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Background and purpose: Spread through air spaces (STAS) is a poor prognostic factor for early lung adenocarcinoma, especially in patients with wedge resection. Preoperative prediction of STAS is helpful to select a better surgical treatment. This study aimed to develop and validate a nomogram based on preoperative clinical and computed tomography (CT) characteristics to predict STAS in stage ⅠA lung adenocarcinoma. Methods: A total of 595 patients with stage ⅠA lung adenocarcinoma who underwent surgical treatment in Zhongshan Hospital Fudan University from January 2017 to December 2018 were retrospectively analyzed. The results of STAS were evaluated by paraffin embedded tissues fixed with 4% formaldehyde solution. Based on preoperative clinical data and chest CT, 4 clinical characteristics and 11 CT characteristics were analyzed. The independent predictors of STAS in clinical and CT characteristics were identified by logistic regression analysis and then used to build a nomogram. Concordance index (C-index), area under the curve (AUC) of receiver operating characteristic (ROC) and calibration plots were used to evaluate the performance of the model. Results: Among the 595 stage ⅠA lung adenocarcinoma patients, 87 patients (14.6%) were STAS positive. Univariate and multivariate logistic regression analyses showed that lobulation (OR=8.156, 95% CI: 1.021-65.099), spiculation (OR=5.258, 95% CI: 2.506-11.032) and consolidation tumor ratio (CTR) (0.50

In this study, three banana varieties, ‘Nantianhuang' ‘Zhongjiao 9' and ‘Hongxiangjiao' were studied as experimental materials to study the effects of sodium selenate solution on the plant growth, yield, fruit quality,contents of MDA, proline and selenium. The results were as follows:(1)The application of 0.25 and 0.50 g·plant-1 sodium selenate could significantly increase plant height of three banana varieties and the growth of basal stem circumference of ‘Nantianhuang' and ‘Hongxiangjiao', but not ‘Zhongjiao 9'.(2)The application of selenium had little effect on MDA content in leaves during vegetative growth, and MDA content increased or decreased significantly only in part time. The proline content in leaves of the three banana varieties were significantly reduced at 0.25 and 0.50 g·plant-1 sodium selenate. Selenium had a significant effect on selenium content in leaves. The higher selenium concentration, the higher the selenium content in leaves.(3)The application of selenium could significantly increase the yield of banana and the single fruit weight of ‘Zhongjiao 9' and ‘Hongxiangjiao'. The yield per plant and single fruit weight of ‘Zhongjiao 9' at 0.25 g·plant-1 sodium selenate were 24.38 kg and 165.86 g, which were 12.80% and 14.69% higher than those of the check(CK). The suitable concentration of sodium selenite could effectively increase the content of vitamin C and potassium in fruits.(4)The highest vitamin C contents of ‘Nantianhuang' ‘Zhongjiao 9' and ‘Hongxiangjiao' were 12.7, 13.9 and 10.6 mg·100g-1, which were 12.72%, 18.84% and 29.39% higher than CK. And the highest contents of potassium were 349, 279 and 397 mg·100g-1, which were 29.62%, 33.28% and 47.77% higher than CK.(5)The higher the concentration of selenium treatment, the higher the content of selenium in fruits. The selenium content of fruits in CK did not reach the standard of selenium enrichment. The three banana varieties reached the standard of selenium enrichment after treatment with 0.25 and 0.50 g·plant-1 sodium selenate. In conclusion, the application of sodium selenate solution in soil can increase the content of selenium in banana fruits, promote the plant growth, improve fruit quality of banana, and decrease the content of MDA and proline in leaves. However, there are differences in the effects of various banana varieties. These findings will provide a theoretical basis for the production and cultivation of selenium enriched banana. [ABSTRACT FROM AUTHOR]

Metal-organic frameworks (MOFs), a new type of nanoporous materials which are composed of metal ions or metal clusters and organic ligands through coordination bonds, have attracted extensive attention in recent years. They have been developed rapidly in environmental analytical chemistry due to their high specific surface area, high porosity, excellent crystallinity and good chemical/thermal stability. In this paper, the synthetic methods and application in adsorption of UiO series metal-organic framework materials are reviewed. The reaction conditions and advantages and disadvantages of the synthetic methods including hydrothermal, micro-assisted synthesis, mechanical grinding, and electrochemical synthesis are introduced. UiO series MOFs, as new adsorption materials, have been widely used in the removal of heavy metal ions, the degradation of organic matter and the adsorption and separation of gas due to their high thermal stability and chemical stability. Meanwhile, the future development trend is prospected of UiO series MOFs, according to the recent research. [ABSTRACT FROM AUTHOR]

An improved YOLOv4 model was proposed to improve the speed and accuracy of orange fruit picking. A lighter structure and a smaller weight size were also designed easy to be migrated into the mobile terminal. Two-dimensional coordinates of the fruit centroid were also obtained from the color image shot by the RealSense depth camera. The depth value of the centroid point in the corresponding depth map was extracted after the registration of the depth and color map, in order to realize the three-dimensional spatial positioning of the fruit. The MobileNet v2 was taken as the backbone network in the structure of the improved YOLOv4 model. The depthwise separable convolutions were used to replace the ordinary convolutions in the neck structure, in order to further reduce the weight of the model for the higher detection speed. A comparison experiment was carried out on the detection effects between the improved YOLOv4, the original YOLOv4, YOLOv4-tiny, Ghostnet-YOLOv4, and classical convolutional neural networks like Faster RCNN and SSD, in order to verify the effectiveness and superiority of the improved model. The results showed that the value of precision, recall, F1, and average precision of the improved model were 97.57%, 92.27%, 94.85%, and 97.24%, respectively, which were close to the original YOLOv4 model at a high level. Meanwhile, the average detection time and the model size were reduced by 11.39 ms, and 197.5 M, respectively. The average precisions of the detection were improved by 2.69 percentage point and 3.11 percentage point, respectively, compared with the Faster RCNN and SSD models. Correspondingly, the model size decreased by 474.5 and 44.1 M, respectively. The recall of the proposed detection model increased by 4.22 percentage point, compared with the YOLOv4-tiny model. Additionally, the average detection time of the improved model decreased by 7.15 ms to that of Ghostnet-YOLOv4. Besides, an investigation was made to explore the influences of occlusion degree on the detection accuracy of the improved model. The average precision for the detection of the improved model in the severe occlusion test set was 95.37%, and 3.98 percentage point lower than those in the slight ones. It seemed that the severe occlusion reduced the detection accuracy. The improved model still retained high detection performance, even under the interference of occlusion. The three-dimensional spatial positioning of orange fruit was used to verify the proposed location, which combined the improved YOLOv4 model and RealSense camera. The improved YOLOv4 model was applied to recognize and locate a total of 78 fruits in actual orchard environment in order to verify the effectiveness of the proposed location algorithm. The results showed that there was a 98.72% success rate in two-dimensional fruit recognition. The mean absolute errors in the horizontal and vertical directions were 0.91 and 1.26 pixels, respectively. The mean absolute percentage errors were both within 1 percentage point. Moreover, the success rate of three-dimensional fruit positioning reached 96.15%. The mean absolute error of depth information was 3.48 cm, and the mean absolute percentage error was 2.72%. Consequently, the prediction errors in the three directions all remained in a small range, which fully met the need of accurate positioning for the picking manipulators. In conclusion, the finding can also provide a target location approach with strong robustness, excellent real-time performance, and high accuracy for the picking operation in complex scenes. [ABSTRACT FROM AUTHOR]

BACKGROUND: Circular RNAs (circRNAs) were initially regarded as by-products of aberrant splicing. Present research on their mechanism has gradually penetrated to the molecular level. Many studies have shown that circRNAs participate in osteogenic differentiation through various ways and play a key role. OBJECTIVE: To discuss the research progress of circRNAs during osteogenic differentiation in human mesenchymal stem cells. METHODS: Using “circRNAs, human mesenchymal stem cells, osteogenic differentiation” as keywords in English and Chinese. PubMed, Web of Science, CNKI, and Wanfang were searched for relevant articles on circRNAs in human mesenchymal stem cells published from 1993 to 2020. Types of retrieved articles included reviews, research papers, and books. RESULTS AND CONCLUSION: CircRNAs play an important role in the osteogenesis of mesenchymal stem cells. These circRNAs have proven to be key targets for the diagnosis and treatment of bone diseases. However, the molecular mechanism of circRNA in osteogenic differentiation needs further research, and in vivo experiments are also needed to support existing conclusions. [ABSTRACT FROM AUTHOR]

目的 观察超声引导旁正中冠状斜位入路穿刺椎管内麻醉在剖宫产术中的应用效果. 方法 60例择期 接受剖宫产手术的足月孕妇, 随机分为A组和B组各30例. A组在剖宫产术前采用超声引导旁正中冠状斜位入路 穿刺腰椎3-4间隙, 注入 0. 5% 的罗哌卡因 3 mL 完成椎管内麻醉, B组采用超声引导旁正中矢状斜位入路穿刺腰椎 3-4间隙, 注入0. 5%的罗哌卡因3 mL, 观察两组麻醉效果, 超声扫查显示前后复合体情况, 穿刺时间, 穿刺次数. 观 察两组患者穿刺过程中穿刺点出血, 一侧肢体麻木异感及血压下降 20% 及术后头痛, 恶心呕吐发生情况. 结果 两组穿刺 5 min时感觉消失平面均能达到 T6及以上. 与 A组比较, B组超声检查可见前复合体较多, 1次穿刺成功 率高, 穿刺操作时患者一侧肢体麻木异感发生率高（P均<0. 05). 结论 超声引导旁正中冠状斜位入路穿刺椎管内 麻醉在剖宫产术中的麻醉效果较好, 不良反应少. [ABSTRACT FROM AUTHOR]

Accurate identification of target depth is the critical premise for the manipulator of fruit and vegetable picking in intelligent agriculture. However, the general ranging of fruit has posed a great challenge on that the orchard in the mountain areas, due mainly to the light change, as well as the branch and leaf occlusion. In this study, a novel imaging algorithm was proposed to detect the monocular distance between the pomelo fruits and camera using target pixels change. The pomelo fruit off the tree in the orchard was chosen as the samples for data collection. Multiple regression was also established to verify the number change of pixels in the target areas and imaging distance. Furthermore, the pomelo fruit on the tree was involved to test the applicability in the samples. Additionally, a systematic investigation was made to explore the influences of initial imaging distance and step interval on prediction accuracy. The specific procedure was as follows. A single camera was utilized to capture the imaging data of the sample fruit side within the imaging distance ranging from 25 to 150 cm, where the common range of picking operation was set at the step interval of 2.5 cm. Therefore, there were 51 images side for each fruit for one group of data. 20 pomelo fruits with the representative shape and size were selected for the imaging data collection, including 14 off-tree and 6 on-tree. In the pomelo fruits off the tree, the surface was equally divided into four sides, where one group of data was acquired from each side. As such, a total of 56 data groups were collected from the samples of the tree. Subsequently, the 40 data groups were randomly selected to establish the multiple regressions between the imaging distance and the number of pixels change in the target area on the image, while the rest 16 data groups were used to optimize the algorithm. In the pomelos fruits on the tree, only the side towards the outside of the canopy was shot as one sample side, where 6 data groups were collected for testing. The numbers of pixels were then measured for the target areas in the image using Photoshop software. MATLAB 2018 platform was finally utilized to calculate the regression and curve fitting. The results showed that the error of predicted distance decreased gradually, as the camera approached the fruit target from 150 to 120 cm. In the fruit samples off the tree, the accuracy of distance prediction was at the medium level closer than 130 cm at the high level of about 120 cm. The relative ranging errors of 16 samples off-tree were less than 5% within the imaging distance of 120 cm, when 150 cm was as the initial distance, indicating that an excellent detection performance of imaging distance between the target and camera. In the fruit samples on the tree, the ranging accuracies were set as 137.5-125 cm and 125.0-25.0 cm for the medium and high levels, respectively. Correspondingly, the relative ranging errors of 6 samples on the tree were less than 5% within 125 cm imaging distance, fully meeting the accuracy requirements of target positioning for the picking manipulator. In addition, there was a significant effect of initial imaging distance on the measurement accuracy. Consequently, the measurement method of monocular distance can widely be expected to realize the rapid prediction of the distance between the fruit target and camera in the complex orchard environment, especially in the hilly mountain areas. Meanwhile, the finding can also provide a feasible scheme for the accurate recognition of fruit targets for picking manipulators in modern orchards. [ABSTRACT FROM AUTHOR]

[Objective] In order to provide theoretical basis for pollen viability identification, artificial pollination and cross breeding of large- fruited yellow passion fruit, the effects of different culture medium in vitro and storage conditions on pollen germination were analyzed. [ Method] Pollens were collected from newly blooming flowers of large-fruited yellow passion fruit The suitable concentrations of sucrose, boric acid, calcium nitrate and suitable pH for pollen in vitro culture were screened by Li, (5 4) onhogonal design. The effects of sampling time of flowers, storage humidity and temperature on pollen viability were studied by using the most suitable pollen culture medium. The suitable storage condition for pollen of large-fruited yellow passion fruit was determined. [Result] The results of onhogonal test showed that the order of influencing factors on pollen germination rate of large-fruited yellow passion fruit was calcium nitrate > sucrose > boric acid > pH. The optimum medium for pollen germination in vitro was 100. 00 g/L sucrose + 0. 02 g/L boric acid + 0. 40 g/L calcium nitrate, and the medium pH was 5. 0. The pollen germination rate in the optimum medium was 85. 55 % . The pollen germination rate of large-fruited yellow passion fruit was more than 80. 00% when the sampling time was from 11 :30 to 17 :30. The pollen viability was the highest in the third hour ( 16: 30) after flowering, which was significantly higher than the germination rate of pol- lens collected at other times except 13 : 30 and 15 : 30 (P <0. 05, the same as below). The results of storage test showed that, the pollen germination rate of natural air drying on sulfur paper treatment for 3 - 48 hours was significantly higher than that of sealed centrifugation tube storage at room temperature and storage in desiccator on sulfur paper for the same time, and the pollen germination rate of 48 h storage was still 34. 28%. The pollen germination rate was 61. 49% after natural air drying for 5 hours and sealed in centrifugal tube at 4 °C for 24 hours, which was significantly higher than that (55. 22%) after natural air drying for 5 hours and sealed in centrifuge tube at - 20 °C for 24 hours. [Conclusion] The optimum medium for pollen germination in vitro of large-fruited yellow passion fruit is 100. 00 g/L sucrose+ 0. 02 g/L boric acid+ 0. 40 g/L calcium nitrate, and pH is 5. 0. The best storage condition is that the pollens collected on the day are dried naturally for 5 hours and sealed in centrifuge tube at 4 °C [ABSTRACT FROM AUTHOR]

BACKGROUND: Muscle weakness is a common symptom after coronavirus disease 2019 (COVID-19) infection and affects the ability to perform daily activities in humans during recovery. Low-frequency pulsed magnetic field stimulation at a strength of 1.5 mT and a frequency of 3 300 Hz can enhance the maximal voluntary contraction and strength endurance of human skeletal muscle by inducing and activating classical transient receptor potential channel 1 (TRPC1), which produces a series of pathological support effects on muscle tissue. It has not been studied whether this means will improve muscle weakness in patients recovering from COVID-19. OBJECTIVE: To select the low-frequency pulsed magnetic field for magnetic stimulation of lower limb muscle groups in patients with COVID-19, in order to observe the effect of this stimulation on the improvement of muscle weakness of lower limb muscle groups in patients with COVID-19 during the recovery period. METHODS: Fourteen patients infected with COVID-19 (Omicron strain) positive for Innovita COVID-19 Ab Test (Colloidal Gold) and accompanied by muscle weakness were recruited and randomly divided into two groups: a test group receiving magnetic field stimulation and a control group receiving sham treatment, respectively. The total duration of the trial was 3 weeks. The test group was given low-frequency pulsed magnetic stimulation of the lower limbs every 48 hours and the control group was given the same intervention procedure as the test group but with sham stimulation. Patients in both groups were not informed whether the magnetic stimulation apparatus was running or not. Nine sessions were performed in both groups and the changes in the maximum voluntary contraction, explosive leg force and strength endurance of the local muscle groups of the lower limbs were subsequently observed in both groups. RESULTS AND CONCLUSION: Among the eight local muscle groups collected, seven local muscle groups in the test group showed an increase in the maximum voluntary contraction value after 3 weeks of low-frequency pulsed magnetic field stimulation. In the control group, there were only three muscle groups with improvement in the maximum voluntary contraction. The rate of improvement in the anterior and posterior muscle groups of the left leg in the test group was significantly higher than that in the control group. The longitudinal jump height and peak angular velocity of the knee joint in both groups were improved compared with the pre-test measurement, and the elevation rate of jumping height in the test group was higher than that in the control group. Under the fatigue condition, the decline rates of peak angular velocity of the knee joint and jumping height in the test group decreased significantly, while those in the control group did not change significantly. The above data confirmed that the low-frequency pulsed magnetic field stimulation with the intensity of 1.5 mT and frequency of 3 300 Hz could improve the muscle strength of more local muscle groups in the lower limbs of patients with COVID-19 during the recovery period compared with the human self-healing process, and the whole-body coordination ability and functional status based on explosive leg force of the legs could be significantly improved. Therefore, low-frequency pulsed magnetic field stimulation can be used as an effective, non-exercise rehabilitation tool to improve muscle weakness in the lower limbs of patients with COVID-19. [ABSTRACT FROM AUTHOR]

To overcome the non-structure-preserving drawbacks in traditional numerical simulation of transmission-line nonlinear vibration responses, the Noether symmetry and conserved quantity of transmission lines’ 2-way galloping under ice and wind excitation were studied. Firstly, in view of the nonlinearity of the aerodynamic force and the line geometry, a 2-DOF galloping model of vertical and torsional vibrations was established based on the analytical mechanics method. Secondly, the group analysis theory was introduced, and the condition and the conserved quantity of the Noether symmetry were given according to the invariance principle. Finally, a conserved quantity-preserving discrete numerical algorithm was constructed. The dynamic characteristics of the nonlinear mechanical structure were studied with the Noether symmetry theory. The results show that, the proposed novel method is structure-preserving in a wide range of application, and is reliable and accurate. [ABSTRACT FROM AUTHOR]

Objective To explore the effect of stepped psychological care combined with early activities on the mental health and gastrointestinal function recovery of patients with gastric cancer after operation. Methods A total of 106 patients who underwent gastric cancer surgery in our hospital from March 2020 to January 2023 were selected as the study subjects. According to the random number table method, they were divided into the control group and the observation group, with 53 cases in each group. The control group received routine care, while the observation group received stepped psychological care combined with early activities. The recovery time of gastrointestinal function, stress state, mental health and quality of life were compared between the two groups. Results The recovery time of gastrointestinal function in the observation group were shorter than those in the control group, and the difference was statistically significant(P <0.05). During the operation, the heart rate(HR), systolic blood pressure(SBP) and diastolic blood pressure(DBP) increased in both groups, but the observation group was lower than the control group, with statistically significant difference(P <0.05). After the operation, HR, SBP, and DBP decreased in both groups, and the observation group was lower than the control group, with a statistically significant differences(P <0.05). After intervention, the scores of the Self-rating Anxiety Scale(SAS) and Self-rating Depression Scale(SDS) in the observation group were lower than those in the control group, and the scores of all dimensions of the Quality of Life Inventory(QLICP) for cancer patients were higher than those in the control group, with statistically significant differences(P <0.05). Conclusion The application of stepped psychological care combined with early activities in patients with gastric cancer surgery accelerate the recovery of gastrointestinal function, effectively reduce the stress level during the operation, and improve their mental health and quality of life. [ABSTRACT FROM AUTHOR]

To investigate the relationship between the expression of micro ribonucleic acid (miRNA)-145, miR-186 and clinical pathological characteristics and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin(mTOR) signaling pathway in non-small cell lung cancer (NSCLC) tissues. 128 NSCLC patients who underwent radical surgery for lung cancer in our hospital From March 2020 to March 2023 were selected, the intraoperative cancer tissues and cancer adjacent tissues (more than 5cm from the cancer tissues) were taken, the expression of miR-145, miR-186, PI3K mRNA, Akt mRNA and mTOR mRNA was detected by real-time fluorescence quantitative polymerase chain reaction (qRT-PCR). The relationship between the expression of miR-145 and miR-186 and the clinical pathological characteristics of NSCLC patients was analyzed. The correlation between the expression of miR-145, miR-186 and the expression of PI3K mRNA, Akt mRNA and mTOR mRNA in NSCLC patients were analyzed by Pearson test. The expression of miR-145 and miR-186 in cancer tissues was lower than that in cancer adjacent tissues (P<0.05), the expression of miR-145 and miR-186 in NSCLC tissues with low differentiation, TNM IIIA stage and lymph node metastasis was lower than that in NSCLC tissues with medium to high differentiation, TNM I～II stage and without lymph node metastasis (P<0.05). The expression of PI3K mRNA, Akt mRNA and mTOR mRNA in cancer tissues was higher than that in cancer adjacent tis-sues (P<0.05), the expression of miR-145 and miR-186 in cancer tissues was negatively correlated with the expression of PI3K mRNA, Akt mRNA and mTOR mRNA (P<0.05). The expression of miR-145 and miR-186 in NSCLC tissues is down-regulate, the down-regulate of miR-145 and miR-186 expression may activate the PI3K/Akt/mTOR signaling pathway to promote the progression of NSCLC, and is associate with poor differentiation of cancer tissue, TNM IIIA stage and lymph node metastasis in NSCLC patients. [ABSTRACT FROM AUTHOR]

Objective To clarify the role of discs large homolog 5 (DLG5) in the diagnosis and prognosis of renal clear cell carcinoma (ccRCC) by studying the expression of DLG5 in the clinical tissue of ccRCC. Methods DLG5 expression in ccRCC tissues and normal renal tissue was measured by using the Cancer Genome Atlas (TCGA) Database and Gene Expression Omnibus (GEO) Database. The correlation of DLG5 expression with the prognosis and clinicopathological parameters of ccRCC was analyzed by LinkedOmics and GEPIA. The interactions protein network of DLG5 was predicted by String-DB. Results Compared with that of the normal kidney tissues, DLG5 expression was significantly upregulated in the ccRCC tissues (P <0.05). The high DLG5 expression was an independent prognostic factor affecting the overall survival rate of ccRCC based on TCGA (P =2.997×10-5). Furthermore, DLG5 expression had a positive correlation with the TNM stage, ethnicity, tumor purity, year-tobirth, PCNA (P =1.1×10-6, R =0.19), and RAD1 (P =5.7×10-6, R =0.18) expression of ccRCC. Conclusion In ccRCC, the high expression of DLG5 is a significant index of poor prognosis. Therefore, DLG5 can be a potential biomarker for predicting the metastasis, recurrence and prognosis of the patients. [ABSTRACT FROM AUTHOR]

As one of the main parameters for evaluating mechanized land leveling technology, which is the basic link of modernization and precision agriculture, soil surface roughness is also a factor that must be considered for field management such as crop planting, irrigation, harvesting and so on. However, a rapid and low-cost accuracy measurement method is absent currently. In this work, we proposed a method for rapidly evaluating soil surface roughness. The soil surface roughness was assessed according to the images generated by a self-design system based on line structure laser light principle. The parameters of the system was determined by a preliminary experiment. The accuracy of the system was 0.126 mm. Considering the requirements by common crops such as oilseed rape, potato, rice and vegetables, we screened the soils with 4 aperture sieves. The obtained soil particle size was higher than 2 mm, higher than 0.9 mm and not less than 2 mm, higher than 0.3 mm and not less than 0.9 mm, and not higher than 0.3 mm. By the self-design system, soil samples images were obtained. After segmentation, morphological processing and edge detection, the images of prepared soil samples were processed for extracting the center sub-pixels of structured light stripe and the sub-pixels were combined together for obtain the 3D point cloud of each sample. With delaunay triangulation algorithm, the 3D surface modeling of the soil surface was established and the curve surface area was calculated. The ratio of curved surface area to surface area was calculated in order to characterize the flatness of the soil surface. The threshold values of the ratio for determining the sample surface roughness were determined by analyzing the ratio values of 4 samples with different particle sizes. The larger ratio values indicate more rough soil surface. Based on the ratio, soil was considered as relatively flat, relatively dense, relatively rough and rough when the difference of ratio and 1 was 0, higher than 0 and not higher than 0.5, higher than 0.5 and not higher than 1, and higher than 1. The method was validated by soil bin test. The soil samples in soil bin with treatments in uncultivated, shallow rotary tillage and deep rotary tillage conditions were used for the validation of the system and algorithm. Meanwhile, our method was compared with probe method. The results showed that the ratio values of surface samples with uncultivated, shallow rotary tillage and deep rotary tillage increased gradually. The ratio was 1.214, 1.633 and 1.939 for the samples in uncultivated, shallow rotary tillage and deep rotary tillage conditions, respectively. The change of the ratio was consistent with that of the standard deviation of relative height difference of sample surface by the probe method. Based on the ratio, the sample surface in the treatments of uncultivated, shallow rotary tillage and deep rotary tillage was considered as relatively dense, relatively rough and relatively rough, respectively. The results were consistent with the actual characteristics of the samples. These results indicated that the presented measurement method could be applied in soil surface roughness assessment. [ABSTRACT FROM AUTHOR]

白藜芦醇是一种可在不同植物物种中发现的多酚类化合物,又称为芪三酚。白藜芦醇具有多种药理作用,包括抗癌、保护心脏、保护神经、抗炎、抗糖尿病、抗肥胖、抗氧化作用和抗纤维化作用。白藜芦醇可通过不同途径、不同分子水平对肺脏、肝脏、肾脏、心脏等脏器发挥抗纤维化作用:通过抗炎和抗氧化作用发挥抗肺纤维化作用;通过减轻氧化应激反应发挥抗肝纤维化和心肌纤维化作用;通过减少巨噬细胞积聚和下调IL-6、细胞间黏附分子1、单核细胞趋化蛋白1表达发挥抗肾纤维化作用。 [ABSTRACT FROM AUTHOR]

This paper aims to investigate the role of white-rot fungus extracellular polysaccharides in the biogenesis of iron (hydrogen) oxides. Fourier transform infrared spectroscopy (FT-IR) was used to study the characteristics of iron (hydrogen) oxides regulated by the extracellular polysaccharide of white-rot fungus under different polysaccharide concentrations, different aging time, different initial concentrations of Fe3+, different pH values of mineralization system and different aging temperature. The crystal composition and transformation between different phases of iron (hydrogen) oxides biomineralized by white-rot fungus under different conditions were investigated. The results showes that the nucleation of iron (hydrogen) oxides in polysaccharides is promoted by increasing the content of polysaccharides, and the crystal type and degree of iron (hydrogen) oxides changed during aging. The increase of the initial concentration of Fe3+ helped to improve the stability of the hydroxyl binding state of iron (hydrogen) oxides. The formation of α-FeOOH is favorable under acidic condition, while the formation of α-Fe2O3 is favorable under alkaline condition. An appropriate increase in temperature is beneficial to the improvement of Fe—O crystallinity, and a further increase in temperature favored the conversion of iron (hydrogen) oxides into a more stable phase. Those results can provide references for revealing the biological formation process of iron (hydrogen) oxides. [ABSTRACT FROM AUTHOR]

Objectives: Taxi drivers are a high-risk population for metabolic syndrome. This study thus developed a mobile health-care model (mHealth) that integrates mobile phones with social media and various supporting strategies to promote healthy behaviors and address metabolic syndrome. Methods: A quasi-experimental design was adopted. Taxi drivers with at least one risk factor for metabolic syndrome or body mass index ≥ 25 were recruited and divided into an experimental group and a control group. A pretest comprising questionnaires and physiological value tests were conducted, and a posttest was conducted after 12 weeks of intervention. For 12 weeks, the experimental group used the mHealth model, which incorporated the predisposing factor, reinforcing factor, and enabling factor of the PRECEDE-PROCEED model. The model’s content included the components of Metabolic Syndrome Online Course, Self-Health Management, Line Online Consultation and Contact Tracing, and Reward Mechanism. Additionally, a pedometer was used for online exercise courses. Generalized estimating equations were primarily used for statistical analysis. Results: In total, 92 participants completed this study (48 experimental group participants and 44 control group participants). The intervention yielded significant improvements in healthy behavior (β = 0.22, 95% confidence interval [CI] = 0.07–0.38), self-efficacy (β = 0.18, 95% CI = 0.02–0.33) and physical activity (t = 2.648, 95% CI = 140.6–1042.3). Conclusions: For high-risk populations with metabolic syndrome, especially those profoundly affected by the COVID-19 pandemic, the mHealth model can not only reduce their risk of infection but also can be a way to improve metabolic syndrome. [ABSTRACT FROM AUTHOR]

The purpose of this study is to analyze the structure and self-assembly behavior of extracellular polysaccharides produced by Phanerochaete chrysosporium BKMF-1767. The structure of extracellular polysaccharides from Phanerochaete chrysosporium is analyzed with Congo red test, molecular weight determination, X-ray diffraction and Fourier transform infrared spectroscopy, and the self-assembly behavior of the polysaccharides is studied with fluorescence microscopy, scanning electron microscopy and transmission electron microscopy. In Congo red test, the maximum absorption wavelength of the polysaccharide-Congo red solution shows obvious redshift phenomenon in low-concentration alkali solution, and the red-shift phenomenon has disappeared with the increase of alkali solution concentration, indicating that the extracellular polysaccharides from Phanerochaete chrysosporium has a triple helix structure and the structure is destroyed into disordered structure in high concentration alkali solution. During molecular weight determination, the molecular weight of the polysaccharide in dimethyl sulfoxide solution is significantly lower than that in aqueous solution, indicating that the configuration of the polysaccharide chain is depolymerized in dimethyl sulfoxide solution. Fourier transform infrared spectroscopy analysis finds that the polysaccharide has characteristic absorption peaks of polysaccharide compounds and contained β-glycosidic bonds. X-ray diffraction analysis shows that it is a kind of amorphous polysaccharide. The comprehensive analysis of fluorescence microscopy, scanning electron microscopy and transmission electron microscopy indicates that the polysaccharide can form a fibrous network-like spatial structure and form aggregates under its self-assembly behavior. The above results indicate that the extracellular polysaccharides from Phanerochaete chrysosporium is one kind of amorphous polysaccharide with triple helical structure, which can self-assemble into fibrous aggregates. [ABSTRACT FROM AUTHOR]

BACKGROUND: Exposure to transient low-frequency pulsed magnetic field can induce and activate classical transient receptor potential channel 1, and enhance the maximal voluntary contraction force and strength endurance of local muscles, such as biceps brachii. OBJECTIVE: To use a specific low-frequency pulsed magnetic field that can activate classical transient receptor potential channel 1 as a means of improving muscle strength and to observe the attenuation process of the maximal voluntary contraction force and strength endurance of human biceps brachii after short-term stimulation. METHODS: A total of 27 normal adult healthy subjects were selected and randomly divided into training group, exposure group, and training+exposure group. The training+exposure group received resistance training immediately after 10-minute exposure to low-frequency pulsed magnetic field; the exposure group was only exposed to low-frequency pulsed magnetic field for 10 minutes; and the training group only received resistance training. The trial duration was 8 weeks. At 1-12 days of the trial, short-term muscle strength enhancement scheme was performed and post-test muscle strength was measured. The attenuation process of maximum voluntary contraction force and strength endurance was then observed in the following 6 weeks. RESULTS AND CONCLUSION: (1) The maximum voluntary contraction force value of all subjects changed significantly over time (P < 0.01), with obvious timedependent interaction effect but no interaction effect between groups, and there was no significant difference between time- and grouping-dependent interaction effects. (2) In the 1st, 2nd, 3rd, and 4th weeks, the maximum voluntary contraction force values for strength attenuation in the exposure group were significantly higher than the initial value. In the 1st and 4th weeks, the maximum voluntary contraction force values for strength attenuation in the training group were significantly higher than the initial value. In the 5th and 6th weeks, the maximum voluntary contraction force values for strength attenuation in the exposure group and training group were significantly lower than the post-test value. In the 1st, 5th, and 6th weeks, the maximum voluntary contraction force values for strength attenuation in the training+exposure group were significantly lower than the post-test value. (3) The correlation analysis of the maximal voluntary contraction force curves in the three groups indicated that the overall changes in the maximal voluntary contraction force in the exposure group were highly positively correlated with the variation trend of maximum voluntary contraction force in the training group and training+exposure group. Their variation trend was highly consistent. Compared with the exposure group, the training group showed stronger positive correlation with the training+exposure group in terms of the maximum voluntary contraction force. (4) The median frequency value of the subjects in each group changed significantly with time (P < 0.01), and there was significant time-dependent interaction effect. Time- and grouping-dependent interactions led to significant changes in the median frequency values (P < 0.01). (5) In the 2nd week, the median frequency values of muscle strength attenuation in the exposure group and training+exposure group was significantly higher than the initial value. However, compared with the post-test value, the median frequency values of muscle strength attenuation showed no significant changes in the exposure group. In the 1st and 4nd weeks, the median frequency values of muscle strength attenuation in the training group were significantly lower than the post-test value. In the 1st and 2th weeks, the median frequency values of muscle strength attenuation in the training+exposure group were significantly lower than the post-test value. (6) The correlation analysis of the median frequency change curves in the three groups indicated that the training+exposure group showed a lower positive correlation with the training group and exposure group. However, compared with the training group, the exposure group had a higher correlation with the training+exposure group. (7) After exposure to the short-term pulsed magnetic field with the intensity of 1.5 mT and the frequency of 3 300 Hz, the maximum voluntary contraction force value of muscle strength attenuates to the initial value within 6 weeks, consistent with the attenuation period of resistance training and attenuation speed after enhancement of muscle strength. During the attenuation process, there is less fluctuation in the two resistance training groups, without fatigue accumulation, in which muscle strength can be better maintained. Improved strength endurance can be maintained for at least 6 weeks. Compared with the resistance training, low-frequency pulsed magnetic field stimulation can avoid fatigue accumulation, and the anti-fatigue ability continues to increase and maintain at a better level. Resistance training combined with pulsed magnetic field has a certain benefit for endurance level. To reduce the fluctuation during the attenuation process is beneficial to the maintenance of the endurance level. [ABSTRACT FROM AUTHOR]

【Objective】stem disinfection, bud induction and proliferation were explored during tissue culture to provide technical support for mass seedling production.【Method】 Taken stem of Hylocereus undatus cultivar Guihonglong No. 1 as the explants, the effects of different factors on stem disinfection, bud inducement and proliferation were studied.【Result】 Stem size was the main factor affecting the pollution rate of stem disinfection, followed by the effect of sterilization time and stem mature degrees. The sterilization time had the greatest influence on the bud induction, followed by the 6-BA concentration. Both the stem mature degrees and stem size had little effect on bud induction. 6-BA 4.0 mg/L had the best induction effect. The higher concentration of 6-BA showed the higher multiplication ratio of buds, but when 6-BA concentration reached 4.0 mg/L, the buds appeared vitrification. The effect of IAA was better than that of NAA, and the effect of bud proliferation was better when IAA was 0.1 mg/L. PP333 was better than AC in inhibiting vitrification and promoted subculture multiplication of Hylocereus undatus. 【Conclusion】 The optimal treatment for stem disinfection and bud induction was suggested as: sliced the health stems of about 1 months into pieces with single bud, and disinfected them with 0.1 % HgCl2 solution, and inoculated the explants in medium of MS + 6-BA 4.0 mg/L. The optimal medium for bud proliferation was MS +6-BA 3.0 mg/L + IAA 0.1 mg/L + PP333 1.0 mg/L. [ABSTRACT FROM AUTHOR]

Undoubtedly, pathological findings is the golden standard for diagnosing prostate cancer. As we all know, targeted prostate biopsy under the guidance of image-guiding is the most efficient and the most convenient. Nevertheless,based on prostate specific antigen (PSA) screening and sextant biopsy, has been criticized for both overdiagnosis of low-grade tumors and underdiagnosis of clinically significant prostate cancers (Gleason score ≥7). So on viewing vertically of both national and abroad, image guidance has been added to perform targeted biopsies of lesions detected on multi-parametric magnetic resonance imaging (mpMRI) scans, including in-boreMRI-guided, cognitive fusion, andMRI/transrectal ultrasound fusion-guided biopsy. This review will examine advances in these image-guided targeted prostate biopsy techniques. [ABSTRACT FROM AUTHOR]

回顾性分析1例广州医科大学附属惠州医院内分泌科既往住院明确诊断的2型糖尿病 合并原发性高血压患者使用司美格鲁肽联合基础胰岛素治疗后，再转换为司美格鲁肽联合口服降糖 药序贯治疗的诊治过程。患者为48岁男性，因“发现血糖升高3年，血糖控制不佳2个月”入院，患者 体型肥胖、血糖明显升高、依从性较差，合并高血压病史，既往使用基础胰岛素联合口服药治疗超6个 月，入院时测糖化血红蛋白8.7%，给予基础胰岛素联合司美格鲁肽控制血糖，逐渐简化方案为司美格 鲁肽联合二甲双胍（1g，2次/d），达格列净（10 mg，1次/d），罗格列酮（4 mg，1次/d），血糖控制平稳后出 院。每 4周门诊随访 1次，随访 12周时，发现其血糖、胰岛素抵抗、胰岛 β细胞功能、血压和体重指数 均较前改善。 [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the efficacy and safety of clopidogrel combined with aspirin in treatment of unstable angina pectoris. METHODS: 110 patients with unstable angina pectoris admitted into Kaifeng Central Hospital from Mar. 2015 to Jun. 2017 were selected and divided into observation group and control group via random number table, with 55 cases in each. The control group was treated with aspirin, while the observation group was given clopidogrel combined with aspirin. Differences of frequency and duration of angina pectoris before and after treatment, clinical efficacy, and incidences of adverse drug reactions between two groups were compared. RESULTS: After treatment, the frequency and duration of angina pectoris of observation group were significantly lower than those of control group, with statistically significant difference (P < 0.05); the total effective rate of observation group (94.55%, 52/55) was significantly higher than that of the control group (69.09%, 38/55), with statistically significant difference (P < 0.05); the incidence of adverse drug reactions of observation group (5.45%, 3/55) was significantly lower than that of the control group (18.18%, 10/55), with statistically significant difference (P < 0.05). CONCLUSIONS： The efficacy of clopidogrel combined with aspirin in treatment of unstable angina pectoris is remarkable, with high safety. [ABSTRACT FROM AUTHOR]

Objective To investigate the adverse effects of nano-titanium dioxide (TiO2) on kidney tissues in healthy rats and rats with oxidative stress (OS). Methods Thirty-six healthy male SD rats were randomly divided into control group, alloxan-treated group, nano-TiO2 treated (NM) group, and alloxan and nano-TiO2 dual treatment (OS-NM) group. Nano-TiO2 of three concentrations (0.5, 5 and 50mg/kg body weight) was injected intraperitoneally. The level of OS biochemical factors and blood urea nitrogen (BUN) and pathological changes of kidney were determined. Results Compared with those in NM and OS groups, the levels of O2-· and superoxide dismutase (SOD) in OS-NM group were significantly increased after exposure to nano-TiO2 of 5 mg/kg body weight (P<0.05). Nano-TiO2 of 50mg/kg body weight led to significant changes of O2-·, SOD, and glutathione (GSH) levels in OS-NM group in comparison with OS and NM groups (P<0.01). The levels of O2-· and GSH between OS group and NM group changed significantly (P<0.05). Compared with healthy rats, OS rats showed significant increased BUN level (P<0.01), cell number and edema of renal tubular epithelial cells after nano-TiO2 exposure. A synergic effect between OS condition and nano-TiO2 level was shown on the increased level of O2-·. Conclusion Nano-TiO2 induced more adverse effects on the kidney in OS rats, suggesting a synergistic effect between nano-TiO2 and OS. This result provides experimental evidence for patients’ safe use of nano-TiO2. [ABSTRACT FROM AUTHOR]

BACKGROUND: Strength quality is an essential element for human physical activity. Short-term low-frequency pulsed electrical magnetic field (PEMF) stimulation can activate classical transient receptor potential channel 1 (TRPC1) and trigger skeletal muscle growth and remodeling in mice, thereby producing a series of physiological support effects on muscle tissue. However, there is no report on whether this mechanism will alter the physiological structure and working ability of human skeletal muscle and act as a new way to improve muscle strength. OBJECTIVE: To select a specific low-frequency PEMF that can activate TRPC1 as an exogenous stimulus to observe and verify the effect of short-term stimulation on the maximum voluntary contraction force and strength endurance of human biceps brachii. METHODS: A total of 27 normal adult healthy subjects were selected and randomly divided into exercise group, PEMF group, and exercise+PEMF group, with 9 cases in each group. The training group was subjected to resistance training. The exercise+PEMF group received 10-min low-frequency PEMF stimulation (intensity 1.5 mT, frequency 3300 Hz) immediately after resistance training. The irradiation group only received 10-minute low-frequency PEMF stimulation. Training or irradiation was performed every 48 hours for 9 days. Electromyography information on the maximum voluntary contraction force was collected before and after five training sessions in the exercise group and the exercise+PEMF group, to observe whether the combination of low-frequency PEMF and resistance training will produce a gain effect. In the PEMF group, the maximum voluntary contraction force was tested only at the 1st, 3rd, and 5th sessions to track the changes in muscle strength. The maximum voluntary contraction force, one-repetition maximum force, endurance duration and median frequency were observed in each group. RESULTS AND CONCLUSION: (1) During the trial, there were significant interaction effects between the changes in maximum voluntary contraction force and time in all the subjects (P < 0.01) as well as in each group as time goes by (P < 0.05). However, there was no interaction effect between groups. (2) There was a significant improvement in the maximum voluntary contraction force, one-repetition maximum force, endurance duration, and median frequency in each group after completion of the trial. These indicators were successively improved by 19%, 23%, 28%, and 18% in the exercise group, 11%, 10%, 53%, and 18% in the exercise+PEMF group, and 28%, 18%, 27%, and 6% in the PEMF group. (3) The median frequency of the exercise+PEMF group was significantly higher than that of the PEMF group (P < 0.05), but there was no significant difference between the exercise+PEMF group and exercise group. (4) Compared with the exercise+PEMF group, the exercise group showed a significant decrease in the root mean square of maximum voluntary contraction after the first two exercise sessions (P < 0.05). (5) All these findings indicate that the short-term PEMF stimulation with intensity of 1.5 mT and frequency of 3 300 Hz can significantly improve the maximum voluntary contraction force and strength endurance of human biceps brachii. That is, low-frequency PEMF can induces TRPC1 to promote the working ability of muscle tissue, which has been effectively verified in human body. Low-frequency PEMF stimulation shares similar effects with conventional resistance training in terms of enhancing the maximum strength. Resistance training combined with PEMF stimulation shows better anti-fatigue ability and stabilizes the increase of muscle strength. This combination can stimulate more motor units of local muscle groups under the same load in the early stage of training and improve the overall training efficiency. In terms of strength endurance improvement, low-frequency PEMF stimulation can prolong isometric muscle contraction time and improve anti-fatigue ability. Compared with simple low-frequency PEMF stimulation, low-frequency PEMF stimulation combined with resistance training is more effective to develop strength endurance. [ABSTRACT FROM AUTHOR]

Objective To establish an HPLC quantitative method for the content determination of baicalin in Kangdeling capsule. Methods The chromatography column was Agilent Tc-C18-WR (4.6 mm×250 mm,5 μm),and the column temperature was 30 ℃. The mobile phase consisted of acetonitrile and 0.5‰ phosphoric acid (26:74). The flow rate was 1.0 ml/min, and the detection wavelength was 265 nm. Results The retention time of baicalin was about 16 min. The calibration equation was Y=22 114.67 X-112 836.7(r=0998 8)with good linearity in the range of 5.410-108.2 μg/ml for baicalin. The average recovery was 98.78% while RSD were 0.74%. Conclusion This method is simple, time-saving and accurate which could be used to routine analysis of baicalin in Kangdeling capsule. [ABSTRACT FROM AUTHOR]

1例50岁男性强直性脊柱炎患者，皮下注射依那西普50 mg后约3 h，四肢、腹部、腰背部及臀部出现散在大面积风团样皮疹，突起明显，伴全身瘙痒不适，嘴唇和头皮有麻木感，诊断为依那西普致全身药疹。给予异丙嗪、地塞米松注射液及葡萄糖酸钙注射液等对症治疗后患者皮肤瘙痒、嘴唇和头皮麻木感逐渐减轻，约3 h后消失，全身各处的丘疹也随之消退。 [ABSTRACT FROM AUTHOR]

Objective To explore the coordination relationship and spatial pattern of health resource allocation and socio- economic development in Sichuan Province, to provide references for promoting the high-quality development of health and social economy. Methods Entropy method, comprehensive evaluation index, and coupling coordination degree model were used to evaluate the level and coupling coordination degree of health resources and socio-economic development. Hot spot analysis was used to explore the characteristics of spatial agglomeration. Results From 2017 to 2021, the development level of health resource allocation in different economic regions of Sichuan Province was in the following order: northwest Sichuan Ecological Demonstration Zone (0.59), Panxi Economic Zone (0.35), Chengdu Plain Economic Zone/Southern Sichuan Economic Zone (0.30), and Northeast Sichuan Economic Zone (0.23). The order of social and economic development level was as the follows: Chengdu Plain Economic Zone (0.25), Panxi Economic Zone (0.16), South Sichuan Economic Zone (0.15), Northeast Sichuan Economic Zone (0.10), and Northwest Sichuan Ecological demonstration Zone (0.08). In the past five years, most of the coupling coordination degree of different economic regions showed an increasing trend. Only the average coupling coordination degree of northeast Sichuan economic zone was less than 0.4, which was in a maladjusted recession, while the average coupling coordination degree of the remaining four economic zones was between 0.4 and 0.5, which was in transition. harmony and generally subject to the lag of social and economic development. The level of coupling coordination showed a spatial pattern of "high in the west and low in the east", and the agglomeration characteristics were mainly "high-high" agglomeration area in western Sichuan and "low-low" agglomeration area in northeastern Sichuan. Conclusion There are obvious regional differences in the allocation of health resources and the level of socio-economic development in Sichuan Province. The trend of coupling and coordination between the two systems is gradually improving, but the degree of coordination is not high. In addition, the coupling coordination level has significant spatial characteristics, and the local area shows agglomeration effect. [ABSTRACT FROM AUTHOR]

Na3V2(PO4)3/C as cathode materials for sodium ion batteries were synthesized by sol-gel method and hydrothermal-sol-gel method respectively.The samples were characterized by XRD, SEM, constant current charge and discharge. The results show that Na3V2(PO4)3/C materials synthesized by sol-gel method and hydrothermal-sol-gel method at all temperatures were pure phase with porous structure. The Na3V2(PO4)3/C sample prepared by the hydrothermal-sol-gel method had smaller particle size. It was more conducive to the deintercalation of sodium ions,which could improve the electrochemical performance of the material. The initial sample prepared by the conventional sol-gel method exhibited a first discharge specific capacity of 98.3 and 31.3 mAh/g at 0.1 and 2 Crates. The initial discharge specific capacity at 2 Crate was as high as 111.9 and 94.1 mAh/g, and the electrochemical performance was significantly improved. [ABSTRACT FROM AUTHOR]

Objectives: This study investigated the use of the driving medication safety training curriculum and evaluated the effectiveness of this curriculum in promoting the knowledge, attitude, and behavior of pharmacists on classification of medication use and driving safety. Methods: This study was designed as a quasi-experimental study that integrated the health belief model into the driving medication safety training curriculum, and adopts with pre- and post-testing control group design as well as tracking of delayed effects. The researchers utilized a current state analysis questionnaire for the promotion of classification of medication use and driving safety as the evaluation tool. After a preliminary evaluation of the validity, reliability, difficulty, and discrimination were established. Sixty pharmacists in Taipei City and New Taipei City were selected as the formal research participants through convenience sampling. The study was conducted by following a waiting list control group design. Results: The study analysis was performed with generalized estimating equations. When the equation controlled for “group” and “time,” the pharmacy education curriculum for the classification of medication use and driving safety had a positive effect on pharmacists’ knowledge, attitude, and behavior. Conclusions: Pharmacists must assist the public in dealing with complex medication problems, and the onus of the safe use of medications is upon pharmacists. Pre-training pharmacists with the knowledge, attitude, and behaviors required for driving safety and medication use can enable them to effectively determine the risk of medication use and driving as well as communicate with the public or doctors to make the most appropriate drug recommendations. It is expected to reduce the risk of medication use while driving and the occurrence of traffic accidents in the general public. [ABSTRACT FROM AUTHOR]

On the basis of incremental dynamic analysis, combined with seismic vulnerability analysis, a seismic vulnerability analysis method of high-rise steel-concrete hybrid buildings was presented to quantitatively assess the seismic performance of structures from the probability point of view. Taking a 50-story high-rise steel-concrete hybrid building as an example, the seismic vulnerability of the structure was estimated. According to the seismic vulnerability probabilities of the limit states under various given ground motion intensity levels, the seismic performance of the structure was evaluated. It is shown that the high-rise steel-concrete hybrid building is in serviceability state or basic serviceability state under frequent ground motions of intensity seven, in basic serviceability state or reparability state under fortification ground motions of intensity seven and in reparability state or life safety state under rare ground motions of intensity seven. The structure has a good seismic performance and can basically meet the requirements of 'perfect subjected to minor earthquake, reparable subjected to moderate earthquake, no collapse subjected to unexpected major earthquake'. [ABSTRACT FROM AUTHOR]

We investigated the diversity and composition features of birds in the Lushan National Nature Reserve from July 2019 to October 2020,using the transect line method.33 lines in total were set and 4,005 individuals from 99 species were recorded,belonging to 37 families and 12 orders.Among them,nine species were listed as the second category of China's nationally key protected animals,23 species were listed as key protected animals of Jiangxi Province.Within all the recorded species,69 were residents,including 10 summer migrants and 19 winter migrants,and the other one was passing birds.Nine new distribution records of this nature reserve were found in this investigation.Among the different habitats,Shannon-Wiener index(3.42)and Margalef index(10.74)were both highest in forest.However,the differences in Pielou index among different habitats was insignificant.Bird resource abundance of Lushan National Nature Reserve was similar as other forest type reserves in Jiangxi Province.The results further enriched the basic data of bird resources in Lushan National Nature Reserve and provided the basis for resource conservation. [ABSTRACT FROM AUTHOR]

To research the age and growth of Cyprinus carpio Linnaes in Tarim River basin from Shengli reservoir, from 2012 to 2013,samplings of Cyprinus carpio Linnaes were collected by using traditional measurement methods to identify biological age and analyzed its growth characteristics. The results showed that Cyprinus carpio Linnaes,the age mean was 3. 88 ± 1. 254+, the age was too distributed,superior individuals aged 5+; Length and weight relationships: W = 0. 192L2. 443( R2= 0. 9590); Length and height relationship: H = 0. 2870 L + 0.0970( R2= 0. 9810); Length and the radius of the scalesis relationship: L = 12. 214R- 78. 810 (R2= 0. 9320) : Length and the radius of the scalesis relationship: L = 0. 023R3. 232 (R2= 0. 9550). Progressive length L∞ = 105. 58 cm,the coefficient of growth k = 0. 0479,W∞ =16862. 08 g,t0=- 2. 699,ti= 4. 208+; The population( n = 25) of progressive length and weight growth relationship: Lt= 105. 58 [1-e-0. 0479( t + 2. 699)],Wt= 16862. 08 [1- e-0. 0479( t + 2. 699)]2. 443. The population of fullness: K = 2. 2108 ± 0. 2959. Cyprinus carpio Linnaes had strong adaptability. Its growth traits was instability,and it played a role in population dynamics and fisheries ecological balance. [ABSTRACT FROM AUTHOR]

目的：探讨慢性阻塞性肺疾病( COPD)稳定期患者COPD评估测试( CAT)评分与肺功能及肺结构的相关性。方法96例COPD稳定期( GOLD分级Ⅰ级18例、Ⅱ级26例、Ⅲ级34例、Ⅳ级18例)患者于就诊当天进行CAT评分及肺功能检测；采用多层螺旋CT检测肺结构指标，即气肿肺组织容积比例( LAA)、气管壁径线( WT)、肺动脉直径(BWT)及WT／BWT，分析CAT评分与肺功能及肺结构的关系，探讨CAT评分的影响因素。结果不同GOLD分级COPD患者CAT评分及肺活量( FVC)、第1秒用力呼气容积( FEV1)、FEV1／FVC、一氧化碳弥散量占预计值百分比(DLCO)、比弥散量占预计值百分比、残气量占肺总量百分比(RV／TLC)、外周气道阻力(R5-R20)、响应频率(Fres)、LAA差异均有统计学意义(P<0．05或<0．01)，呼吸总阻抗(Z5)、周边弹性阻力(X5)、WT、BWT、WT／BWT；差异均无统计学意义(P均>0．05)。 CAT评分与RV／TLC、R5-R20、Fres、LAA呈正相关(r分别为0．550、0．352、0．397、0．393，P <0．05或<0．01)，与 DLCO、DLCO／VA、FVC、FEV1、FEV1／FVC%呈负相关(r 分别为-0．453、-0．356、-0．363、-0．388、-0．352，P<0．05或<0．01)，与Z5、X5、WT、 BWT、WT／BWT无明显相关性(P均>0．05)。 FEV1、FVC、LAA是COPD稳定期患者CAT评分的影响因素(P均<0．05)。结论 COPD稳定期患者CAT评分与肺功能及肺结构均相关，定期评估CAT评分可反映患者病情. [ABSTRACT FROM AUTHOR]

Objective To investigate the anti-prostate cancer activity, pharmacokinetic analysis and acute toxicity of 17β-hydroxysteroid dehydrogenase 3 (17β-HSD3) inhibitor. Methods The logarithmic growth phase androgen-dependent prostate cancer LNCaP cells were divided into the blank control group (Con group), curcumin group (Cur group, Cur 150 μmol/L), androgen receptor (AR) inhibitor group (AR inhibitor group, 5 μmol/L) and curcumin analog H7 group (H7 group, H7 150 μmol/L). After grouping treatment, the xCELLience RTCA DP cell analyzer was used to detect cell viability, and flow cytometry was used to detect cell apoptosis. The changes of Caspase-3 and AR protein expression levels in cells were detected by Western blot assay. Thirty-two C57 mice were divided into 4 groups (n=8 for each group), namely the blank control group and the high, medium and low-dose curcumin analog H7 groups. The high, medium and low-dose groups of mice were treated with 1% carboxymethyl sodium cellulose (CMC-Na) dissolved H7 (100, 50 and 25 mg/kg), and gavage once a day. At the same time, mice in the blank control group were gavage 1% CMC-Na to observe whether the mice were dead or abnormal. After 14 days, samples were taken and stained with hematoxylin-eosin (HE) to observe the pathological changes of liver and kidney. Ten SD rats were used to gavage with 1% CMC-Na dissolved H7 (5 mg/kg), and then the plasma concentration was detected by high performance liquid chromatography (HPLC) to analyze the pharmacokinetic parameters. In addition, another 10 SD rats were taken and H7 (5 mg/kg) was gavage for 30 min. The drug concentrations in rat brain, liver, spleen, lung, small intestine, stomach, kidney, heart and testis were detected by HPLC, and the distribution of the drug tissue was investigated. Results Compared with the Con group, the cell index (CI value) of LNCaP cells significantly decreased in the Cur group, AR inhibitor group and H7 group. The flow cytometry results showed that the apoptosis rate was significantly increased (P＜0.05). The Western blot results showed that Caspase-3 protein expression levels were significantly increased (P＜0.05), while AR protein expression levels decreased (P＜0.05). Compared with Cur group and AR inhibitor group, flow cytometry results showed that the apoptosis rate was significantly increased in H7 group (P＜0.05). After treatment with H7 for 14 days, no abnormalities such as increased activity, salivation, convulsions and coma were found in the mice. Compared with the control group, HE staining showed no obvious pathological changes in mouse liver and kidney. The results of pharmacokinetic parameters showed that the area under the curve (AUC) was (557.31±36.12) mg/(L·h), the peak concentration (Cmax) was (36.92±1.29) mg/L, the highest peak time (tmax) was 2 h and the elimination half-life (t1/2) was (22.13±1.74) h. The H7 concentrations in the small intestine were 5 000 times higher than that in brain tissue. Conclusion As a 17β-HSD3 inhibitor, H7 has obvious anti-hormone-dependent prostate cancer activity and good pharmacokinetic parameters, no obvious acute toxicity, mainly gastrointestinal absorption, and has further research and development prospects. [ABSTRACT FROM AUTHOR]

Life cycle assessment (LCA) is an important method that can fully evaluate the natural resources consumed in the production process and activities, as well as its impacts on the environment. In recent years, LCA has been widely used in the biodiesel production process. China is enriched in various biodiesel feedstocks, such as soybean oil, colza oil, jatropha, microalgae and waste cooking oil. In the current study, a life cycle assessment methodology was applied to evaluate the energy consumption and emissions of biodiesel products derived from soybean oil and waste cooking oil in the process of a whole life cycle. The results showed that in the whole life cycle, the total energy consumption of soybean-derived biodiesel was about 2.65 times higher than that of biodiesel derived from waste cooking oil. In the life cycle of soybean oil production for biodiesel, the majority energy consumption was contributed by the soybean planting stage, accounting for 62.55% of the total energy consumption. Particularly, the energy consumption of methanol production was rather high, accounting for 25.88% of the total energy consumption. In the life cycle of biodiesel made from cooking waste oil, the main energy consumption was in the production stage of methanol and catalyst, accounting for 81.12% of the total energy consumption. It was followed by the pretreatment stage of gutter oil, consuming 11.25% of the total energy input. In combustion, the CO2, SO2 and CO emissions from biodiesels either from soybean oil or waste cooking oil were both lower than those from the conventional diesel. Moreover, compared with the emissions of biodiesel derived from soybean oil, the CO2, SO2, NOx, CO, and dust emissions of biodiesel from the waste cooking oil were reduced by 82.92%, 45.68%, 94.91%, 53.40% and 90.61%, respectively. It infers that the application of biodiesel can significantly reduce the emissions of greenhouse and acid gas. It also confirms that the greenhouse effect can be inevitably slowed down when using the biodiesel on a large scale. According to the environmental impact analysis of biodiesel production and utilization processes in the concept of LCA, the potential value of life cycle for the environmental impact of soybean oil as raw material was 11.70 times that of waste cooking oil, which was 8.42 and 0.72, respectively. Global warming was the predominant environmental impact of the biodiesel from soybean oil. In the case of biodiesel derived from waste cooking oil, the regional acidification was the most significant factor. Compared with soybean oil, the biodiesel made from waste cooking oil can effectively reduce the consumption of energy and the emission of pollutants. In addition, it can realize the efficient reuse of waste resources. The life cycle assessment method was of practical significance to evaluate the biodiesel industry. Nevertheless, it is still challenging to form a unified standard among different processes, because of the complex calculation involved in the LCA process. In the future, it is highly necessary to construct a standard database of Chinese biodiesel industry, further to optimize different processes in the production stage. The findings can provide a sound reference for industrial upgrading and department decision-making, and a specific data support for the sustainable development of agricultural industry. [ABSTRACT FROM AUTHOR]

BACKGROUND: Previous studies have found that panax notoginseng saponins have a certain protective effect on immunological liver injury in mice. OBJECTIVE: To explore the therapeutic effect of notoginsenoside R1 on carbon tetrachloride-induced liver fibrosis in rats. METHODS: Experimental liver fibrosis model was made by carbon tetrachloride in male Sprague-Dawley rats. Then 30 g/L notoginsenoside R1 (60 mg/kg) was given once daily for 4 and 6 weeks in the treatment group. Rats in the control and model group were given distilled water of the same volume. Histopathological observation with hematoxylin-eosin staining and Masson’s trichrome staining was used to evaluate the changes of liver structure and fibrosis degree. The expression of collage type I, α-smooth muscle actin and transforming growth factor-β1 mRNA of hepatic tissue was measured by qRT-PCR method. The experimental protocol was approved by the Animal Experiment Ethics Committee of Kunming Medical University (approval No. KMMU2018018). RESULTS AND CONCLUSION: Liver histopathology showed that notoginsenoside R1 improved the degree of liver fibrosis. The expression levels of collagen type I, α-smooth muscle actin and transforming growth factor-β1 mRNA were reduced significantly in the treatment group compared with the model group (P < 0.05). But there was no significant difference after 4 and 6 weeks of treatment with notoginsenoside R1. Overall findings indicate that notoginsenoside R1 can slow down the progression of carbon tetrachloride-induced liver fibrosis in rats to a certain extent. [ABSTRACT FROM AUTHOR]

Egg-break blade is a key component in a high-efficiency egg separator. Two failures of egg-break blade usually occurred in the turning of cutting edge and blade wear. The strategy to prolong the lifetime of egg-break blade is to increase the hardness without too much sacrifice of toughness. In this study, the boriding and thermal diffused vanadizing were applied to a blade stainless steel of 2Cr13, thereby to achieve an excellent wear resistance. The microstructure, mechanical properties, and wear behaviors of the layers were investigated after the treatment. A scanning electric microscopy (SEM) equipped with energy dispersive X-ray spectroscopy (EDS) was employed to observe the thickness, microstructure, and chemical composition from the cross section of the layers. The crystal structure was detected by X-ray diffraction (XRD) from the top surface. The results suggested that the boride and vanadizing layers were successfully fabricated on the surface of 2Cr13 stainless steel, showing excellent adhesion with the substrate. The thicknesses of boride and vanadizing layer were 15 μm and 5μm, respectively. The much thinner vanadizing layer was related to the larger diameter of atom, resulting in a sluggish diffusion. It can also be confirmed by the content of B and V in the corresponding layer. There was nearly 30 at. % B in the boride layer, while, only 12.3 at. % V content in the vanadizing layer. According to XRD patterns, the boride layer consisted of FeB, Fe2B, Fe3B, while, the vanadizing layer mainly consisted of VCx carbides. The borides and carbides formed via the diffusion and reaction with the interior elements of the substrate. The micro-hardness of coating and substrate can be measured from the surface with a load of 0.49 N. The hardness of boride layer and vanadizing layer were 1554HV and 1037HV, respectively, which were three and two times higher than that of the treated stainless steel. The high hardness can be attributed to the formation of borides and carbides after the treatment. The relatively low hardness in the vanadizing layer can be related to the low content of VCx. Nano-indentation test was carried out to further determine the mechanical properties, including the nano-hardness, elastic recovery ability (We) and energy dissipation coefficient (Kd). The nano-hardness of diffusion layers was like the results of micro-hardness. The boride layer presented a higher elastic recovery ability than the vanadizing layer, whereas, the vanadizing layer showed the better performance of plastic deformation. In friction test, the results demonstrated that the coefficient of friction (COF) in the vanadizing layer was relatively lower of 0.5, compared with the boride layer, where the COF was about 0.68. Nevertheless, the boride layer presented a lower wear rate under non-impact load, indicating better wear resistance due to its higher hardness. Taking the thickness and mechanical properties into account, the vanadizing layer with better performance of plastic deformation can be a potential application to protect the cutting edge from turning, whereas, the boride layer with higher hardness can be a candidate to improve the wear resistance of blade body served under a stable load. [ABSTRACT FROM AUTHOR]

Ａｉｍｉｎｇ ａｔ ｔｈｅ ｐｒａｃｔｉｃａｌ ｐｒｏｂｌｅｍ ｏｆ ａｃｃｕｒａｔｅｌｙ ｍｅａｓｕｒｉｎｇ ｔｈｅ ｐｏｓｉｔｉｏｎ ｏｆ ｔｈｅ ｐａｒｔｓ ｉｎ ｔｈｅ ｐｒｏｃｅｓｓ ｏｆ ｍｅｃｈａｎｉｃａｌ ｐａｒｔｓ ｈａｎｄｌｉｎｇ,ａ ｍｅｃｈａｎｉｃａｌ ｐａｒｔ ｐｏｓｅ ｄｅｔｅｃｔｉｏｎ ｓｙｓｔｅｍ ｗａｓ ｄｅｓｉｇｎｅｄ ｂｙ ｔｈｅ ｂｉｎｏｃｕｌａｒ ｓｔｅｒｅｏ ｖｉｓｉｏｎ ｍｅａｓｕｒｅｍｅｎｔ ｓｙｓｔｅｍ ｐｌａｔｆｏｒｍ (ＶＳ２２０). Ｔｈｅ ｉｍｐｒｏｖｅｄ Ｃａｎｎｙ ｅｄｇｅ ｄｅｔｅｃｔｉｏｎ ａｌｇｏｒｉｔｈｍ ｗａｓ ｕｓｅｄ ｔｏ ｉｄｅｎｔｉｆｙ ｔｈｅ ｅｄｇｅ ｃｏｎｔｏｕｒ ｏｆ ｔｈｅ ｃｏｍｐｏｎｅｎｔｓ. Ｔｈｅ ｆｅａｔｕｒｅ ｅｘｔｒａｃｔｉｏｎ ａｎｄ ｓｔｅｒｅｏ ｍａｔｃｈｉｎｇ ｏｆ ｔｈｅ ｃｏｍｐｏｎｅｎｔｓ ｆｅａｔｕｒｅ ｐｏｉｎｔｓ ｗｅｒｅ ｐｅｒｆｏｒｍｅｄ ｂｙ ｔｈｅ ｓｃａｌｅ ｉｎｖａｒｉａｎｔ ｆｅａｔｕｒｅ ｔｒａｎｓｆｏｒｍ ｍｅｔｈｏｄ. Ｔｈｅ ｍａｔｈｅｍａｔｉｃａｌ ｍｏｄｅｌ ｏｆ ｐｏｓｅ ｄｅｔｅｃｔｉｏｎ ｓｙｓｔｅｍ ｗａｓ ｅｓｔａｂｌｉｓｈｅｄ ｂｙ ｓｔｅｒｅｏｓｃｏｐｉｃ ｔｈｒｅｅ ｄｉｍｅｎｓｉｏｎａｌ ｒｅｃｏｎｓｔｒｕｃｔｉｏｎ ｍｅｔｈｏｄ. Ｂｙ ｓｏｌｖｉｎｇ ｔｈｅ ｃｏｎｖｅｒｓｉｏｎ ｒｅｌａｔｉｏｎｓｈｉｐ ｂｅｔｗｅｅｎ ｔｈｅ ｃｏｏｒｄｉｎａｔｅ ｓｙｓｔｅｍｓ, ｔｈｅ ｐｏｓｉｔｉｏｎ ａｎｄ ｄｉｒｅｃｔｉｏｎ ｏｆ ｔｈｅ ｃｏｍｐｏｎｅｎｔｓ ｐｌａｃｅｄ ｏｎ ｔｈｅ ｃｏｎｖｅｙｏｒ ｂｅｌｔ ｗｅｒｅ ｃａｌｃｕｌａｔｅｄ. Ｔｈｅ ｐｏｓｅ ｒｅｃｏｇｎｉｔｉｏｎ ａｌｇｏｒｉｔｈｍ ｐｒｏｇｒａｍ ｗａｓ ｗｒｉｔｔｅｎ ｂｙ ＶＣ ＋ ＋ ｔｏ ｒｅａｌｉｚｅ ｔｈｅ ｓｈａｐｅ ａｎｄ ｐｏｓｅ ｒｅｃｏｇｎｉｔｉｏｎ ｏｆ ｔｈｅ ｃｏｍｐｏｎｅｎｔｓ. Ａ ｔｅｓｔ ｐｌａｔｆｏｒｍ ｆｏｒ ｔｈｅ ｐｏｓｅ ｔｅｓｔ ｓｙｓｔｅｍ ｗａｓ ｂｕｉｌｔ ａｎｄ ａ ｔｅｓｔ ｅｘｐｅｒｉｍｅｎｔ ｗａｓ ｃａｒｒｉｅｄ ｏｕｔ. Ｔｈｅ ｅｘｐｅｒｉｍｅｎｔａｌ ｒｅｓｕｌｔｓ ｓｈｏｗ ｔｈａｔ ｔｈｅ ｄｅｔｅｃｔｉｏｎ ｓｙｓｔｅｍ ｃａｎ ｑｕｉｃｋｌｙ ａｎｄ ｅｆｆｅｃｔｉｖｅｌｙ ｄｅｔｅｃｔ ｔｈｅ ｐｏｓｉｔｉｏｎ ｏｆ ｔｈｅ ｃｏｍｐｏｎｅｎｔｓ, ａｎｄ ｐｒｏｖｉｄｅ ｔｅｃｈｎｉｃａｌ ｓｕｐｐｏｒｔ ｆｏｒ ａｕｔｏｍａｔｉｃ ｌｏａｄｉｎｇ ａｎｄ ｕｎｌｏａｄｉｎｇ ｏｆ ｔｈｅ ｃｏｍｐｏｎｅｎｔｓ. [ABSTRACT FROM AUTHOR]

Objectives: To understand the mediating effect of social support on the relationship between work stress and wellbeing experienced by school nurses. Methods: School nurses from elementary, junior high, high, and vocational schools in Taiwan were selected using stratified random sampling, to whom questionnaires were given to collect the required data. A descriptive analysis, correlation analysis, and hierarchical regression analysis and various mediation methods were performed to examine the mediating effect of social support on the relationship between work stress and wellbeing. Results: School nurses’ social support exerted a mediating effect on the relationship between work stress and well-being. Therefore, increasing school nurses’ social support can reduce the effect of work stress on their well- being. Conclusions: According to the research results, this study recommended that the school and government authorities should provide administrative and policy support for school nurses, and the peer support from other school nurses can enhance school nurses’ work abilities. Professional school nurse organizations should enhance school nurses’ professionalism and facilitate instrument development, promoting a new horizon for student care. [ABSTRACT FROM AUTHOR]

[Objectives]The study aimed to investigate the sequence and expression characteristics of caffeoyl-CoA O-methyltransferase gene in Oenanthe javanica(OjCCoAOMT) and to understand its role in lignin metabolism. [Methods]The OjCCoAOMT gene was cloned from O.javanica using RT-PCR technique. The bioinformatics methods were used to analyze putative amino acid sequence and RT-qPCR method was used to study the expression profiles of OjCCoAOMT gene in different tissues of O.javanica and under different storage conditions. [Results]Sequence analysis result showed that OjCCoAOMT gene contained an open reading frame(ORF) with length of 726 bp,encoded 241 amino acids. The relative molecular mass of OjCCoAOMT protein was 27.111×103. Theoretical isoelectric point was 5.38. The protein belonged to hydrophobic protein and the ratio of its unordered sequence was 12.45%. Tertiary structure of OjCCoAOMT protein mainly consisted of eight α-helix and seven β-sheet. The analysis results of multiple alignment and phylogenetic tree showed that OjCCoAOMT had the nearest phylogeny with CCoAOMT protein from the same family species Petroselinum crispum. RT-qPCR analysis showed that the expression profiles of OjCCoAOMT gene were significantly different in different tissues(leaf blade and petiole) of ‘Baguazhoushuiqin’ and ‘Nanxuanbaguazhouzishuiqin’. The expression levels of OjCCoAOMT gene were different under various storage conditions,such as room temperature(25℃),low temperature(4℃) and darkness at room temperature(25℃). The expression level was peak at 4℃. Moreover,significant differences also existed between two varieties. [Conclusions]OjCCoAOMT protein has high conservation. The relative expression level of OjCCoAOMT gene has tissue and material specialties under different treatments. Moreover,OjCCoAOMT gene has high expression level under the treatment of 4℃. [ABSTRACT FROM AUTHOR]

[Objective] This paper aimed to the tolerance and behavioral changes of Triplophysa (Itedinichthys) yarkandensis (Day) under the salinity and alkalinity.[Method] Triplophysa (Itedinichthys) yarkandensis (Day) was used as objects, defining a low-temperature environment (13 ± 0.5) Ti, their preferences under the gradient concentrations of salinity (S)/alkalinity (Aik ) were determined, and the effects of salinity (S)/alkalinity (Aik) toxicity on the Triplophysa (iledinichthys) yarkandensis (Day) in Tarim river were studied.[Result] When Aik was around pH 6.5 -7.5 with temperature(13 ± 1 ) Ti, the TC%) of S to T.(H.)yarkandensis (Day) were 20.0870 %c, 16.2490 %c, 13.3300 %c, 12.5680 %c and 12.3930 %c at 12, 24, 48, 72 and 96 hours, respectively, and the safe S was 4.1676 %c.The LC50 of Alkto T.(H.) yarkandensis (Day) were 12.1590, 9.9776, 9.5076, 8.6485 and 4.5220 g · I.1 at 12, 24, 48, 72 and 96 hours, respectively, and the safe Aik was 2.7179 g · L-l.Among them, 4 %c was the main preference area, and 3 -4 g · L-l was the range of Aik preference.In conclusion, although the low temperature of S/Alk toxicity tolerance slowed, behavior preferences were also different of T.(II.) yarkandensis (Day), and the S/Alk stress of Tarim water salinization seriously affected the growth and development of T.(II.) yarkandensis (Day).[Conclusion]The present study would provide a scientific basis for the enhancement and protection of T.(II.) yarkandensis (Day). [ABSTRACT FROM AUTHOR]

Objective: To evaluate the safety and effects of ultrasound-guided percutaneous catheter drainage (PCD) in the treatment of severe acute pancreatitis (SAP). Methods: The clinical data of 273 cases of SAP patients undergoing ultrasound-guided percutaneous catheter drainage treatment from January 2011 to December 2015 were retrospectively analyzed. The levels of peripheral blood white blood cells (WBC), IL-6, C-reactive protein (CRP), serum TNF-α before and after the drainage were compared between two groups. Results: Ultrasound-guided percutaneous catheter drainage was performed on all 273 patients. 131 patients were cured by ultrasound-guided percutaneous catheter drainage only and the systemic symptom of 103 patients were improved significantly and they were cured by the following-up retroperitoneal endoscopic necrosectomy. While progression of disease was found in 39 patients, they were directly converted to open operation finally. All the patients were performed successfully. Two patients died after the following-up retroperitoneal endoscopic necrosectomy. 13 patients of the open operation were died. After drainaging, the levels of peripheral blood white blood cells (WBC), IL-6, C-reactive protein (CRP) and serum TNF-α dropped dramatically compared with those before the drainage(P<0.05). Conclusions: Ultrasound-guided percutaneous catheter drainage was an effective method with less trauma and precious positioning for SAP. With successful Ultrasound-guided percutaneous catheter drainage, patients could be free from operation or create an ideal surrounding for the following-up treatment. [ABSTRACT FROM AUTHOR]

The effects of salinity, alkali and weight on oxygen consumption and ammonia excretion rate of Triplophysa (Hedinichthys) yarkandensis (Day) were studied by means of the experimental ecology method in laboratory. Results showed that salinity, alkali and weight had significant effects on the oxygen consumption and ammonia excretion rate( P<0.05), when salinity was 5 g · L-1and the oxygen consumption rate of T. H. yarkandensis (Day) increased as the salinity decreased. The ammonia excretion rate of T. H. yarkandensis (Day) decreased as the salinity increased, the ammonia excretion rate was 0. 084 mg · （g · h）-1 when the salinity was 20 g · L-1. The oxygen consumption rate from the first of T. H. yarkandensis (Day), then as the alkali decreased, the alkali maximum was 11.922 mmol · L-1, and when alkali was 31.922 mmol · L-1the ammonia excretion rate from the first of T. H. yarkandensis (Day) increased. The oxygen consumption rate of T.H. yarkandensis (Day) increased as weight increased, and ammonia excretion rate of T. H. yarkandensis (Day) increased as weight decreased. The O/N ratio of T. H. yarkandensis (Day) increased with the salinity and alkali decreased, and the O/N ratio T. H. yarkandensis(Day) increased as weight increased, when the salinity was 5 g · L-1and the alkali was 11. 922 mmol · L-1. Therefore, so that salinity, alkali and weight were involved in osmoregulation of T. H. yarkandensis (Day) adapting for different salinity, to change the oxygen consumption and ammonia excretion rate of T. H. yarkandensis (Day). It is good at the oxygen consumption and ammonia excretion rate of T. H.yarkandensis (Day), when the salinity is 5 g · L-1and the alkali is 11.922 mmol · L-1, may be related to the Na+/K+-ATP. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical curative effects of aspirin combined with clopidogrel in treatment of cerebral infarction with vascular stenosis. Methods: 60 patients with cerebral infarction patients in our hospital were selected and randomly divided into experimental group and control group. The patients in control group was given aspirin orally once 1 day, and the patients in the experimental group were treated with clopidogrel 75 mg oral administration once a day on the base of conventional therapy. The level of Hcy, uric acid (UA), PLT, hemodynamics of cerebral vascular stenosis and NIHSS score were compared. Results: The level of Hcy, UA and PLT were decreased after the treatment in two groups, and compared with the control group, the level of Hcy, UA and PLT of the experimental group were lower (P<0.05). NIHSS score and stenosis level was decreased in two groups, and it was more obviously in experimental group compared with the control group (P<0.05). Conclusions: Combination of aspirin and clopidogrel can improve platelet aggregation degree and reduce the fibrinogen coagulability, which is superior to single aspirin medication. [ABSTRACT FROM AUTHOR]