151. Cryptococcal meningitis: A neglected NTD?
- Author
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Nelesh P. Govender, Gregory S. Greene, Cecilia Kanyama, Françoise Dromer, Yacouba Mapoure, Sayoki Mfinanga, Síle F. Molloy, David W. Denning, Sokoine Lesikari, Neil Stone, Olivier Lortholary, Angela Loyse, Thomas S. Harrison, David R. Boulware, Tihana Bicanic, Jeremy N. Day, Victor Sini, Charles Kouanfack, Shabbar Jaffar, Jessica Burry, Elvis Temfack, Joseph N Jarvis, Tom Chiller, Zunt, Joseph Raymond, University of London [London], Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, Médecins Sans Frontières, University of Cape Town, University of North Carolina Project-Malawi (UNC Project), National Institute of Medical Research, CHU de Yaoundé, Hôpital Général de Douala, University of Minnesota [Twin Cities] (UMN), University of Minnesota System, Mycologie moléculaire, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Global action fund for fungal infections [Geneva] (GAFFI), University of Oxford [Oxford], London School of Hygiene and Tropical Medicine (LSHTM), University of Pennsylvania [Philadelphia], University of Botswana, Liverpool School of Tropical Medicine (LSTM), The authors received no specific funding for this work., CryptoMAG members: Centers for Disease Control and Prevention (CDC), Médecins Sans Frontieres (MSF), Clinton Health Access Initiative (CHAI), Management Sciences for Health (MSH), Institut Pasteur, Global Action Fund for Fungal Infections (GAFFI), South Africa’s National Institute for Communicable Diseases (NICD), and academic experts including from the University of Minnesota, University of Oxford, Liverpool School of Tropical Medicine, and St George’s, University of London., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), University of Oxford, and University of Pennsylvania
- Subjects
0301 basic medicine ,RNA viruses ,Antifungal Agents ,Biomedical Research ,[SDV]Life Sciences [q-bio] ,wc_503 ,Drug research and development ,Meningitis, Cryptococcal ,Global Health ,Pathology and Laboratory Medicine ,Pharmacology, Toxicology and Pharmaceutics(all) ,Immunodeficiency Viruses ,Infectious Diseases of the Nervous System ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Medicine and Health Sciences ,Amphotericin ,Neglected tropical diseases ,wa_30 ,Death rates ,Antimicrobials ,Mortality rate ,lcsh:Public aspects of medicine ,Neglected Diseases ,Drugs ,3. Good health ,Viewpoints ,Infectious Diseases ,Neurology ,Medical Microbiology ,Viral Pathogens ,Viruses ,Pathogens ,Cryptococcal meningitis ,medicine.medical_specialty ,lcsh:Arctic medicine. Tropical medicine ,lcsh:RC955-962 ,030106 microbiology ,wc_503_5 ,Mycology ,Microbiology ,wc_245 ,03 medical and health sciences ,Tropical Medicine ,Microbial Control ,Retroviruses ,medicine ,Humans ,Intensive care medicine ,Microbial Pathogens ,Demography ,Pharmacology ,Antifungals ,business.industry ,Lentivirus ,Public Health, Environmental and Occupational Health ,Organisms ,Biology and Life Sciences ,HIV ,lcsh:RA1-1270 ,Tropical Diseases ,Health Care ,Low and middle income countries ,Immunology ,People and Places ,Health Statistics ,Morbidity ,business - Abstract
International audience; Although HIV/AIDS has been anything but neglected over the last decade, opportunistic infections (OIs) are increasingly overlooked as large-scale donors shift their focus from acute care to prevention and earlier antiretroviral treatment (ART) initiation. Of these OIs, cryptococcal meningitis, a deadly invasive fungal infection, continues to affect hundreds of thousands of HIV patients with advanced disease each year and is responsible for an estimated 15%–20% of all AIDS-related deaths [1, 2]. Yet cryptococcal meningitis ranks amongst the most poorly funded “neglected” diseases in the world, receiving 0.2% of available relevant research and development (R&D) funding, according to Policy Cures’ 2016 Global Funding of Innovation for Neglected Diseases (G-Finder) Report [3, 4].
- Published
- 2017