Back to Search
Start Over
Eradication of Helicobacter pylori infection after ranitidine bismuth citrate, metronidazole and tetracycline for 7 or 10 days.
- Source :
-
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 1999 Mar; Vol. 13 (3), pp. 323-6. - Publication Year :
- 1999
-
Abstract
- Background: We assessed the efficacy, tolerance, and compliance of twice-daily triple therapy for Helicobacter pylori with ranitidine bismuth citrate, metronidazole and tetracycline for 7 or 10 days.<br />Methods: 105 subjects with H. pylori infection documented by the 13C-urea breath test were randomly assigned to a 7 or 10-day course of ranitidine bismuth citrate 400 mg b.d., metronidazole 500 mg b.d. and tetracycline 500 mg b.d. Subjects returned at the end of therapy for assessment of side-effects and pill count. A repeat 13C-urea breath test was obtained 4 or more weeks after completion of therapy and cure of infection was defined as a negative test result.<br />Results: Poor compliance (< 80% of medications) was seen in 2% of subjects randomized to 7 days of therapy and in 10% randomized to 10 days of therapy (P = N.S.). Intention-to-treat eradication rates were 56% for 7-day and 60% for 10-day therapy (P = N.S.). Per protocol eradication rates were 58% for 7-day and 61% for 10-day therapy (P = N.S.). The 10-day intention-to-treat eradication rate for males was 78% and 32% for females (P < 0.01) and per protocol eradication rates were 79% and 31%, respectively (P < 0.01).<br />Conclusions: Despite excellent compliance and tolerance, neither 7 nor 10 days of therapy with twice-daily ranitidine bismuth citrate, metronidazole and tetracycline are adequate as a treatment of H. pylori infection.
- Subjects :
- Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents adverse effects
Anti-Ulcer Agents administration & dosage
Anti-Ulcer Agents adverse effects
Bismuth administration & dosage
Bismuth adverse effects
Breath Tests
Drug Therapy, Combination
Female
Helicobacter Infections microbiology
Helicobacter Infections pathology
Humans
Male
Metronidazole administration & dosage
Metronidazole adverse effects
Middle Aged
Patient Compliance
Ranitidine administration & dosage
Ranitidine adverse effects
Ranitidine therapeutic use
Tetracycline administration & dosage
Tetracycline adverse effects
Urea metabolism
Anti-Bacterial Agents therapeutic use
Anti-Ulcer Agents therapeutic use
Bismuth therapeutic use
Helicobacter Infections drug therapy
Helicobacter pylori drug effects
Metronidazole therapeutic use
Ranitidine analogs & derivatives
Tetracycline therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0269-2813
- Volume :
- 13
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Alimentary pharmacology & therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 10102965
- Full Text :
- https://doi.org/10.1046/j.1365-2036.1999.00485.x