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A new strategy toward the total synthesis of stachyflin, a potent anti-influenza A virus agent: concise route to the tetracyclic core structure.
- Source :
-
Organic letters [Org Lett] 2002 Dec 12; Vol. 4 (25), pp. 4483-6. - Publication Year :
- 2002
-
Abstract
- [reaction: see text] A new strategy directed toward the total synthesis of stachyflin, a potent and novel anti-influenza A virus agent isolated from a microorganism, has been presented through the enantioselective synthesis of the tetracyclic core structure. The synthetic method features a BF(3) x Et(2)O-induced domino epoxide-opening/rearrangement/cyclization reaction as the key step.
Details
- Language :
- English
- ISSN :
- 1523-7060
- Volume :
- 4
- Issue :
- 25
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 12465918
- Full Text :
- https://doi.org/10.1021/ol0271032