Search

Researchers at the Chinese Academy of Sciences have developed a novel multifunctional textile fabric by coating polyethylene terephthalate (PET) with cobalt ferrite nanoparticle/graphene oxide (CoFe2O4/GO). This coated fabric exhibited excellent catalytic and antibacterial properties, with high catalytic performance, stability, and reusability in degradation reactions. The study highlights the potential applications of this textile-based catalyst in medicine, heterogeneous catalysis, and wastewater treatment. The findings provide valuable insights into the development of advanced nanomaterials for efficient contaminant treatment. [Extracted from the article]

Researchers at Xinjiang Medical University have reported that the protein CELSR1 plays a significant role in enhancing resistance to the chemotherapy drug doxorubicin in breast cancer cells by activating the Wnt/Planar Cell Polarity signaling pathway. The study found that silencing CELSR1 reduced the proliferation and motility of breast cancer cells and increased their sensitivity to doxorubicin treatment. This research sheds light on potential new therapeutic strategies to overcome drug resistance in breast cancer. [Extracted from the article]

A recent study from Xinjiang University in Urumqi, People's Republic of China, explored the impact of the KLF15-Cyp3a11 axis on rifampicin-induced liver injury. Rifampicin is known for its antibacterial effects in treating pulmonary tuberculosis but can cause severe liver damage. The research found that manipulating the KLF15-Cyp3a11 axis could potentially mitigate the hepatotoxicity of rifampicin, offering a novel regulatory pathway for detoxification and reducing associated liver injury. This study was supported by various funding sources and has been peer-reviewed, providing valuable insights into antibiotic therapy and liver health. [Extracted from the article]

Researchers at Xinjiang University in Urumqi, People's Republic of China, have developed an efficient numerical simulation model for dendritic crystal growth with melt convection in complex domains. The study addresses challenges such as complex boundaries, high computational costs, and nonlinear equations. The research findings demonstrate that melt convection can promote dendritic crystal growth under certain conditions, impacting the growth pattern. This peer-reviewed study provides valuable insights into mathematical modeling in crystal growth and its applications in academic and industrial settings. [Extracted from the article]

A recent study conducted in Urumqi, People's Republic of China, focused on isolating a protein from red deer abomasum, known as RDA4-1, which showed potential as a hyaluronidase inhibitor. The research found that RDA4-1 exhibited antioxidant properties and effectively inhibited hyaluronidase activity. These findings suggest that RDA4-1 could be utilized as a nutraceutical in the development of health products. The study was supported by financial backers and conducted by researchers from the Chinese Academy of Sciences. [Extracted from the article]

A recent study conducted at Xinjiang Medical University in Urumqi, People's Republic of China, focused on optimizing the cut-off value of phenylalanine (Phe) for phenylketonuria (PKU) screening in newborns based on the time of blood sampling. The study involved over 110,000 neonates born in Xinjiang Uygur Autonomous Region between 2017 and 2019 and found that optimizing the cut-off value based on sampling time is feasible and may reduce false positive rates. The research was supported by the State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Fund and has been peer-reviewed. [Extracted from the article]

A report from Xinjiang Medical University in Urumqi, People's Republic of China, analyzes the global burden of lower respiratory tract infections (LRIs) attributed to non-optimal temperatures from 1990 to 2019. The study reveals a significant downward trend in the burden of deaths and disability-adjusted life years (DALYs) globally, with variations across regions and populations. Efforts to reduce the burden of LRIs, especially in infants, young children, and older adults, are recommended through sustained public health policies and interventions. [Extracted from the article]

Researchers at Xinjiang University in Urumqi, People's Republic of China, have identified a new splicing variant of the MYBL2 gene, named MYBL2c, which plays a crucial role in cell growth, differentiation, and survival. This variant is expressed in both undifferentiated human embryonic stem cells and neural stem cells, suggesting its importance in maintaining stem cell pluripotency. The study was supported by the National Natural Science Foundation of China and published in the Indian Journal of Biochemistry & Biophysics. [Extracted from the article]

A study conducted at Xinjiang Medical University in Urumqi, People's Republic of China, focused on the concentrations of synovial vancomycin and meropenem in patients undergoing single-stage revision combined with intra-articular infusion for periprosthetic joint infection (PJI). The study included 14 patients with PJI, showing peak concentrations of vancomycin and meropenem in the joint cavity at one hour post-injection. The research highlighted the effectiveness of intra-articular antibiotic infusion in delivering sustained high antibiotic concentrations within the joint space, with no significant adverse events observed. Further validation through larger studies is recommended to enhance clinical treatment strategies. [Extracted from the article]

Researchers at Xinjiang University in Urumqi, China, have developed a Cross Branch Co-attention Network model that combines Raman and FTIR spectroscopy for the diagnosis of multiple cancers. This innovative approach utilizes vibrational spectroscopy to analyze molecular structural information and achieve accurate cancer diagnosis. The research findings demonstrate that the proposed model outperforms traditional deep learning algorithms, providing a new method for rapid and non-invasive cancer identification. The study was supported by the Xinjiang Uygur Autonomous Region Youth Science Foundation Project and has been peer-reviewed for accuracy and reliability. [Extracted from the article]

Researchers at Xinjiang University have developed a non-local delayed reaction-diffusion model to analyze the transmission dynamics of Avian Influenza (Bird Flu) with vaccination and multiple transmission routes in a spatially heterogeneous environment. The study calculated the basic reproduction number (R-0) of the model and established the global dynamics based on R-0, showing that controlling the movement of infected poultry, prolonging the incubation period, and regular disinfection can effectively prevent Avian Influenza outbreaks. The research was supported by the National Natural Science Foundation of China and has been peer-reviewed, providing valuable insights into disease prevention strategies. [Extracted from the article]

A study conducted by Xinjiang Agricultural University in Urumqi, China, examined the impact of polyethylene microplastics (PE-MPs) on potato growth and development, as well as on the interactions between Colorado potato beetles and their predators. The research found that the presence of PE-MPs in the soil negatively affected potato plants, reduced potato yield, and impacted the survival rates of the beetles and their predators. These findings highlight the potential risks of microplastics on terrestrial food chains and ecosystems. The study was funded by various organizations in China and has been peer-reviewed for accuracy. [Extracted from the article]

A study conducted in Urumqi, People's Republic of China, focused on the efficacy of noninvasive ventilator treatment for patients with severe chronic obstructive pulmonary disease (COPD) and type II respiratory failure. The research found that patients who received noninvasive ventilator intervention showed significant improvements in lung function, arterial blood gas levels, and inflammatory markers compared to those who received standard treatments. The study suggests that noninvasive ventilator treatment may have broader clinical applications for patients with COPD and respiratory failure. [Extracted from the article]

Researchers at the Chinese Academy of Sciences in Urumqi, People's Republic of China, have conducted a critical review on the efficiency of engineered/modified biochars-based adsorbents for removing pollutants from aquatic environments. The study highlights the potential of biochar as a globally applicable adsorbent due to its physio-chemical surface properties and diverse functional groups. The research emphasizes the importance of modification technologies such as alkaliacid treatment and metal loading to enhance the removal of pollutants from water systems. The study also addresses existing challenges and future research directions in the remediation of pollutants using modified biochars. [Extracted from the article]

A study conducted by researchers at Xinjiang University in Urumqi, China, examined the mechanical properties of cortical bone using nanoindentation. The study found that the elastic modulus and hardness of cortical bone varied significantly across different anatomical regions and bearing surfaces. The anterior and medial sides had significantly greater elastic modulus and hardness compared to the posterior and lateral sides. Additionally, the elastic modulus was higher in the axial direction compared to the radial direction, and there was a positive correlation between elastic modulus and hardness. The study concluded that the stresses in the axial direction of cortical bone exceeded those in the radial direction. This research provides new insights into the mechanical behavior of cortical bone and was supported by the National Natural Science Foundation of China. [Extracted from the article]

A recent study conducted at Xinjiang Medical University in Urumqi, People's Republic of China, explored the application of deep learning radiomics in oral squamous cell carcinoma (OSCC). The researchers conducted a systematic review and meta-analysis of scientific literature from 2012 to 2023, analyzing 26 studies involving 64,731 medical images. The results showed that deep learning radiomics combined with learning algorithms can be effective in diagnosing OSCC, assessing efficacy, and predicting prognosis. The study also discussed the limitations of deep learning radiomics and its future development in medical imaging diagnosis. [Extracted from the article]

A recent study conducted by the Chinese Academy of Sciences in Urumqi, People's Republic of China, focused on the isolation and analysis of guaianolide sesquiterpene lactones from Cichorium glandulosum Boiss et Huet. The researchers identified eight previously unknown lactones, along with twelve known ones. The structures of these compounds were determined using various analytical techniques. Four of the compounds exhibited strong anti-neuroinflammation activity. The study also explored the mechanism by which one of the compounds inhibited neuroinflammation. This research provides valuable insights into the potential therapeutic applications of these compounds. [Extracted from the article]

Researchers at Xinjiang University in Urumqi, China have developed a new network called ALKU-Net that improves the accuracy of lung nodule segmentation in computed tomography (CT) images. The network utilizes adaptive large kernel attention (ALK) blocks to extract multi-scale features from lung nodules of varying sizes. Through extensive experiments, the researchers found that ALKU-Net outperformed other state-of-the-art models in lung nodule segmentation. This research has important implications for the early screening and diagnosis of lung cancer. [Extracted from the article]

Researchers at Xinjiang University in Urumqi, People's Republic of China, have conducted a study on the dynamics of disease transmission in a space heterogeneous environment. They developed an SVEQIRV model with degenerate diffusion to analyze the impact of vaccination, quarantine, and spatial heterogeneity on disease dynamics. The study found that the disease-free equilibrium is globally asymptotically stable when the principal eigenvalue of the linearized system is less than zero, and the system is uniformly persistent when the eigenvalue is greater than zero. Numerical simulations and sensitivity analysis were conducted to visualize the theoretical results and the effect of vaccination rate on disease dynamics. This research has been peer-reviewed and published in the Journal of Applied Analysis & Computation. [Extracted from the article]

Researchers from Xinjiang Medical University in Urumqi, People's Republic of China, have conducted a study on the anticancer potential of oleanolic acid conjugated chitosan nanocomplex (OAC) in lung cancer. The study found that OAC inhibited lung cancer cell viability, migration, and invasion, and induced apoptosis and autophagy. The activation of the signal transducers and activators of transcription 3 (STAT3) was weakened after OAC treatment, suggesting that OAC is a promising compound for lung cancer therapy. The research has been peer-reviewed and published in the Journal of Physiology and Pharmacology. [Extracted from the article]

A recent study conducted by researchers at Xinjiang Medical University in Urumqi, China, explored the relationship between vimentin and PD-L1 in esophageal squamous cell carcinoma (ESCC). The study found that vimentin, a marker of epithelial-mesenchymal transition (EMT), is inversely correlated with CD8+ T-cell infiltration and promotes nuclear translocation of PD-L1 in ESCC. The researchers also identified several cytokines modulated by vimentin, including SEMA6C, STC-2, and TRAILR2. These findings suggest that targeting vimentin could be a potential strategy to overcome immune evasion in ESCC. [Extracted from the article]

A study conducted by researchers at Xinjiang University in Urumqi, People's Republic of China, explored the use of different charged hydrocolloids in stabilizing fermented tomato juice (FTJ). The study found that pullulan polysaccharide (PUL) exhibited better storage stability compared to soluble soybean polysaccharide (SSPS) and chitosan (CS) when used individually. Additionally, the combination of hydrocolloids had a greater impact on the storage stability of FTJ, with the best results achieved when 0.15% SSPS, 0.03% PUL, and 0.15% CS were added. The research lays the groundwork for the development of stable fruit juice beverages. [Extracted from the article]

Researchers at Xinjiang University in Urumqi, People's Republic of China, have conducted a study on the synthesis and properties of nanocomposites. The researchers used a surface modification technique to create Hec-g@PS, which was then added to poly(lactic acid) (PLA) to create PLA/Hec-g@PS nanocomposite films. The study found that Hec-g@PS improved the thermal stability of PLA and promoted the alignment of PLA molecular chains, leading to enhanced crystallization and reduced thermal degradation. The researchers suggest that these findings have potential applications in biomedicine and packaging. The study was supported by the National Natural Science Foundation of China. [Extracted from the article]

A study conducted by researchers at Xinjiang Medical University in Urumqi, China, has developed a simple and accurate method for detecting Mycoplasma pneumoniae (MP), a major cause of respiratory infections in children and adolescents. The method combines loop-mediated isothermal amplification (LAMP) with the CRISPR/Cas12b assay, allowing for quick and reliable MP diagnosis. The study found that the LAMP-CRISPR/Cas12b method had a sensitivity of 88.11% and a specificity of 100% when compared to the gold standard results from real-time PCR. The researchers concluded that this method is a valuable tool for MP diagnosis, particularly in resource-limited regions. [Extracted from the article]

A recent bibliometric analysis conducted by researchers from People's Hospital in Urumqi, China, provides insights into the trends, key contributors, and research hotspots in the field of Normal Pressure Hydrocephalus (NPH). The analysis, which examined data from 2003 to 2023, revealed a steady increase in publications on NPH, with the United States being the largest contributor. The study identified pathophysiology, precise diagnosis, and individualized treatment as the primary research directions, while recent hotspots focused on epidemiology, the glymphatic system, and cerebrospinal fluid biomarkers. The findings of this analysis serve as a valuable reference for further research on NPH. [Extracted from the article]

A recent study conducted by researchers from the Chinese Academy of Sciences has discovered new compounds with potential anti-vitiligo and cytotoxic activities. The study focused on sesquiterpene coumarins found in the roots of Ferula samarkandica Korovin, a plant native to Uzbekistan. The researchers isolated two previously unknown compounds and eight known analogues, and determined their structures through comprehensive spectroscopic analysis. These compounds demonstrated anti-vitiligo and cytotoxic effects, with some showing more potent effects than the positive control. The study provides valuable insights into potential treatments for vitiligo and highlights the medicinal properties of natural compounds. [Extracted from the article]

A study conducted by Xinjiang Medical University in Urumqi, People's Republic of China, examined the clinical efficiency of anatomical hepatectomy in the treatment of hepatic cystic echinococcosis (CE). The study analyzed the data of 74 patients who underwent anatomical hepatectomy and were classified into different groups based on the severity of the disease. The results showed that anatomical hepatectomy was an effective and feasible surgical procedure for patients with severe invasion of intrahepatic biliary ducts and vessels or those with large lesions occupying one hepatic lobe. The study also found that the procedure helped avoid complications related to residual cavities. [Extracted from the article]

A recent study conducted by researchers at Xinjiang Medical University in Urumqi, China, explored the role of M2-like tumor-associated macrophages (M2-TAM) and long intergenic noncoding RNA 00161 (LINC00161) in the progression of hepatocellular carcinoma (HCC), a type of liver cancer. The study found that M2-TAM stimulated the transcription and expression of LINC00161 in HCC cells, which in turn suppressed the expression of HACE1, a gene involved in tumor suppression. The researchers also observed a binding relationship between LINC00161 and EZH2, a protein that promotes gene methylation. The study highlights the significant involvement of LINC00161 in the development and progression of HCC. [Extracted from the article]

A study conducted at Xinjiang University in Urumqi, People's Republic of China, has explored the use of nanoparticle-based delivery systems to overcome challenges in the clinical application of messenger RNA (mRNA) therapy for cancer treatment. mRNA therapy has shown promise in treating various diseases, including cancer, infectious diseases, and genetic disorders, due to its ability to regulate targeted cells and activate immune cells. However, the instability of RNA, physiological barriers, and immunogenic hurdles have hindered its clinical application. The study provides an overview of the current status, advantages, limitations, delivery strategies, and applications of mRNA therapy, offering insights into the prospects and challenges of mRNA technologies. [Extracted from the article]

A study conducted by researchers at the College of Ecology and Environment in Urumqi, People's Republic of China, has developed a photocatalytic method for the rapid reduction of Cr(VI) pollution in water. The method involves modifying TiO2 with carbon dots (CPC-CDs) that possess a quaternary ammonium structure. The CPC-CDs/TiO2 exhibited excellent reduction performance, achieving more than 95% reduction efficiency over a wide pH range and various concentrations of Cr(VI). The research aims to provide technical support for the rapid reduction of Cr(VI) in high concentration, neutral and alkaline environments, and under natural sunlight. [Extracted from the article]

Researchers at Xinjiang University in Urumqi, China have developed a new method for disease prediction by combining chaos theory with FTIR spectra, a technique based on infrared spectroscopy. The study used datasets from various diseases, including glioma, non-small cell lung cancer, and systemic lupus erythematosus, and found that the proposed model achieved improved accuracy, precision, sensitivity, specificity, F1 score, and area under the ROC curve compared to traditional methods. This research marks the first demonstration of chaotic characteristics in FTIR spectra and paves the way for further exploration in this interdisciplinary field. The study has been peer-reviewed and published in Applied Soft Computing. [Extracted from the article]

The article reports on a study from Xinjiang Medical University evaluating the effectiveness of combining transabdominal and transvaginal ultrasonography for diagnosing gynecological acute abdomen. Topics discussed include the comparative effectiveness of combined versus single ultrasound methods, higher disease detection rates and patient satisfaction with the combined approach, and the recommendation of this method for clinical use due to its superior diagnostic performance.

The article highlights research from the Chinese Academy of Sciences on how total flavonoid extract from Dracocephalum moldavica L. (TFDM) alleviates pulmonary fibrosis by reducing inflammation and inhibiting the Hedgehog signaling pathway. It demonstrates that TFDM improves lung function and decreases fibrosis and inflammation in a mouse model of bleomycin-induced pulmonary fibrosis.

A recent study conducted by researchers at the Chinese Academy of Sciences in Urumqi, People's Republic of China, focused on the isolation, purification, and biological aspects of food protein-derived zinc-binding peptides. The study aimed to develop effective mineral supplements and explore the potential of zinc-peptide complexes as drug candidates against various diseases. The researchers reviewed recent advances in isolating and identifying zinc-binding peptides from food sources, preparing protein hydrolysate-zinc complexes, and studying their biological activities. The study also discussed the structural features of peptides that affect their zinc-binding property. This research provides valuable insights into the potential benefits of zinc supplementation and the development of zinc-peptide complexes. [Extracted from the article]

A study conducted by researchers at Xinjiang Medical University in Urumqi, People's Republic of China, has found that calycosin, a compound with anti-cancer properties, can inhibit the proliferation, migration, and invasion of pancreatic cancer cells. The researchers conducted experiments on SW1990 cells and found that calycosin treatment led to a decrease in cell proliferation, migration, and invasion, as well as a decrease in the expression of circ_0000285 and N-cadherin, and an increase in the expression of E-cadherin. The study suggests that calycosin may be effective in blocking the development of pancreatic cancer cells by down-regulating circ_0000285. This research has been peer-reviewed and published in the Indian Journal of Pharmaceutical Sciences. [Extracted from the article]

A study conducted at Xinjiang Medical University in Urumqi, China compared the clinical outcomes of using Mineral Trioxide Aggregate (MTA) and Bioceramic Materials in pulpotomy procedures for early-stage chronic pulpitis in deciduous teeth. The study included 100 children and found that the group treated with TheraCal LC, a bioceramic material, had a significantly higher success rate, lower inflammatory markers, lower pain scores, and higher comfort and satisfaction scores compared to the group treated with MTA. The researchers concluded that TheraCal LC is an effective therapeutic option for treating early chronic pulpitis in deciduous teeth. The study has been peer-reviewed and published in the Journal of Clinical Pediatric Dentistry. [Extracted from the article]