1. Poor outcome in hypoxic endometrial carcinoma is related to vascular density
- Author
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Maria Santacana, Marc P.L.M. Snijders, Antonio Gil-Moreno, Xavier Matias-Guiu, Jutta Huvila, Johan P. Peters, Frédéric Amant, Johan Bulten, Camilla Krakstad, Eva Colas, Ingfrid S. Haldorsen, Martijn Arts, Willem Jan van Weelden, P.F.J.W. Rijken, Eva Jandáková, Peter Bronsert, Koen Van de Vijver, Gemma Mancebo, Heidi V.N. Küsters-Vandevelde, Martin Koskas, Lubos Minar, Johanna M.A. Pijnenborg, Vít Weinberger, Saskia van den Berg-van Erp, Marc Hirschfeld, Leon F.A.G. Massuger, Johan Bussink, Jone Trovik, Casper Reijnen, Armando Reques, ENITEC consortium, ARD - Amsterdam Reproduction and Development, CCA - Cancer biology and immunology, and Obstetrics and Gynaecology
- Subjects
Oncology ,Cancer Research ,Angiogenesis ,CD34 ,ANGIOGENESIS ,TUMOR HYPOXIA ,Neovascularization ,Prognostic markers ,0302 clinical medicine ,Endometrial cancer ,PROGNOSTIC-SIGNIFICANCE ,Medicine ,SPACE INVASION ,MICROVESSEL DENSITY ,INDUCIBLE FACTOR-1 ,Aged, 80 and over ,Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17] ,Neovascularization, Pathologic ,Hazard ratio ,Middle Aged ,Cell Hypoxia ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,030220 oncology & carcinogenesis ,Female ,medicine.symptom ,Life Sciences & Biomedicine ,Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] ,Adult ,EXPRESSION ,medicine.medical_specialty ,CARBONIC-ANHYDRASE-IX ,Article ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,Internal medicine ,Carcinoma ,Humans ,BREAST-CANCER ,Carbonic Anhydrase IX ,Aged ,Science & Technology ,Tumor hypoxia ,business.industry ,Proportional hazards model ,LYMPH-NODE METASTASIS ,Hypoxia (medical) ,medicine.disease ,Endometrial Neoplasms ,business - Abstract
BACKGROUND: Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. METHODS: Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). CAIX expression was determined in epithelial tumour cells, with a cut-off of 1%. MVD was assessed according to the Weidner method. Correlations with disease-specific survival (DSS), disease-free survival (DFS) and distant disease-free survival (DDFS) were calculated using Kaplan-Meier curves and Cox regression analysis. RESULTS: Sixty-three (16.4%) of 385 ECs showed positive CAIX expression with high vascular density. These ECs had a reduced DSS compared to tumours with either hypoxia or high vascular density (log-rank p = 0.002). Multivariable analysis showed that hypoxic tumours with high vascular density had a reduced DSS (hazard ratio [HR] 3.71, p = 0.002), DDFS (HR 2.68, p = 0.009) and a trend for reduced DFS (HR 1.87, p = 0.054). CONCLUSIONS: This study has shown that adverse outcome in hypoxic ECs is seen in the presence of high vascular density, suggesting an important role of angiogenesis in the metastatic process of hypoxic EC. Differential adjuvant treatment might be indicated for these patients. ispartof: BRITISH JOURNAL OF CANCER vol:120 issue:11 pages:1037-1044 ispartof: location:England status: published
- Published
- 2019