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Bisabosquals, novel squalene synthase inhibitors. II. Physico-chemical properties and structure elucidation.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2001 Nov; Vol. 54 (11), pp. 896-903. - Publication Year :
- 2001
-
Abstract
- The squalene synthase inhibitor bisabosqual A was isolated from the culture broth of Stachybotrys sp. RF-7260, and its structure was determined on the basis of spectroscopic methods including detailed 2D NMR analyses. The structures of bisabosquals B, C and D isolated from Stachybotrys ruwenzoriensis RF-6853 were determined by spectroscopic methods and chemical reactions. The absolute stereochemistry of bisabosquals A, B and D was determined by X-ray crystallographic analysis. They have novel cis-fused tetracyclic structures with a bisabolane-type sesquiterpene and phenol moieties.
- Subjects :
- Crystallography, X-Ray
Gas Chromatography-Mass Spectrometry
Magnetic Resonance Spectroscopy
Molecular Weight
Optical Rotation
Pyrans pharmacology
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Stereoisomerism
Enzyme Inhibitors chemistry
Farnesyl-Diphosphate Farnesyltransferase antagonists & inhibitors
Pyrans isolation & purification
Stachybotrys chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8820
- Volume :
- 54
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 11827031
- Full Text :
- https://doi.org/10.7164/antibiotics.54.896