51. Stachybotrydial selectively enhances fibrin binding and activation of Glu-plasminogen.
- Author
-
Sasaoka M, Wada Y, and Hasumi K
- Subjects
- Benzofurans isolation & purification, Biotransformation drug effects, Fibrin drug effects, Fibrinolysin metabolism, Fibrinolytic Agents pharmacology, Humans, Molecular Conformation, Peptide Fragments metabolism, Plasminogen Activators isolation & purification, Protein Binding drug effects, Spiro Compounds isolation & purification, Stachybotrys chemistry, Stachybotrys metabolism, Tissue Plasminogen Activator metabolism, Urokinase-Type Plasminogen Activator metabolism, Benzofurans pharmacology, Fibrin metabolism, Plasminogen metabolism, Plasminogen Activators pharmacology, Spiro Compounds pharmacology
- Abstract
Stachybotrydial, a triprenyl phenol metabolite from a fungus, has a plasminogen modulator activity selective to Glu-plasminogen. Stachybotrydial enhanced fibrin binding and activation of Glu-plasminogen (2- to 4-fold enhancement at 60-120 microM) but not of Lys-plasminogen. Approximately 1.2-1.6 moles of [3H]stachybotrydial bound to Glu-plasminogen to exert such effects. The selective modulation of the Glu-plasminogen function by stachybotrydial may be related to alteration of its conformational status.
- Published
- 2007
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