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Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice
- Source :
- Pharmacology Biochemistry and Behavior. 98:286-291
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Many studies of Parkinson's disease suggest that oxidative stress is involved in the neurodegenerative process. Baicalein has been shown to have antioxidant effects. The present study examines the effect of baicalein on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice. MPTP treatment impaired spontaneous motor activity and rotarod performance, but baicalein improved this deficit. Moreover, baicalein at 280 and 560 mg/kg exhibited a protective effect against the MPTP-induced decrease in tyrosine hydroxylase (TH)-positive fibers in the substantia nigra, demonstrated by the immunohistological, morphological and behavioral outcomes. MPTP treatment also decreased dopamine levels in the striatum. However, treatment with baicalein attenuated these decreases in dopamine levels by changing dopamine catabolism and inhibiting dopamine turnover. The neuroprotective effect of baicalein on dopaminergic neurons may partly be due to its antioxidant properties. Therefore, we speculate that baicalein might be a promising candidate for prevention or treatment of oxidative stress-related neurodegenerative disorders such as Parkinson's disease.
- Subjects :
- Male
medicine.medical_specialty
Tyrosine 3-Monooxygenase
Dopamine
Clinical Biochemistry
Substantia nigra
Toxicology
Biochemistry
Neuroprotection
Antioxidants
Mice
Behavioral Neuroscience
chemistry.chemical_compound
Malondialdehyde
Internal medicine
medicine
Animals
Biological Psychiatry
Neurons
Pharmacology
Glutathione Peroxidase
Behavior, Animal
Tyrosine hydroxylase
Superoxide Dismutase
MPTP
Dopaminergic
Brain
MPTP Poisoning
Corpus Striatum
Baicalein
Mice, Inbred C57BL
Substantia Nigra
Oxidative Stress
Endocrinology
nervous system
chemistry
Flavanones
medicine.drug
Subjects
Details
- ISSN :
- 00913057
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Pharmacology Biochemistry and Behavior
- Accession number :
- edsair.doi.dedup.....3e05377a5d1f70c998c65d1637cf76f4