803 results on '"Mosqueda-Taylor A"'
Search Results
2. An elderly Hispanic male with mucosal erosions
- Author
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Juan D. Dufflart Ocampo, Emma Pérez Campos, Elisa Vega Memije, Sonia Toussaint Caire, Claudia I. Sáenz Corral, and Adalberto Mosqueda Taylor
- Subjects
cicatricial pemphigoid ,mucous membrane pemphigoid ,ocular cicatricial pemphigoid ,Dermatology ,RL1-803 ,Diseases of the genitourinary system. Urology ,RC870-923 - Published
- 2023
- Full Text
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3. Mapping oral medicine (stomatology) & oral and maxillofacial pathology international organizations: a scoping review of global data and historical analysis
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Pereira, Thaís Cristina Esteves, Santana dos Santos, Erison, Hanemann, João Adolfo Costa, Vargas, Pablo Agustin, Lopes, Márcio Ajudarte, van Heerden, Willie F.P., Bissonnette, Caroline, Panico, René Luis, González-Arriagada, Wilfredo Alejandro, Nava-Villalba, Mario, Gallagher, Karen Patricia Domínguez, Molina, Ronell Bologna, Saldivia-Siracusa, Cristina, Wiriyakijja, Paswach, Radhakrishnan, Raghu Anekal, Farag, Arwa Mohammad, Nagao, Toru, Huang, Yu-Feng, Riordain, Richeal Ni, Diniz-Freitas, Márcio, Bertin, Hélios, Farah, Camile S., Mosqueda-Taylor, Adalberto, Perez, Danyel Elias da Cruz, Hunter, Keith David, Villa, Alessandro, and Santos-Silva, Alan Roger
- Published
- 2024
- Full Text
- View/download PDF
4. Clinicopathological features of myofibromas and myofibromatosis affecting the oral and maxillofacial region: A systematic review
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Silveira, Felipe Martins, primary, Kirschnick, Laura Borges, additional, Só, Bruna Barcelos, additional, Schuch, Lauren Frenzel, additional, Pereira Prado, Vanesa, additional, Sicco, Estefania, additional, Lima, Rafael Rodrigues, additional, Bologna‐Molina, Ronell Eduardo, additional, Mosqueda‐Taylor, Adalberto, additional, Vasconcelos, Ana Carolina Uchoa, additional, and Martins, Manoela Domingues, additional
- Published
- 2024
- Full Text
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5. An international collaborative study of 105 new cases of adenomatoid odontogenic tumors
- Author
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Roza, Ana Luiza Oliveira Corrêa, Carlos, Román, van Heerden, Willie F.P., de Andrade, Bruno Augusto Benevenuto, Mosqueda-Taylor, Adalberto, Santos-Silva, Alan Roger, Lopes, Márcio Ajudarte, de Almeida, Oslei Paes, Romañach, Mário José, and Vargas, Pablo Agustin
- Published
- 2021
- Full Text
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6. Perfil inmunohistoquímico del Tumor Odontogénico Primordial
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VANESA PEREIRA PRADO, ADALBERTO MOSQUEDA TAYLOR, MIKAMI TOSHINARI, and RONELL BOLOGNA MOLINA
- Subjects
tumor odontogénico primordial ,análisis inmunohistoquímico ,odontogénesis ,Dentistry ,RK1-715 - Abstract
El tumor odontogénico primordial (TOP) es un tumor odontogénico benigno mixto, descrito por primera vez en el 2014 por el Dr. Mosqueda Taylor y considerado como tal en la última clasificación de tumores de cabeza y cuello de la Organización Mundial de la Salud. Clínicamente se presenta como una lesión radiolúcida, bien definida, próxima a la corona de una pieza no erupcionada, pudiendo provocar expansión ósea, reabsorción radicular y desplazamiento de piezas vecinas. Presenta predilección por el sector posterior mandibular, el género masculino y en un rango etario de 2-19 años. Histopatológicamente presenta un tejido fibroso laxo con áreas similares a la papila dental, cubierto por un epitelio cuboide-columnar, que se asemeja al epitelio interno del órgano del esmalte, y se encuentra rodeado al menos parcialmente por una cápsula fibrosa. Objetivo: investigar la posible histogénesis y comportamiento biológico de TOP mediante el análisis inmunohistoquímico de sus componentes epitelial y mesenquimático, aplicando un amplio panel de anticuerpos. Materiales y métodos: se evaluaron 4 casos de TOP con un panel de 23 anticuerpos. Resultados. Las células epiteliales mostraron positividad en toda su extensión para citoqueratina 14 y 19, mientras que los anticuerpos amelogenina, glut-1, moc-31, caveolina-1, galectina-3, PITX2, p53, bax, bcl2, Survivina y PTEN presentaron positividad en áreas focales. El componente mesenquimático tumoral presentó positividad para vimentina, CD-138, PITX2, CD-105, CD-34, ciclina D1, bax, bcl-2, Survivina y p53. BRAFV600E y calretinina fueron negativos para todas las muestras. Los marcadores de proliferación celular Ki-67 y MCM-7 se expresaron en menos del 5% de las células tumorales. Conclusión: de acuerdo con los resultados inmunohistoquímicos podemos sugerir que TOP es un tumor que se desarrolla en las etapas inmaduras, o primordiales, de la odontogénesis, presentando zonas focales con diferentes grados de maduración y un bajo índice de proliferación celular.
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- 2022
7. Central odontogenic fibroma: an international multicentric study of 62 cases
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Roza, Ana Luiza Oliveira Corrêa, Sousa, Emanuel Mendes, Leite, Amanda Almeida, Amaral-Silva, Gleyson Kleber, Morais, Thayná Melo de Lima, Wagner, Vivian Petersen, Schuch, Lauren Frenzel, Vasconcelos, Ana Carolina Uchoa, de Arruda, José Alcides Almeida, Mesquita, Ricardo Alves, Fonseca, Felipe Paiva, Abrahão, Aline Corrêa, Agostini, Michelle, de Andrade, Bruno Augusto Benevenuto, da Silveira, Ericka Janine Dantas, Martínez-Flores, René, Rondanelli, Benjamin Martínez, Alberdi-Navarro, Javier, Robinson, Liam, Marin, Constanza, Assunção Júnior, José Narciso Rosa, Valiati, Renato, Fregnani, Eduardo Rodrigues, Santos-Silva, Alan Roger, Lopes, Marcio Ajudarte, Hunter, Keith D., Khurram, Syed Ali, Speight, Paul M., Mosqueda-Taylor, Adalberto, van Heerden, Willie F.P., Carlos, Román, Wright, John M., de Almeida, Oslei Paes, Romañach, Mário José, and Vargas, Pablo Agustin
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- 2021
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8. Salivary Gland Tumors: A Retrospective Study of 164 Cases from a Single Private Practice Service in Mexico and Literature Review
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Cunha, John Lennon Silva, Hernandez-Guerrero, Juan Carlos, de Almeida, Oslei Paes, Soares, Ciro Dantas, and Mosqueda-Taylor, Adalberto
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- 2021
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9. An elderly Hispanic male with mucosal erosions
- Author
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Dufflart Ocampo, Juan D., primary, Pérez Campos, Emma, additional, Vega Memije, Elisa, additional, Toussaint Caire, Sonia, additional, Sáenz Corral, Claudia I., additional, and Mosqueda Taylor, Adalberto, additional
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- 2023
- Full Text
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10. Value of the toluidine blue test as an aid to determine the biopsy site in actinic prurigo cheilitis
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Lily Margoth Cedeño-Suárez, María Elisa Vega-Memije, Juan Carlos Cuevas-González, and Adalberto Mosqueda-Taylor
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Actinic Prurigo ,toluidine blue O-polyacrylamide polymer ,Tertiary Lymphoid Structures ,Medicine ,Internal medicine ,RC31-1245 - Abstract
Actinic prurigo (AP) is a type of photodermatosis that primarily affects the Latin American mestizo population. Histologically, AP cheilitis exhibits acanthosis with spongiosis and vacuolation of the basal cell layer overlying a dense lymphocytic inflammatory infiltrate that forms well-defined lymphoid follicles. Toluidine blue is a thiazide, acidophilic, and metachromatic dye used in vivo to selectively stain the acidic components of tissues such as sulfates, carboxylates, and phosphate radicals that are incorporated into DNA and RNA. It is necessary to develop a method that allows detecting, on clinical grounds the area of the lesion in which it is more feasible to find such structures. Thus to increase the sensitivity of the biopsy, in AP cheilitis to accurately identify where the lymphoid follicles reside, based on the higher concentration of DNA in such structures and thus confirm the diagnosis. In this study, staining was positive in 85% of patients with AP cheilitis, in 14 of whom 82% lymphoid follicles were observed by histopathology. One of the pathologist’s problems in establishing the diagnosis of AP is that the main histopathological characteristics are not always identified in the submitted samples because it is not easy to clinically identify the most representative site of the lesion selected for performing a biopsy. Based on our results, we propose using toluidine blue as an auxiliary method to choose a tissue sample to facilitate the diagnosis and allow clinicians to make clinical correlations between the histopathological and therapeutic findings.
- Published
- 2021
11. Oct-4 and CD44 in epithelial stem cells like of benign odontogenic lesions
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Monroy, Eduardo Alonso Cruz, de Andrade Santos, Pedro Paulo, de Sousa Lopes, Maria Luiza Diniz, Mosqueda-Taylor, Adalberto, Pinto, Leão Pereira, and de Souza, Lélia Batista
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- 2018
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12. Spatial distribution of <scp>CD34</scp> protein in primordial odontogenic tumour, ameloblastic fibroma and the tooth germ
- Author
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Vanesa Pereira Prado, Gabriel Landini, Adalberto Mosqueda Taylor, Pablo Vargas, and Ronell Bologna Molina
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Cancer Research ,Otorhinolaryngology ,Periodontics ,Oral Surgery ,Pathology and Forensic Medicine - Abstract
Primordial odontogenic tumour is a benign mixed neoplasm of recent description, which has histological similarities with other odontogenic tumours such as the ameloblastic fibroma. In this article, we investigate the architecture of the sub-epithelial layer of mesenchymal cells expressing the marker CD34 in primordial odontogenic tumour.Analyse the spatial patterns of CD34 expression in primordial odontogenic tumour and compare them with those in ameloblastic fibroma and the normal tooth germ by means of objective imaging approaches, to better characterise these lesions.Two cases of primordial odontogenic tumour, four cases of ameloblastic fibroma and two cases of tooth germ in cap and bell stages were used for morphological, structural and immunohistochemical analyses.CD34 expression was found in vascular endothelium of primordial odontogenic tumour, ameloblastic fibroma and tooth germ. In addition, a characteristic sub-epithelial expression was observed only in primordial odontogenic tumour, corresponding to 84%-86% of the sample boundaries. Moreover, the zone expressing CD34 corresponded with a higher cellularity, which was absent in ameloblastic fibroma and tooth germ.Image analysis of the primordial odontogenic tumour architecture revealed characteristics absent in other odontogenic tumours and tooth germs. This study provides additional information to support the idea that this neoplasm is a distinct entity from early stage AF or developing odontoma.
- Published
- 2022
13. Synchronous odontogenic tumors: A systematic review.
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Neumann, Bruna Luísa, Só, Bruna Barcelos, Santos, Lucas Gonçalves, Silveira, Felipe Martins, Wagner, Vivian Petersen, Vargas, Pablo Agustin, dos Santos, Jean Nunes, Mosqueda‐Taylor, Adalberto, Fonseca, Felipe Paiva, Schuch, Lauren Frenzel, and Martins, Manoela Domingues
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ODONTOGENIC tumors ,ONLINE information services ,MEDICAL information storage & retrieval systems ,ORAL health ,SYSTEMATIC reviews ,ORAL diseases ,HEALTH ,INFORMATION resources ,DESCRIPTIVE statistics ,ADENOMATOID tumors ,MEDLINE ,LITERATURE - Abstract
This systematic review aimed to incorporate published information about synchronous odontogenic tumors (SOTs) with an analysis of the demographic and clinical characteristics from the cases published in the literature. Case reports and case series of SOT were searched in PubMed, Web of Science, Scopus, and EMBASE. A descriptive statistical analysis was performed. Twenty‐eight studies comprising 30 cases of SOTs were included. Considering all cases published, SOTs mostly occurred simultaneously in the maxilla and mandible (n = 19/63.3%). Lesions were bifocal in 13 (43.3% of all the 30 cases) and multifocal in 17 cases (56.7% of all the 30 cases). All SOTs available in the literature presented the same type of lesion, and two of them also involved another different SOT (n = 2/6.7% of all the 30 cases). Out of all published cases, the most frequent SOTs in the literature were odontomas (n = 10/33.3% of all the 30 cases), squamous odontogenic tumors (OTs) (n = 8/26.7% of all the 30 cases), calcifying epithelial OTs (n = 8/26.7% of all the 30 cases), and adenomatoid OTs (n = 2/6.7% of all the 30 cases). Considering all SOTs cases included, the overall recurrence was 13.3%. Inside a subgroup of the lesion, synchronous calcifying epithelial OT presented the highest (25%). Five cases (16.7% of all the 30 cases) had a previously associated syndrome, with two cases of Schimmelpenning syndrome being reported. Among published SOTs, odontomas were the most common. All SOTs available in the scientific literature showed the same type of OT and mainly affected both jaws simultaneously. Only a few of these cases were associated with a syndrome. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
14. Symptomatic subgemmal neurogenous plaque in patients with COVID‐19: Is there an association?
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Soares, Ciro Dantas, primary, de Souza, Lucas Lacerda, additional, Laffitte, Caroline Medeiros, additional, Pontes, Hélder Antônio Rebelo, additional, de Almeida, Oslei Paes, additional, Mosqueda‐Taylor, Adalberto, additional, Hernandez‐Guerrero, Juan Carlos, additional, Vargas, Pablo Agustin, additional, Lopes, Márcio Ajudarte, additional, dos Santos‐Silva, Alan Roger, additional, da Costa Gurgel, Alberto, additional, de Andrade Pacheco, Maíra Medeiros, additional, de Oliveira Sales, Alexandre, additional, and de Oliveira Ramos, Carlos Cesar, additional
- Published
- 2023
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15. Citoqueratinas 14 y 19 en quistes y tumores de origen odontogénico. Una revisión
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Sabrina Nieves, Delmira Apellaniz, Gabriel Tapia, Álvaro mAGLIA, Adalberto Mosqueda-Taylor, and Ronell Bologna-Molina
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Citoqueratina 14, Citoquerarina 19, Quistes odontogénicos, Tumores odontogénicos ,Dentistry ,RK1-715 - Abstract
Todas las células de los mamíferos contienen un sistema citoplasmático de fbras esencial para la movilidad celular, el citoesqueleto, el cual se encuentra integrado por tres unidades estructurales principales y proteínas asociadas: microflamentos, microtúbulos y flamentos intermedios. Las citoqueratinas son flamentos intermedios que forman una red compleja que se extiende desde la superfcie del núcleo a la porción periférica de la célula, donde se insertan en desmosomas y hemidesmosomas. Las citoquerarinas 14 y 19 han sido utilizadas como marcadores de diagnóstico y pronóstico en diversas neoplasias de origen epitelial, no sólo permiten identifcar a una célula como epitelial, sino que permiten identifcar diferentes etapas durante diferenciación del epitelio y caracterizar el tumor. Existen numerosos trabajos en la literatura biomédica que han ejemplifcado la utilidad de citoqueratinas 14 y 19 para identifcar epitelio odontogénico. Esta revisión analiza la utilidad de su inmunoexpresión en los diferentes quistes y tumores odontogénicos.
- Published
- 2019
16. Oral medicine (stomatology) across the globe: birth, growth, and future
- Author
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Scully, Crispian, Miller, Craig S., Aguirre Urizar, Jose-Manuel, Alajbeg, Ivan, Almeida, Oslei P.D., Bagan, Jose Vicente, Birek, Catalena, Chen, Qianming, Farah, Camile S., Figueirido, José Pedro, Hasséus, Bengt, Jontell, Mats, Kerr, A. Ross, Laskaris, George, Lo Muzio, Lorenzo, Mosqueda-Taylor, Adalberto, Nagesh, Kikkeri S., Nikitakis, Nikolaos G., Peterson, Douglas, Sciubba, James, Thongprasom, Kobkan, Tovaru, Şerban, and Zadik, Yehuda
- Published
- 2016
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17. Symptomatic subgemmal neurogenous plaque in patients with COVID‐19: Is there an association?
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Ciro Dantas Soares, Lucas Lacerda de Souza, Caroline Medeiros Laffitte, Hélder Antônio Rebelo Pontes, Oslei Paes de Almeida, Adalberto Mosqueda‐Taylor, Juan Carlos Hernandez‐Guerrero, Pablo Agustin Vargas, Márcio Ajudarte Lopes, Alan Roger dos Santos‐Silva, Alberto da Costa Gurgel, Maíra Medeiros de Andrade Pacheco, Alexandre de Oliveira Sales, and Carlos Cesar de Oliveira Ramos
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Cancer Research ,Otorhinolaryngology ,Periodontics ,Oral Surgery ,Pathology and Forensic Medicine - Published
- 2023
18. Oral Medicine and Pathology at a Glance
- Author
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Pedro Diz Dios, Crispian Scully, Oslei Paes de Almeida, José V. Bagán, Adalberto Mosqueda Taylor and Pedro Diz Dios, Crispian Scully, Oslei Paes de Almeida, José V. Bagán, Adalberto Mosqueda Taylor
- Published
- 2017
19. Spatial distribution of CD34 protein in primordial odontogenic tumour, ameloblastic fibroma and the tooth germ
- Author
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Pereira Prado, Vanesa, primary, Landini, Gabriel, additional, Mosqueda Taylor, Adalberto, additional, Vargas, Pablo, additional, and Bologna Molina, Ronell, additional
- Published
- 2022
- Full Text
- View/download PDF
20. Oral Manifestations of Coronavirus Disease 2019 (COVID-19)
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Sanderson D do Nascimento Medeiros, Ciro Dantas Soares, Fábio de Abreu Alves, Oslei Paes de Almeida, Alexandre de Oliveira Sales, Clovis Antonio Lopes Pinto, Maria Goretti Freire de Carvalho, Hélder Antônio Rebelo Pontes, Adalberto Mosqueda-Taylor, Lucas Lacerda de Souza, and Juan Carlos Hernández-Guerrero
- Subjects
Pathology ,medicine.medical_specialty ,Anosmia ,Disease ,Pathology and Forensic Medicine ,Tongue ,Humans ,Medicine ,Oral mucosa ,SARS-CoV-2 ,business.industry ,COVID-19 ,Endothelial Cells ,Middle Aged ,medicine.disease ,Dysgeusia ,Pneumonia ,Dyspnea ,medicine.anatomical_structure ,Severe acute respiratory syndrome-related coronavirus ,Surgery ,Anatomy ,medicine.symptom ,Chronic Inflammatory Infiltrate ,business ,Viral load - Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents rapid transmission and significant mortality worldwide. It is responsible for coronavirus disease 2019 (COVID-19). The disease presents diverse clinical symptoms, including fever, cough, dyspnea, and pneumonia. However, other manifestations associated with COVID-19 need to be clarified, leading specialists to an early diagnosis and better prognosis. We describe the spectrum of clinicopathologic COVID-19-related oral lesions that can be the first and/or the unique manifestation of the disease. Fourteen patients with a mean age of 58 years (range: 23 to 88 y) with oral lesions were included. All patients were confirmed to be infected with SARS-CoV-2 by reverse transcription polymerase chain reaction testing. Patients demonstrated mild symptoms, including dysgeusia, anosmia, fever, and headache. The lesions were recognized and classified into 2 groups: (1) lesions caused by ischemia and/or hemorrhage and (2) lesions secondary to inflammatory events associated with viral load. The palate was most affected (n=8), followed by the tongue (n=4), and both the lip and palate (n=2). Histologic analysis demonstrated thrombosis of small arteries and capillaries, associated with areas of hemorrhage and chronic inflammatory infiltrate. Immunohistochemistry showed positive staining for spike protein (SARS-CoV and SARS-CoV-2) and angiotensin-converting enzyme 2 in the surface epithelium, salivary glands, inflammatory cells, and endothelial cells. Although the incidence of oral lesions among patients infected with SARS-CoV-2 appears to be uncommon, these findings suggest that the oral mucosa can also be a target organ for SARS-CoV-2.
- Published
- 2021
21. Synchronous odontogenic tumors: A systematic review
- Author
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Bruna Luísa Neumann, Bruna Barcelos Só, Lucas Gonçalves Santos, Felipe Martins Silveira, Vivian Petersen Wagner, Pablo Agustin Vargas, Jean Nunes dos Santos, Adalberto Mosqueda‐Taylor, Felipe Paiva Fonseca, Lauren Frenzel Schuch, and Manoela Domingues Martins
- Subjects
Otorhinolaryngology ,General Dentistry - Abstract
This systematic review aimed to incorporate published information about synchronous odontogenic tumors (SOTs) with an analysis of the demographic and clinical characteristics from the cases published in the literature. Case reports and case series of SOT were searched in PubMed, Web of Science, Scopus, and EMBASE. A descriptive statistical analysis was performed. Twenty-eight studies comprising 30 cases of SOTs were included. Considering all cases published, SOTs mostly occurred simultaneously in the maxilla and mandible (n = 19/63.3%). Lesions were bifocal in 13 (43.3% of all the 30 cases) and multifocal in 17 cases (56.7% of all the 30 cases). All SOTs available in the literature presented the same type of lesion, and two of them also involved another different SOT (n = 2/6.7% of all the 30 cases). Out of all published cases, the most frequent SOTs in the literature were odontomas (n = 10/33.3% of all the 30 cases), squamous odontogenic tumors (OTs) (n = 8/26.7% of all the 30 cases), calcifying epithelial OTs (n = 8/26.7% of all the 30 cases), and adenomatoid OTs (n = 2/6.7% of all the 30 cases). Considering all SOTs cases included, the overall recurrence was 13.3%. Inside a subgroup of the lesion, synchronous calcifying epithelial OT presented the highest (25%). Five cases (16.7% of all the 30 cases) had a previously associated syndrome, with two cases of Schimmelpenning syndrome being reported. Among published SOTs, odontomas were the most common. All SOTs available in the scientific literature showed the same type of OT and mainly affected both jaws simultaneously. Only a few of these cases were associated with a syndrome.
- Published
- 2022
22. An international collaborative study of 105 new cases of adenomatoid odontogenic tumors
- Author
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Oslei Paes de Almeida, Roman Carlos, Willie F. P. van Heerden, Ana Luiza Oliveira Corrêa Roza, Alan Roger Santos-Silva, Pablo Agustin Vargas, Mário José Romañach, Márcio Ajudarte Lopes, Bruno Augusto Benevenuto de Andrade, and Adalberto Mosqueda-Taylor
- Subjects
Adult ,Male ,medicine.medical_specialty ,Anterior maxilla ,Odontogenic Tumors ,Mandible ,Pathology and Forensic Medicine ,Ameloblastoma ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Oral and maxillofacial pathology ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Back ,Posterior mandible ,Adenomatoid odontogenic tumor ,business.industry ,030206 dentistry ,medicine.disease ,Dermatology ,Odontogenic ,Multicenter study ,030220 oncology & carcinogenesis ,Female ,Surgery ,Oral Surgery ,business ,Posterior maxilla ,Brazil - Abstract
Objective The aim of this study was to report the clinicopathologic features of 105 new cases of adenomatoid odontogenic tumor (AOT) from Brazil, Guatemala, Mexico, and South Africa. Study Design Clinical and radiographic data were collected from records of 5 oral pathology laboratories, and all cases were microscopically reviewed. Results This series of cases included 36 (34.2%) from South Africa; 33 (31.4%) from Brazil; 23 (21.9%) from Mexico; and 13 (12.3%) from Guatemala. Seventy-two patients (68.5%) were females and 33 patients (31.4%) were males, with an average age of 19.2 years. The tumors predominantly affected the anterior maxilla (48.5%), followed by the anterior mandible (29.5%); posterior mandible (15.2%); and posterior maxilla (6.6%). Sixty-three tumors (63.6%) were follicular, 34 (34.3%) were extrafollicular, and 2 (2%) were peripheral. In most cases, the tumors caused considerable cortical expansion (average size 3.4 cm). Microscopically, most cases showed rosette-like and duct-like structures. Conclusions This is one of the largest case series of AOTs reported in the literature and the first multicenter study involving populations from Latin America and South Africa. In a fifth of the present cases, the posterior regions of the gnathic bones were affected and the tumors demonstrated larger sizes compared with cases occurring in other populations.
- Published
- 2021
23. Primordial odontogenic tumor: report of 2 new cases
- Author
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Carine Ervolino de Oliveira, Thayná Melo de Lima Morais, Wilson Delgado-Azañero, Gustavo Florez-Valderrama, Adalberto Mosqueda-Taylor, Alessandro Antônio Costa Pereira, Oslei Paes de Almeida, Márcio Américo Dias, and Bruno Augusto Linhares Almeida Mariz
- Subjects
Molar ,Pathology ,medicine.medical_specialty ,Radiography ,Pathology and Forensic Medicine ,03 medical and health sciences ,Basal (phylogenetics) ,0302 clinical medicine ,medicine ,Premolar ,case report ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Primordial odontogenic tumor ,business.industry ,Mandible ,Odontogenic tumor ,030206 dentistry ,medicine.disease ,Epithelium ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Immunohistochemistry ,Surgery ,Oral Surgery ,business - Abstract
Primordial odontogenic tumor (POT) is a recently described benign odontogenic tumor, with only 16 cases reported in the literature. We present 2 new cases of POT affecting the mandible. Case 1 is that of 12-year-old girl with an asymptomatic, slow-growing mass, causing facial asymmetry. Radiography showed a well-defined unilocular radiolucency surrounding an impacted second premolar. Case 2 is that of a 13-year-old girl with a mass involving the crown of the unerupted third molar and showing similar radiographic features. Microscopically, both lesions were composed of variably cellular fibromyxoid tissue surrounded by thin ameloblastic epithelium, with stellate reticulum-like areas, but no mineralized tissue, yielding the diagnosis of POT. Immunohistochemical analysis showed diffuse expression of CK14 in epithelial cells, whereas CK19 was expressed mainly in the basal layer. Syndecan-1 (CD138) was expressed in the stellate-like regions and in the subepithelial zone. Both patients were treated surgically, with no signs of recurrence seen after 15 and 60 months, respectively.
- Published
- 2021
24. Author response for 'Synchronous odontogenic tumors: a systematic review'
- Author
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null Bruna Luísa Neumann, null Bruna Barcelos Só, null Lucas Gonçalves Santos, null Felipe Martins Silveira, null Vivian Petersen Wagner, null Pablo Agustin Vargas, null Jean Nunes dos Santos, null Adalberto Mosqueda‐Taylor, null Felipe Paiva Fonseca, null Lauren Frenzel Schuch, and null Manoela Domingues Martins
- Published
- 2022
25. Primordial odontogenic tumor: Subepithelial expression of Syndecan‐1 and Ki‐67 suggests origin during early odontogenesis
- Author
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Bologna‐Molina, R, Mikami, T, Pereira‐Prado, V, Tapia‐Repetto, G, Pires, FR, Carlos, R, and Mosqueda‐Taylor, A
- Published
- 2018
- Full Text
- View/download PDF
26. Central odontogenic fibroma: an international multicentric study of 62 cases
- Author
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Renato Valiati, Roman Carlos, Javier Alberdi-Navarro, Emanuel Mendes Sousa, José Narciso Rosa Assunção Júnior, Adalberto Mosqueda-Taylor, Benjamin Martínez Rondanelli, Lauren Frenzel Schuch, Pablo Agustin Vargas, Ricardo Alves Mesquita, Aline Corrêa Abrahão, Liam Robinson, Thayná Melo de Lima Morais, Oslei Paes de Almeida, Constanza Marin, Felipe Paiva Fonseca, Ana Luiza Oliveira Corrêa Roza, Mário José Romañach, Syed Ali Khurram, Bruno Augusto Benevenuto de Andrade, René Martínez-Flores, Márcio Ajudarte Lopes, Willie F. P. van Heerden, Gleyson Kleber do Amaral-Silva, Amanda Almeida Leite, Ana Carolina Uchoa Vasconcelos, Vivian Petersen Wagner, José Alcides Almeida de Arruda, John M. Wright, Paul M. Speight, Eduardo Rodrigues Fregnani, Keith D. Hunter, Éricka Janine Dantas da Silveira, Alan Roger Santos-Silva, and Michelle Agostini
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Adolescent ,Odontogenic Tumors ,Fibroma ,Mandible ,Asymptomatic ,Pathology and Forensic Medicine ,Lesion ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Oral and maxillofacial pathology ,Maxilla ,Central odontogenic fibroma ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Child ,Depression (differential diagnoses) ,business.industry ,030206 dentistry ,Middle Aged ,medicine.disease ,Giant cell ,030220 oncology & carcinogenesis ,Female ,Surgery ,Neoplasm Recurrence, Local ,Oral Surgery ,medicine.symptom ,business - Abstract
Objective The aim of this study was to report the clinicopathologic features of 62 cases of central odontogenic fibroma (COdF). Study Design Clinical and radiographic data were collected from the records of 13 oral pathology laboratories. All cases were microscopically reviewed, considering the current World Health Organization classification of tumors and were classified according to histopathologic features. Results There were 43 females and 19 males (average age 33.9 years; range 8–63 years). Clinically, COdF lesions appeared as asymptomatic swellings, occurring similarly in the maxilla (n = 33) and the mandible (n = 29); 9 cases exhibited palatal depression. Imaging revealed well-defined, interradicular unilocular (n = 27), and multilocular (n = 12) radiolucencies, with displacement of contiguous teeth (55%) and root resorption (46.4%). Microscopically, classic features of epithelial-rich (n = 33), amyloid (n = 10), associated giant cell lesion (n = 7), ossifying (n = 6), epithelial-poor (n = 3), and granular cell (n = 3) variants were seen. Langerhans cells were highlighted by CD1a staining in 17 cases. Most patients underwent conservative surgical treatments, with 1 patient experiencing recurrence. Conclusions To the best of our knowledge, this study represents the largest clinicopathologic study of COdF. Most cases appeared as locally aggressive lesions located in tooth-bearing areas in middle-aged women. Inactive-appearing odontogenic epithelium is usually observed within a fibrous/fibromyxoid stroma, occasionally exhibiting amyloid deposits, multinucleated giant cells, or granular cells.
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- 2021
27. Primordial Odontogenic Tumor: A case report with histopathological analyses
- Author
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Mikami, Toshinari, Ohashi, Yu, Bologna‐Molina, Ronell, Mosqueda‐Taylor, Adalberto, Fujiwara, Naoki, Tsunoda, Naoko, Yamada, Hiroyuki, and Takeda, Yasunori
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- 2017
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28. MicroRNAs expression profile in solid and unicystic ameloblastomas.
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A Setién-Olarra, X Marichalar-Mendia, N G Bediaga, P Aguirre-Echebarria, J M Aguirre-Urizar, and A Mosqueda-Taylor
- Subjects
Medicine ,Science - Abstract
Odontogenic tumors (OT) represent a specific pathological category that includes some lesions with unpredictable biological behavior. Although most of these lesions are benign, some, such as the ameloblastoma, exhibit local aggressiveness and high recurrence rates. The most common types of ameloblastoma are the solid/multicystic (SA) and the unicystic ameloblastoma (UA); the latter considered a much less aggressive entity as compared to the SA. The microRNA system regulates the expression of many human genes while its deregulation has been associated with neoplastic development. The aim of the current study was to determine the expression profiles of microRNAs present in the two most common types of ameloblastomas.MicroRNA expression profiles were assessed using TaqMan® Low Density Arrays (TLDAs) in 24 samples (8 SA, 8 UA and 8 control samples). The findings were validated using quantitative RTqPCR in an independent cohort of 19 SA, 8 UA and 19 dentigerous cysts as controls.We identified 40 microRNAs differentially regulated in ameloblastomas, which are related to neoplastic development and differentiation, and with the osteogenic process. Further validation of the top ranked microRNAs revealed significant differences in the expression of 6 of them in relation to UA, 7 in relation to SA and 1 (miR-489) that was related to both types.We identified a new microRNA signature for the ameloblastoma and for its main types, which may be useful to better understand the etiopathogenesis of this neoplasm. In addition, we identified a microRNA (miR-489) that is suggestive of differentiating among solid from unicystic ameloblastoma.
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- 2017
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29. Adenoid Cystic Carcinoma in a Mexican Population
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Luna-Ortiz, Kuauhyama, Villavicencio-Valencia, Veronica, Rodríguez-Falconi, Alfredo, Peteuil, Nathalie, and Mosqueda-Taylor, Adalberto
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- 2016
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30. Peripheral odontogenic keratocyst: Clinicopathological and immunohistochemical characterization
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Irene Lafuente-Ibáñez de Mendoza, José‐Julio Magaña‐Quiñones, Verónica Villatoro-Ugalde, José Manuel Aguirre-Urizar, Adalberto Mosqueda-Taylor, and Jessica Lana‐Ojeda
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Adult ,Male ,medicine.medical_specialty ,Pathology ,Adolescent ,Odontogenic Tumors ,Mandible ,Lesion ,Young Adult ,03 medical and health sciences ,Cytokeratin ,Basal (phylogenetics) ,0302 clinical medicine ,Humans ,Medicine ,Keratocyst ,General Dentistry ,Aged ,business.industry ,Basal Cell Nevus Syndrome ,030206 dentistry ,Middle Aged ,Dental lamina ,stomatognathic diseases ,Ki-67 Antigen ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Maxilla ,Odontogenic Cysts ,Female ,Histopathology ,Differential diagnosis ,medicine.symptom ,business - Abstract
OBJECTIVE The aim of this study is to present and discuss the salient clinicopathological features, differential diagnosis and epithelial immunohistochemical profile of three additional cases of peripheral odontogenic keratocyst (POKC) and to present a review of the literature. POKC is a locally aggressive odontogenic lesion. The peripheral variant of the odontogenic keratocyst is rare and more frequently located in anterior gingiva. MATERIAL AND METHODS We present the clinicopathological features of 3 new cases of POKC (2 women and 1 man; age range: 14-74 years). Immunohistochemical study included CK7, CK14, CK19 and Ki-67, and a systematic review of the literature was performed in PubMed, Scopus and Web of Science databases. RESULTS All cases were located in the anterior gingiva (2 in maxilla and 1 mandible), and none corresponded to Gorlin-Goltz syndrome. High expression of CK14 was seen in all cases, with CK19 and CK7 been only focally positive. The expression of Ki-67 was located in the basal and parabasal cells in all cases. CONCLUSIONS POKC is a rare gingival lesion that seems to originate from remnants of dental lamina or from the basal cells of the gingival epithelium and present a similar histopathology as compared to intraosseous OKC.
- Published
- 2021
31. Clear cell odontogenic carcinoma involving the periapical region
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Manieri, Patricia Rubia, primary, Melo, Leonardo Araújo, additional, Maranhão, Samário Cintra, additional, Mosqueda-Taylor, Adalberto, additional, Cury, Patrícia Ramos, additional, Martins, Manoela Domingues, additional, and dos Santos, Jean Nunes, additional
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- 2022
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32. Expression of minichromosome maintenance 2, Ki-67, and geminin in oral nevi and melanoma
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de Andrade, Bruno Augusto Benevenuto, León, Jorge Esquiche, Carlos, Román, Delgado-Azañero, Wilson, Mosqueda-Taylor, Adalberto, and de Almeida, Oslei Paes
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- 2013
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33. Oral Squamous Cell Carcinoma Frequency in Young Patients from Referral Centers Around the World
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Rafael Ferreira e Costa, Marina Luiza Baião Leão, Maria Sissa Pereira Sant’Ana, Ricardo Alves Mesquita, Ricardo Santiago Gomez, Alan Roger Santos-Silva, Syed Ali Khurram, Artysha Tailor, Ciska-Mari Schouwstra, Liam Robinson, Willie F. P. van Heerden, Ramiro Alejandro Tomasi, Romina Gorrino, Ruth Salomé Ferreyra de Prato, Adalberto Mosqueda Taylor, José Manuel Aguirre Urizar, Irene Lafuente Ibañez de Mendoza, Raghu Radhakrishnan, Chetana Chandrashekar, Siu-Wai Choi, Peter Thomson, Hélder Antônio Rebelo Pontes, and Felipe Paiva Fonseca
- Subjects
Original Paper ,Oncology ,Otorhinolaryngology ,Pathology and Forensic Medicine - Abstract
Oral squamous cell carcinoma (OSCC) commonly affects older patients; however, several studies have documented an increase in its incidence among younger patients. Therefore, it is important to investigate if this trend is also found in different geographic regions. The pathology files of diagnostic and therapeutic institutions from different parts of the globe were searched for OSCC cases diagnosed from 1998 to 2018. Data regarding the sex, age, and tumor location of all cases, as well as the histologic grade and history of exposure to risk habits of cases diagnosed as OSCC in young patients (≤ 40 years of age) were obtained. The Chi-square test was used to determine any increasing trend. A total of 10,727 OSCC cases were identified, of which 626 cases affected young patients (5.8%). Manipal institution (India) showed the highest number of young patients (13.2%). Males were the most affected in both age groups, with the tongue and floor of the mouth being the most affected subsites. OSCC in young individuals were usually graded as well or moderately differentiated. Only 0.9% of the cases occurred in young patients without a reported risk habit. There was no increasing trend in the institutions and the period investigated (p > 0.05), but a decreasing trend was observed in Hong Kong and the sample as a whole (p
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- 2022
34. Histomorphological evaluation, cell proliferation and endothelial immunostaining in oral and maxillofacial myofibroblastic lesions
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AG. Hassaf-Arreola, CH. Caro-Sánchez, H. Domínguez-Malagón, ME. Irigoyen-Camacho, OP. Almeida, C. Sánchez-Romero, and A. Mosqueda-Taylor
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Adolescent ,orthognathic surgery ,Immunohistochemistry ,Granuloma, Plasma Cell ,Cross-Sectional Studies ,Otorhinolaryngology ,systematic review ,Biomarkers, Tumor ,Humans ,Surgery ,virtual planning ,Female ,Myofibroblasts ,General Dentistry ,UNESCO:CIENCIAS MÉDICAS ,Biomarkers ,Retrospective Studies ,Cell Proliferation - Abstract
Myofibroblasts (MF) are mesenchymal cells with features of both fibroblasts and smooth muscle cells. Although these are usually reactive cells, they can lead to myofibroblastic tumors that may share clinical and histomorphological characteristics but with different prognosis. The aim of this study is to perform a histomorphological evaluation as well as to compare and evaluate two different cell proliferation immunomarkers and two endothelial markers in a group of oral and maxillofacial myofibroblastic lesions (MFL). Cross-sectional and retrospective study. Demographic, clinical, histomorphological and immunohistochemical characteristics of 39 cases of MFL were analyzed. Immunohistochemical reactions were performed with the Ki67, MCM2, CD34 and CD105 antibodies. Kruskal-Wallis test and Spearman correlation analysis were used. Four cases of nodular fasciitis (NF), 18 myofibromas (My), 6 desmoplastic fibromas (DF), 7 inflammatory myofibroblastic tumors (IMT) and 4 myofibroblastic sarcomas (MFS) were studied. There were twenty women (51.2%); the median age was 13 [Q1-Q3: 8-24] years and most cases occurred in the mandible (48.7%). A statistically significant difference with MCM2 immunostaining (p=0.0221) was observed between the MFL; furthermore, a correlation between CD34 and CD105 immunostaining in NF (p
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- 2022
35. Carcinoma Ameloblástico Mandibular: Un diagnóstico infrecuente y desafiante
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Melián Rivas,Andrés, Donoso-Hofer,Francisca, Fernández Toro,María de los Ángeles, Ortega Pinto,Ana Verónica, and Mosqueda Taylor,Adalberto
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ameloblastoma ,Carcinoma ameloblástico ,Otorhinolaryngology ,Surgery ,Oral Surgery ,tumor odontogénico ,diagnóstico - Abstract
RESUMEN El carcinoma ameloblástico es un tumor odontogénico epitelial maligno, infrecuente y de mal pronóstico. Histopatológicamente es una lesión que conserva un patrón de diferenciación ameloblastomatoso, pero presenta características citológicas de malignidad. Debido a su rareza, existe poca información sobre su comportamiento biológico, el cual es reconocido en la literatura por ser inespecífico y variable, ya que puede presentarse como una lesión con características compatibles con una lesión benigna o como una entidad patológica agresiva altamente maligna. Esto último ha supuesto una dificultad no solo en su diagnóstico, sino también en la planificación terapéutica. Se reporta un caso de un carcinoma ameloblástico mandibular en un paciente perteneciente a la séptima década de la vida, destacando sus características clínicas, imagenológicas e histológicas variables que permitieron llegar a un diagnóstico correcto.
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- 2022
36. Immunohistochemical expression of podoplanin (D2‐40), lymphangiogenesis, and neoangiogenesis in tooth germ, ameloblastomas, and ameloblastic carcinomas
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Sánchez‐Romero, Celeste, Bologna‐Molina, Ronell, Mosqueda‐Taylor, Adalberto, and de Almeida, Oslei Paes
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- 2017
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37. Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas
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Ronell Bologna-Molina, Setién-Olarra A, Adalberto Mosqueda-Taylor, María del Carmen González-Galván, José-Manuel Aguirre-Urizar, Xabier Marichalar-Mendia, González Galván María del Carmen, Mosqueda Taylor Adalberto, Bologna Molina Ronell, Setien Olarra Amaia, Marichalar Mendia Xabier, Aguirre Urizar José Manuel, González-Galván MC, Universidad Nacional de Asunción (Paraguay), Mosqueda-Taylor A., Universidad Autónoma Metropolitana. Unidad Xochimilco (México), Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología, Setien-Olarra A., Universidad del País Vasco (España). Facultad de Medicina y Enfermería., Marichalar-Mendia Xabier, Universidad del País Vasco (España). Facultad de Medicina y Enfermería., and Aguirre-Urizar JM, Universidad del País Vasco (España). Facultad de Medicina y Enfermería.
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musculoskeletal diseases ,Male ,Odontogenic myxoma ,RANK-L ,RANK ,03 medical and health sciences ,0302 clinical medicine ,Osteoprotegerin ,Osteoclastogenesis ,Medicine ,Neoplasm ,Humans ,MIXOMA ,Receptor ,General Dentistry ,Language ,OSTEOGENESIS ,Dental follicle ,Oral Medicine and Pathology ,biology ,Activator (genetics) ,business.industry ,Research ,030206 dentistry ,CIENCIAS MÉDICAS [UNESCO] ,medicine.disease ,LIGANDO RANK ,Otorhinolaryngology ,RANKL ,030220 oncology & carcinogenesis ,UNESCO::CIENCIAS MÉDICAS ,Cancer research ,biology.protein ,Immunohistochemistry ,OPG ,Surgery ,business ,Myxoma - Abstract
Background Odontogenic myxoma (OM) is a benign intraosseous neoplasm that exhibits local aggressiveness and high recurrence rates. Osteoclastogenesis is an important phenomenon in the tumor growth of maxillary neoplasms. RANK (Receptor Activator of Nuclear Factor κappa B) is the signaling receptor of RANK-L (Receptor activator of nuclear factor kappa-Β ligand) that activates the osteoclasts. OPG (osteoprotegerin) is a decoy receptor for RANK-L that inhibits pro-osteoclastogenesis. The RANK / RANKL / OPG system participates in the regulation of osteolytic activity under normal conditions, and its alteration has been associated with greater bone destruction, and also with tumor growth. Objectives To analyze the immunohistochemical expression of OPG, RANK and RANK-L proteins in odontogenic myxomas (OMs) and their relationship with the tumor size. Material and Methods Eighteen OMs, 4 small ( 3cm) and 18 dental follicles (DF) that were included as control were studied by means of standard immunohistochemical procedure with RANK, RANKL and OPG antibodies. For the evaluation, 5 fields (40x) of representative areas of OM and DF were selected where the expression of each antibody was determined. Descriptive and comparative statistical analyses were performed with the obtained data. Results There are significant differences in the expression of RANK in OM samples as compared to DF (p = 0.022) and among the OMSs and OMLs (p = 0.032). Also a strong association is recognized in the expression of RANK-L and OPG in OM samples. Conclusions Activation of the RANK / RANK-L / OPG triad seems to be involved in the mechanisms of bone balance and destruction, as well as associated with tumor growth in odontogenic myxomas. Key words:Odontogenic myxoma, dental follicle, RANK, RANK-L, OPG, osteoclastogenesis.
- Published
- 2018
38. Spatial distribution of CD34 protein in primordial odontogenic tumour, ameloblastic fibroma and the tooth germ.
- Author
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Pereira Prado, Vanesa, Landini, Gabriel, Mosqueda Taylor, Adalberto, Vargas, Pablo, and Bologna Molina, Ronell
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ODONTOGENIC tumors ,AMELOBLASTS ,CD34 antigen ,TOOTH germ (Dentition) ,FIBROMAS - Abstract
Background: Primordial odontogenic tumour is a benign mixed neoplasm of recent description, which has histological similarities with other odontogenic tumours such as the ameloblastic fibroma. In this article, we investigate the architecture of the sub‐epithelial layer of mesenchymal cells expressing the marker CD34 in primordial odontogenic tumour. Objective: Analyse the spatial patterns of CD34 expression in primordial odontogenic tumour and compare them with those in ameloblastic fibroma and the normal tooth germ by means of objective imaging approaches, to better characterise these lesions. Methods: Two cases of primordial odontogenic tumour, four cases of ameloblastic fibroma and two cases of tooth germ in cap and bell stages were used for morphological, structural and immunohistochemical analyses. Results: CD34 expression was found in vascular endothelium of primordial odontogenic tumour, ameloblastic fibroma and tooth germ. In addition, a characteristic sub‐epithelial expression was observed only in primordial odontogenic tumour, corresponding to 84%–86% of the sample boundaries. Moreover, the zone expressing CD34 corresponded with a higher cellularity, which was absent in ameloblastic fibroma and tooth germ. Conclusion: Image analysis of the primordial odontogenic tumour architecture revealed characteristics absent in other odontogenic tumours and tooth germs. This study provides additional information to support the idea that this neoplasm is a distinct entity from early stage AF or developing odontoma. [ABSTRACT FROM AUTHOR]
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- 2023
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39. Histomorphological evaluation, cell proliferation and endothelial immunostaining in oral and maxillofacial myofibroblastic lesions
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Hassaf-Arreola, AG., primary, Caro-Sánchez, CH., additional, Domínguez-Malagón, H., additional, Irigoyen-Camacho, ME., additional, Almeida, OP., additional, Sánchez-Romero, C., additional, and Mosqueda-Taylor, A., additional
- Published
- 2022
- Full Text
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40. Odontogenic Carcinoma with Dentinoid: A New Odontogenic Carcinoma
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Mosqueda-Taylor, Adalberto, Neville, Brad W., Tatemoto, Yukihiro, Ogawa, Ikuko, and Takata, Takashi
- Published
- 2014
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41. Therapeutic management of the odontogenic keratocyst. An energetic approach with a conservative perspective and review of the current therapeutic options
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Adalberto Mosqueda-Taylor, José-Manuel Aguirre-Urizar, Javier Alberdi-Navarro, Alba Sánchez-Torres, Cosme Gay-Escoda, and Jordi Borrás-Ferreres
- Subjects
medicine.medical_specialty ,Unicystic Ameloblastoma ,medicine.medical_treatment ,Enucleation ,Case Report ,Quistos ,Carnoy's solution ,Mucosa oral ,03 medical and health sciences ,Ameloblastic fibroma ,0302 clinical medicine ,stomatognathic system ,medicine ,Teeth extraction ,Cyst ,Keratocyst ,General Dentistry ,Extracció dental ,Oral Medicine and Pathology ,business.industry ,030206 dentistry ,Dent molar ,medicine.disease ,Marsupialization ,CIENCIAS MÉDICAS [UNESCO] ,Molar ,Surgery ,Dentigerous cyst ,Cysts (Pathology) ,stomatognathic diseases ,030220 oncology & carcinogenesis ,UNESCO::CIENCIAS MÉDICAS ,Oral mucosa ,medicine.symptom ,business - Abstract
Background Odontogenic keratocysts (OKC) are cystic lesions appearing in the jaws, usually asymptomatic with a progressive growth into the bone. Many of them are diagnosed by a routine radiological examination. Material and methods This study reports a 12-year-old girl that presented an asymptomatic large radiolucent unilocular lesion associated to the crown of 3.8 that caused displacement of the molar and the inferior alveolar canal. Differential diagnosis included OKC, unicystic ameloblastoma, ameloblastic fibroma, dentigerous cyst and orthokeratinized odontogenic cyst. Two surgical interventions were performed; first, a marsupialization, and 10 months after, the third molar extraction plus cyst enucleation, mucosa excision and the application of Carnoy's solution. Results The anatomopathological exam confirmed diagnosis of OKC. There was no evidence of recurrence after 2 years of follow-up. Conclusions Marsupialization followed by surgical enucleation with mucosa excision and Carnoy's solution can help manage treatment of OKC, a lesion characterized by an aggressive behavior. Key words:Odontogenic keratocyst, mucosa excision, carnoy solution, third molar, tooth extraction.
- Published
- 2020
42. Oral Amelanotic Melanomas: Clinicopathologic Features of 8 Cases and Review of the Literature
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Michelle Agostini, Ciro Dantas Soares, Roman Carlos, Mário José Romañach, Juan Carlos Hernández-Guerrero, John Lennon Silva Cunha, Bruno Augusto Benevenuto de Andrade, Jacks Jorge, Adalberto Mosqueda-Taylor, and Oslei Paes de Almeida
- Subjects
Adult ,Male ,medicine.medical_specialty ,Oral Surgical Procedures ,Lymph node metastasis ,Oral cavity ,Disease-Free Survival ,Pathology and Forensic Medicine ,Diagnosis, Differential ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Antineoplastic Combined Chemotherapy Protocols ,Oral and maxillofacial pathology ,Humans ,Medicine ,Amelanotic melanoma ,Aged ,Retrospective Studies ,Melanins ,Oral melanoma ,business.industry ,Mouth Mucosa ,Melanoma, Amelanotic ,Delayed treatment ,Middle Aged ,medicine.disease ,Dermatology ,Chemotherapy, Adjuvant ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Immunohistochemistry ,Female ,Mouth Neoplasms ,Surgery ,Lymph Nodes ,Anatomy ,business ,Melanin pigment ,Neck ,Follow-Up Studies - Abstract
Mucosal melanomas are aggressive tumors, rarely observed in the oral cavity. The diagnosis is based on the clinical and microscopical features. Often these tumors had variable amounts of melanin pigmentation. However, when melanin is absent, the tumors are denominated amelanotic, presenting a tendency to misdiagnosis and delayed treatment. The aim of this study was to describe the clinicopathologic features of a series of oral amelanotic melanomas (OAM). Records of all cases of OAM were retrospectively retrieved from oral pathology services from January 2002 to January 2019. Data regarding the clinical features, morphological aspects, immunohistochemical reactions, treatment, and follow-up status were collected. Eight cases of OAM were included, 6 in men and 2 in women (ratio of 3:1) ranging in age from 33 to 77 years (mean 53.6 years). Clinically, the tumors presented as masses or ulcerated swellings. The most common intraoral locations of the tumors were gingiva and palate. Cervical lymph node metastasis was detected in 3 patients at the first examination. All but one patient died from complications of the tumors after a mean follow-up period of 8.5 months. In conclusion, OAM is a very aggressive malignant tumor, and when melanin is absent, an immunohistochemical panel comprising S100, melan A, HMB45, and SOX10 should be performed.
- Published
- 2020
43. CTNNB1 and APC mutations in odontogenic carcinoma with dentinoid
- Author
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Elisa Carvalho de Siqueira, Albina Altemani, Fernanda Viviane Mariano, Leandro Aurelio Liporoni Martins, Rogério Gondak, Carolina Cavaliéri Gomes, Katya Pulido Díaz, Sílvia Ferreira de Sousa, Ricardo Santiago Gomez, and Adalberto Mosqueda-Taylor
- Subjects
Mouth neoplasm ,Mutation ,business.industry ,Wnt signaling pathway ,030206 dentistry ,medicine.disease ,medicine.disease_cause ,Pathology and Forensic Medicine ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Odontogenic carcinoma ,law ,030220 oncology & carcinogenesis ,Carcinoma ,medicine ,Cancer research ,Suppressor ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,business ,Gene ,Human cancer - Abstract
The purpose of the present study is to report 2 cases of odontogenic carcinoma with dentinoid, a rare low-grade odontogenic carcinoma associated with facial deformity and bone loss, and to investigate the presence of pathogenic mutations in these samples. By using a next-generation sequencing approach, we sequenced a panel of 50 oncogenes and tumor suppressor genes commonly mutated in human cancer. Microscopic features of both cases revealed solid areas of malignant odontogenic tumor with a large amount of dentinoid material. We identified pathogenic mutations in the genes CTNNB1 and APC, both of which are part of the Wnt-signaling pathway. Consistent with Wnt-signaling activation, both tumors showed strong β-catenin accumulation in the cytoplasm and in the nuclei. The molecular profile of odontogenic carcinoma with dentinoid may help in its diagnosis, as well as in the identification of potential molecular targets for therapy in the future.
- Published
- 2020
44. Author Correction: Oral Squamous Cell Carcinoma Frequency in Young Patients from Referral Centers Around the World
- Author
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Rafael Ferreira e Costa, Marina Luiza Baião Leão, Maria Sissa Pereira Sant’Ana, Ricardo Alves Mesquita, Ricardo Santiago Gomez, Alan Roger Santos‑Silva, Syed Ali Khurram, Artysha Tailor, Ciska‑Mari Schouwstra, Liam Robinson, Willie F. P. van Heerden, Ramiro Alejandro Tomasi, Romina Gorrino, Ruth Salomé Ferreyra de Prato, Adalberto Mosqueda Taylor, José Manuel Aguirre Urizar, Irene Lafuente Ibañez de Mendoza, Raghu Radhakrishnan, Chetana Chandrashekar, Siu‑Wai Choi, Peter Thomson, Hélder Antônio Rebelo Pontes, and Felipe Paiva Fonseca
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Male ,Oncology ,Otorhinolaryngology ,Head and Neck Neoplasms ,Squamous Cell Carcinoma of Head and Neck ,Carcinoma, Squamous Cell ,Humans ,Female ,Mouth Neoplasms ,Author Correction ,Referral and Consultation ,Pathology and Forensic Medicine - Abstract
Oral squamous cell carcinoma (OSCC) commonly affects older patients; however, several studies have documented an increase in its incidence among younger patients. Therefore, it is important to investigate if this trend is also found in different geographic regions. The pathology files of diagnostic and therapeutic institutions from different parts of the globe were searched for OSCC cases diagnosed from 1998 to 2018. Data regarding the sex, age, and tumor location of all cases, as well as the histologic grade and history of exposure to risk habits of cases diagnosed as OSCC in young patients (≤ 40 years of age) were obtained. The Chi-square test was used to determine any increasing trend. A total of 10,727 OSCC cases were identified, of which 626 cases affected young patients (5.8%). Manipal institution (India) showed the highest number of young patients (13.2%). Males were the most affected in both age groups, with the tongue and floor of the mouth being the most affected subsites. OSCC in young individuals were usually graded as well or moderately differentiated. Only 0.9% of the cases occurred in young patients without a reported risk habit. There was no increasing trend in the institutions and the period investigated (p 0.05), but a decreasing trend was observed in Hong Kong and the sample as a whole (p 0.001). In conclusion there was no increase of OSCC in young patients in the institutions investigated and young white females not exposed to any known risk factor represented a rare group of patients affected by OSCC.
- Published
- 2022
45. Central odontogenic fibroma: new findings and report of a multicentric collaborative study
- Author
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Mosqueda-Taylor, Adalberto, Martínez-Mata, Guillermo, Carlos-Bregni, Roman, Vargas, Pablo Agustin, Toral-Rizo, Victor, Cano-Valdéz, Ana María, Palma-Guzmán, José Mario, Carrasco-Daza, Daniel, Luna-Ortiz, Kuauhyama, Ledesma-Montes, Constantino, and de Almeida, Oslei Paes
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- 2011
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46. Oral Manifestations of Coronavirus Disease 2019 (COVID-19)
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Soares, Ciro D., primary, Souza, Lucas L., additional, de Carvalho, Maria G.F., additional, Pontes, Hélder A.R., additional, Mosqueda-Taylor, Adalberto, additional, Hernandez-Guerrero, Juan C., additional, do Nascimento Medeiros, Sanderson D., additional, de Oliveira Sales, Alexandre, additional, Alves, Fábio A., additional, Lopes Pinto, Clóvis A., additional, and de Almeida, Oslei P., additional
- Published
- 2021
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47. Assessment of CD-105 as an Angiogenic Modulator in Odontogenic Myxomas and Dental Follicles
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del Carmen González-Galván, María, Aguirre-Urizar, José Manuel, Bologna-Molina, Ronell, Farfán-Morales, Eduardo J., Gainza-Cirauqui, Maria Luisa, Marichalar-Mendia, Xabier, and Mosqueda-Taylor, Adalberto
- Published
- 2016
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48. Primary intraosseous squamous cell carcinoma arising in an odontogenic keratocyst previously treated with marsupialization: case report and immunohistochemical study
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Martínez-Martínez, Marisol, Mosqueda-Taylor, Adalberto, Delgado-Azañero, Wilson, Rumayor-Piña, Alicia, and de Almeida, Oslei Paes
- Published
- 2016
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49. CLEAR CELL ODONTOGENIC CARCINOMA MIMICKING A PERIAPICAL LESION
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Patricia Rubia Manieri, Leonardo Araújo Melo, Samário Cintra Maranhão, Priscila Rubia Manieri, Manoela Domingues Martins, Adalberto Mosqueda Taylor, and Jean Nunes Dos Santos
- Subjects
Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Pathology and Forensic Medicine - Published
- 2022
50. Primordial odontogenic tumor : a systematic review
- Author
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Rogelio González-González, Ronell Bologna-Molina, Adalberto Mosqueda-Taylor, Vanesa Pereira-Prado, Celeste Sánchez-Romero, Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología, Mosqueda-Taylor Adalberto, Pereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de Odontología, Sánchez-Romero Celeste, Universidad de la República (Uruguay). Facultad de Odontología, and González-González Rogelio
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Adolescent ,CD34 ,Vimentin ,Odontogenic Tumors ,Mandible ,Review ,Epithelium ,Lesion ,Variable Expression ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Survivin ,medicine ,Humans ,Primordial odontogenic tumor ,Child ,General Dentistry ,Oral Medicine and Pathology ,biology ,business.industry ,Odontogenic tumor ,030206 dentistry ,CIENCIAS MÉDICAS [UNESCO] ,medicine.disease ,stomatognathic diseases ,Otorhinolaryngology ,Child, Preschool ,UNESCO::CIENCIAS MÉDICAS ,biology.protein ,Systematic review ,Immunohistochemistry ,Odontogenesis ,Surgery ,medicine.symptom ,Amelogenin ,Neoplasm Recurrence, Local ,business - Abstract
Background The primordial odontogenic tumor (POT) is a recently described benign entity with histopathological and immunohistochemical features suggesting its origin during early odontogenesis. Aim: To integrate the available data published on POT into a comprehensive analysis to better define its clinicopathological and molecular features. Material and Methods An electronic systematic review was performed up to September 2019 in multiple databases. Results A total of 13 publications were included, representing 16 reported cases and 3 molecular studies. The mean age of the affected patients was 11.6 years (range 2-19), with a slight predominance in males (56.25%). The posterior mandible was the main location (87.5%), with only two cases affecting the posterior maxilla. All cases appeared as a radiolucent lesion in close relationship to an unerupted tooth. Recurrences have not been reported to date. Microscopically, POT comprises fibromyxoid tissue with variable cellularity surrounded by a cuboidal to columnar odontogenic epithelium but without unequivocal dental hard tissue formation. A delicate fibrous capsule surrounds (at least partially) the tumor. The epithelial component shows immunohistochemical positivity for amelogenin, CK19, and CK14, and variable expression of Glut-1, Galectin-3 and Caveolin-1, Vimentin, p-53, PITX2, Bcl-2, Bax and Survivin; the mesenchymal tissue is positive for Vimentin, CD90, p-53, PITX2, Bcl-2, Bax, and Survivin, and the subepithelial region exhibits the strong expression of Syndecan-1 and CD34. The Ki-67 index is low (
- Published
- 2020
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