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Comparative safety of tetracycline, minocycline, and doxycycline.
- Source :
-
Archives of dermatology [Arch Dermatol] 1997 Oct; Vol. 133 (10), pp. 1224-30. - Publication Year :
- 1997
-
Abstract
- Background: Because minocycline can cause serious adverse events including hypersensitivity syndrome reaction (HSR), serum sicknesslike reaction (SSLR), and drug-induced lupus, a follow-up study based on a retrospective review of our Drug Safety Clinic and the Health Protection Branch databases and a literature review was conducted to determine if similar rare events are associated with tetracycline and doxycycline. Cases of isolated single organ dysfunction (SOD) attributable to the use of these antibiotics also were identified.<br />Observations: Nineteen cases of HSR due to minocycline, 2 due to tetracycline, and 1 due to doxycycline were identified. Eleven cases of SSLR due to minocycline, 3 due to tetracycline, and 2 due to doxycycline were identified. All 33 cases of drug-induced lupus were attributable to minocycline. Forty cases of SOD from minocycline, 37 cases from tetracycline, and 6 from doxycycline were detected. Hypersensitivity syndrome reaction, SSLR, and SOD occur on average within 4 weeks of therapy, whereas minocycline-induced lupus occurs on average 2 years after the initiation of therapy.<br />Conclusions: Early serious events occurring during the course of tetracycline antibiotic treatment include HSR, SSLR, and SOD. Drug-induced lupus, which occurs late in the course of therapy, is reported only with minocycline. We theorize that minocycline metabolism may account for the increased frequency of serious adverse events with this drug.
- Subjects :
- Adolescent
Adult
Adverse Drug Reaction Reporting Systems
Anti-Bacterial Agents metabolism
Arthralgia chemically induced
Canada epidemiology
Databases as Topic
Drug Eruptions etiology
Drug Hypersensitivity etiology
Drug Prescriptions statistics & numerical data
Female
Fever chemically induced
Follow-Up Studies
Humans
Liver drug effects
Liver enzymology
Lupus Erythematosus, Systemic chemically induced
Male
Middle Aged
Minocycline metabolism
Retrospective Studies
Safety
Serum Sickness chemically induced
Syndrome
Time Factors
Anti-Bacterial Agents adverse effects
Doxycycline adverse effects
Minocycline adverse effects
Tetracycline adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0003-987X
- Volume :
- 133
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Archives of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 9382560