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Omeprazole plus clarithromycin and either tinidazole or tetracycline for Helicobacter pylori infection: a randomized prospective study.
- Source :
-
The American journal of gastroenterology [Am J Gastroenterol] 1997 Nov; Vol. 92 (11), pp. 2029-31. - Publication Year :
- 1997
-
Abstract
- Objective: Helicobacter pylori has begun to show resistance to imidazoles and could result in the low efficacy of short-term triple therapy. The aim of this study was to assess whether administration of tetracycline instead of tinidazole in short-term low-dose triple therapy could increase the H. pylori eradication rate.<br />Methods: In a prospective study, 113 patients with peptic ulcer (n = 36) or non-ulcer dyspepsia (n = 77) were randomized to receive 1-wk treatment, composed of omeprazole 20 mg b.i.d., clarithromycin 250 mg b.i.d., and either tinidazole 500 mg b.i.d. (n = 57) or tetracycline 500 mg b.i.d. (n = 56), upon detection of H. pylori infection at endoscopy.<br />Results: H. pylori eradication, defined as a negative bacterial finding in a rapid urease test and upon histologic assessment at least 4 wk after cessation of therapy, was achieved in 86% (49 of 57; 95% confidence interval = 76.9-95) of patients in the first group and in 71.4% (40 of 56; 95% confidence interval = 59.6-83.3) in the second group (p = not significant). Side effects occurred in 28% of patients from the tinidazole-based group and in 12.5% from the tetracycline group (p = not significant). Two patients in the tinidazole group discontinued therapy at 5 and 6 days because of side effects.<br />Conclusions: The administration of tetracycline instead of tinidazole in short-term triple therapy yielded disappointing results in H. pylori eradication.
- Subjects :
- Adolescent
Adult
Aged
Anti-Bacterial Agents adverse effects
Drug Therapy, Combination
Female
Humans
Male
Middle Aged
Prospective Studies
Tetracycline adverse effects
Tinidazole adverse effects
Anti-Bacterial Agents therapeutic use
Anti-Ulcer Agents therapeutic use
Clarithromycin therapeutic use
Dyspepsia drug therapy
Helicobacter Infections drug therapy
Helicobacter pylori
Omeprazole therapeutic use
Peptic Ulcer drug therapy
Tetracycline therapeutic use
Tinidazole therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9270
- Volume :
- 92
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The American journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 9362185