1,317 results on '"Tetracycline adverse effects"'
Search Results
202. Tetracycline and nicotinamide for the treatment of bullous pemphigoid: our experience in Singapore.
- Author
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Goon AT, Tan SH, Khoo LS, and Tan T
- Subjects
- Aged, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents adverse effects, Complement C3 analysis, Diarrhea chemically induced, Doxycycline administration & dosage, Doxycycline therapeutic use, Drug Combinations, Female, Fluorescent Antibody Technique, Indirect, Follow-Up Studies, Headache chemically induced, Humans, Immunoglobulin G analysis, Male, Niacinamide administration & dosage, Pemphigoid, Bullous diagnosis, Recurrence, Remission Induction, Skin pathology, Tetracycline administration & dosage, Tetracycline adverse effects, Vomiting chemically induced, Anti-Bacterial Agents therapeutic use, Niacinamide therapeutic use, Pemphigoid, Bullous drug therapy, Tetracycline therapeutic use
- Abstract
Aim of Study: To study the efficacy of tetracycline (or doxycycline) and nicotinamide in the treatment of less extensive bullous pemphigoid., Methods: An open trial of 11 patients with bullous pemphigoid. Treatment was initiated with tetracycline 1.5-2 g/day and nicotinamide 1.5-2 g/day and gradually tapered down. Doxycycline was substituted for tetracycline in patients who could not tolerate tetracycline due to gastrointestinal side effects or headache., Results: 6 out of 11 patients achieved complete response (> 90% decrease in lesions) while another 2 had partial response (50-90% decrease in lesions)., Conclusion: Tetracycline/doxycycline and nicotinamide is a useful alternative treatment for localized bullous pemphigoid, especially in those whose concurrent medical illnesses preclude the use of systemic corticosteroids.
- Published
- 2000
203. Enterobacter agglomerans spondylodiscitis: a possible, unrecognized complication of tetracycline therapy.
- Author
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Porter P and Wray CC
- Subjects
- Acne Vulgaris drug therapy, Adult, Discitis diagnostic imaging, Enterobacteriaceae Infections drug therapy, Humans, Low Back Pain microbiology, Lumbar Vertebrae, Magnetic Resonance Imaging, Male, Radiography, Tetracycline Resistance, Anti-Bacterial Agents adverse effects, Discitis microbiology, Enterobacter, Enterobacteriaceae Infections complications, Tetracycline adverse effects
- Abstract
Study Design: This case report describes infection in a lumbar disc in a healthy young man with an organism of low pathogenicity. The patient was taking a prolonged course of antibiotics at the time the infection occurred., Objective: To describe this unique case of infective spondylodiscitis., Summary of Background Data: To the authors' knowledge, spinal infection with Enterobacter agglomeranshas never been reported. This organism is a transient gut colonizer, and may have established itself secondary to the patient's prolonged ingestion of tetracycline for acne., Methods: This 22-year-old farmer had spontaneous lumbar back pain. Radiologic investigations showed an abnormality in the L4-L5 disc region, and together with other investigations, were suggestive of infection. The diagnosis was confirmed by surgical aspiration., Results: Antibiotic therapy was administered, and the patient made a complete recovery. Follow-up radiographs showed a complete loss of the L4-L5 disc space with only minimal bone destruction., Conclusion: A unique cause of infective lumbar discitis is presented. Several features of this case are unusual. The magnetic resonance findings were not readily diagnostic. The cultured organism is usually nonpathogenic. The infection may have been secondary to prolonged tetracycline therapy.
- Published
- 2000
- Full Text
- View/download PDF
204. Combined professional and home care nightguard bleaching of tetracycline-stained teeth.
- Author
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Fiedler RS and Reichl RB
- Subjects
- Carbamide Peroxide, Dental Devices, Home Care, Drug Combinations, Humans, Military Personnel, Peroxides, Tooth Discoloration etiology, Treatment Outcome, Anti-Bacterial Agents adverse effects, Tetracycline adverse effects, Tooth Bleaching methods, Tooth Discoloration therapy, Urea analogs & derivatives
- Abstract
The effectiveness of combining in-office and at-home nightguard vital bleaching on tetracycline-stained teeth was evaluated. Grade 1 and grade 2 tetracycline stains were eliminated completely in two months by this combination approach. Grade 3 stains, the most severe, were lightened significantly with a reduction in the banding effect. The most common side effect was an increase in tooth sensitivity, especially to cold, while actively in treatment. All patients reported disappearance of the sensitivity after termination of the treatment phase.
- Published
- 2000
205. A single drug for Helicobacter pylori infection: first results with a new bismuth triple monocapsule.
- Author
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de Boer WA, van Etten RJ, Schneeberger PM, and Tytgat GN
- Subjects
- Adult, Aged, Anti-Ulcer Agents adverse effects, Capsules, Female, Gastroscopy, Humans, Male, Metronidazole adverse effects, Middle Aged, Organometallic Compounds adverse effects, Pilot Projects, Tetracycline adverse effects, Treatment Outcome, Anti-Ulcer Agents administration & dosage, Gastritis drug therapy, Helicobacter Infections drug therapy, Helicobacter pylori drug effects, Metronidazole administration & dosage, Organometallic Compounds administration & dosage, Peptic Ulcer drug therapy, Tetracycline administration & dosage
- Abstract
Objective: In this pilot study we investigated the efficacy and tolerability of a new monocapsule that contains a bismuth compound, tetracycline, and metronidazole. If proven to be effective, this monotherapy would turn the well-accepted multidrug regimen of standard bismuth-based triple therapy into an easy and more patient-friendly regimen. It can be used in patients allergic to penicillin., Methods: A total of 53 consecutive H. pylori-infected patients (30 with proven ulcer disease, 23 with gastritis only) from a single center were prescribed two monocapsules q.i.d. after the three meals and after an evening snack during 10 days. Each capsule contained 60 mg colloidal bismuth subcitrate (as Bi2O3 equivalent), 125 mg tetracycline, and 125 mg metronidazole. Repeat endoscopy with biopsies for urease test, Giemsa stain, and culture was carried out > or =5 wk later. Side effect data were collected., Results: One patient was lost to follow-up, two failed to respond, and 50 were cured. The intention-to-treat cure rate was 50 of 53 (94.4%, 95% CI 88.1-100%). Antibiotic sensitivity was available from 51 isolates. The cure rate in the metronidazole sensitive strains was 44 of 45 (97.8%, 95% CI: 93.5-100%), whereas it was four of five in the resistant strains. The regimen was well tolerated, with only two drop-outs (4%) because of side effects., Conclusions: The new monocapsule is an inexpensive, well tolerated, and patient-friendly formulation of a bismuth based triple therapy. A 10-day course with this multidrug capsule reached a very high cure rate in metronidazole-sensitive strains. The number of cases with resistant strains was insufficient to allow firm conclusions about its efficacy in case of resistance. The results are in agreement with previous data with bismuth triple therapy using separate drugs. From the high cure rate, we can conclude that the new capsule dissolves adequately, with proper delivery of its ingredients at the site of action.
- Published
- 2000
- Full Text
- View/download PDF
206. Tetracycline-induced benign intracranial hypertension.
- Author
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Nagarajan L and Lam GC
- Subjects
- Acne Vulgaris drug therapy, Adolescent, Female, Humans, Intracranial Hypertension diagnosis, Anti-Bacterial Agents adverse effects, Intracranial Hypertension chemically induced, Tetracycline adverse effects
- Abstract
We report on a young adolescent with benign intracranial hypertension which we attribute to the use of minocycline for acne.
- Published
- 2000
- Full Text
- View/download PDF
207. Furazolidone combination therapies for Helicobacter pylori infection in the United States.
- Author
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Graham DY, Osato MS, Hoffman J, Opekun AR, Anderson SY, and El-Zimaity HM
- Subjects
- Anti-Ulcer Agents administration & dosage, Anti-Ulcer Agents adverse effects, Clarithromycin administration & dosage, Clarithromycin adverse effects, Clarithromycin therapeutic use, Drug Resistance, Microbial physiology, Female, Furazolidone adverse effects, Furazolidone therapeutic use, Humans, Male, Metronidazole administration & dosage, Metronidazole adverse effects, Metronidazole therapeutic use, Middle Aged, Omeprazole administration & dosage, Omeprazole adverse effects, Omeprazole therapeutic use, Prospective Studies, Tetracycline administration & dosage, Tetracycline adverse effects, Tetracycline therapeutic use, Time Factors, United States, Anti-Ulcer Agents therapeutic use, Drug Therapy, Combination therapeutic use, Furazolidone administration & dosage, Helicobacter Infections drug therapy, Helicobacter pylori
- Abstract
Background: Antibiotic resistance has begun to impair the ability to cure Helicobacter pylori infection., Aim: To evaluate furazolidone as a component of combination therapies for treatment of H. pylori infection in the United States., Methods: Patients with active H. pylori infection received furazolidone combination therapy for 14 days (furazolidone 100 mg and tetracycline 500 mg t.d.s.; omeprazole 20 mg o.d. in the morning and, depending on the pre-treatment antimicrobial susceptibility pattern, 500 mg of metronidazole or clarithromycin t.d.s.)., Results: A total of 27 patients received the metronidazole containing combination (cure rate 100%) and seven received the clarithromycin combination (cure rate 86%). Overall the cure rates for intention-to-treat was 97% (95% CI: 85% to 100%). The single failure took the clarithromycin containing combination for only 2 days (per protocol cure rate = 100%). Side-effects were common and led to discontinuation of therapy in 26% of patients. An attempt to eliminate metronidazole and clarithromycin and use furazolidone, tetracycline, and lansoprazole b.d. produced an unsatisfactory cure rate of 72%., Conclusion: Furazolidone combination therapy appears to be effective. Additional studies with different antimicrobial combinations and duration of therapy are warranted.
- Published
- 2000
- Full Text
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208. Current status of nightguard vital bleaching.
- Author
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Haywood VB
- Subjects
- Anti-Bacterial Agents adverse effects, Carbamide Peroxide, Consumer Product Safety, Dental Devices, Home Care, Dentin Sensitivity chemically induced, Dentin Sensitivity drug therapy, Drug Combinations, Fees, Dental, Gingival Diseases chemically induced, Humans, Nitrates therapeutic use, Oxidants therapeutic use, Peroxides therapeutic use, Potassium Compounds therapeutic use, Tetracycline adverse effects, Tooth Bleaching adverse effects, Tooth Bleaching economics, Tooth Bleaching instrumentation, Tooth Discoloration chemically induced, Tooth Discoloration drug therapy, Urea therapeutic use, Tooth Bleaching methods, Urea analogs & derivatives
- Abstract
Indications for using a 10% carbamide peroxide material in a custom-fitted tray to whiten teeth include teeth discolored from aging, chromogenic foods and drinks, and smoking, and also brown fluorosis-stained teeth, single dark teeth, and tetracycline-stained teeth. Tetracycline-stains may require 2 to 6 months of nightly treatment, whereas after discolorations generally resolve in 2 to 6 weeks. After an initial relapse in the first 2 weeks after the end of treatment, color tends to be stable for 1 to 3 years, with some treatments being permanent. The ADA has approved only six 10% carbamide peroxide materials, which have extensive research and publications on safety and efficacy. Considering the average cost of $196 per arch, and the noninvasive nature of this treatment, nightguard vital bleaching is probably the safest, most cost-effective, patient-pleasing method to improve the appearance of a smile. However, it should be supervised by a dentist for the proper examination, diagnosis of the cause of discoloration, treatment options, and fabrication and fitting of the carrier. Sensitivity during whitening may be treated with fluoride and potassium nitrate.
- Published
- 2000
209. Nightguard vital bleaching: dark stains and long-term results.
- Author
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Leonard RH Jr
- Subjects
- Anti-Bacterial Agents adverse effects, Carbamide Peroxide, Dental Pulp pathology, Dentin Sensitivity chemically induced, Drug Combinations, Gingival Diseases chemically induced, Humans, Oxidants therapeutic use, Patient Satisfaction, Peroxides therapeutic use, Tetracycline adverse effects, Time Factors, Tooth Discoloration chemically induced, Tooth Discoloration pathology, Treatment Outcome, Urea therapeutic use, Tooth Bleaching methods, Tooth Discoloration drug therapy, Urea analogs & derivatives
- Abstract
Since its introduction to dentistry in 1989, nightguard vital bleaching has proven to be a simple and safe procedure for lightening discolored teeth. Efficacy of the technique is 98% for non-tetracycline-stained teeth, and with extended treatment time, tetracycline-stained teeth can be expected to lighten in 86% of cases. Satisfactory retention of the shade change without additional treatment can be expected in 63% of patients 3 years post-treatment and in at least 42% of patients at 7 years. Side effects are usually mild and transient, disappearing within days of treatment completion. Patients report that they are glad they went through the procedure and 98% recommend the procedure to a friend.
- Published
- 2000
210. Discolouration of permanent teeth and enamel hypoplasia due to tetracycline.
- Author
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Kashyap AS and Sharma HS
- Subjects
- Adolescent, Female, Humans, Anti-Bacterial Agents adverse effects, Dental Enamel Hypoplasia chemically induced, Tetracycline adverse effects, Tooth Discoloration chemically induced
- Published
- 1999
211. Impact of community-based mass treatment for trachoma with oral azithromycin on general morbidity in Gambian children.
- Author
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Whitty CJ, Glasgow KW, Sadiq ST, Mabey DC, and Bailey R
- Subjects
- Administration, Oral, Administration, Topical, Adolescent, Anti-Bacterial Agents adverse effects, Azithromycin adverse effects, Child, Child Welfare, Child, Preschool, Community Health Services, Female, Humans, Infant, Male, Morbidity, Tetracycline adverse effects, Anti-Bacterial Agents administration & dosage, Azithromycin administration & dosage, Tetracycline administration & dosage, Trachoma drug therapy
- Abstract
Background: The World Health Organization has recently targeted the elimination of trachoma as a public health problem by the year 2020. Community-based treatment with antibiotics, including oral azithromycin, is recommended for severely affected communities. The incidence of adverse effects after azithromycin treatment is not known in trachoma endemic communities., Methods: We compared the effects of azithromycin with those of topical tetracycline given as mass treatment for trachoma on childhood morbidity in eight rural Gambian villages. The entire population of four villages received oral azithromycin suspension (Zithromax, Pfizer) in doses of 20 mg/kg on Days 1, 8 and 15; the other four villages received topical tetracycline eye ointment for 42 days. Morbidity surveys of subjects 3 months to 14 years old were conducted on Days 0, 7, 14, 21 and 28., Results: Of the 804 subjects recruited complete follow-up data were available on 791 (412 azithromycin, 379 tetracycline). Fever and headache were the most common complaints. Apart from cough other symptoms were equally prevalent in both groups at baseline. The azithromycin group had 20% fewer illness, fever and headache episodes and 40% fewer diarrhea and vomiting episodes at follow-up than did the tetracycline group., Conclusions: Azithromycin treatment for trachoma had favorable short term effects on childhood morbidity in rural Gambian villages, particularly in the high malaria transmission season, and adverse effects were not a problem.
- Published
- 1999
- Full Text
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212. Oral and maxillofacial pathology case of the month. Myospherulosis.
- Author
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McGuff HS, Jones AC, Alderson G, and Aufdemorte TB
- Subjects
- Adult, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents adverse effects, Diagnosis, Differential, Female, Granuloma, Giant Cell chemically induced, Humans, Mandibular Diseases chemically induced, Odontogenic Cysts diagnosis, Petrolatum adverse effects, Tetracycline administration & dosage, Tetracycline adverse effects, Granuloma, Giant Cell pathology, Iatrogenic Disease, Mandibular Diseases pathology
- Published
- 1999
213. A randomized controlled trial of an enhanced patient compliance program for Helicobacter pylori therapy.
- Author
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Lee M, Kemp JA, Canning A, Egan C, Tataronis G, and Farraye FA
- Subjects
- Adult, Aged, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents adverse effects, Bismuth administration & dosage, Bismuth adverse effects, Drug Administration Schedule, Drug Therapy, Combination, Female, Health Maintenance Organizations, Humans, Male, Massachusetts, Metronidazole administration & dosage, Metronidazole adverse effects, Middle Aged, Organometallic Compounds administration & dosage, Organometallic Compounds adverse effects, Program Evaluation, Salicylates administration & dosage, Salicylates adverse effects, Tetracycline administration & dosage, Tetracycline adverse effects, Treatment Outcome, Anti-Bacterial Agents therapeutic use, Bismuth therapeutic use, Helicobacter Infections drug therapy, Helicobacter pylori, Metronidazole therapeutic use, Organometallic Compounds therapeutic use, Patient Compliance, Salicylates therapeutic use, Tetracycline therapeutic use
- Abstract
Objectives: To determine whether an enhanced compliance program (ECP) improves patient compliance with bismuth subsalicylate, metronidazole, and tetracycline hydrochloride (BMT) triple therapy for the treatment of Helicobacter pylori infection and to identify factors that affect compliance with therapy., Design: A randomized controlled trial conducted in 4 staff-model health centers of a health maintenance organization in Massachusetts., Patients and Methods: A total of 125 patients 18 years of age or older with peptic ulcer disease or dyspepsia whose clinicians prescribed BMT triple therapy for 14 days were randomized to a control group or to the ECP group. The ECP group received medication counseling (written and oral) from a pharmacist, along with a medication calendar and a minipillbox, as well as a follow-up telephone call after initiation of therapy. Compliance was assessed by a pill count, and factors affecting adherence to the regimen were identified by patients' reports., Results: There was no statistically significant difference between the 2 groups in the number of patients taking more than 60% of the medications (89% of the control group vs 95% of the ECP group; P>.30). However, there was a statistically significant difference in the number of patients taking more than 90% of the medications (67% of the control group vs 89% of the ECP group; P<.01). An intention-to-treat analysis confirmed these results. The most frequently reported adverse effect was gastrointestinal intolerance. Other factors reported to affect compliance included the frequency of dosing and the number of pills., Conclusions: These findings suggest that although adverse effects were common, most patients were able to complete 60% or more of the 2-week regimen. An ECP further improved the percentage of medications taken.
- Published
- 1999
- Full Text
- View/download PDF
214. Seven-day 'rescue' therapy after Helicobacter pylori treatment failure: omeprazole, bismuth, tetracycline and metronidazole vs. ranitidine bismuth citrate, tetracycline and metronidazole.
- Author
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Gisbert JP, Gisbert JL, Marcos S, Grávalos RG, Carpio D, and Pajares JM
- Subjects
- Adult, Amoxicillin therapeutic use, Anti-Bacterial Agents adverse effects, Anti-Bacterial Agents therapeutic use, Anti-Ulcer Agents adverse effects, Anti-Ulcer Agents therapeutic use, Bismuth adverse effects, Clarithromycin therapeutic use, Drug Administration Schedule, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Metronidazole adverse effects, Middle Aged, Omeprazole adverse effects, Penicillins therapeutic use, Prospective Studies, Ranitidine adverse effects, Ranitidine therapeutic use, Tetracycline adverse effects, Treatment Failure, Bismuth therapeutic use, Helicobacter Infections drug therapy, Helicobacter pylori, Metronidazole therapeutic use, Omeprazole therapeutic use, Ranitidine analogs & derivatives, Tetracycline therapeutic use
- Abstract
Background: Eradication therapy with omeprazole (O), amoxycillin (A) and clarithromycin (C) is used extensively, although it often fails. A 'rescue' therapy with a quadruple combination of O, bismuth (B), tetracycline (T) and metronidazole (M) has been recommended., Aim: : To assess ranitidine bismuth citrate (Rbc) instead of O and B for treatment failure., Methods: Sixty consecutive patients (13 duodenal ulcer, 47 non-ulcer dyspepsia) in whom a previous eradication trial with O, A and C had failed were randomized to receive one of two regimens for 7 days: O (20 mg b.d.), B (120 mg q. d.s.), T (500 mg q.d.s.) and M (250 mg q.d.s.) (group OBTM, n=30); or Rbc (400 mg b.d.), T (500 mg q.d.s.) and M (250 mg q.d.s.) (group RbcTM, n=30). Eradication was defined as a negative 13C-urea breath test 1 month after completing therapy., Results: Mean age +/- s.d. was 45 +/- 12 years, 47% were males. Distribution of studied variables (age, sex, smoking, duodenal ulcer/non-ulcer dyspepsia) was similar in both therapeutic groups. Per protocol eradication was achieved in 17 out of 29 patients (59%) in group OBTM and in 25 out of 29 patients (86%) in group RbcTM (P < 0.05). Intention-to-treat eradication was achieved, respectively, in 17 out of 30 (57%) and in 25 out of 30 (83%) (P < 0.05). In the multivariate analysis the variables which influenced on H. pylori eradication were the type of therapy (odds ratio, OR=3.9; 95%CI: 1.02-15; P < 0.05) and diagnosis (duodenal ulcer/non-ulcer dyspepsia) (OR=0.1; CI: 0.02-0.4). Adverse effects were infrequent and mild with both regimens., Conclusion: Therapy with RbcTM is a promising option after H. pylori eradication failure with OCA, achieving a higher efficacy than quadruple therapy with OBTM.
- Published
- 1999
- Full Text
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215. Overdose of tetracycline for pleurodesis leading to chemical burns of the pleura.
- Author
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Chaugle H, Parchment C, Keenan DJ, and Grötte GJ
- Subjects
- Adult, Biopsy, Burns, Chemical pathology, Burns, Chemical surgery, Drug Overdose etiology, Humans, Male, Pleura drug effects, Pleura pathology, Pleural Diseases pathology, Pleural Diseases surgery, Pneumothorax therapy, Respiratory Care Units, Suction, Tetracycline administration & dosage, Thoracotomy, Anti-Bacterial Agents adverse effects, Burns, Chemical etiology, Pleura injuries, Pleural Diseases chemically induced, Pleurodesis adverse effects, Tetracycline adverse effects
- Abstract
Chemical pleurodesis using tetracycline is an accepted and commonly employed treatment of pneumothorax and pleural effusions. We describe a case of chemical burn of the pleura in a ventilated 41-year-old who came to thoracotomy after 3 days of continuous intrapleural infusion of tetracycline at another hospital. To our knowledge this has not been previously reported although other adverse effects of this procedure are documented. We suggest that damage to the pleura and underlying lung may occur if excessive amounts of tetracycline are used in attempted pleurodesis.
- Published
- 1999
- Full Text
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216. Asymptomatic intracranial hypertension associated with tetracycline use.
- Author
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Bonioli E, Bellini C, and Di Stefano A
- Subjects
- Adolescent, Female, Humans, Intracranial Hypertension etiology, Anti-Bacterial Agents adverse effects, Intracranial Hypertension chemically induced, Tetracycline adverse effects
- Published
- 1999
- Full Text
- View/download PDF
217. [Symptomatic improvement of patients with nonulcer dyspepsia after Helicobacter pylori eradication].
- Author
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Zwimpfer J
- Subjects
- Amoxicillin administration & dosage, Amoxicillin adverse effects, Anti-Ulcer Agents adverse effects, Breath Tests, Drug Therapy, Combination adverse effects, Humans, Metronidazole administration & dosage, Metronidazole adverse effects, Omeprazole adverse effects, Tetracycline administration & dosage, Tetracycline adverse effects, Treatment Outcome, Anti-Ulcer Agents administration & dosage, Drug Therapy, Combination administration & dosage, Dyspepsia drug therapy, Helicobacter Infections drug therapy, Helicobacter pylori drug effects, Omeprazole administration & dosage
- Published
- 1999
218. The current status of vital tooth whitening techniques.
- Author
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Blankenau R, Goldstein RE, and Haywood VB
- Subjects
- Anti-Bacterial Agents adverse effects, Carbamide Peroxide, Dental Devices, Home Care, Drug Combinations, Fluorosis, Dental complications, Fluorosis, Dental diagnosis, Humans, Hydrogen Peroxide, Peroxides, Tetracycline adverse effects, Tooth Discoloration etiology, Urea analogs & derivatives, Tooth Bleaching methods
- Abstract
Tooth whitening of vital teeth continues to have a major impact on the practice of dentistry. The growing public interest in having whiter, brighter teeth is clearly evident in the advertisements from toothpaste manufacturers on "whitening" formulations of their products and by the number of individuals seeking whitening procedures from their dentists. In addition, new over-the-counter whitening products continue to emerge in a marketplace that cannot seem to get teeth white enough, bright enough, fast enough. What new products and procedures have evolved over the past decade to whiten teeth? Are they better, safer, faster, and more effective now? Are dentists meeting public demand for whiter teeth and is this quest having a positive or negative impact on the practice of dentistry or the patient's dental health? I posed these questions to a group of experts on whitening procedures to get their opinions and recommendations.
- Published
- 1999
219. [Images of the month. What is your diagnosis? An acutely painful and recurrent macule].
- Author
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Henry F
- Subjects
- Anti-Bacterial Agents therapeutic use, Drug Eruptions pathology, Female, Humans, Knee, Middle Aged, Pain etiology, Skin Diseases diagnosis, Tetracycline therapeutic use, Anti-Bacterial Agents adverse effects, Drug Eruptions diagnosis, Skin Diseases chemically induced, Tetracycline adverse effects
- Published
- 1999
220. Prospective evaluation of ranitidine bismuth citrate-based triple therapy for the treatment of Helicobacter pylori infection.
- Author
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Mönkemüller KE and Hirschowitz BI
- Subjects
- Adult, Aged, Bismuth adverse effects, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Male, Metronidazole administration & dosage, Metronidazole adverse effects, Middle Aged, Prospective Studies, Ranitidine administration & dosage, Ranitidine adverse effects, Tetracycline administration & dosage, Tetracycline adverse effects, Anti-Ulcer Agents administration & dosage, Bismuth administration & dosage, Helicobacter Infections drug therapy, Helicobacter pylori drug effects, Ranitidine analogs & derivatives
- Abstract
Background: There is a need for effective and inexpensive therapy for Helicobacter pylori with good patient compliance., Aim: To evaluate a simplified twice daily schedule for treating H. pylori., Methods: Patients infected with H. pylori (positive by CLO- and 13C-urea breath tests [UBT]) and not previously treated with anti-H. pylori therapy were treated with ranitidine bismuth citrate (RBC) and two inexpensive antibiotics (metronidazole, tetracycline) twice daily for 14 days in an open-label study. Eradication was established by a negative UBT 4 weeks after ending therapy., Results: Twenty men and 30 women (age 54+/-14 years, range 26-74) were included in the study. Five patients were prematurely withdrawn (side-effects 2, took additional antibiotics 2 and surgery 1) and one patient was lost to follow-up; therefore, 44 (88%) patients completed the H. pylori eradication protocol. Per protocol (PP) cure rate was 82% (36/44 patients, 95% CI: 68-95%), and intention-to-treat cure rate was 72% (36/50 patients, 95% CI: 58-82%). Five patients (10%) developed side-effects during therapy, most commonly nausea (3 patients). Four weeks after the end of treatment, 78% (PP) of patients were symptomatically improved., Conclusions: A 2-week course of twice-daily RBC-based triple therapy was well tolerated, eradicated H. pylori in 72% (ITT) and 82% (PP) of patients, respectively, and relieved symptoms in 78%.
- Published
- 1999
- Full Text
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221. Observations on the use of tetracycline and niacinamide as antipruritic agents in atopic dogs.
- Author
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Beningo KE, Scott DW, Miller WH Jr, and Rothstein E
- Subjects
- Animals, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents adverse effects, Diarrhea chemically induced, Diarrhea veterinary, Dog Diseases pathology, Dogs, Drug Therapy, Combination, Hypersensitivity, Immediate drug therapy, Niacinamide administration & dosage, Niacinamide adverse effects, Pruritus drug therapy, Tetracycline administration & dosage, Tetracycline adverse effects, Treatment Outcome, Anti-Bacterial Agents therapeutic use, Dog Diseases drug therapy, Hypersensitivity, Immediate veterinary, Niacinamide therapeutic use, Pruritus veterinary, Tetracycline therapeutic use
- Abstract
Tetracycline and niacinamide were administered in combination to 19 atopic dogs to determine their effectiveness in controlling pruritus. The pruritus was controlled successfully in only one dog. One dog experienced diarrhea that was severe enough to warrant stopping the medication.
- Published
- 1999
222. One-week ranitidine bismuth citrate versus colloidal bismuth subcitrate-based anti-Helicobacter triple therapy: a prospective randomized controlled trial.
- Author
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Kung NN, Sung JJ, Yuen NW, Li TH, Ng PW, Lai WM, Lui YH, Lam KN, Choi CH, and Leung EM
- Subjects
- Adolescent, Adult, Aged, Anti-Bacterial Agents adverse effects, Anti-Ulcer Agents adverse effects, Bismuth adverse effects, Drug Administration Schedule, Drug Resistance, Microbial, Drug Therapy, Combination, Female, Helicobacter Infections complications, Humans, Male, Metronidazole administration & dosage, Metronidazole adverse effects, Middle Aged, Organometallic Compounds adverse effects, Peptic Ulcer microbiology, Prospective Studies, Ranitidine administration & dosage, Ranitidine adverse effects, Tetracycline administration & dosage, Tetracycline adverse effects, Anti-Bacterial Agents administration & dosage, Anti-Ulcer Agents administration & dosage, Bismuth administration & dosage, Helicobacter Infections drug therapy, Helicobacter pylori drug effects, Organometallic Compounds administration & dosage, Peptic Ulcer drug therapy, Ranitidine analogs & derivatives
- Abstract
Objective: The efficacy of 1 wk bismuth triple therapy is adversely influenced by the presence of metronidazole resistance. In vitro studies suggest that ranitidine bismuth citrate (RBC) plus metronidazole exhibit synergistic activity against metronidazole resistant strains of Helicobacter pylori (H. pylori). Whether this confers a superior clinical efficacy remains unproven. This study compared the efficacy of RBC-based triple therapy with bismuth triple therapy in eradication of H. pylori., Methods: Patients with H. pylori-related ulcer disease or gastritis were randomized to receive either 400/mg of RBC twice daily plus 400/mg of metronidazole and 500/mg of tetracycline four times daily for 1 wk (RMT) or 120/mg of colloidal bismuth subcitrate, 400/mg of metronidazole, and 500/mg of tetracycline, all given four times daily for 1 wk (BMT). Metronidazole susceptibility was determined by the E-test and pretreatment resistance was defined as minimum inhibitory concentration > or = 32/mg/L., Results: Of 100 consecutive patients randomized, two patients were lost to follow-up in each group. Forty-three of 85 (51%) H. pylori isolates were metronidazole resistant. Per-protocol cure rate for RMT and BMT was 40 of 41 (98%) and 37 of 44 (84%), respectively (p = 0.058). Intent-to-treat cure rate for RMT and BMT was 46 of 50 and 41 of 50, respectively (92% vs 82%, p = 0.23). A significantly higher eradication of metronidazole resistant H. pylori was observed in the RMT group (25 of 25, 100%) than in the BMT group (12 of 16, 75%), (p = 0.018). Side effects observed in the two treatment groups were comparable., Conclusions: One week of RBC triple therapy with metronidazole and tetracycline is an effective anti-Helicobacter therapy. This regimen is more appropriate in areas of high prevalence of metronidazole resistance.
- Published
- 1999
- Full Text
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223. Tetracycline: effect on fetal bone growth.
- Author
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Briggs GG
- Subjects
- Female, Humans, Infant, Newborn, Infant, Premature, Pregnancy, Bone Development drug effects, Embryonic and Fetal Development drug effects, Maternal-Fetal Exchange, Tetracycline adverse effects
- Published
- 1999
224. Eradication of Helicobacter pylori infection after ranitidine bismuth citrate, metronidazole and tetracycline for 7 or 10 days.
- Author
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Knigge K, Kelly C, Peterson WL, and Fennerty MB
- Subjects
- Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents adverse effects, Anti-Ulcer Agents administration & dosage, Anti-Ulcer Agents adverse effects, Bismuth administration & dosage, Bismuth adverse effects, Breath Tests, Drug Therapy, Combination, Female, Helicobacter Infections microbiology, Helicobacter Infections pathology, Humans, Male, Metronidazole administration & dosage, Metronidazole adverse effects, Middle Aged, Patient Compliance, Ranitidine administration & dosage, Ranitidine adverse effects, Ranitidine therapeutic use, Tetracycline administration & dosage, Tetracycline adverse effects, Urea metabolism, Anti-Bacterial Agents therapeutic use, Anti-Ulcer Agents therapeutic use, Bismuth therapeutic use, Helicobacter Infections drug therapy, Helicobacter pylori drug effects, Metronidazole therapeutic use, Ranitidine analogs & derivatives, Tetracycline therapeutic use
- Abstract
Background: We assessed the efficacy, tolerance, and compliance of twice-daily triple therapy for Helicobacter pylori with ranitidine bismuth citrate, metronidazole and tetracycline for 7 or 10 days., Methods: 105 subjects with H. pylori infection documented by the 13C-urea breath test were randomly assigned to a 7 or 10-day course of ranitidine bismuth citrate 400 mg b.d., metronidazole 500 mg b.d. and tetracycline 500 mg b.d. Subjects returned at the end of therapy for assessment of side-effects and pill count. A repeat 13C-urea breath test was obtained 4 or more weeks after completion of therapy and cure of infection was defined as a negative test result., Results: Poor compliance (< 80% of medications) was seen in 2% of subjects randomized to 7 days of therapy and in 10% randomized to 10 days of therapy (P = N.S.). Intention-to-treat eradication rates were 56% for 7-day and 60% for 10-day therapy (P = N.S.). Per protocol eradication rates were 58% for 7-day and 61% for 10-day therapy (P = N.S.). The 10-day intention-to-treat eradication rate for males was 78% and 32% for females (P < 0.01) and per protocol eradication rates were 79% and 31%, respectively (P < 0.01)., Conclusions: Despite excellent compliance and tolerance, neither 7 nor 10 days of therapy with twice-daily ranitidine bismuth citrate, metronidazole and tetracycline are adequate as a treatment of H. pylori infection.
- Published
- 1999
- Full Text
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225. Pemphigus vulgaris: benefits of tetracycline as adjuvant therapy in a series of thirteen patients.
- Author
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Calebotta A, Sáenz AM, González F, Carvalho M, and Castillo R
- Subjects
- Adult, Anti-Bacterial Agents adverse effects, Anti-Bacterial Agents therapeutic use, Azathioprine therapeutic use, Chemotherapy, Adjuvant, Drug Therapy, Combination, Female, Gastrointestinal Diseases chemically induced, Glucocorticoids therapeutic use, Hospitalization, Humans, Immunosuppressive Agents therapeutic use, Male, Middle Aged, Pemphigus pathology, Prednisone therapeutic use, Severity of Illness Index, Skin drug effects, Skin pathology, Tetracycline adverse effects, Tetracycline therapeutic use, Time Factors, Treatment Outcome, Pemphigus drug therapy
- Abstract
Background: Tetracycline is an antibiotic which has been proven beneficial as an immunomodulating drug in the treatment of autoimmune bullous diseases., Methods: Thirteen hospitalized patients with pempigus vulgaris received tetracycline 2 g/day for 1 month, then 1 g/day for the following 4 weeks. Prednisone 0.5-1 mg/kg/day was then gradually reduced. The control group consisted of seven patients with pemphigus who had received prednisone and azathioprine., Results: A total of 13 patients in the study group achieved cessation of new blister formation within 5.4 days, compared to 23.71 days (p < 0.0001). The average initial dose of prednisone was 76.53 mg/day for the study group and 118.57 mg/day in the control group (p < 0.014). The average number of days before reduction of the prednisone dosage could begin was 16.53 days for the study group compared to 31.28 days in the control (p < 0.049). Total hospitalization time was also significantly lower: 34.07 days (p < 0.001). The clinical response was not linked to the location of lesions nor to severity of disease., Conclusions: Tetracycline was shown to be effective as an adjuvant therapy for pemphigus with low toxicity and safety.
- Published
- 1999
- Full Text
- View/download PDF
226. Drug interactions with antimalarial agents.
- Author
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Griffin JP
- Subjects
- Dapsone adverse effects, Drug Interactions, Humans, Malaria prevention & control, Proguanil adverse effects, Pyrimethamine adverse effects, Quinolines adverse effects, Sulfadoxine adverse effects, Tetracycline adverse effects, Antimalarials adverse effects
- Published
- 1999
227. Porcelain veneers: a challenging case.
- Author
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Fortin DJ
- Subjects
- Adult, Anti-Bacterial Agents adverse effects, Dental Porcelain, Humans, Male, Tetracycline adverse effects, Tooth Preparation, Prosthodontic, Dental Veneers, Tooth Discoloration chemically induced, Tooth Discoloration therapy
- Abstract
A patient in his early 20s with teeth badly discoloured by tetracycline was seeking treatment to improve his esthetics. Because retreatment and cost were important considerations, porcelain veneers were the treatment of choice. The challenge in this case was to mask the underlying tetracycline stain before the final cementation and thus gain more control over the final shade of the veneers.
- Published
- 1999
228. Pediatric tetracycline-induced pseudotumor cerbri.
- Author
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Quinn AG, Singer SB, and Buncic JR
- Subjects
- Acetazolamide therapeutic use, Acne Vulgaris drug therapy, Adolescent, Child, Dexamethasone therapeutic use, Diuretics therapeutic use, Drug Therapy, Combination, Female, Follow-Up Studies, Glucocorticoids therapeutic use, Humans, Magnetic Resonance Imaging, Male, Pseudotumor Cerebri diagnosis, Pseudotumor Cerebri drug therapy, Retrospective Studies, Tomography, X-Ray Computed, Visual Acuity, Anti-Bacterial Agents adverse effects, Pseudotumor Cerebri chemically induced, Tetracycline adverse effects
- Abstract
Background: Tetracyclines have long been recognized as a cause of pseudotumor cerebri in adults, but the role of tetracyclines in the pediatric age group has not been well characterized in the literature and there have been few reported cases. We present 6 cases to better delineate the problem, the patient profile, the response to treatment, and the sequelae., Methods: We retrospectively analyzed the records of all patients admitted with a diagnosis of pseudotumor cerebri who had documented usage of a tetracycline-class drug immediately before presentation at the Hospital For Sick Children in Toronto, Canada, from January 1, 1986, to March 1, 1996., Results: Six patients (5 female, 1 male) who met all inclusion and exclusion criteria were identified; their ages ranged from 12 to 17 years. All were being treated for acne vulgaris. Duration of use before diagnosis was as short as 2 weeks and as long as 10 months, with a mean of 4.4 months. Duration of symptoms ranged from 0.57 to 4 weeks. Symptoms included headache (6 of 6), nausea (5 of 6), and diplopia (4 of 6). All for whom height and weight data were known (5 of 6) were in the upper quartile for body mass index. Visual acuity was 6/6 in all but 1 eye of one patient (6/9) at diagnosis, and final visual acuity was 6/6 in all patients. All had normal color vision, where this was recorded (5 of 6). The only recorded field defect was enlargement of the blind spot (4 of 6). All patients responded to treatment, with loss of symptoms in 1 day to 4 weeks., Conclusions: Pseudotumor cerebri as a result of tetracycline-class drugs does occur in the pediatric population. With prompt and appropriate medical treatment, long-term sequelae can almost always be avoided. Physicians who treat patients with tetracyclines need to be aware of the potential complications in children.
- Published
- 1999
- Full Text
- View/download PDF
229. Drug-induced disorders of the esophagus.
- Author
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Levine MS
- Subjects
- Anti-Inflammatory Agents, Non-Steroidal adverse effects, Diagnosis, Differential, Doxycycline adverse effects, Esophagitis diagnostic imaging, Humans, Potassium Chloride adverse effects, Quinidine adverse effects, Radiography, Tetracycline adverse effects, Esophagitis chemically induced
- Published
- 1999
- Full Text
- View/download PDF
230. Tetracycline-induced acute interstitial nephritis as a cause of acute renal failure.
- Author
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Bihorac A, Ozener C, Akoglu E, and Kullu S
- Subjects
- Acute Kidney Injury therapy, Adult, Diuretics therapeutic use, Furosemide therapeutic use, Humans, Kidney Glomerulus pathology, Male, Renal Dialysis, Acute Kidney Injury chemically induced, Acute Kidney Injury pathology, Anti-Bacterial Agents adverse effects, Nephritis, Interstitial chemically induced, Nephritis, Interstitial pathology, Tetracycline adverse effects
- Abstract
Acute interstitial nephritis with severe acute renal failure is reported following tetracycline treatment in a 22-year-old male medical student. Acute renal failure developed within 48 h of a single repeated tetracycline dose and presented 2 days after taking the drug when there was oliguria, nausea, vomiting and bilateral loin pain without rash and fever. The serum creatinine concentration was 8.6 mg/dl and blood urea nitrogen 84 mg/dl. Examination of the urinary sediment revealed 15-20 RBCs per high-power field, and occasional granular and hyaline casts. Percutaneous renal biopsy performed immediately after admission revealed acute interstitial nephritis with immune complexes along the tubular basement membrane and intact glomeruli and was consistent with type 2 interstitial nephritis. Within 4 days of commencement of steroid treatment and hemodialysis, the urine output started to increase with improvement in serum creatinine and BUN levels and after 2 weeks of therapy hemodialysis was discontinued. He remains well 1 year following his illness with complete normalization of his renal function. Although a number of renal side effects of tetracycline antibiotics have been reported, acute interstitial nephritis is rarely caused by tetracycline treatment having been reported just twice following systemic use of minocycline.
- Published
- 1999
- Full Text
- View/download PDF
231. Drug-induced urolithiasis.
- Author
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Osborne CA, Lulich JP, Bartges JW, Ulrich LK, Koehler LA, Bird KA, Swanson LL, Austin GW, Prien EL Jr, and Steinam KU
- Subjects
- Allopurinol adverse effects, Animals, Anti-Bacterial Agents adverse effects, Anti-Infective Agents adverse effects, Anticonvulsants adverse effects, Cats, Dogs, Enzyme Inhibitors adverse effects, Fluoroquinolones, Primidone adverse effects, Sulfonamides adverse effects, Tetracycline adverse effects, Urinary Calculi chemically induced, Xanthine Oxidase antagonists & inhibitors, Cat Diseases chemically induced, Dog Diseases chemically induced, Urinary Calculi veterinary
- Abstract
Diagnostic and therapeutic drugs may enhance urolithiasis in one or a combination of ways, including: (1) alteration of urine pH in such fashion as to create an environment that increases the solubility of some lithogenic substances, (2) alteration of glomerular filtration rate, tubular reabsorption, and tubular secretion of drugs of endogenous substances so as to enhance promoters or impair inhibitors of urolithiasis, and (3) precipitation (e.g., drugs or their metabolites) to form a portion or all of a urolith.
- Published
- 1999
- Full Text
- View/download PDF
232. Combining treatment modalities for tetracycline-discolored teeth.
- Author
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Sadan A and Lemon RR
- Subjects
- Carbamide Peroxide, Combined Modality Therapy, Dental Porcelain, Drug Combinations, Humans, Incisor, Maxilla, Occlusal Splints, Peroxides, Tetracycline adverse effects, Tooth Bleaching instrumentation, Tooth Discoloration etiology, Urea analogs & derivatives, Dental Veneers, Tooth Bleaching methods, Tooth Discoloration therapy, Tooth Preparation, Prosthodontic
- Abstract
Tetracycline-discolored teeth that are to be restored by porcelain laminate veneers present a clinical challenge. Successfully bleaching such teeth prior to veneering will permit the clinician and technician to overcome the technical difficulties associated with masking dark teeth. This article describes a combined treatment modality in which the teeth are bleached after the preparation for porcelain laminate veneers.
- Published
- 1998
233. Aesthetic treatment of tetracycline stains.
- Author
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Farsirotu S
- Subjects
- Adult, Dental Porcelain, Esthetics, Dental, Humans, Male, Metal Ceramic Alloys, Tooth Discoloration therapy, Anti-Bacterial Agents adverse effects, Crowns, Dental Veneers, Tetracycline adverse effects, Tooth Discoloration chemically induced
- Published
- 1998
234. Acid suppression with ranitidine plus oral triple therapy improves ulcer healing but not Helicobacter pylori eradication.
- Author
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Magalhaes AF, Macedo C, Hauck JR, Carvalhaes A, De Nucci G, Magna LA, and Pedrazzoli J Jr
- Subjects
- Adolescent, Adult, Anti-Ulcer Agents adverse effects, Brazil, Drug Administration Schedule, Drug Therapy, Combination, Duodenal Ulcer microbiology, Endoscopy, Gastrointestinal, Female, Follow-Up Studies, Furazolidone administration & dosage, Furazolidone adverse effects, Helicobacter Infections microbiology, Humans, Male, Middle Aged, Organometallic Compounds administration & dosage, Organometallic Compounds adverse effects, Prospective Studies, Pyloric Antrum microbiology, Ranitidine adverse effects, Tetracycline administration & dosage, Tetracycline adverse effects, Treatment Outcome, Anti-Ulcer Agents administration & dosage, Duodenal Ulcer drug therapy, Gastric Acidity Determination, Helicobacter Infections drug therapy, Helicobacter pylori drug effects, Ranitidine administration & dosage
- Abstract
Background/aims: To evaluate whether the addition of 2 weeks of ranitidine to a 1-week oral triple therapy (OTT) regimen improved ulcer healing and H. pylori eradication., Methodology: Two hundred and eleven consecutive patients with an endoscopic diagnosis of active duodenal ulcer (DU) and a positive antrum biopsy for H. pylori were enrolled. Those attending the Hospital Vera Cruz (Group A, n=142) received a 14-day course of ranitidine (150 mg after breakfast and dinner) plus a 1-week OTT, consisting of bismuth subcitrate, (240 mg after the 3 meals), tetracycline (500 mg, 10 min before the three meals and at bedtime), and furazolidone (200 mg after breakfast and dinner). Patients from the Hospital das Clinicas (Group B, n=69) received the same OTT as Group A but without ranitidine. Patients underwent endoscopy again on average 40 days (range: 30-60 days) after completing therapy in order to assess ulcer healing and H. pylori status., Results: Both schedules were equally efficient in eradicating H. pylori with 90% (128/142) eradication in group A, and 84% (58/69) in group B (p=0.2). In contrast, the addition of ranitidine to OTT improved ulcer healing when compared with OTT alone (96%, 137/142, vs. 70%, 48/69; p<0.001)., Conclusions: Our results demonstrate that the association of acid suppression, obtained with 2 week ranitidine administration with OTT improved ulcer healing but did not enhance H. pylori eradication.
- Published
- 1998
235. Long-term prognosis of intentional endodontics and internal bleaching of tetracycline-stained teeth.
- Author
-
Abou-Rass M
- Subjects
- Adult, Female, Follow-Up Studies, Humans, Male, Patient Selection, Prognosis, Tooth Discoloration therapy, Anti-Bacterial Agents adverse effects, Root Canal Therapy, Tetracycline adverse effects, Tooth Bleaching methods, Tooth Discoloration chemically induced
- Abstract
A total of 112 severely tetracycline-stained teeth in 20 patients were treated by endodontics and nonthermal internal bleaching. All teeth were healthy, intact, and had no history of trauma. The patients were monitored for 5 to 15 years. Excellent, permanent esthetic results were obtained with no side effects. The quality of endodontic treatment and lingual access restoration were important factors in the longevity of the bleaching results.
- Published
- 1998
236. Enamel staining and hypoplasia due to multiple causes in a Nigerian adolescent: report of a case.
- Author
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Ogunyinka A
- Subjects
- Adolescent, Dental Enamel Hypoplasia complications, Dental Enamel Hypoplasia therapy, Dental Veneers, Female, Humans, Nigeria, Tooth Bleaching, Tooth Discoloration complications, Tooth Discoloration therapy, Anti-Bacterial Agents adverse effects, Dental Enamel Hypoplasia chemically induced, Tetracycline adverse effects, Tooth Discoloration chemically induced
- Abstract
The aim of this report is to discuss the effects of childhood drug ingestion and metabolic disturbances of ill health in childhood on the coloration, structure and therefore the aesthetics of permanent dentition. To illustrate this, the report presents a case of a 15 year old Nigerian girl with combined tetracycline staining and chronological enamel hypoplastic defects on her teeth. The relationship between the clinical appearance of her teeth and her childhood medical and drug history are analysed. The various treatment modalities available for the management of the dental anomalies are discussed along with the rationale for the treatment given. Strategies for the prevention of these conditions are emphasised.
- Published
- 1998
237. [Thrombopenic purpura caused by tetracyclines?].
- Author
-
Navarro Seisdedos LA, Juan Vidal O, de Paz Arias L, and Peláez Hernández A
- Subjects
- Humans, Male, Middle Aged, Anti-Bacterial Agents adverse effects, Purpura, Thrombocytopenic chemically induced, Tetracycline adverse effects
- Published
- 1998
238. Efficacy, longevity, side effects, and patient perceptions of nightguard vital bleaching.
- Author
-
Leonard RH Jr
- Subjects
- Anti-Bacterial Agents adverse effects, Carbamide Peroxide, Dentin Sensitivity chemically induced, Drug Combinations, Gingiva drug effects, Humans, Hydrogen Peroxide therapeutic use, Patient Satisfaction, Peroxides therapeutic use, Tetracycline adverse effects, Time Factors, Tooth Discoloration chemically induced, Tooth Discoloration drug therapy, Treatment Outcome, Urea analogs & derivatives, Urea therapeutic use, Dental Devices, Home Care, Tooth Bleaching adverse effects, Tooth Bleaching instrumentation, Tooth Bleaching psychology
- Abstract
Since its introduction into dentistry in 1989, nightguard vital bleaching has been proven to be a simple and safe procedure to whiten discolored teeth. Efficacy of the technique is 95% for nontetracycline-stained teeth, and with extended treatment time, tetracycline-stained teeth can be expected to lighten in 90% of cases. Satisfactory retention of the shade change can be expected in 63% of patients 3 years posttreatment and at least 35% at 7 years. Side effects are usually mild and transient, disappearing within days of treatment completion. Patients report that they are glad they went through the procedure, and 97% recommend the procedure to a friend.
- Published
- 1998
239. Efficacy of tetracycline and metronidazole alone or with ranitidine on the healing of duodenal ulcer and eradication of Helicobacter pylori. A randomized controlled multicenter study. Tetra-Metro-Ran Study Group.
- Author
-
Massarrat S, Ihm P, and Koch HK
- Subjects
- Anti-Bacterial Agents adverse effects, Anti-Ulcer Agents adverse effects, Drug Combinations, Female, Helicobacter Infections microbiology, Humans, Male, Metronidazole adverse effects, Middle Aged, Ranitidine adverse effects, Tetracycline adverse effects, Time Factors, Urease metabolism, Anti-Bacterial Agents therapeutic use, Anti-Ulcer Agents therapeutic use, Duodenal Ulcer drug therapy, Duodenal Ulcer microbiology, Helicobacter Infections drug therapy, Helicobacter pylori, Metronidazole therapeutic use, Ranitidine therapeutic use, Tetracycline therapeutic use
- Abstract
In almost all eradication regimens, which contain antibiotics and bismuth derivatives, the administration of acid suppressing drugs for 4-6 weeks is recommended for healing of duodenal ulcer. The aim of this multicenter double blind study is to elucidate the effect of two classic antibiotics tetracycline (CAS 60-54-8) and metronidazole (CAS 443-48-1) alone or combined with ranitidine (CAS 66357-35-5) on the healing of duodenal ulcer and eradication of Helicobacter Pylori. Patients with duodenal ulcer were randomized to two treatment groups: group A received either ranitidine 4 x 150 mg or tetracycline 4 x 500 mg or metronidazole 3 x 250 mg for 2 weeks. Group B received 4 x placebo + tetracycline and metronidazole as in group A for 2 weeks. A final endoscopy was performed after 8 weeks. Four biopsy specimens were obtained from the antrum (two) and corpus (two) for both urease test and hematoxylin stain for detection of H. pylori. Out of 201 patients entering the study 156 completed the study (78 in A and 78 in B). The healing rate of duodenal ulcer was 98.7% in group A and 97.5 in group B. The eradication rate was only 33.3% in group B but 64% in group A (p < 0.001), when additionally ranitidine was given. The present study shows that treatment with the two antibiotics tetracycline and metronidazole alone results in a very low H. pylori eradication, but almost complete healing of duodenal ulcer after 8 weeks. Prolonged administration of antisecretory drugs in eradication regimens containing two antibiotics is not necessary for duodenal ulcer healing. However, the addition of H2-receptor antagonists or proton pump inhibitors to antibiotics increases the eradication rate.
- Published
- 1998
240. Esthetic restoration of discolored teeth using porcelain laminate veneers.
- Author
-
Strassler HE
- Subjects
- Aging, Anti-Bacterial Agents adverse effects, Composite Resins, Female, Fluorosis, Dental complications, Humans, Minocycline adverse effects, Prosthesis Coloring, Tetracycline adverse effects, Tooth Discoloration etiology, Tooth Injuries complications, Dental Porcelain, Dental Veneers, Tooth Discoloration therapy
- Published
- 1998
241. [Pleural reaction pattern after talc pleurodesis].
- Author
-
Krismann M, Pieper K, and Müller KM
- Subjects
- Follow-Up Studies, Humans, Microscopy, Electron, Scanning, Mitoxantrone administration & dosage, Mitoxantrone adverse effects, Pleural Effusion, Malignant pathology, Pleural Neoplasms pathology, Talc administration & dosage, Tetracycline administration & dosage, Tetracycline adverse effects, Foreign-Body Reaction pathology, Pleura pathology, Pleurodesis, Talc adverse effects
- Abstract
Because of the rising importance of talcum pleurodesis in the therapeutic management of malignant and benign pleural effusions in Germany, pleural samples after talcum pleurodesis were compared to microscopic, immunohistochemical, and scanning electron microscopy findings after Tetracyclin and Novantron pleurodesis in 24 patients up to 18 months after intrapleural therapy. The histomorphological findings after talcum pleurodesis show an early phase of up to 4 weeks, characterized by the presence of talcum-containing granulation tissue with giant-cell foreign-body reaction, and a subsequent late phase with organization of the granulation tissue and connective tissue formation and obliteration of the pleura sheets. The resulting characteristic linear talcum zone in the pleural connective tissue is missing in cases with tumorous infiltration of the pleura. Continuous fibroblast activation, e.g., by macrophage or foreign-body giant-cell-released mediators, seems to be the decisive factor in the fibrosing process. No therapy-related tumor growth alterations could be demonstrated.
- Published
- 1998
- Full Text
- View/download PDF
242. Intrinsic staining of teeth secondary to tetracycline.
- Author
-
Livingston HM and Dellinger TM
- Subjects
- Adult, Humans, Male, Anti-Bacterial Agents adverse effects, Tetracycline adverse effects, Tooth drug effects, Tooth Discoloration chemically induced
- Published
- 1998
- Full Text
- View/download PDF
243. Tetracycline and its analogues: a therapeutic paradigm in periodontal diseases.
- Author
-
Weinberg MA and Bral M
- Subjects
- Adult, Aggressive Periodontitis drug therapy, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents adverse effects, Anti-Bacterial Agents pharmacokinetics, Anti-Bacterial Agents pharmacology, Drug Delivery Systems, Humans, Periodontitis drug therapy, Tetracycline administration & dosage, Tetracycline adverse effects, Tetracycline pharmacokinetics, Tetracycline pharmacology, Tetracycline Resistance, Anti-Bacterial Agents therapeutic use, Periodontal Diseases drug therapy, Tetracycline therapeutic use
- Abstract
This article discusses the use of tetracyclines in the clinical management of periodontal infections. A review of the drugs pharmacology, pharmacokinetics, and potential adverse effects shows that they are relatively safe if used in appropriate dosages and under controlled conditions. Current data suggest that the routine use of tetracyclines in conjunction with the treatment of periodontitis is unnecessary. However, their distinctive characteristics can be utilized in different delivery systems as an adjunctive aid to conventional treatment of juvenile and refractory forms of periodontitis.
- Published
- 1998
- Full Text
- View/download PDF
244. Randomized comparison of ranitidine bismuth citrate-based triple therapies for Helicobacter pylori.
- Author
-
Laine L, Estrada R, Trujillo M, and Emami S
- Subjects
- Adult, Amoxicillin administration & dosage, Amoxicillin adverse effects, Amoxicillin therapeutic use, Antacids administration & dosage, Antacids adverse effects, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents adverse effects, Anti-Bacterial Agents therapeutic use, Anti-Ulcer Agents administration & dosage, Anti-Ulcer Agents adverse effects, Biopsy, Bismuth administration & dosage, Bismuth adverse effects, Bismuth therapeutic use, Breath Tests, Carbon Isotopes, Clarithromycin administration & dosage, Clarithromycin adverse effects, Clarithromycin therapeutic use, Drug Combinations, Female, Follow-Up Studies, Gastroscopy, Helicobacter Infections pathology, Histamine H2 Antagonists administration & dosage, Histamine H2 Antagonists adverse effects, Humans, Male, Metronidazole administration & dosage, Metronidazole adverse effects, Metronidazole therapeutic use, Organometallic Compounds administration & dosage, Organometallic Compounds adverse effects, Penicillins administration & dosage, Penicillins adverse effects, Penicillins therapeutic use, Peptic Ulcer drug therapy, Peptic Ulcer microbiology, Peptic Ulcer pathology, Proton Pump Inhibitors, Ranitidine administration & dosage, Ranitidine adverse effects, Salicylates administration & dosage, Salicylates adverse effects, Salicylates therapeutic use, Tetracycline administration & dosage, Tetracycline adverse effects, Tetracycline therapeutic use, Urea, Antacids therapeutic use, Anti-Ulcer Agents therapeutic use, Helicobacter Infections drug therapy, Helicobacter pylori, Histamine H2 Antagonists therapeutic use, Organometallic Compounds therapeutic use, Ranitidine therapeutic use
- Abstract
Objectives: In an attempt to increase the efficacy and simplicity of FDA-approved regimens for Helicobacter pylori, we studied (1) addition of an inexpensive antibiotic (amoxicillin) to twice-daily ranitidine bismuth citrate (RBC)-clarithromycin dual therapy, and (2) substitution of RBC for bismuth subsalicylate + H2-receptor antagonist in bismuth-based triple therapy., Methods: Subjects with previously untreated Helicobacter pylori infection documented by 13C-urea breath test plus either endoscopic biopsy or serology were randomly assigned to a 2-wk course of (1) RBC 400 mg b.i.d., amoxicillin 1 g b.i.d., and clarithromycin 500 mg b.i.d. (RAC), or (2) RBC 400 mg b.i.d., metronidazole 250 mg t.i.d., and tetracycline 500 mg t.i.d. (RMT). Repeat breath test was performed 4 wk after the completion of therapy., Results: Intent-to-treat and per-protocol cure rates for RAC were 46 of 50 patients (92%) and 45 of 47 patients (96%); for RMT they were 40 of 50 patients (80%) and 37 of 42 patients (88%). Study drugs were stopped due to side effects in three patients (6%) taking RAC and six patients (12%) taking RMT., Conclusions: Twice-daily RBC-based triple therapy with clarithromycin and amoxicillin produces Helicobacter pylori eradication rates over 90%, which is comparable to rates seen with proton pump inhibitor-based triple therapies. RBC also may be substituted for bismuth subsalicylate and an + H2-receptor antagonist in standard bismuth-based triple therapy.
- Published
- 1997
245. Four-day quadruple therapy as a routine treatment for Helicobacter pylori infection.
- Author
-
de Boer SY and Siem TH
- Subjects
- 2-Pyridinylmethylsulfinylbenzimidazoles, Adolescent, Adult, Aged, Anti-Bacterial Agents adverse effects, Anti-Ulcer Agents adverse effects, Drug Administration Schedule, Drug Therapy, Combination, Dyspepsia microbiology, Female, Humans, Lansoprazole, Male, Metronidazole adverse effects, Metronidazole therapeutic use, Middle Aged, Omeprazole adverse effects, Omeprazole analogs & derivatives, Omeprazole therapeutic use, Organometallic Compounds adverse effects, Organometallic Compounds therapeutic use, Peptic Ulcer microbiology, Prospective Studies, Tetracycline adverse effects, Tetracycline therapeutic use, Anti-Bacterial Agents therapeutic use, Anti-Ulcer Agents therapeutic use, Dyspepsia drug therapy, Helicobacter Infections drug therapy, Helicobacter pylori isolation & purification, Peptic Ulcer drug therapy
- Abstract
Background: H. pylori eradication usually involves treatment with three or four drugs for at least 7 days. Possible advantages of short treatment regimens are better patient compliance and tolerability. and less adverse effects. Recently two reports have shown a cure rate of > 90% using a 4-day quadruple therapy., Aim: To confirm these data and to evaluate the efficacy and tolerability of 4-day quadruple therapy in a single centre., Methods: Thirty-eight consecutive patients with non-ulcer dyspepsia or peptic ulcer disease, and proven H. pylori infection, received 4 days of quadruple therapy (bismuth, tetracycline, metronidazole, lansoprazole). At least 6 weeks after treatment, endoscopy was repeated with six biopsies of antrum and corpus for histology and culture., Results: The intention-to-treat cure rate was 34/38 (89.5%, 95% CI: 79.7-99.2%). In the per protocol analysis the cure rate was 34/37 (91.9%, 95% CI: 83.1-100%). Primary metronidazole resistance was observed in two patients; both were cured. Metronidazole resistance induction was observed in one patient in whom therapy failed. The treatment was generally well tolerated., Conclusion: Routine use of 4-day quadruple anti-H. pylori treatment is effective and well tolerated.
- Published
- 1997
- Full Text
- View/download PDF
246. Omeprazole plus clarithromycin and either tinidazole or tetracycline for Helicobacter pylori infection: a randomized prospective study.
- Author
-
Zullo A, Rinaldi V, Pugliano F, Diana F, and Attili AF
- Subjects
- Adolescent, Adult, Aged, Anti-Bacterial Agents adverse effects, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Prospective Studies, Tetracycline adverse effects, Tinidazole adverse effects, Anti-Bacterial Agents therapeutic use, Anti-Ulcer Agents therapeutic use, Clarithromycin therapeutic use, Dyspepsia drug therapy, Helicobacter Infections drug therapy, Helicobacter pylori, Omeprazole therapeutic use, Peptic Ulcer drug therapy, Tetracycline therapeutic use, Tinidazole therapeutic use
- Abstract
Objective: Helicobacter pylori has begun to show resistance to imidazoles and could result in the low efficacy of short-term triple therapy. The aim of this study was to assess whether administration of tetracycline instead of tinidazole in short-term low-dose triple therapy could increase the H. pylori eradication rate., Methods: In a prospective study, 113 patients with peptic ulcer (n = 36) or non-ulcer dyspepsia (n = 77) were randomized to receive 1-wk treatment, composed of omeprazole 20 mg b.i.d., clarithromycin 250 mg b.i.d., and either tinidazole 500 mg b.i.d. (n = 57) or tetracycline 500 mg b.i.d. (n = 56), upon detection of H. pylori infection at endoscopy., Results: H. pylori eradication, defined as a negative bacterial finding in a rapid urease test and upon histologic assessment at least 4 wk after cessation of therapy, was achieved in 86% (49 of 57; 95% confidence interval = 76.9-95) of patients in the first group and in 71.4% (40 of 56; 95% confidence interval = 59.6-83.3) in the second group (p = not significant). Side effects occurred in 28% of patients from the tinidazole-based group and in 12.5% from the tetracycline group (p = not significant). Two patients in the tinidazole group discontinued therapy at 5 and 6 days because of side effects., Conclusions: The administration of tetracycline instead of tinidazole in short-term triple therapy yielded disappointing results in H. pylori eradication.
- Published
- 1997
247. Comparative safety of tetracycline, minocycline, and doxycycline.
- Author
-
Shapiro LE, Knowles SR, and Shear NH
- Subjects
- Adolescent, Adult, Adverse Drug Reaction Reporting Systems, Anti-Bacterial Agents metabolism, Arthralgia chemically induced, Canada epidemiology, Databases as Topic, Drug Eruptions etiology, Drug Hypersensitivity etiology, Drug Prescriptions statistics & numerical data, Female, Fever chemically induced, Follow-Up Studies, Humans, Liver drug effects, Liver enzymology, Lupus Erythematosus, Systemic chemically induced, Male, Middle Aged, Minocycline metabolism, Retrospective Studies, Safety, Serum Sickness chemically induced, Syndrome, Time Factors, Anti-Bacterial Agents adverse effects, Doxycycline adverse effects, Minocycline adverse effects, Tetracycline adverse effects
- Abstract
Background: Because minocycline can cause serious adverse events including hypersensitivity syndrome reaction (HSR), serum sicknesslike reaction (SSLR), and drug-induced lupus, a follow-up study based on a retrospective review of our Drug Safety Clinic and the Health Protection Branch databases and a literature review was conducted to determine if similar rare events are associated with tetracycline and doxycycline. Cases of isolated single organ dysfunction (SOD) attributable to the use of these antibiotics also were identified., Observations: Nineteen cases of HSR due to minocycline, 2 due to tetracycline, and 1 due to doxycycline were identified. Eleven cases of SSLR due to minocycline, 3 due to tetracycline, and 2 due to doxycycline were identified. All 33 cases of drug-induced lupus were attributable to minocycline. Forty cases of SOD from minocycline, 37 cases from tetracycline, and 6 from doxycycline were detected. Hypersensitivity syndrome reaction, SSLR, and SOD occur on average within 4 weeks of therapy, whereas minocycline-induced lupus occurs on average 2 years after the initiation of therapy., Conclusions: Early serious events occurring during the course of tetracycline antibiotic treatment include HSR, SSLR, and SOD. Drug-induced lupus, which occurs late in the course of therapy, is reported only with minocycline. We theorize that minocycline metabolism may account for the increased frequency of serious adverse events with this drug.
- Published
- 1997
248. Comparison of polidocanol and tetracycline in the sclerotherapy of testicular hydrocele and epididymal cyst.
- Author
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Daehlin L, Tønder B, and Kapstad L
- Subjects
- Adult, Aged, Aged, 80 and over, Follow-Up Studies, Humans, Male, Middle Aged, Patient Satisfaction, Polidocanol, Polyethylene Glycols adverse effects, Sclerosing Solutions adverse effects, Testicular Hydrocele therapy, Tetracycline adverse effects, Treatment Outcome, Cysts therapy, Polyethylene Glycols therapeutic use, Sclerosing Solutions therapeutic use, Sclerotherapy methods, Testicular Diseases therapy, Tetracycline therapeutic use
- Abstract
Objective: To compare the effects and side-effects of polidocanol and tetracycline when used as sclerosants for testicular hydrocele and epididymal cyst., Patients and Methods: Forty-five men (median age 67 years, range 42-81) with 46 hydroceles or epididymal cysts were assessed. After puncture and aspiration, the empty sac was instilled with either polidocanol or tetracycline, assigned randomly. Patients recorded any treatment-associated pain on a visual analogue scale., Results: At 9 months of follow-up, nine of 17 men were cured after sclerotherapy with polidocanol compared with 17 of 20 men treated with tetracycline (P < 0.05). Tetracycline produced some pain for 3 days after treatment while polidocanol therapy was almost pain-free. Re-instillation should be considered for recurrences. At the follow-up after 35 months, 16 of 18 men treated with polidocanol and 20 of 22 men treated with tetracycline were satisfied with the outcome., Conclusion: Both polidocanol and tetracycline are useful sclerosants for treating testicular hydrocele and epididymal cyst. We prefer polidocanol as a first choice in older patients because there were few short-term side-effects.
- Published
- 1997
- Full Text
- View/download PDF
249. Drug-associated pancreatitis: facts and fiction.
- Author
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Frick T
- Subjects
- Acute Disease, Azathioprine adverse effects, Furosemide adverse effects, Humans, Sulfonamides adverse effects, Tetracycline adverse effects, Pancreatitis chemically induced
- Published
- 1997
- Full Text
- View/download PDF
250. Bleaching tetracycline-stained teeth. A combined approach.
- Author
-
Weinberg SP
- Subjects
- Adult, Dental Impression Technique, Follow-Up Studies, Hot Temperature therapeutic use, Humans, Male, Tooth Bleaching instrumentation, Tooth Discoloration chemically induced, Anti-Bacterial Agents adverse effects, Tetracycline adverse effects, Tooth Bleaching methods, Tooth Discoloration therapy
- Published
- 1997
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