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Central odontogenic fibroma: an international multicentric study of 62 cases
- Source :
- Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 131:549-557
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Objective The aim of this study was to report the clinicopathologic features of 62 cases of central odontogenic fibroma (COdF). Study Design Clinical and radiographic data were collected from the records of 13 oral pathology laboratories. All cases were microscopically reviewed, considering the current World Health Organization classification of tumors and were classified according to histopathologic features. Results There were 43 females and 19 males (average age 33.9 years; range 8–63 years). Clinically, COdF lesions appeared as asymptomatic swellings, occurring similarly in the maxilla (n = 33) and the mandible (n = 29); 9 cases exhibited palatal depression. Imaging revealed well-defined, interradicular unilocular (n = 27), and multilocular (n = 12) radiolucencies, with displacement of contiguous teeth (55%) and root resorption (46.4%). Microscopically, classic features of epithelial-rich (n = 33), amyloid (n = 10), associated giant cell lesion (n = 7), ossifying (n = 6), epithelial-poor (n = 3), and granular cell (n = 3) variants were seen. Langerhans cells were highlighted by CD1a staining in 17 cases. Most patients underwent conservative surgical treatments, with 1 patient experiencing recurrence. Conclusions To the best of our knowledge, this study represents the largest clinicopathologic study of COdF. Most cases appeared as locally aggressive lesions located in tooth-bearing areas in middle-aged women. Inactive-appearing odontogenic epithelium is usually observed within a fibrous/fibromyxoid stroma, occasionally exhibiting amyloid deposits, multinucleated giant cells, or granular cells.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Adolescent
Odontogenic Tumors
Fibroma
Mandible
Asymptomatic
Pathology and Forensic Medicine
Lesion
Young Adult
03 medical and health sciences
0302 clinical medicine
Oral and maxillofacial pathology
Maxilla
Central odontogenic fibroma
medicine
Humans
Radiology, Nuclear Medicine and imaging
Dentistry (miscellaneous)
Child
Depression (differential diagnoses)
business.industry
030206 dentistry
Middle Aged
medicine.disease
Giant cell
030220 oncology & carcinogenesis
Female
Surgery
Neoplasm Recurrence, Local
Oral Surgery
medicine.symptom
business
Subjects
Details
- ISSN :
- 22124403
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
- Accession number :
- edsair.doi.dedup.....ee0752c81490830b5945d8bab344b1ed