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A study conducted by researchers at the University of Jinan in China explores the impact of parental control on the future planning of rural adolescents. The study found that parental psychological control had a direct negative effect on future planning, but also had a positive influence due to the masking effect of meaning in life. Parental behavioral control, on the other hand, had a direct and positive impact on future planning. The study concludes that the influence of parental control on adolescents' future planning is a complex process that should be considered in educational practices and future research. [Extracted from the article]

A recent study conducted by researchers at Shandong University of Finance and Economics in Jinan, China, explores the factors that influence users' intention and behavior in ridesharing. The study develops a theoretical framework and uses questionnaire responses from 1044 users in China to evaluate the impact of basic and advanced needs on ridesharing. The results show that basic needs have a greater influence on ridesharing intention and behavior, mediated through psychological factors, while advanced needs directly stimulate ridesharing intention and behavior. The study also highlights the variations in the effects of these factors among users with different genders, ages, incomes, and education levels. The findings can contribute to the development of ridesharing intervention strategies and guide policymakers and ride-sourcing platforms at the national level. [Extracted from the article]

A study conducted by researchers at Shandong University in Jinan, China, has developed an intelligent tongue diagnosis model for gastrointestinal diseases based on tongue images. The researchers collected a dataset of tongue coating images from healthy individuals and patients with various gastrointestinal conditions. By utilizing hand-crafted and auto-encoded features, as well as disease detection mechanisms, the model achieved satisfactory performance in diagnosing gastrointestinal diseases, including Helicobacter pylori infection, bile reflux, reflux esophagitis, gastric erosion, and duodenal erosion. The study concludes that tongue diagnosis could be a convenient, cost-effective, and noninvasive method for diagnosing and screening gastrointestinal diseases. [Extracted from the article]

A recent study conducted by the Shandong First Medical University & Shandong Academy of Medical Sciences in Jinan, People's Republic of China, has found that the foodborne bacteria Shigella uses the amino acid leucine to promote its virulence gene expression and invasion of colon epithelial cells. The researchers discovered that Shigella responds to the high levels of leucine in the colon by activating a regulatory mechanism that leads to the expression of a small RNA called SsrV. This RNA then activates the expression of virulence genes, enabling Shigella to invade colon cells. The findings suggest that Shigella uses leucine as an environmental cue to establish colonization and cause disease. [Extracted from the article]

A recent study conducted by researchers at the University of Jinan in China has developed a new fluorescent probe, LD-TCE, for the precise identification of liver cancer. The probe detects carboxylesterase (CE) and lipid droplet polarity in liver cancer cells, allowing for specific imaging with higher contrast and accuracy. The researchers believe that this probe could be a powerful tool for early diagnosis of liver cancer. The study was funded by various organizations, including the National Natural Science Foundation of China. [Extracted from the article]

Researchers at the Shandong Academy of Agricultural Sciences in Jinan, China have conducted a study on the immunomodulatory effects of Lactarius deliciosus, a mushroom known for its taste and texture. The study focused on the polysaccharide extracted from the mushroom and its impact on tumor-bearing mice. The results showed that the polysaccharide had a positive effect on the immune organs of the mice, suppressed tumor growth, and improved intestinal lactobacillus contents. The findings suggest potential applications of Lactarius deliciosus polysaccharide in the food and drug industries. [Extracted from the article]

A report from QILU University of Technology in Jinan, China discusses the efficient removal of non-steroidal anti-inflammatory drugs (NSAIDs) from water systems. The researchers synthesized a magnetic LDH with a three-dimensional hollow structure to remove carprofen and flurbiprofen from water environments. The study found that the adsorption capacity of the synthesized material for the two NSAIDs was high, making it a promising adsorbent for NSAIDs. The research provides valuable insights into the removal of emerging pollutants from aquatic environments. [Extracted from the article]

Researchers at Shandong University in Jinan, China have conducted a study on the impact of miR-137-3p on the pathogenesis of Alzheimer's disease (AD) and developed a novel drug delivery system for its therapeutic potential. The study found that miR-137-3p deficiency is present in both AD cells and animal models. The researchers engineered lipid nanoparticles (LNPs) functionalized with rabies virus glycoprotein to deliver miR-137-3p across the blood-brain barrier and target neurons, resulting in increased miR-137-3p levels in the hippocampus of AD mice. The study suggests that miR-137-3p could be a key factor in AD pathogenesis and a potential avenue for treatment. [Extracted from the article]

A recent study conducted by researchers at Shandong University in Jinan, China, explored the role of autophagy and immunity in Wilms' tumor (WT), a type of malignant tumor. The study aimed to identify differentially expressed immune genes related to autophagy in WT and analyze their correlation with disease prognosis. The researchers found that the plasminogen activator urokinase (PLAU) gene was associated with survival and prognosis in WT patients and could serve as an independent prognostic biomarker. The study also provided insights into the pathways associated with PLAU gene expression, which could be valuable for the development of new therapies for WT. [Extracted from the article]

A recent study conducted at Shandong University in Jinan, China, has explored the use of endoplasmic reticulum (ER)-targeted photosensitizers for photodynamic immunotherapy. The researchers aimed to address the limitations of current agents, such as the slow intersystem crossing process and insufficient production of reactive oxygen species (ROS). By modifying the excited state characteristics of xanthene-based cyanine photosensitizers, the researchers were able to optimize ROS generation and activate the immunogenic cell death pathway. The results showed significant inhibition of both primary and distant tumors, highlighting the potential efficacy of this strategy for developing photodynamic immunotherapy drugs. This research provides a pioneering pathway for the design of such drugs. [Extracted from the article]

A systematic review and meta-analysis conducted by researchers at Shandong University of Traditional Chinese Medicine in Jinan, China, examined the efficacy of acupuncture combined with medication in the treatment of sciatica. The review analyzed relevant literature from various databases and found that acupuncture combined with medication reduced pain and improved the overall effectiveness and cure rate of sciatica treatment. However, the researchers concluded that larger-scale and multi-center randomized controlled trials are needed to confirm these findings. This study provides valuable insights into the potential benefits of acupuncture in managing sciatica. [Extracted from the article]

A recent study conducted by researchers at Shandong University in Jinan, China, has developed a new class of drugs for the treatment of cancer. The study focused on the development of a dual inhibitor that targets two enzymes involved in epigenetic regulation, DNMT1 and HDAC. The compound (R)-23a showed promising results in inhibiting these enzymes and reactivating tumor suppressor genes, leading to significant tumor growth inhibition in mouse models. The researchers believe that (R)-23a has the potential to be further developed as a cancer therapeutic agent. [Extracted from the article]

A recent research study conducted at Shandong University in Jinan, China, has investigated the role of the TNFSF11/TNFRSF11A axis in asthma. The study found that TNFSF11 protein was overexpressed in the airway and serum of asthmatic patients and was closely correlated with lung function. Deficiency of the TNFSF11/TNFRSF11A axis in mice attenuated house dust mite-induced airway remodeling. Blocking TNFSF11 with denosumab was found to alleviate airway remodeling in a mouse model of asthma. The study suggests that targeting the TNFSF11/TNFRSF11A axis may be a potential strategy for treating asthma. [Extracted from the article]

A recent report discusses research conducted at the University of Jinan in China on the use of electroencephalogram (EEG) technology for music intervention therapy in autistic children. The proposed system can identify the emotions of autistic children in real-time and play music tailored to their emotions as a form of treatment. The system uses edge computing devices combined with cloud computing resources to process EEG signals efficiently. The research concludes that the system can provide real-time emotional state feedback to music therapists for evaluation. [Extracted from the article]

A scoping review conducted by researchers at Shandong Xiehe University in Jinan, China, explored the implementation and strategies of triadic communication in pediatric oncology. Triadic communication refers to the communication between the child, parent, and healthcare professional. The review found that healthcare professionals typically initiate triadic communication, but topics such as prognosis, emotions, and end-of-life care are rarely discussed. The roles and responsibilities of each participant in the triad, particularly nurses, were unclear. Factors influencing the implementation of triadic communication were identified, and strategies to facilitate implementation were suggested. The study emphasizes the importance of delineating roles and responsibilities within the triadic communication framework to enhance collaboration and informed decision-making. [Extracted from the article]

A recent study conducted in Jinan, People's Republic of China, explored the use of echocardiography in diagnosing and managing pediatric pulmonary artery sling (PAS). The study analyzed data from 145 patients between January 2017 and December 2023, including echocardiography, CT angiography, bronchoscopy, and surgical records. The results showed that echocardiography accurately diagnosed PAS in 98.62% of cases, with tracheal compression and intracardiac anomalies being common. The study concluded that echocardiography plays a crucial role in the clinical management and surgical planning of these complex conditions. [Extracted from the article]

A recent study conducted by researchers at Shandong University in Jinan, China, examined the hemodynamic behavior of umbrella-shaped inferior vena cava filters (IVCFs) using computational fluid dynamics. The study found that all five IVCFs analyzed exhibited prothrombotic stagnation zones downstream of the filter head, which could potentially lead to life-threatening conditions such as IVC lesions, filter rupture, and displacement. The researchers also observed that alterations in the morphology of the filter wires significantly impacted the flow resistance of the filter and the distribution pattern of wall shear stress on the IVC. This research provides valuable insights into the hemodynamic characteristics of umbrella-shaped IVCFs and highlights the importance of considering these factors in clinical practice. [Extracted from the article]

A study conducted by researchers at the University of Jinan in China has found that a combination of beta-nicotinamide mononucleotide (NMN), Lactobacillus plantarum, and lactulose, known as NMN synbiotics, can have a positive impact on the gut microbiota and metabolism in mice with Alzheimer's disease (AD). The study showed that NMN synbiotics led to a restructuring of the gut microbiota, a reduction in microbial diversity, and a shift towards a more balanced microbial community structure. Additionally, the intervention had a significant impact on the gut metabolome and reduced the formation of amyloid plaques in the brain. These findings suggest that synbiotics could be a potential therapeutic intervention for AD. [Extracted from the article]

A report from Shandong University in Jinan, China, explores the relationship between psychiatric disorders and glioma, a type of brain tumor. The study identifies genetic markers associated with eight psychiatric disorders and uses Mendelian randomization to analyze their impact on glioma risk. The findings suggest that attention deficit hyperactivity disorder (ADHD), schizophrenia (SCZ), and insomnia may be causal factors for glioma. The study also reveals potential biological mechanisms linking these psychiatric disorders to glioma, such as neurotransmitter signaling pathways and immune reactions. However, the researchers caution that the results may not be applicable to other ethnic and geographical groups due to the European data used in the study. [Extracted from the article]

A recent study conducted by the Shandong University of Traditional Chinese Medicine in Jinan, China, aimed to determine the causal relationship between knee osteoarthritis (KOA) and its risk factors. The researchers used a two-sample Mendelian randomization analysis with genetic variants associated with risk factors as instrumental variables. The study found that several modifiable risk factors, such as hypothyroidism, hyperthyroidism, educational level, income level, metabolic syndrome, essential hypertension, height, hot drink temperature, diet, and psychological and psychiatric disorders, were causally associated with KOA. The findings provide new insights for preventing and treating KOA and developing public health policies. [Extracted from the article]

A recent study conducted by researchers from Shandong University in Jinan, China, explores the positive evaluations given by speech therapists to children with hearing impairment during speech-language therapy sessions. The study utilizes conversation analysis to examine the nature and impact of these positive evaluations on the interpretation and learning of the children. The findings highlight the diverse range of formats used by therapists and the delicate nature of these evaluations, emphasizing the importance of clear indexicality and recipient-orientedness. The study aims to enhance the efficiency and effectiveness of rehabilitation practices and shed light on interactions involving individuals with communicative impairments. [Extracted from the article]

A recent study conducted at Qilu Hospital of Shandong University in Jinan, People's Republic of China, aimed to develop a nomogram for predicting sepsis-induced coagulopathy (SIC) in pediatric patients admitted to the pediatric intensive care unit (PICU). The researchers screened 948 sepsis patients and identified several variables associated with the risk of SIC, including age, fibrinogen, prothrombin time, C-reactive protein, lactate, and the pediatric sequential organ failure assessment score. The developed nomogram showed excellent predictive performance for SIC, potentially aiding healthcare professionals in early identification and intervention for this severe complication of sepsis. [Extracted from the article]

A study conducted by researchers at Shandong University in Jinan, China, explores the use of surveillance video analysis for the detection of delirium in an Intensive Care Unit (ICU). The study addresses the challenges of irregular movements and similar movements in delirium and normal situations. The researchers propose a Long-Short-View Aware Multi-Agent Reinforcement Learning (LS-MARL) method that outperforms existing methods. Additionally, a Self-Adjusting Ensemble Learning (SAEL) strategy is developed to improve classification tasks in the LS-MARL method. The study was supported by the National Natural Science Foundation of China and other organizations. [Extracted from the article]

A recent study conducted by researchers at Shandong University of Traditional Chinese Medicine in Jinan, China, has found that the gene CCDC25 may serve as a biomarker for a favorable prognosis in colorectal cancer (CRC) patients. The study utilized gene expression data, GWAS data, and clinical information to investigate the regulatory role of CCDC25 in CRC. The researchers discovered that high CCDC25 expression reduces the risk of CRC and is associated with increased infiltration of immune cells, elevated levels of immune checkpoints, and an enhanced response to anti-PD1 therapy. Additionally, eight genes were identified as prognostic genes for CRC. This research suggests that CCDC25 could potentially be used as a diagnostic and prognostic marker for CRC patients. [Extracted from the article]

A recent report from Shandong University of Traditional Chinese Medicine in Jinan, China discusses the challenges of delivering drugs to the brain due to the blood-brain barrier (BBB). The researchers review various strategies for crossing the BBB, including receptor/transporter-mediated crossing, focused ultrasound, adenosine agonist reversible opening, aromatic resuscitation, transnasal administration, cell-mediated crossing, and viral vector system-mediated delivery. The potential applications, advantages, and disadvantages of these strategies are analyzed, and the researchers conclude that these strategies hold promise for treating brain diseases. This research has been peer-reviewed and provides valuable insights into gene therapy and drug delivery for brain diseases. [Extracted from the article]

A study conducted by researchers at Shandong University in Jinan, People's Republic of China, explored the potential of oleanolic acid, a natural pentacyclic triterpenoid, to alleviate lipid accumulation induced by a high-fat diet. The study involved in vitro experiments and animal assays, which showed that oleanolic acid reduced lipid accumulation in cells and promoted the nuclear translocation of PPAR gamma, a transcription factor involved in lipid metabolism. In vivo experiments also demonstrated that dietary intervention with oleanolic acid improved fat accumulation in liver tissue and reduced the levels of inflammatory markers in the blood. The study suggests that oleanolic acid may have potential in preventing nonalcoholic fatty liver disease. [Extracted from the article]

A recent study conducted at Shandong University in Jinan, China, has developed a sensor-free force estimation method for a notched continuum surgical robot (NCR). The NCR is commonly used in the design of minimally invasive surgical robots but integrating sensors into the robot in a limited surgical environment is challenging. The proposed method establishes an accurate static model of the NCR based on the beam constraint model and introduces cable length changes as constraints into the model, enabling sensor-free force estimation. The research concludes that the proposed method demonstrates a significant improvement compared to models using traditional assumptions. [Extracted from the article]

A study conducted by researchers at Shandong University of Traditional Chinese Medicine in Jinan, China, examined the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on cardiovascular and cerebrovascular diseases. The study found that SGLT2i had significant preventive effects on cardiovascular death, myocardial infarction, heart failure, and all-cause mortality. Empagliflozin, dapagliflozin, and canagliflozin were found to reduce the incidence of heart failure, while only dapagliflozin displayed a favorable effect on inhibiting stroke. SGLT2i was also found to prevent stroke, heart failure, and all-cause mortality compared to DPP-4i. The study concluded that SGLT2i significantly reduced the development of heart failure and cardiovascular death in patients with high-risk factors. [Extracted from the article]

A research report from the First Affiliated Hospital in Jinan, People's Republic of China, discusses the role of oxytocin in stabilizing cardiac mast cells and improving sympathetic innervation in rats after myocardial infarction (heart attack). The study found that oxytocin reduced the number of degranulated cardiac mast cells and attenuated sympathetic hyperinnervation. Oxytocin was shown to stabilize mast cells through the PI3K/Akt signaling pathway. The research suggests that oxytocin may have potential therapeutic benefits in preventing fatal ventricular arrhythmias after a heart attack. [Extracted from the article]

A systematic review conducted by researchers at Shandong University in Jinan, China, evaluated the quality and applicability of clinical practice guidelines for the rehabilitation of knee osteoarthritis (OA). The study analyzed 24 guidelines published between 2008 and 2022 and used the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument for evaluation. The review found that the overall quality of the guidelines was good, but the applicability was slightly poor. The study suggests the need for improvement in factors that promote and hinder guideline application, as well as recommendations, tools, and resources for developing relevant guidelines. [Extracted from the article]

Researchers at the University of Jinan in China have developed a method for precisely manipulating steric hindrance in DNA walkers to detect microRNA-21 (miR-21) with tunable dynamic range and sensitivity. By adjusting the length of empty bases and the volumetric dimensions of the hairpin structure, the researchers achieved a tunable limit of detection for miR-21 ranging from 3.6 aM to 35.6 nM, with successful identification of cancer cells and clinical serum samples. This novel strategy has potential applications in personalized medicine, early disease detection, and drug development. The research has been peer-reviewed and published in Analytical Chemistry. [Extracted from the article]

A study conducted by researchers at Shandong University in Jinan, China, explores the role of epigenetics in regulating gene expression during adolescent brain maturation. The study focuses on the relationship between microglia-mediated chronic neuroinflammation and depression in adolescents. The researchers found that the expression of polycomb group 1 (PCGF1), an important epigenetic regulator, was decreased in both adolescent major depressive disorder patients and in the microglia of adolescent mice with depression. They demonstrated that PCGF1 alleviates neuroinflammation, reduces neuronal damage, and improves depression-like behavior in adolescent mice. The study provides insights into the pathogenesis of adolescent depression and highlights potential links between histone modifications, neuroinflammation, and nerve damage. [Extracted from the article]

A recent report from Shandong University in Jinan, China discusses research findings on adenomas, which are benign polyps that can lead to colorectal cancer. The study focused on the role of the CUL4B gene in adenoma formation and found that its deficiency in the gut epithelium accelerated adenoma growth. The researchers also discovered that CUL4B inhibited the accumulation of tumor-infiltrating myeloid-derived suppressor cells (MDSCs), and inhibiting MDSCs slowed the growth of CUL4B-deleted adenomas. These findings provide new insights into the role of CUL4B in regulating adenomas and suggest a potential therapeutic strategy for colorectal cancer. [Extracted from the article]

A study conducted by researchers at Shandong University in Jinan, China, has found that the protein NONO plays a role in vascular calcification, a process associated with conditions such as atherosclerosis, chronic kidney disease, and diabetes. The researchers observed that NONO expression was decreased in calcified arteries of mice and patients with chronic kidney disease. They also found that NONO deficiency exacerbated vascular calcification in mice, while NONO overexpression had a protective effect. The study suggests that NONO may be a promising target for the prevention and treatment of vascular calcification. [Extracted from the article]

A scoping review conducted by researchers at Shandong University of Traditional Chinese Medicine in Jinan, China, aimed to summarize the current evidence and provide recommendations for future research on acupuncture for patients after percutaneous coronary intervention (PCI). The review included 38 eligible studies, primarily from China and published in 2023. The studies focused on the application of acupuncture in patients post-PCI, with psychological issues and cardiovascular problems being the main areas of concern. The review highlighted the need for more rigorous research with standardized methodologies and larger sample sizes to better understand the role of acupuncture in post-PCI care. [Extracted from the article]

A recent study conducted by Shandong University in China explored the relationship between solid cooking fuel use and psychological distress among older adults in rural Shandong. The study found that solid cooking fuel use was significantly associated with psychological distress, and sleep quality mediated this association. The findings suggest that interventions should focus on addressing cooking fuel types and poor sleep quality to reduce psychological distress in this population. The researchers also emphasized the need for aggressive environmental protection policies to mitigate the adverse effects of indoor air pollution on the health of older adults in rural China. [Extracted from the article]

A study conducted by researchers at Shandong University in Jinan, China, has explored the use of nanohydrogels in stem cell transplantation for intervertebral disc degeneration (IDD) repair. The researchers developed an injectable manganese oxide (MnOx)-functionalized thermosensitive nanohydrogel that protects bone marrow-derived mesenchymal stem cells (BMSCs) from damage caused by shear force, mechanical stress, and the reactive oxygen species (ROS)-rich microenvironment in degenerative intervertebral discs. The nanohydrogel not only increases the viability of BMSCs and resident nucleus pulposus cells (NPCs), but also delays IDD progression. This research provides a promising stem cell delivery platform for the treatment of IDD. [Extracted from the article]

A recent study conducted at the Shandong Cancer Hospital and Institute in Jinan, China, has developed a novel therapy for endometriosis. The researchers created a hydrogel nanostructure that can be activated by near-infrared light, which combines photothermal therapy, ferroptosis, and immune therapy to treat endometriosis. The hydrogel releases calcium ascorbate and ultrathin ferrous sulfide nanosheets, which have high photothermal conversion efficiency and can inhibit the proliferation of endometrial cells. The therapy also induces immunogenic cell death and enhances subsequent immunotherapy. The researchers believe that this therapy has significant potential for clinical application. [Extracted from the article]

A recent study conducted by researchers at QILU University of Technology in Jinan, China, investigated the hepatoxic effects of borneol using zebrafish. Borneol is commonly used in food and cosmetics without much safety evaluation. The study found that high doses of borneol caused liver size decrease or lateral lobe absence in zebrafish. It also disrupted hepatic protein metabolism and lipid metabolism, leading to lipid accumulation and hepatic injury. The study provides a better understanding of borneol hepatoxicity and can contribute to the safe use of this compound. [Extracted from the article]

A study conducted at Qilu Hospital of Shandong University in Jinan, People's Republic of China, investigated the levels of leptin and adiponectin and their associations with allergic sensitization in pediatric adenotonsillar hypertrophy (ATH). The study found that serum levels of leptin and the leptin/adiponectin (L/A) ratio were significantly increased in children with ATH. Leptin was associated with an increased risk of atopy to certain allergens, while adiponectin was associated with a decreased risk. The researchers concluded that further mechanistic studies are needed to understand the involvement of adipokines in allergic sensitization in pediatric ATH. [Extracted from the article]

A study conducted by researchers at Shandong University in Jinan, China explores the relationship between peer bullying and internet addiction among Chinese adolescents. The study found that peer bullying directly predicts internet addiction, and loneliness plays a mediating role in this relationship. Additionally, physical activity was found to moderate the effects of peer bullying and loneliness on internet addiction. The study provides theoretical references for mitigating adolescent internet addiction. [Extracted from the article]

A recent study conducted by researchers at Shandong University in Jinan, People's Republic of China, explores the formation of alliances and conflicts in social networks. The study examines a network formation game in which players form alliances and engage in bullying attacks. The researchers found that the frequency of peaceful and bullying outcomes increases with the cost of attack. The study provides insights into social dynamics and group coordination. The research has been peer-reviewed and published in Games and Economic Behavior. [Extracted from the article]

A recent study conducted by the University of Jinan in China explores the relationship between parental psychological control and internet gaming disorder tendency (IGDT) among junior high school students. The study found that parental psychological control was positively related to IGDT, while core self-evaluation and intentional self-regulation were negatively related to IGDT. Core self-evaluation was found to partially mediate the relationship between parental psychological control and IGDT. The study suggests the need to weaken parental psychological control, strengthen core self-evaluation and intentional self-regulation, and recognize the important role of parents and their children's positive traits in the healthy development of junior high school students. [Extracted from the article]