1. The 2022 Report on the Human Proteome from the HUPO Human Proteome Project
- Author
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Gilbert S. Omenn, Lydie Lane, Christopher M. Overall, Charles Pineau, Nicolle H. Packer, Ileana M. Cristea, Cecilia Lindskog, Susan T. Weintraub, Sandra Orchard, Michael H. A. Roehrl, Edouard Nice, Siqi Liu, Nuno Bandeira, Yu-Ju Chen, Tiannan Guo, Ruedi Aebersold, Robert L. Moritz, Eric W. Deutsch, University of Michigan [Ann Arbor], University of Michigan System, Université de Genève = University of Geneva (UNIGE), University of British Columbia [Vancouver], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Macquarie University, Princeton University, University of California [San Diego] (UC San Diego), University of California (UC), Institute for Systems Biology [Seattle] (ISB), G.S.O. acknowledges support from National Institutes of Health Grants P30ES017885-01A1 and U24CA210967, E.W.D. and R.L.M. from National Institutes of Health Grants R01GM087221, R24GM127667, U19AG023122, S10OD026936, and from National Science Foundation Grant DBI-1933311, C.M.O. by Canadian Institutes of Health Research Foundation Grant 148408 and a Canada Research Chair in Protease Proteomics and Systems Biology, N.B. from NIH grant 1R01LM013115, and NSF grant ABI 1759980, M.S.B. by Australian Research Council (CE140100003), C.L. by the Knut and Alice Wallenberg Foundation for the Human Protein Atlas, M.H.R by National Institutes of Health Grants R21 CA263262, U01 CA253217, R21 CA251992, P30 CA008748 (MSKCC CCSG, Pathology Component), NIH-Leidos CPTAC contract 17X173, and Farmer Family Foundation, and and I.M.C. from National Institutes of Health Grant R01GM114141 and Stand Up To Cancer Convergence 3.1416.
- Subjects
Mass Spectrometry Interactive Virtual Environment (MassIVE) ,MESH: Databases, Protein ,MESH: Mass Spectrometry ,PeptideAtlas ,MESH: Humans ,chromosome-centric HPP (C-HPP) ,missing proteins (MP) ,MESH: Proteomics ,General Chemistry ,MESH: Open Reading Frames ,Biochemistry ,Article ,Human Protein Atlas ,non-MS PE1 proteins ,neXtProt protein existence (PE metrics) ,MESH: Proteome ,Human Proteome Project (HPP) ,Ribo-Seq ,uncharacterized protein existence 1 (uPE1) ,[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN] ,Grand Challenge Project ,Biology and Disease-HPP (B/D-HPP) ,small open reading frames (smORFs) - Abstract
International audience; The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP) illustrates that protein expression has now been credibly detected (neXtProt PE1 level) for 18,407 (93.2%) of the 19,750 predicted proteins coded in the human genome, a net gain of 50 since 2021 from datasets generated around the world and reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 78 from 1421 to 1343. This represents continuing experimental progress on the proteome parts list across all the chromosomes, as well as significant reclassifications. Meanwhile, applying proteomics in a vast array of biological and clinical studies continues to yield significant findings and growing integration with other omics platforms. We present highlights from the Chromosome-Centric HPP, Biology and Disease-driven HPP, and HPP Resource Pillars, compare features of mass spectrometry and Olink and Somalogic platforms, note the emergence of translation products from ribosome profiling of small open reading frames, and discuss the launch of the initial HPP Grand Challenge Project, "A Function for Each Protein".
- Published
- 2022