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Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas
- Source :
- Medicina Oral, Patología Oral y Cirugía Bucal, COLIBRI, Universidad de la República, instacron:Universidad de la República, Gonzalez Galvan, Maria del Carmen ; Mosqueda Taylor, Adalberto ; Bologna Molina, Ronell ; Setién Olarra, Amaia ; Marichalar Mendia, Xabier ; Aguirre Urízar, José Manuel. Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 3 2018: 9, RODERIC. Repositorio Institucional de la Universitat de Valéncia, instname
- Publication Year :
- 2018
- Publisher :
- Medicina Oral S.L., 2018.
-
Abstract
- Background Odontogenic myxoma (OM) is a benign intraosseous neoplasm that exhibits local aggressiveness and high recurrence rates. Osteoclastogenesis is an important phenomenon in the tumor growth of maxillary neoplasms. RANK (Receptor Activator of Nuclear Factor κappa B) is the signaling receptor of RANK-L (Receptor activator of nuclear factor kappa-Β ligand) that activates the osteoclasts. OPG (osteoprotegerin) is a decoy receptor for RANK-L that inhibits pro-osteoclastogenesis. The RANK / RANKL / OPG system participates in the regulation of osteolytic activity under normal conditions, and its alteration has been associated with greater bone destruction, and also with tumor growth. Objectives To analyze the immunohistochemical expression of OPG, RANK and RANK-L proteins in odontogenic myxomas (OMs) and their relationship with the tumor size. Material and Methods Eighteen OMs, 4 small ( 3cm) and 18 dental follicles (DF) that were included as control were studied by means of standard immunohistochemical procedure with RANK, RANKL and OPG antibodies. For the evaluation, 5 fields (40x) of representative areas of OM and DF were selected where the expression of each antibody was determined. Descriptive and comparative statistical analyses were performed with the obtained data. Results There are significant differences in the expression of RANK in OM samples as compared to DF (p = 0.022) and among the OMSs and OMLs (p = 0.032). Also a strong association is recognized in the expression of RANK-L and OPG in OM samples. Conclusions Activation of the RANK / RANK-L / OPG triad seems to be involved in the mechanisms of bone balance and destruction, as well as associated with tumor growth in odontogenic myxomas. Key words:Odontogenic myxoma, dental follicle, RANK, RANK-L, OPG, osteoclastogenesis.
- Subjects :
- musculoskeletal diseases
Male
Odontogenic myxoma
RANK-L
RANK
03 medical and health sciences
0302 clinical medicine
Osteoprotegerin
Osteoclastogenesis
Medicine
Neoplasm
Humans
MIXOMA
Receptor
General Dentistry
Language
OSTEOGENESIS
Dental follicle
Oral Medicine and Pathology
biology
Activator (genetics)
business.industry
Research
030206 dentistry
CIENCIAS MÉDICAS [UNESCO]
medicine.disease
LIGANDO RANK
Otorhinolaryngology
RANKL
030220 oncology & carcinogenesis
UNESCO::CIENCIAS MÉDICAS
Cancer research
biology.protein
Immunohistochemistry
OPG
Surgery
business
Myxoma
Subjects
Details
- Language :
- English
- ISSN :
- 16986946 and 16984447
- Volume :
- 23
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Medicina Oral, Patología Oral y Cirugía Bucal
- Accession number :
- edsair.doi.dedup.....0b8ec7e96daa80da28a0494464c2c50d