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A recent report discusses research on sepsis conducted by a researcher at Kyushu University in Fukuoka, Japan. The study focused on the association between histidine-rich glycoprotein (HRG) concentrations and critical conditions such as septic shock, disseminated intravascular coagulation (DIC), and acute respiratory distress syndrome (ARDS). Blood samples were collected from 53 critically ill patients, and it was found that HRG levels were significantly reduced in patients with septic shock and DIC but not in those with ARDS. Decreased HRG levels were also associated with higher mortality rates. The study suggests that HRG could be a potential intervention for sepsis patients, but further research is needed to explore its therapeutic potential. [Extracted from the article]

Researchers at Addis Ababa University conducted a study to explore the genetic diversity of Plasmodium falciparum histidine-rich protein 2/3 (PfHRP2/3) in malaria cases in Ethiopia. They collected blood samples from three health centers and analyzed the DNA using molecular techniques. The study found small variations in the frequency and number of amino acid repeat types in PfHRP2/3 across the health centers. The researchers concluded that there is significant diversity in PfHRP2/3 among clinical isolates of Plasmodium falciparum in Ethiopia, highlighting the need for monitoring the efficacy of PfHRP2-based rapid diagnostic tests. [Extracted from the article]

A patent application has been submitted for the approval of formulations of anti-PD1 antibodies. PD-1 is a cell surface protein that regulates immune responses, and inhibiting its interaction with PD-L1 can enhance T cell responses and mediate antitumor activity. Several antibodies targeting PD-1 have been developed, including pembrolizumab and nivolumab. The patent application describes liquid pharmaceutical compositions containing an anti-PD1 antibody, amino acids, a non-ionic surfactant, and citrate buffer, with a pH between 5.0 and 5.8. These compositions may be used for the treatment of various cancers. [Extracted from the article]

A study conducted at Ain Shams University in Cairo, Egypt compared the effectiveness of two cardioplegia methods, histidine-tryptophan-ketoglutarate (HTK) cardioplegia and cold blood cardioplegia (CBC), in patients undergoing surgical repair for tetralogy of Fallot. The study found that the HTK group showed a significant reduction in vasoactive inotropic score and lower lactate levels compared to the CBC group. Additionally, postoperative echocardiographic assessments showed better right ventricular function in the HTK group. The researchers concluded that HTK cardioplegia may offer better cardiac protection and recovery for patients undergoing tetralogy of Fallot repair. [Extracted from the article]

The article reports on a study from Harbin Medical University that examines the relationship between dietary amino acids glycine and histidine and their effects on hyperlipidemia and hypertension. Topics discussed include the nutritional roles of these amino acids, their antioxidant and anti-inflammatory properties, and the findings of a significant inverse association between high dietary intake of glycine and histidine and the prevalence of these health conditions.

A recent study conducted at Brigham and Women's Hospital has shed light on the role of membrane proteins in the production of outer membrane vesicles (OMVs) in Gram-negative bacteria. The researchers found that the outer membrane protein PagC plays a crucial role in OMV production through pH-dependent interactions with lipopolysaccharide (LPS). Specifically, a pH-sensitive amino acid motif in PagC, containing histidine residues, was found to be essential for OMV formation. These findings provide insights into the mechanisms by which bacteria sense and respond to environmental pH and control membrane dynamics through outer membrane proteins. [Extracted from the article]

A study conducted by researchers at the University of Hawaii at Manoa has provided new insights into Burkholderia pseudomallei, the bacterium that causes the tropical disease melioidosis. The study identified a transcriptional regulator called BP1026B_II1561 that plays a role in the pathogenesis of the bacterium. The regulator controls secondary metabolite biosynthesis, fatty acid degradation, and propanoate metabolism, as well as the expression of an outer membrane porin and genes in the shikimate biosynthetic pathway. The study suggests that these pathways could be potential targets for therapeutic intervention against melioidosis. [Extracted from the article]

A recent study conducted by the Russian Academy of Sciences has explored the potential of synthetic antimicrobial peptides (SAMPs) as antifungal agents. The researchers synthesized a series of histidine-containing SAMPs with a "linear" type of amphipathicity and compared their antifungal activity to that of a natural antifungal peptide. The results showed that the histidine-containing SAMPs exhibited increased antifungal activity with an increase in the number of histidine residues. The peptide H10, which had the highest antifungal activity and low hemolytic toxicity, was identified as a promising antifungal peptide drug. [Extracted from the article]

The article highlights research from the Department of Chemical and Process Engineering at Midlands State University, Zimbabwe, focusing on a histidine-functionalised polypyrrole nanocomposite for effectively removing toxic hexavalent chromium from water. It demonstrates that the nanocomposite exhibits high adsorption capacity and excellent recyclability, making it suitable for large-scale water purification.

The article focuses on a patent application for the acute and rapid treatment of headaches, such as migraines, using anti-CGRP antibodies. Topics include the role of Calcitonin Gene Related Peptide (CGRP) in migraine development, the use of CGRP-targeting antibodies for treatment, and the advancement of these therapies compared to existing treatments.

A patent has been issued to the University of California for compositions and methods related to ordered and continuous complementary DNA (cDNA) synthesis across non-continuous templates. The invention addresses the challenge of converting RNA to cDNA for various research and clinical applications, such as nucleic acid hybridization and high-throughput sequencing. The patent describes an isolated eukaryotic non-long terminal repeat reverse transcriptase (non-LTR RT) protein with specific characteristics, including a truncated N-terminal region and a mutation that abolishes endonuclease function. The protein is derived from the Bombyx mori arthropod. The patent also includes claims related to the protein's structure and additional components, such as stabilizer proteins and purification tags. [Extracted from the article]

A recent report from Washington University discusses the study of plant proteins known as phytochromes. Phytochromes are proteins that detect light and undergo a conformational change between dark-adapted and photoactivated states. The researchers used high-resolution cryo-EM maps to build models of these proteins and found that light absorption leads to a cascade of conformational changes that accelerate signaling by phytochrome kinases. This research provides insights into how plants respond to light and may have implications for understanding plant growth and development. [Extracted from the article]

A study conducted in Bouake, Cote d'Ivoire aimed to estimate the prevalence of asymptomatic and subpatent Plasmodium falciparum infections and investigate potential gene deletions. The study found that 97.2% of individuals were asymptomatic, and the prevalence of P. falciparum infection was higher in school-age children compared to younger and older age groups. The study also found that light microscopy and rapid diagnostic tests were reliable only at high parasite densities. No gene deletions were observed. The high prevalence of asymptomatic and subpatent infections highlights the need for targeted strategies to reduce malaria in urban Cote d'Ivoire. [Extracted from the article]

The article provides information on a patent issued for anti-vascular endothelial cell growth factor (anti-VEGF) protein compositions and methods for producing the same, filed by the inventors including Thomas Daly, Ning Li, and Nisha Palackal on July 6, 2022 and published online on August 6, 2024. It mentions the assignee for the patent application, quote from the background information supplied by the inventors, and claims supplied by the inventors.

A recent study conducted at the William S. Middleton Memorial Veterans Hospital in Madison, Wisconsin, has found that reducing dietary levels of the amino acid histidine can lead to weight loss and improved metabolic health in male mice. The researchers observed that reducing histidine intake by 67% resulted in decreased weight gain, reduced adipose and lean mass, and increased insulin sensitivity in the mice. These findings suggest that reducing histidine intake may be a potential treatment for obesity in humans. The study also found that variation in dietary histidine levels may help explain differences in body mass index among humans. [Extracted from the article]

A study conducted at Yan'an University in Shaanxi, China, has developed a smart two-dimensional photonic hydrogel sensor for detecting the amino acid histidine. The sensor, called CD-2DPCH, was created by modifying a hydrogel with NH2-beta-cyclodextrin and polystyrene two-dimensional photonic crystal array. The sensor demonstrated a good linear correlation in detecting histidine concentrations ranging from 0.1 to 1 and 10 to 400 μM, with a limit of detection of 58 nM. The researchers believe this sensor could be used to detect other amino acids by modifying different recognition groups. [Extracted from the article]

A patent application has been made available online for pharmaceutical compositions containing bispecific anti-CD37 antibodies. These antibodies target a protein called CD37, which is found on B cells and certain cancer cells. The patent application describes the development of stable formulations of these antibodies that have enhanced effectiveness and interaction with the target. The compositions include specific sequences of antibodies, as well as other ingredients such as a buffer, sugar or polyol, and polysorbate 80. The patent application also covers methods of using these compositions for the treatment of cancer, specifically B-cell malignancies like non-Hodgkin lymphoma and chronic lymphocytic leukemia. [Extracted from the article]

A new report from the University of Puerto Rico explores the relationship between branched-chain and aromatic amino acids (BCAAs/AAAs) and type 2 diabetes (T2D) in Puerto Rican adults. The study found that higher levels of BCAAs were associated with a higher risk of prevalent and incident T2D, as well as increases in measures of glycemia, dyslipidemia, and obesity. Additionally, the amino acid tyrosine was identified as a significant predictor of incident T2D and worsening insulin resistance over time. These findings suggest that BCAAs and tyrosine could serve as early markers of future glycemic changes in Puerto Ricans. [Extracted from the article]

The article focuses on the recent issuance of a patent for pharmaceutical formulations containing IL-6 antagonists, specifically designed to modulate IL-6 cytokines and treat various disorders. It states that the patent, assigned to F. Hoffmann-La Roche Inc., details specific formulations of IL-6 antibodies and their potential therapeutic uses, particularly in treating diseases associated with IL-6.

According to a preprint abstract from biorxiv.org, researchers have discovered that the VanS sensor histidine kinase from type-B vancomycin-resistant enterococci (VRE) is able to directly recognize vancomycin, an antibiotic commonly used to treat infections. The VanS protein plays a crucial role in antibiotic resistance by detecting vancomycin and transmitting this signal to the VanR transcription factor. This finding represents the first confirmation of a direct sensing mechanism for any VanS protein. The research has not yet undergone peer review. [Extracted from the article]

A new report discusses research findings on amino acids, specifically focusing on the peptide/histidine transporter PHT1 (SLC15A4). This transporter is found in the lysosomal membranes of immune cells and plays a role in metabolic and inflammatory signaling. The research presents a novel transport assay based on solid-supported membrane-based electrophysiology (SSME) to study PHT1 in its native lysosomal environment. The findings include the first recordings of electrophysiological properties, a pH dependence analysis, substrate selectivity, and transport kinetics. This new assay is expected to contribute to the understanding of PHT1's functional properties and its pharmacological potential. [Extracted from the article]

A patent has been issued to Nanyang Technological University for peptide coacervates derived from histidine-rich proteins, which can be used for the efficient delivery of active agents. These peptide coacervates have the potential to be used in the management and treatment of diseases such as cancer and diabetes. The coacervates can encapsulate multiple active agents and can be designed to respond to specific conditions or stimuli. This patent provides guidelines for designing peptides with liquid-liquid phase separation ability for various applications, including smart drug-delivery systems. [Extracted from the article]

A new report from the Department of Nutrition in Tehran, Iran explores the relationship between dietary factors and mental health disorders in teenage girls. The study found that there was a significant negative correlation between branched-chain amino acids (BCAAs) and mental health, with lower BCAA levels observed in patients with mental disorders. Additionally, the study found that weight and energy intake were positively correlated with stress levels. However, after adjusting the results, no significant relationship was found between mental health and the studied factors. The researchers suggest that further studies in different age and sex groups are needed to better understand the relationship between BCAAs and mental health. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the deletions of the pfhrp2 and pfhrp3 genes in Plasmodium falciparum, the parasite that causes malaria. These deletions make the parasites undetectable by most malaria rapid diagnostic tests (RDTs). The study analyzed over 19,000 P. falciparum field samples and found that pfhrp2 deletion occurred through chromosomal breakage and subsequent telomere healing, while pfhrp3 deletions involved loss from pfhrp3 to the telomere and showed different patterns. The researchers also identified a hybrid chromosome with long-read sequencing, suggesting a translocation product arising from recombination between large interchromosomal ribosome-containing segmental duplications. The findings can help refine surveillance strategies for malaria. [Extracted from the article]

A recent study conducted by researchers at the University of Jeddah in Saudi Arabia explored the role of miR-877 and histidine-rich glycoprotein (HRG) in preeclampsia (PE), a pregnancy complication. The study analyzed placental and serum samples from patients with PE and normal controls. The findings revealed that miR-877 and HRG may play a role in the development and progression of PE, and they could potentially serve as biomarkers for detecting and differentiating mild and severe cases of the condition. Further research is needed to fully understand the clinical significance of these molecules in PE. [Extracted from the article]

A recent report from the National Institute of Malaria Research provides new insights into malaria, specifically focusing on deletions of histidine-rich protein 2/3 genes in natural Plasmodium falciparum populations from Cameroon and India. The study found that these deletions, which can result in false negative rapid diagnostic tests for malaria, are relatively uncommon in these settings. The research emphasizes the importance of active molecular surveillance for these deletions in order to improve malaria control and elimination efforts. [Extracted from the article]

A study conducted by researchers at Changwon National University in South Korea examined the association between serum branched chain amino acids (BCAAs) and aromatic amino acids (AAAs) ratio and metabolic disease in Korean adults with normal-weight or obesity. The study included 78 adults aged 20-59 years and compared serum amino acid levels, blood profile, and body composition between the normal-weight and obesity groups. The results showed that the group with obesity had higher levels of BCAA, AAA, and BCAA and AAA ratio, which were positively correlated with triglyceride levels, body weight, and skeletal muscle mass. The study suggests that the elevated BCAA and AAA ratio could serve as early biomarkers for predicting future metabolic diseases in the Korean population. [Extracted from the article]

A report from the Tokyo University of Agriculture and Technology discusses a study comparing different methods of DNA extraction for genotyping equine histidine-rich glycoprotein insertion/deletion polymorphisms. The researchers found that DNA samples collected from oral mucosa swabs were sufficient in quantity and quality for genotyping, making it a less invasive alternative to blood sampling. However, DNA samples derived from fecal samples were of lower quality due to contamination with non-horse DNA. The study recommends collecting DNA samples from oral mucosa swabs for genetic analysis in horses and other animals that are not accustomed to humans. [Extracted from the article]

A study conducted by researchers at Sichuan University in Chengdu, People's Republic of China, compared the outcomes of two different cardioplegia solutions in a pig model of cardiopulmonary bypass. The study found that the solution containing natural blood and crystalloid, called "Huaxi-1," resulted in better outcomes compared to the entirely crystalloid solution. Animals given Huaxi-1 cardioplegia required less time to be weaned off bypass, received lower doses of norepinephrine, and showed higher levels of adenosine triphosphate and other biomarkers in the myocardium. The study suggests that Huaxi-1 cardioplegia may be superior in promoting energy generation and attenuating ischemia/reperfusion injury in the myocardium. [Extracted from the article]

A study conducted by researchers at the University of Tubingen in Germany has found that delays in diagnosing malaria can lead to treatment failures and deaths. The standard diagnostic methods for malaria in endemic regions are microscopy and malaria rapid diagnostic tests (mRDTs), but gene deletions can allow certain parasites to go undetected. The study found that mRDTs were more sensitive and specific than microscopy, with a higher positive predictive value and negative predictive value. The researchers recommend enhanced training and the use of molecular testing methods to address the limitations of microscopy in endemic areas. [Extracted from the article]

A recent study conducted at NIMS University in Rajasthan, India, explores the role of bacterial histidine kinase (BHK) in various bacterial processes, including pathogenicity, virulence, biofilm development, antibiotic resistance, and bacterial persistence. The researchers suggest that inhibiting BHK could be a promising strategy for developing antibiotics and other therapeutic agents. The study highlights the importance of understanding the two-component signaling (TCS) pathway and the potential of BHK inhibitors in blocking multiple TCS regulatory networks. For more information, the full article can be accessed through the link provided. [Extracted from the article]

A study conducted by researchers at National Cheng Kung University Hospital in Taiwan examined the potential neurological impact of intraoperative hyponatremia using histidine-tryptophan-ketoglutarate (HTK) cardioplegia infusion in adult cardiac surgery patients. The study involved 60 patients who underwent cardiac surgery, with 13 receiving HTK infusion and 47 receiving conventional hyperkalemic cardioplegia. The results showed that acute hyponatremia occurred in the HTK group during cardiopulmonary bypass, but was corrected with ultrafiltration and normal saline administration. While there was a short-term increase in relative delta power in the HTK group, there were no significant long-term neurological impacts. Further research is needed to determine the necessity of correcting HTK-induced hyponatremia. [Extracted from the article]

A study conducted at Ashoka University in Haryana, India, explores the precise chemical modification of histidine-containing bioactive peptide sequences. The research focuses on the modification of peptides to generate peptide drugs, antibody-drug conjugates, and probes for molecular imaging. The study highlights strategies for the chemical modification of histidine and its potential applications in peptide research and synthetic chemistry. Financial support for the research came from the Ministry of Education in India. The research has been peer-reviewed and can be accessed through the journal Synlett. [Extracted from the article]

A study conducted at Ludwig-Maximilians-University Munich in Germany focused on Aspergillus fumigatus, a fungus that causes infections in humans. The researchers investigated a specific protein called TcsC, which is involved in a signaling pathway related to the fungus's response to stress. They found that the N-terminus of TcsC is essential for its activity and its localization in the nucleus. The study highlights the importance of understanding the dynamics of signaling pathways in order to develop effective treatments for fungal infections. The research was supported by the German Research Foundation. [Extracted from the article]

A patent application titled "High Concentration Antibody Formulations" has been published online by the US Patent and Trademark Office. The patent application, filed by inventors Nien-Yi Chen and Wei-Ting Kao, and assigned to Oneness Biotech Co. Ltd., describes the development of antibody formulations with high concentrations of biologic molecules. These formulations show superior stability and injectability and may be used in the treatment of disorders associated with immunoglobulin E (IgE), such as allergic asthma, allergic rhinitis, atopic dermatitis, or hyper IgE syndrome. The antibody formulations consist of specific concentrations of antibodies, histidine, amino acids (arginine or threonine), sodium chloride, and polysorbate 80. [Extracted from the article]

A patent has been issued for aflibercept formulations and their uses in ophthalmic administration. Aflibercept is a recombinant fusion protein used in the treatment of various eye disorders, including macular edema and age-related macular degeneration. The patent describes an ophthalmic formulation of aflibercept that includes specific concentrations of the drug, a histidine buffer, a non-ionic surfactant, and a tonicifying agent. The formulation has enhanced stability and can be administered intravitreally or topically. The patent also includes methods of treating eye disorders using the formulation. [Extracted from the article]

A report from Tianjin University in China discusses research on the selective crystallization of l-histidine polymorphs. The study focuses on the role and mechanism of additives in achieving the selective crystallization of one pure polymorph. The researchers discovered a series of additives with selective abilities, and through various analyses and simulations, they determined that the additives bind to the -COO- group of l-histidine, affecting the molecular stacking and stability of the polymorphs. The findings provide valuable insights into the crystallization of l-histidine in the pharmaceutical industry and offer guidance for regulating polymorphs using additive strategies. [Extracted from the article]

The USPTO has published a patent application titled "Anti-Nectin-4 Antibody Amanitin Conjugates" by inventors from various locations and assigned to Emergence Therapeutics Ag. The application focuses on Nectin-4, an adhesion molecule associated with certain viruses and various cancers. It describes an antibody-drug conjugate (ADC) that targets Nectin-4 using a toxic drug molecule called a-amanitin. The research aims to develop more effective cancer treatments, particularly in oncology, gynecology, and gastroenterology. [Extracted from the article]

The given text is a patent application for antibody-drug conjugates that target Nectin-4, a protein associated with cancer. The patent application describes various amino acid sequences and substitutions that can be used to create the antibody or antigen-binding fragment. The application also includes claims related to the variable heavy chain (VH) and variable light chain (VL) regions of the antibody. The antibody-drug conjugates have potential applications in cancer treatment. For more detailed information, please refer to the full patent application. [Extracted from the article]

A patent application has been submitted by inventors Gearing, Guo, Li, Petaipimol, and Wang for pharmaceutical compositions containing antibodies that bind to the TSLP receptor (TSLP-R) and their use in treating diseases. The application describes different concentrations of the antibodies, buffers, excipients, surfactants, and amino acids. These compositions aim to inhibit TSLP and improve treatment for TSLP-related diseases. The application provides detailed information on the antibody's amino acid sequences and their potential medical applications. For more information, please refer to the full patent application. [Extracted from the article]

Researchers at Thiruvalluvar University in Tamil Nadu, India have conducted a study on the potential use of chitosan/histidine nanoparticles (CS/HIS-NPs) for controlled delivery of curcumin, an anticancer agent. The study found that curcumin was efficiently incorporated into the nanoparticles, which exhibited a robust encapsulation efficiency of 98.4%. The nanoparticles showed promising results in terms of cytotoxicity and in vitro release studies, suggesting their potential efficacy as a delivery system for curcumin. The researchers concluded that chitosan/histidine nanoparticles could be a promising avenue for advancing anticancer drug delivery. [Extracted from the article]

A patent application has been filed for a new immunogenic composition that delivers a peptide antigen to induce an immune response. The composition utilizes polymer nanoparticles that contain a peptide antigen linked to a peptide tag, along with an adjuvant. The nanoparticles can enter immune cells and generate an immune response to the peptide antigen. The method has the potential to be used in personalized cancer vaccines that target tumor-specific neoantigens. [Extracted from the article]

A recent study conducted by the National Organization for Drug Control and Research (NODCAR) in Giza, Egypt, explores the potential of a combined administration of a GABA agonist and L-histidine in alleviating obesity-induced neuro-lipotoxicity. The study involved experimentally obese rats and found that the combined treatment exhibited significant behavioral improvement and normalized neurochemical and cellular parameters. The research suggests that this approach could offer a promising solution for addressing the complexities of obesity. Further information on the study can be found in the article published in Scientific African. [Extracted from the article]

Researchers from Josip Juraj Strossmayer University of Osijek in Croatia have developed a new microfluidic method for analyzing L-histidine and beta-alanine in dietary supplements. The method utilizes capacitively coupled contactless conductivity detection for the microchip electrophoresis of amino acids in real samples. The researchers found a linear relationship between detector response and concentration for both L-histidine and beta-alanine, and the method allows for the simultaneous analysis of amino acids with metal cations. This research provides a new approach to analyzing amino acids in dietary supplements without the need for chemical derivatization. [Extracted from the article]