistochemistry Techniques ,Differentiated Tumors ,Colorectal Cancer ,business.industry ,lcsh:R ,Cancers and Neoplasms ,Biology and Life Sciences ,Cell Biology ,Odds ratio ,Phosphoproteins ,medicine.disease ,Confidence interval ,Histochemistry and Cytochemistry Techniques ,030104 developmental biology ,Immunologic Techniques ,lcsh:Q ,Lymph Nodes ,business ,Mathematics ,Meta-Analysis ,Developmental Biology - Abstract
Objective High expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) has been detected in a variety of human tumors. However, the association of positive p-STAT3 expression with clinicopathological parameters and the prognosis of colorectal cancer patients remain controversial. To identify the relationship between p-STAT3 expression and clinicopathological parameters and prognosis in patients with colorectal cancer, a systematic review and meta-analysis were performed. Methods We performed a comprehensive literature search from PubMed, EMBASE, and SinoMed through 27 March, 2016. Hazard ratios (HRs) with 95% confidence intervals (CI) were combined to evaluate the association between p-STAT3 expression and overall survival of colorectal cancer patients. Odds ratios (ORs) with 95% CI were combined to evaluate the association between p-STAT3 expression and clinicopathological parameters in patients with colorectal cancer. Results Seventeen studies including a total of 2,346 colorectal cancer patients were included in this meta-analysis. The combined HR was 1.43 (95% CI: 1.23–1.67, P < 0.001), which suggested a positive relationship between p-STAT3 overexpression and poorer overall survival of colorectal cancer patients. In addition, the results indicated that positive p-STAT3 expression was significantly associated with the presence of lymph node metastasis (OR: 2.43, 95% CI: 1.18–5.01, P = 0.02) but was not associated with TNM stage, tumor differentiation or gender. Conclusion The meta-analysis results suggest that p-STAT3 overexpression is unfavorable for the prognosis of colorectal cancer patients, and p-STAT3 overexpression is associated with the presence of lymph node metastasis among colorectal cancer patients.
- Published
- 2016
29. Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats
- Author
-
Guanhua Du, Bei Xu, Xiaoxiu Li, Guorong He, Juan-Juan Hu, Xin Mu, and Shuo Tian
- Subjects
Male ,Time Factors ,Long-Term Potentiation ,Hippocampus ,Hippocampal formation ,CREB ,Synaptic Transmission ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Cognition ,Memory ,medicine ,Animals ,Phosphorylation ,Cyclic AMP Response Element-Binding Protein ,Luteolin ,Maze Learning ,Pharmacology ,Neurons ,biology ,Behavior, Animal ,Brain ,Long-term potentiation ,Neurodegenerative Diseases ,medicine.disease ,Rats ,nervous system ,chemistry ,Cerebrovascular Circulation ,Synaptic plasticity ,biology.protein ,Memory consolidation ,Alzheimer's disease ,Psychology ,Neuroscience - Abstract
Processes of synaptic plasticity, such as long-term potentiation (LTP), has been considered a cellular correlate of learning and memory and many neurological disorders accompanied by cognitive deficits exhibit abnormal synaptic function. This emerging concept is exemplified by Alzheimer's disease. Mounting evidence suggests that Alzheimer's disease begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, which make it critical to identify LTP enhancers to slow down or stop the progression of Alzheimer's disease. In this study, we found flavonoid luteolin could enhance basal synaptic transmission and facilitate the induction of LTP by high frequency stimulation in the dental gyrus of rat hippocampus. Furthermore, we investigated the effects of luteolin on chronic cerebral hypoperfusion-induced spatial learning dysfunction and LTP impairment in rat. The results showed chronic cerebral hypoperfusion produced by 2-vessel occlusion significantly impaired spatial learning and memory, and luteolin reversed the learning and memory deficit. 2-vessel occlusion resulted in dramatic inhibition of LTP formation in the hippocampus and luteolin significantly rescued the LTP impairment. These results demonstrate that luteolin not only directly modulates LTP formation, but also protects synapses from the detrimental effects of chronic cerebral hypoperfusion on LTP formation, which may contribute to the protective effects of luteolin on learning and memory. By immunoblotting, we found the effects of luteolin on LTP and memory may due to the activation of cAMP response element-binding protein (CREB). Therefore, flavonoid luteolin shows great potential as a novel treatment agent for protecting synaptic function and enhancing memory in neurodegenerative disorders.
- Published
- 2009
30. Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile
- Author
-
Juan-Juan Hu, Cheng Yinxia, Tiantai Zhang, Xin Mu, Xiaoxiu Li, Guorong He, Bei Xu, and Guanhua Du
- Subjects
Male ,Tyrosine 3-Monooxygenase ,Cell Count ,Pharmacology ,medicine.disease_cause ,Neuroprotection ,chemistry.chemical_compound ,Mice ,Glial Fibrillary Acidic Protein ,Neurotoxin ,Medicine ,Animals ,Biogenic Monoamines ,Drug Interactions ,Brain Chemistry ,Dopamine Plasma Membrane Transport Proteins ,biology ,Behavior, Animal ,business.industry ,General Neuroscience ,MPTP ,Dopaminergic ,Neurotoxicity ,MPTP Poisoning ,biology.organism_classification ,medicine.disease ,nervous system diseases ,Baicalein ,Mice, Inbred C57BL ,Neuroprotective Agents ,nervous system ,chemistry ,1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ,Flavanones ,Scutellaria baicalensis ,business ,Neuroscience ,Oxidative stress ,Psychomotor Performance - Abstract
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes the damage of dopaminergic neurons as seen in Parkinson's disease (PD). Oxidative stress has been implicated in the pathogenesis of PD. Baicalein, isolated from the traditional Chinese herbal medicine Huangqin (Scutellaria baicalensis Georgi), has been shown to have antioxidant effects. Here we investigated the effect of baicalein on MPTP-induced neurotoxicity in mice. Pretreatment with baicalein for a week was followed by challenge with MPTP for 4 consecutive days; the subsequent behavioral, biochemical and immunohistochemical manifestations in mice were determined and compared to those in untreated mice and mice challenged only with MPTP. The present study showed that baicalein could improve the abnormal behavior in MPTP-treated mice. The protective effect may be caused by increasing the levels of DA and 5-HT in the striatum, increasing the counts of dopaminergic neurons, inhibiting oxidative stress and the astroglia response. These results suggest that baicalein possesses potent neuroprotective activity and may be a potential anti-Parkinson's disease drug that is worthy of further study.
- Published
- 2008
31. Study on the Long-Term Performance and Efficiency of Single-Well Circulation Coupled Groundwater Heat Pump System Based on Field Test
- Author
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Ke Zhu, Yifan Zeng, Qiang Wu, Shengheng Xu, Kun Tu, and Xiaoxiu Liu
- Subjects
single-well circulation ,groundwater heat pump ,efficiency ,energy consumption ,coefficient of performance ,Science - Abstract
Although buildings are often heated and cooled by single-well circulation coupled groundwater heat pump systems, few studies have evaluated the long-term performance of these systems. Therefore, the present study investigated the performance of these systems by analyzing the efficiency and energy consumption using 4 years of operating data. The results indicate that the coefficient of performance (COP) of the system gradually decreases because of thermal breakthrough or an accumulation of cold. In addition, the sealing clapboards could effectively slow down thermal breakthrough. In addition, compared with the heating period, the COP of the heat pump unit (HPU) and system increases, and its energy consumption decreases in the cooling period. It was also found that partial heat loss occurs when water from the single-well circulation outlet penetrates the main pipeline. Moreover, the heat-exchange efficiency of a single HPU exceeds that of multiple HPUs, and the COP of a HPU decreases during operation with increasing indoor temperature. Accordingly, we improved the performance of system by increasing the underground heat storage. Herein, we focus on optimizing the system design during long-term operation, which includes taking steps such as lengthening the sealing clapboards, using insulated pipes, discharging the remaining water and adding intelligent control devices.
- Published
- 2021
- Full Text
- View/download PDF
32. Data analysis and discussion of thermal response test under a power outage and variable heating power
- Author
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Wei Song, Tuanfeng Zheng, Xiaoxiu Liu, Jiaming Yang, and Changxing Zhang
- Subjects
In-situ thermal response test ,Power outage ,Variable heating power ,Heat transfer balance ,Rock-soil thermal properties ,Pump heat generation ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
In this research, a comprehensive study of power outage and variable heating power were conducted during an in-situ thermal response test (TRT) with a 261-m deep double U-tube borehole heat exchanger. The TRT data obtained during a power outage were measured using the indirect, superposition, equivalent time, and separation methods to obtain the thermal properties of rock-soil. The thermal conductivity of rock-soil, volumetric heat capacity, and thermal resistance were 1.21 W/(m·°C), 2413 kJ/(m3·°C), and 0.41 m2·°C/W, respectively. In the analysis of the test data of the variable heating power conditions, the additional heating as a result of the pump power cannot be ignored, and heat generated by the circulating water pump was stable. The heat transfer rate and average fluid temperature gradually stabilized as the test progressed, and the relationship between them is linear. The trends in the heat exchange rate and average fluid temperature after changing the heating power were expressed using a formula. A thermal response test method with variable heating power was proposed for this test, and the thermal conductivity and initial ground temperature of rock-soil were obtained using this method.
- Published
- 2020
- Full Text
- View/download PDF
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