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Assessment of the neovascular permeability in glioma xenografts by dynamicT1MRI with Gadomer-17
- Source :
- Magnetic Resonance in Medicine. 47:305-313
- Publication Year :
- 2002
- Publisher :
- Wiley, 2002.
-
Abstract
- The uptake of Gadomer-17, as probed by fast dynamic T(1) measurements, was used to assess the vascular permeability surface-area product per leakage volume of tissue (k(Tofts)) of human glioma xenografts implanted in mice. With this approach we could discriminate between two types of glioma xenograft lines with a known difference in the perfused vascular architecture and degree of hypoxia. The T(1) data were analyzed according to the Tofts-Kermode compartment model. The fast-growing E102 tumor demonstrated a homogeneous distribution of the vascular permeability surface area across the tumor (mean k(Tofts) value = 0.18 +/- 0.05 min(-1)). The slowly growing E106 tumor showed a more heterogeneous pattern. Three perfused tumor areas with differences in vascular permeability surface area could be distinguished: a well-perfused periphery with high k(Tofts) values (0.24 +/- 0.04 min(-1)), perfused capillaries inside the tumor with low k(Tofts) values (0.108 +/- 0.026 min(-1)), and perfused capillaries adjacent to necrotic regions with high k(Tofts) values (0.29 +/- 0.10 min(-1)). On a different series of tumors, the hypoxic fractions were measured, and these were significantly higher in E106 tumors (0.14 +/- 0.05) compared to tumors of the E102 line (0.03 +/- 0.02).
- Subjects :
- Pathology
medicine.medical_specialty
Human glioma
medicine.diagnostic_test
Gadolinium
chemistry.chemical_element
Magnetic resonance imaging
Vascular permeability
medicine.disease
Vascular architecture
Neovascularization
Nuclear magnetic resonance
chemistry
Permeability (electromagnetism)
Glioma
medicine
Radiology, Nuclear Medicine and imaging
medicine.symptom
Subjects
Details
- ISSN :
- 07403194
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Magnetic Resonance in Medicine
- Accession number :
- edsair.doi...........6d7528b5363e4c4d9cdb0c90205acfae