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52. Immune regulation and therapeutic application of T regulatory cells in liver diseases

Author

Ananya Ajith, Makram Merimi, Mandana Kazem Arki, Nikoo Hossein-khannazer, Mehdi Najar, Massoud Vosough, Etienne Marc Sokal, and Mustapha Najimi

Subjects
T regulatory cells, foxp3, hepatic microenvironment, liver fibrosis, liver cirrhosis, HCC, Immunologic diseases. Allergy, RC581-607
Abstract

CD4+ CD25+ FOXP3+ T regulatory cells (Tregs) are a subset of the immunomodulatory cell population that can inhibit both innate and adaptive immunity by various regulatory mechanisms. In hepatic microenvironment, proliferation, plasticity, migration, and function of Tregs are interrelated to the remaining immune cells and their secreted cytokines and chemokines. In normal conditions, Tregs protect the liver from inflammatory and auto-immune responses, while disruption of this crosstalk between Tregs and other immune cells may result in the progression of chronic liver diseases and the development of hepatic malignancy. In this review, we analyze the deviance of this protective nature of Tregs in response to chronic inflammation and its involvement in inducing liver fibrosis, cirrhosis, and hepatocellular carcinoma. We will also provide a detailed emphasis on the relevance of Tregs as an effective immunotherapeutic option for autoimmune diseases, liver transplantation, and chronic liver diseases including liver cancer.

Published
2024
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53. Total positivity of some polynomial matrices that enumerate labeled trees and forests, I. Forests of rooted labeled trees

Author

Sokal, Alan D.

Subjects
Mathematics - Combinatorics, Mathematics - Classical Analysis and ODEs, 05A15 (Primary), 05A19, 05A20, 05C05, 05C30, 15B05, 15B36, 15B48, 30E05, 44A60 (Secondary)
Abstract

We consider the lower-triangular matrix of generating polynomials that enumerate $k$-component forests of rooted trees on the vertex set $[n]$ according to the number of improper edges (generalizations of the Ramanujan polynomials). We show that this matrix is coefficientwise totally positive and that the sequence of its row-generating polynomials is coefficientwise Hankel-totally positive. More generally, we define the generic rooted-forest polynomials by introducing also a weight $m! \, \phi_m$ for each vertex with $m$ proper children. We show that if the weight sequence $\phi$ is Toeplitz-totally positive, then the two foregoing total-positivity results continue to hold. Our proofs use production matrices and exponential Riordan arrays., Comment: LaTex2e, 65 pages. arXiv admin note: text overlap with arXiv:1907.02645. Version 2 makes some minor changes. To be published in Monatshefte f\"ur Mathematik

Published
2021
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54. Multiple Laguerre polynomials: Combinatorial model and Stieltjes moment representation

Author

Sokal, Alan D.

Subjects
Mathematics - Classical Analysis and ODEs, Mathematics - Combinatorics, 33C45 (Primary), 05A15, 05A19, 30E05, 42C05 (Secondary)
Abstract

I give a combinatorial interpretation of the multiple Laguerre polynomials of the first kind of type II, generalizing the digraph model found by Foata and Strehl for the ordinary Laguerre polynomials. I also give an explicit integral representation for these polynomials, which shows that they form a multidimensional Stieltjes moment sequence whenever $x \le 0$., Comment: LaTeX2e, 11 pages. Version 2 fixes Remark 2 on page 5. To be published in Proceedings of the AMS

Published
2021
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57. Polish household default risk and physical risk of climate change

Author

Kurowski Łukasz and Sokal Katarzyna

Subjects
physical risk, credit risk, household debt, extreme weather, g21, g28, Finance, HG1-9999
Abstract

This paper aims to assess the level of credit risk (from the perspective of default risk) among Polish households associated with the physical risks of climate change. In order to determine the potential impact of the physical risk of climate change on household credit risk, we conducted CAWI interviews with 1,006 borrowers residing in different Polish voivodeships (to account for heterogeneity of credit exposures to extreme weather events). According to these respondents, wildfires and storms in Poland are the greatest source of physical risk of climate change. In the event of a wildfire or storm, approximately 13% of borrowers would not be able to repay their loans while not being insured, which potentially increases banks’ credit risk and exposes banks to losses. However, we find that households underestimate the credit risk that could arise from a drought.

Published
2023
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58. Deoxyguanosine kinase deficiency and recurrent spontaneous pneumothorax: a case report

Author

Alice Ramboux, Alain Poncelet, Philippe Clapuyt, Isabelle Scheers, Etienne Sokal, Raymond Reding, and Xavier Stephenne

Subjects
Deoxyguanosine kinase deficiency, Mitochondrial DNA depletion syndrome, Mitochondriopathy, Amyotrophy, Recurrent spontaneous pneumothorax, Case report, Medicine
Abstract

Abstract Background Deoxyguanosine kinase deficiency is mainly manifested by hepatic and neurological damage, hence it belongs to the hepatocerebral form of mitochondrial deoxyribonucleic acid depletion syndrome. The association between deoxyguanosine kinase deficiency and recurrent spontaneous pneumothorax has not currently been reported. Case presentation A 12-year-old Russian boy with deoxyguanosine kinase deficiency, a recipient of a liver transplant with amyotrophy secondary to his mitochondriopathy, presented with recurrent spontaneous bilateral pneumothorax refractory to drainage and surgery. Conclusion To our knowledge, this is the first documented case of deoxyguanosine kinase deficiency associated with recurrent spontaneous pneumothorax, which could be considered a late complication of deoxyguanosine kinase deficiency. At this point, this is only an association and further studies and research need to be performed to help confirm the pathogenesis of this association.

Published
2023
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59. Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Author

Dharmayat, Kanika Inamdar, Vallejo-Vaz, Antonio J., Stevens, Christophe A.T., Brandts, Julia M., Lyons, Alexander R.M., Groselj, Urh, Abifadel, Marianne, Aguilar-Salinas, Carlos A., Alhabib, Khalid, Alkhnifsawi, Mutaz, Almahmeed, Wael, Alnouri, Fahad, Alonso, Rodrigo, Al-Rasadi, Khalid, Ashavaid, Tester F., Banach, Maciej, Béliard, Sophie, Binder, Christoph, Bourbon, Mafalda, Chlebus, Krzysztof, Corral, Pablo, Cruz, Diogo, Descamps, Olivier S., Drogari, Euridiki, Durst, Ronen, Ezhov, Marat V., Genest, Jacques, Harada-Shiba, Mariko, Holven, Kirsten B., Humphries, Steve E., Khovidhunkit, Weerapan, Lalic, Katarina, Laufs, Ulrich, Liberopoulos, Evangelos, Roeters van Lennep, Jeanine, Lima-Martinez, Marcos Miguel, Lin, Jie, Maher, Vincent, März, Winfried, Miserez, André R., Mitchenko, Olena, Nawawi, Hapizah, Panayiotou, Andrie G., Paragh, György, Postadzhiyan, Arman, Reda, Ashraf, Reiner, Željko, Reyes, Ximena, Sadiq, Fouzia, Sahebkar, Amirhossein, Schunkert, Heribert, Shek, Aleksandr B., Stroes, Eric, Su, Ta-Chen, Subramaniam, Tavintharan, Susekov, Andrey, Vázquez Cárdenas, Alejandra, Huong Truong, Thanh, Tselepis, Alexandros D., Vohnout, Branislav, Wang, Luya, Yamashita, Shizuya, Al-Sarraf, Ahmad, Al-Sayed, Nasreen, Davletov, Kairat, Dwiputra, Bambang, Gaita, Dan, Kayikcioglu, Meral, Latkovskis, Gustavs, Marais, A. David, Thushara Matthias, Anne, Mirrakhimov, Erkin, Nordestgaard, Børge G., Petrulioniene, Zaneta, Pojskic, Belma, Sadoh, Wilson, Tilney, Myra, Tomlinson, Brian, Tybjærg-Hansen, Anne, Viigimaa, Margus, Catapano, Alberico L., Freiberger, Tomas, Hovingh, G. Kees, Mata, Pedro, Soran, Handrean, Raal, Frederick, Watts, Gerald F., Schreier, Laura, Bañares, Virginia, Greber-Platzer, Susanne, Baumgartner-Kaut, Margot, de Gier, Charlotte, Dieplinger, Hans, Höllerl, Florian, Innerhofer, Reinhold, Karall, Daniela, Lischka, Julia, Ludvik, Bernhard, Mäser, Martin, Scholl-Bürgi, Sabine, Thajer, Alexandra, Toplak, Hermann, Demeure, Fabian, Mertens, Ann, Balligand, Jean-Luc, Stephenne, Xavier, Sokal, Etienne, Petrov, Ivo, Goudev, Assen, Nikolov, Fedya, Tisheva, Snejana, Yotov, Yoto, Tzvetkov, Ivajlo, Hegele, Robert A, Gaudet, Daniel, Brunham, Liam, Ruel, Isabelle, McCrindle, Brian, Cuevas, Ada, Perica, Dražen, Symeonides, Phivos, Trogkanis, Efstratios, Kostis, Andreas, Ioannou, Andreas, Mouzarou, Angeliki, Georgiou, Anthoula, Stylianou, Andreas, Miltiadous, George, Iacovides, Paris, Deltas, Constantinos, Vrablik, Michal, Urbanova, Zuzana, Jesina, Pavel, Tichy, Lukas, Hyanek, Josef, Dvorakova, Jana, Cepova, Jana, Sykora, Josef, Buresova, Kristyna, Pipek, Michal, Pistkova, Eva, Bartkova, Ivana, S|ulakova, Astrid, Toukalkova, Lenka, Spenerova, Michaela, Maly, Jan, Benn, Marianne, Bendary, Ahmed, Elbahry, Atef, Ferrières, Jean, Ferrieres, Dorota, Peretti, Noel, Bruckert, Eric, Gallo, Antonio, Valero, René, Mourre, Florian, Aouchiche, Karine, Reynaud, Rachel, Tounian, Patrick, Lemale, Julie, Boccara, Franck, Moulin, Philippe, Charrières, Sybil, Di Filippo, Mathilde, Cariou, Bertrand, Paillard, François, Dourmap, Caroline, Pradignac, Alain, Verges, Bruno, Simoneau, Isabelle, Farnier, Michel, Cottin, Yves, Yelnik, Cecile, Hankard, Regis, Schiele, François, Durlach, Vincent, Sultan, Ariane, Carrié, Alain, Rabès, Jean-Pierre, Sanin, Veronika, Schmieder, Raphael S., Ates, Sara, Rizos, Christos V., Skoumas, Ioannis, Tziomalos, Konstantinos, Rallidis, Loukianos, Kotsis, Vasileios, Doumas, Michalis, Skalidis, Emmanouil, Kolovou, Genovefa, Kolovou, Vana, Garoufi, Anastasia, Koutagiar, Iosif, Polychronopoulos, Georgios, Kiouri, Estela, Antza, Christina, Zacharis, Evangelos, Attilakos, Achilleas, Sfikas, George, Koumaras, Charalambos, Anagnostis, Panagiotis, Anastasiou, Georgia, Liamis, George, Adamidis, Petros-Spyridon, Milionis, Haralambos, Lambadiari, Vaia, Stabouli, Stella, Filippatos, Theodosios, Mollaki, Vicky, Tsaroumi, Anastasia, Lamari, Frida, Proyias, Pavlos, Harangi, Mariann, Reddy, Lakshmi Lavanya, Shah, Swarup A. V, Ponde, Chandrashekhar K., Dalal, Jamshed J., Sawhney, Jitendra P.S., Verma, Ishwar C., Hosseini, Susan, Jamialahmadi, Tannaz, Alareedh, Mohammed, Shaghee, Foaad, Rhadi, Sabah Hasan, Abduljalal, Maryam, Alfil, Sarmad, Kareem, Huda, Cohen, Hofit, Leitersdorf, Eran, Schurr, Daniel, Shpitzen, Shoshi, Arca, Marcello, Averna, Maurizio, Bertolini, Stefano, Calandra, Sebastiano, Tarugi, Patrizia, Casula, Manuela, Galimberti, Federica, Gazzotti, Marta, Olmastroni, Elena, Sarzani, Riccardo, Ferri, Claudio, Repetti, Elena, Giorgino, Francesco, Suppressa, Patrizia, Bossi, Antonio Carlo, Borghi, Claudio, Muntoni, Sandro, Cipollone, Francesco, Scicali, Roberto, Pujia, Arturo, Passaro, Angelina, Berteotti, Martina, Pecchioli, Valerio, Pisciotta, Livia, Mandraffino, Giuseppe, Pellegatta, Fabio, Mombelli, Giuliana, Branchi, Adriana, Fiorenza, Anna Maria, Pederiva, Cristina, Werba, José Pablo, Parati, Gianfranco, Nascimbeni, Fabio, Iughetti, Lorenzo, Fortunato, Giuliana, Cavallaro, Raimondo, Iannuzzo, Gabriella, Calabrò, Paolo, Cefalù, Angelo Baldassare, Capra, Maria Elena, Zambon, Alberto, Pirro, Matteo, Sbrana, Francesco, Trenti, Chiara, Minicocci, Ilenia, Federici, Massimo, Del Ben, Maria, Buonuomo, Paola Sabrina, Moffa, Simona, Pipolo, Antonio, Citroni, Nadia, Guardamagna, Ornella, Lia, Salvatore, Benso, Andrea, Biolo, Gianni Biolo, Maroni, Lorenzo, Lupi, Alessandro, Bonanni, Luca, Rinaldi, Elisabetta, Zenti, Maria Grazia, Masuda, Daisaku, Mahfouz, Linda, Jambart, Selim, Ayoub, Carine, Ghaleb, Youmna, Kasim, Noor Alicezah Mohd, Nor, Noor Shafina Mohd, Al-Khateeb, Alyaa, Kadir, Siti Hamimah Sheikh Abdul, Chua, Yung-An, Razman, Aimi Zafira, Nazli, Sukma Azureen, Ranai, Norashikin Mohd, Latif, Ahmad Zubaidi Abd, Torres, María Teresa Magaña, Mehta, Roopa, Martagon, Alexandro J., Ramirez, Gabriela A. Galan, Antonio-Villa, Neftali Eduardo, Vargas-Vazquez, Arsenio, Elias-Lopez, Daniel, Retana, Gustavo Gonzalez, Encinas, Bethsabel Rodrıguez, Macıas, Jose J. Ceballos, Zazueta, Alejandro Romero, Alvarado, Rocio Martinez, Portano, Julieta D. Morales, Lopez, Humberto Alvares, Sauque-Reyna, Leobardo, Gomez Herrera, Laura G., Simental Mendia, Luis E., Aguilar, Humberto Garcia, Cooremans, Elizabeth Ramirez, Aparicio, Berenice Pe~na, Zubieta, Victoria Mendoza, Gonzalez, Perla A. Carrillo, Ferreira-Hermosillo, Aldo, Portilla, Nacu Caracas, Dominguez, Guadalupe Jimenez, Garcia, Alinna Y. Ruiz, Arriaga Cazares, Hector E., Gonzalez Gonzalez, Jesus R., Mendez Valencia, Carla V., Padilla Padilla, Francisco G., Prado, Ramon Madriz, De los Rios Ibarra, Manuel O., Arjona Villica~na, Ruy D., Acevedo Rivera, Karina J., Carrera, Ricardo Allende, Alvarez, Jose A., Amezcua Martinez, Jose C., Barrera Bustillo, Manuel de los Reyes, Vargas, Gonzalo Carazo, Chacon, Roberto Contreras, Figueroa Andrade, Mario H., Ortega, Ashanty Flores, Alcala, Hector Garcia, Garcia de Leon, Laura E., Guzman, Berenice Garcia, Gardu~no Garcia, Jose J., Garnica Cuellar, Juan C., Gomez Cruz, Jose R., Garcia, Anell Hernandez, Holguin Almada, Jesus R., Herrera, Ursulo Juarez, Sobrevilla, Fabiola Lugo, Rodriguez, Eduardo Marquez, Sibaja, Cristina Martinez, Medrano Rodriguez, Alma B., Morales Oyervides, Jose C., Perez Vazquez, Daniel I., Reyes Rodriguez, Eduardo A., Osorio, Ma. Ludivina Robles, Saucedo, Juan Rosas, Tamayo, Margarita Torres, Valdez Talavera, Luis A., Vera Arroyo, Luis E., Zepeda Carrillo, Eloy A., Galema-Boers, Annette, Weigman, Albert, Bogsrud, Martin P., Malik, Munir, Shah, Saeedullah, Khan, Sabeen Abid, Rana, Muhammad Asim, Batool, Hijab, Starostecka, Ewa, Konopka, Agnieszka, Lewek, Joanna, Bielecka-Dąbrowa, Agata, Gach, Agnieszka, Jóźwiak, Jacek, Pajkowski, Marcin, Romanowska-Kocejko, Marzena, Żarczyńska-Buchowiecka, Marta, Hellmann, Marcin, Chmara, Magdalena, Wasąg, Bartosz, Parczewska, Aleksandra, Gilis-Malinowska, Natasza, Borowiec-Wolna, Justyna, Stróżyk, Aneta, Michalska-Grzonkowska, Aleksandra, Chlebus, Izabela, Kleinschmidt, Mariola, Wojtecka, Agnieszka, Zdrojewski, Tomasz, Myśliwiec, Małgorzata, Hennig, Matylda, Medeiros, Ana Margarida, Alves, Ana Catarina, Almeida, Ana Filipa, Lopes, Andreia, Guerra, António, Bilhoto, Carla, Simões, Fernando, Silva, Francisco, Lobarinhas, Goreti, Gama, Guida, Palma, Isabel, Salgado, José Miguel, Matos, Luísa Diogo, Moura, Márcio de, Virtuoso, Maria João, Tavares, Mónica, Ferreira, Patrícia, Pais, Patrícia, Garcia, Paula, Coelho, Raquel, Ribeiro, Raquel, Correia, Susana, Sadykova, Dinara, Slastnikova, Evgenia, Alammari, Dalal, Mawlawi, Horia Ahmed, Alsahari, Atif, Khudary, Alia Abdullah, Alrowaily, Nawal Lafi, Rajkovic, Natasa, Popovic, Ljiljana, Singh, Sandra, Rasulic, Iva, Petakov, Ana, Lalic, Nebojsa M., Peng, Fabian Kok, Vasanwala, Rashida Farhan, Venkatesh, Sreedharan Aravind, Raslova, Katarina, Fabryova, Lubomira, Nociar, Jan, Šaligova, Jana, Potočňáková, Ludmila, Kozárová, Miriam, Varga, Tibor, Kadurova, Michaela, Debreova, Marianna, Novodvorsky, Peter, Gonova, Katarina, Klabnik, Alexander, Buganova, Ingrid, Battelino, Tadej, Bizjan, Barbara Jenko, Debeljak, Marusa, Kovac, Jernej, Mlinaric, Matej, Molk, Neza, Sikonja, Jaka, Sustar, Ursa, Podkrajsek, Katarina Trebusak, Muñiz-Grijalvo, Ovidio, Díaz-Díaz, Jose Luis, de Andrés, Raimundo, Fuentes-Jiménez, Francisco, Blom, Dirk, Miserez, Eleonore B., Shipton, Janine L., Ganokroj, Poranee, Futema, Marta, Ramaswami, Uma, Alieva, Rano B., Fozilov, Khurshid G., Khoshimov, Shavkat U., Nizamov, Ulugbek I., Abdullaeva, Guzal J., Kan, Liliya E., Abdullaev, Alisher A., Zakirova, Daria V., Do, Doan-Loi, Nguyen, Mai-Ngoc-Thi, Kim, Ngoc-Thanh, Le, Thanh-Tung, Le, Hong-An, Santos, Raul, and Ray, Kausik K.

Published
2024
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62. Projected Rotational Velocities and Fundamental Properties of Low-Mass Pre-Main Sequence Stars in the Taurus-Auriga Star Forming Region

Author

Nofi, Larissa A., Johns-Krull, Christopher M., López-Valdivia, Ricardo, Biddle, Lauren, Carvalho, Adolfo S., Huber, Daniel, Jaffe, Daniel, Llama, Joe, Mace, Gregory, Prato, Lisa, Skiff, Brian, Sokal, Kimberly R., Sullivan, Kendall, and Tayar, Jamie

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The projected stellar rotational velocity ($v \sin i$) is critical for our understanding of processes related to the evolution of angular momentum in pre-main sequence stars. We present $v \sin i$ measurements of high-resolution infrared and optical spectroscopy for 70 pre-main sequence stars in the Taurus-Auriga star-forming region, in addition to effective temperatures measured from line-depth ratios, and stellar rotation periods determined from optical photometry. From the literature, we identified the stars in our sample that show evidence of residing in circumstellar disks or multiple systems. The comparison of infrared $v \sin i$ measurements calculated using two techniques shows a residual scatter of $\sim$ 1.8 km s$^{-1}$, defining a typical error floor for the $v \sin i$ of pre-main sequence stars from infrared spectra. A comparison of the $v \sin i$ distributions of stars with and without companions shows that binaries/multiples typically have a higher measured $v \sin i$, which may be caused by contamination by companion lines, shorter disk lifetimes in binary systems, or tidal interactions in hierarchical triples. A comparison of optical and infrared $v \sin i$ values shows no significant difference regardless of whether the star has a disk or not, indicating that CO contamination from the disk does not impact $v \sin i$ measurements above the typical $\sim$ 1.8 km s$^{-1}$ error floor of our measurements. Finally, we observe a lack of a correlation between the $v \sin i$, presence of a disk, and H-R diagram position, which indicates a complex interplay between stellar rotation and evolution of pre-main sequence stars., Comment: 20 pages, 11 figures, accepted for publication in ApJ

Published
2021
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63. Can Nutraceuticals Support the Treatment of MASLD/MASH, and thus Affect the Process of Liver Fibrosis?

Author

Aneta Sokal-Dembowska, Sara Jarmakiewicz-Czaja, Katarzyna Ferenc, and Rafał Filip

Subjects
antioxidants, beta-carotene, curcumin, liver fibrosis, nutraceuticals, omega-3 fatty acids, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Currently, metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are considered to be the main causes of fibrosis. In turn, fibrosis may lead to the development of hepatocellular carcinoma or advanced cirrhosis, i.e., potentially life-threatening conditions. It is likely that therapy aimed at reducing the risk of developing hepatic steatosis and inflammation could be helpful in minimizing the threat/probability of organ fibrosis. In recent years, increasing attention has been paid to the influence of nutraceuticals in the prevention and treatment of liver diseases. Therefore, the aim of this review was to describe the precise role of selected ingredients such as vitamin C, beta-carotene, omega-3 fatty acids, and curcumin. It is likely that the use of these ingredients in the treatment of patients with MASLD/MASH, along with behavioral and pharmacological therapy, may have a beneficial effect on combating inflammation, reducing oxidative stress, and thereby preventing liver damage.

Published
2024
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64. Nutritional Support: The Use of Antioxidants in Inflammatory Bowel Disease

Author

Sara Jarmakiewicz-Czaja, Katarzyna Ferenc, Aneta Sokal-Dembowska, and Rafał Filip

Subjects
antioxidants, Crohn’s disease, inflammatory bowel diseases, minerals, ulcerative colitis, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

The problem of treating inflammatory bowel disease continues to be a topic of great interest for researchers. Despite the complexity surrounding their treatment and strategies to prolong periods of remission, there is a promising exploration of various compounds that have potential in combating inflammation and alleviating symptoms. Selenium, calcium, magnesium, zinc, and iron are among these compounds, offering a glimpse of hope in the treatment of IBD. These essential minerals not only hold the promise of reducing inflammation in these diseases, but also show the potential to enhance immune function and possibly influence the balance of intestinal microflora. By potentially modulating the gut microbiota, they may help support overall immune health. Furthermore, these compounds could play a crucial role in mitigating inflammation and minimising complications in patients with IBD. Furthermore, the protective effect of these compounds against mucosal damage in IBD and the protective effect of calcium itself against osteoporosis in this group of patients are notable.

Published
2024
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65. Coefficientwise total positivity of some matrices defined by linear recurrences

Author

Chen, Xi, Deb, Bishal, Dyachenko, Alexander, Gilmore, Tomack, and Sokal, Alan D.

Subjects
Mathematics - Combinatorics, 05A19 (Primary), 05A18, 05A20, 15B48 (Secondary)
Abstract

We exhibit a lower-triangular matrix of polynomials $T(a,c,d,e,f,g)$ in six indeterminates that appears empirically to be coefficientwise totally positive, and which includes as a special case the Eulerian triangle. We prove the coefficientwise total positivity of $T(a,c,0,e,0,0)$, which includes the reversed Stirling subset triangle., Comment: LaTeX2e, 12 pages with 2 figures: extended abstract submitted to FPSAC 2021

Published
2020

66. California Oral Health Literacy Toolkit

Author

Neuhauser, Linda, Eleftherion, Anthony, Freed, Rebecca, Sokal-Gutierrez, Karen, Jackson, Rosanna, Liu, Jessica, Ivey, Susan L, Hoeft, Kristin, Horowitz, Alice M, and Kumar, Jayanth

Subjects
Biomedical and Clinical Sciences, Dentistry
Published
2021

69. Effect of temperature on shielding efficiency of phosphate-bonded CoFe2O4 – xBaTiO3 multiferroic composite ceramics in microwaves

Author

D. Meisak, A. Plyushch, J. Macutkevič, R. Grigalaitis, A. Sokal, K.N. Lapko, A. Selskis, P.P. Kuzhir, and J. Banys

Subjects
Phosphate-bonded ceramics, Barium titanate, Cobalt ferrite, EMI shielding efficiency, Microwaves, Mining engineering. Metallurgy, TN1-997
Abstract

A series of novel CoFe2O4 – xBaTiO3 (x = 0.6–0.9) phosphate-bonded multifunctional ceramic composites were synthesized and studied both in ‘Salisbury screen’ geometry and as free-standing films in the frequency range of 25–54 GHz and temperature interval of 120–500 K. Experiments prove that the studied system is prospective for shielding applications in both modes providing total transmission losses of the free-standing sample layer of 40 dB for x = 0.9 dominated by absorption and more than 40 dB of reflection losses at resonant conditions in the Salisbury screen geometry. It was demonstrated that the electromagnetic response of multiferroic composite ceramics in microwaves is very sensitive to the temperature changes in the application's significant temperature range, i.e. 150 – 400 K. Notably, a small, i.e. 5 – 10 K, temperature variation drastically changes the shielding efficiency of the Salisbury screen (SER). In particular, SER ≥ 40 dB is achieved in the range of 302–309 K for the sample with x = 0.9, outside of the range SE rapidly decreases to 10–15 dB. The impact of temperature has to be considered for the efficient use of shielding materials in Ka and V bands for different applications.

Published
2023
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70. Effect of Nigella sativa on Selected Gastrointestinal Diseases

Author

Sara Jarmakiewicz-Czaja, Magdalena Zielińska, Kacper Helma, Aneta Sokal, and Rafał Filip

Subjects
anti-inflammation, bioactives, intestinals, liver, nigella sativa, pancreas, Biology (General), QH301-705.5
Abstract

Nigella sativa L. (family Ranunculaceae), also known as black cumin, has been used in cuisine around the world for many years. Due to its health-promoting properties, it can be used not only in the food industry but also in medicine. The main bioactive compound contained in the black cumin extract is thymoquinone (TQ), which has a special therapeutic role. The results of research in recent years confirmed its hypoglycemic, hypolipemic, and hepatoprotective effects, among others. In addition, the results of laboratory tests also indicate its immunomodulatory and anticancer effects, although there is still a lack of data on the mechanisms of how they are involved in the fight against cancer. Including this plant material in one’s diet can be both an element of prophylaxis and therapy supporting the treatment process, including pharmacological treatment. However, attention should be paid to its potential interactions with drugs used in the treatment of chronic diseases.

Published
2023
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71. The Graham--Knuth--Patashnik recurrence: Symmetries and continued fractions

Author

Salas, Jesús and Sokal, Alan D.

Subjects
Mathematics - Combinatorics
Abstract

We study the triangular array defined by the Graham--Knuth--Patashnik recurrence $T(n,k) = (\alpha n + \beta k + \gamma)\, T(n-1,k)+(\alpha' n + \beta' k + \gamma') \, T(n-1,k-1)$ with initial condition $T(0,k) = \delta_{k0}$ and parameters $\mathbf{\mu} = (\alpha,\beta,\gamma, \alpha',\beta',\gamma')$. We show that the family of arrays $T(\mathbf{\mu})$ is invariant under a 48-element discrete group isomorphic to $S_3 \times D_4$. Our main result is to determine all parameter sets $\mathbf{\mu} \in \mathbb{C}^6$ for which the ordinary generating function $f(x,t) = \sum_{n,k=0}^\infty T(n,k) \, x^k t^n$ is given by a Stieltjes-type continued fraction in $t$ with coefficients that are polynomials in $x$. We also exhibit some special cases in which $f(x,t)$ is given by a Thron-type or Jacobi-type continued fraction in $t$ with coefficients that are polynomials in $x$., Comment: The document contains the main paper (pdflatex, 72 pages), a Supplementary Material file (pdflatex, 31 pages, 1 pdf figure) with the detailed proof of Theorem 3.1 of the main paper, and the e-jc.sty file. Version published in journal

Published
2020
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72. 2MASS J04435686+3723033 B: A Young Companion at the Substellar Boundary with Potential Membership in the $\beta$ Pictoris Moving Group

Author

Phillips, Caprice, Bowler, Brendan, Mace, Gregory, Liu, Michael, and Sokal, Kimberly

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

We present a detailed characterization of 2MASS J04435750+3723031, a low-mass companion orbiting the young M2 star, 2MASS J04435686+3723033, at 7.6 arcseconds (550 AU) with potential membership in the 23 Myr $\beta$ Pictoris moving group ($\beta$PMG). Using near-infrared spectroscopy of the companion from IRTF/SpeX we have found a spectral type of M6 $\pm$ 1 and indications of youth through age-sensitive absorption lines and a low surface gravity index (VL-G). A young age is supported by H$\alpha$ emission and lithium absorption in the host. We re-evaluate the membership of this system and find that it is a marginally consistent kinematic match to the $\beta$PMG using $Gaia$ parallaxes and new radial velocities for the host and companion. If this system does belong to the $\beta$PMG, it would be a kinematic outlier and the companion would be over-luminous compared to other similar ultracool objects like PZ Tel B; this would suggest 2M0443+3723 B could be a close brown dwarf binary ($\approx$52+52 M$_\mathrm{Jup}$ if equal-flux, compared with 99 $\pm$ 5 M$_\mathrm{Jup}$ if single), and would make it the sixth substellar companion in this group. To test this hypothesis, we acquired NIR AO images with Keck II/NIRC2, but they do not resolve the companion to be a binary down to the diffraction limit of $\sim$3 AU. If 2M0443+3723 AB does not belong to any moving group then its age is more uncertain. In this case it is still young ($\lesssim$30 Myr), and the implied mass of the companion would be between $\sim$30--110 M$_\mathrm{Jup}$., Comment: 18 pages, 18 figures, Accepted to ApJ

Published
2020
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73. Some multivariate master polynomials for permutations, set partitions, and perfect matchings, and their continued fractions

Author

Sokal, Alan D. and Zeng, Jiang

Subjects
Mathematics - Combinatorics, 05A19 (Primary), 05A05, 05A10, 05A15, 05A18, 05A30, 30B70, 33C45, 33D45 (Secondary)
Abstract

We find Stieltjes-type and Jacobi-type continued fractions for some "master polynomials" that enumerate permutations, set partitions or perfect matchings with a large (sometimes infinite) number of simultaneous statistics. Our results contain many previously obtained identities as special cases, providing a common refinement of all of them., Comment: LaTeX2e, 122 pages, includes 9 tikz figures. Version 2 includes a new footnote 27 on page 81. To be published in Advances in Applied Mathematics

Published
2020
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74. Fluorine in the solar neighbourhood: the need for several cosmic sources

Author

Ryde, Nils, Jönsson, Henrik, Mace, Gregory, Cunha, Katia, Spitoni, Emanuele, Afsar, Melike, Jaffe, Daniel, Forsberg, Rebecca, Kaplan, Kyle F., Kidder, Benjamin T., Lee, Jae-Joon, Oh, Heeyoung, Smith, Verne V., Sneden, Christopher, Sokal, Kimberly R., Strickland, Emily, and Thorsbro, Brian

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract

The cosmic origin of fluorine is still not well constrained. Several nucleosynthetic channels at different phases of stellar evolution have been suggested, but these must be constrained by observations. For this, the fluorine abundance trend with metallicity spanning a wide range is required. Our aim is to determine stellar abundances of fluorine for -1.1<[Fe/H]<+0.4. We determine the abundances from HF lines in infrared K-band spectra (at 2.3 microns) of cool giants, observed with the IGRINS and Phoenix high-resolution spectrographs. We derive accurate stellar parameters for all our observed K giants, which is important since the HF lines are very temperature sensitive. We find that [F/Fe] is flat as a function of metallicity at [F/Fe]~0, but increases as the metallicity increases. The fluorine slope shows a clear secondary behavior in this metallicity range. We also find that the [F/Ce] ratio is relatively flat for -0.6<[Fe/H]<0, and that for two metal-poor ([Fe/H]<-0.8), s-process element enhanced giants, we do not detect an elevated fluorine abundance. We interpret all these observational constraints to indicate that several major processes are at play for the cosmic budget of fluorine over time; from those in massive stars at low metallicities, through the asymptotic giant branch-star contribution at -0.6<[Fe/H]<0, to processes with increasing yields with metallicity at super-solar metallicities. The origins of the latter, and whether or not Wolf-Rayet stars and/or novae could contribute at super-solar metallicities, is currently not known. To quantify these observational results, theoretical modelling is required. More observations in the metal-poor region are required to clarify the processes there., Comment: Accepted by ApJ, 17 pages, 10 figures

Published
2020
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75. Skier and loop-the-loop with friction

Author

Kufel, Dominik and Sokal, Alan D.

Subjects
Physics - Classical Physics
Abstract

We solve analytically the differential equations for a skier on a circular hill and for a particle on a loop-the-loop track when the hill or track is endowed with a coefficient of kinetic friction $\mu$. For each problem, we determine the exact "phase diagram" in the two-dimensional parameter plane., Comment: LaTeX2e, 22 pages (main text plus two appendices) including 10 figures. Version 2 is much revised, thanks to helpful comments by referees. To be published in the American Journal of Physics

Published
2020
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76. Phylogenetic trees, augmented perfect matchings, and a Thron-type continued fraction (T-fraction) for the Ward polynomials

Author

Price, Andrew Elvey and Sokal, Alan D.

Subjects
Mathematics - Combinatorics, 05A19 (Primary), 05A10, 05A15, 05A18, 30B70, 92B10 (Secondary)
Abstract

We find a Thron-type continued fraction (T-fraction) for the ordinary generating function of the Ward polynomials, as well as for some generalizations employing a large (indeed infinite) family of independent indeterminates. Our proof is based on a bijection between super-augmented perfect matchings and labeled Schr\"oder paths, which generalizes Flajolet's bijection between perfect matchings and labeled Dyck paths., Comment: LaTeX2e, 36 pages (includes 4 figures). Version 2 corrects a small error in the definition of crossing number (p. 6) and includes a proof of the previously conjectured (1.25)/(1.26)

Published
2020
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77. Effects of a school-based, post-pandemic recovery intervention on Canadian educators

Author

Laura Sokal and Lesley Eblie Trudel

Subjects
Educators, Mental health, Pandemic, Recovery, Intervention, Theory and practice of education, LB5-3640
Abstract

Although copious research has documented elevated stress and burnout in teachers worldwide during the COVID-19 pandemic, few studies have provided empirical evidence of effective interventions to support post-pandemic educator recovery and resilience. Attention to educator well-being is essential not only to healthy schools, but also to preventing teacher shortages. In the current study, Canadian educators (n = 621) who participated in a school-based mental health intervention program offered by a national mental health organization demonstrated significantly higher levels of well-being and recovery post-intervention than pre-intervention. Moreover, when compared with a control group (n = 86), the intervention group demonstrated significantly higher levels of connectedness, recovery, well-being, and resilience, although no differences in organizational commitment were demonstrated. Implications on teacher attrition and shortages are discussed.

Published
2023
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78. Immunomodulatory and endocrine effects of deep brain stimulation and spinal cord stimulation – A systematic review

Author

Oskar Puk, Magdalena Jabłońska, and Paweł Sokal

Subjects
Spinal cord stimulation, SCS, Deep brain stimulation, DBS, Cytokines, Immunomodulation, Therapeutics. Pharmacology, RM1-950
Abstract

Introduction: Deep Brain Stimulation (DBS) and Spinal Cord Stimulation (SCS) represent burgeoning treatments for diverse neurological disorders. This systematic review aims to consolidate findings on the immunological and endocrine effects of DBS and SCS, shedding light on the intricate mechanisms of neuromodulation. Materials and methods: This systematic review, aligned with PRISMA protocols, synthesizes findings from 33 references—20 on DBS and 13 on SCS—to unravel the immunological and endocrine impacts of neuromodulation. Results: DBS interventions exhibited divergent effects on cytokines, with an increase in hepcidin levels and a variable impact on the IL-6/IL-10 ratio. While some studies reported elevated IL-6, animal studies consistently demonstrated a reduction in IL-1β and IL-6, with no significant changes in TNF-α and an increase in IL-10. Noteworthy hormonal changes included decreased corticosterone and ACTH concentrations and increased oxytocin levels following DBS of the hypothalamus. SCS mirrored similar effects on interleukins, indicating a reduction in IL-6 and IL-1β and an increase in IL-10 levels. Additionally, SCS led to reduced VEGF levels and elevated expression of neurotrophic factors such as BDNF and GDNF, particularly under burst stimulation. Conclusions: Both DBS and SCS exert anti-inflammatory effects, manifesting as a decrease in pro-inflammatory cytokines alongside the stimulation of anti-inflammatory cytokine synthesis. These findings, observed in both animal and human models, imply that neurostimulation may modify the trajectory of neurological diseases by modulating local immune responses in an immunomodulatory and endocrine manner. This comprehensive exploration sets the stage for future research endeavors in this evolving domain.

Published
2023
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79. 5,8-Quinolinedione Attached to Quinone Derivatives: XRD Diffraction, Fourier Transform Infrared Spectra and Computational Analysis

Author

Arkadiusz Sokal, Roman Wrzalik, Joanna Klimontko, Elwira Chrobak, Ewa Bębenek, and Monika Kadela-Tomanek

Subjects
Fourier transform infrared spectroscopy, 5,8-quinolinedione, DFT, Inorganic chemistry, QD146-197
Abstract

Quinoline and isoquinoline moieties occur in many natural and synthetic compounds exhibiting high biological activity. The purpose of this study was to analyze the chemical structures of 5,8-quinolinedione and 5,8-isoquinoline derivatives using FT-IR spectroscopy supplemented with theoretical DFT calculations. Spectroscopic measurements were conducted using the attenuated total reflection (ATR) mode in the frequency range of 4000–400 cm−1. An analysis of FT-IR spectra was carried out, assigning the characteristic vibration frequencies of various functional groups to individual peaks. It was found that the experimental and calculated FT-IR spectra showed a good correlation for all the compounds under study. The most significant difference in the spectra occurred in the region of carbonyl bands. For compounds with the 5,8-quinolinedione moiety, two separated C=O vibration peaks were observed, while for compounds with the 5,8-isoquinolinedione moiety, the carbonyl vibrations created only one peak. This difference makes it possible to distinguish between the 5,8-quinolinedione and 5,8-isoquinolinedione derivatives.

Published
2023
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80. The Mean Magnetic Field Strength of CI Tau

Author

Sokal, Kimberly R., Johns-Krull, Christopher M., Mace, Gregory N., Nofi, Larissa, Prato, L., Lee, Jae-Joon, and Jaffe, Daniel T.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

We present a blind comparison of two methods to measure the mean surface magnetic field strength of the classical T Tauri star CI Tau based on Zeeman broadening of sensitive spectral lines. Our approach takes advantage of the greater Zeeman broadening at near-infrared compared to optical wavelengths. We analyze a high signal-to-noise, high spectral resolution spectrum from 1.5-2.5um observed with IGRINS (Immersion GRating INfrared Spectrometer) on the Discovery Channel Telescope. Both stellar parameterization with MoogStokes (which assumes an uniform magnetic field) and modeling with SYNTHMAG (which includes a distribution of magnetic field strengths) yield consistent measurements for the mean magnetic field strength of CI Tau is B of ~2.2 kG. This value is typical compared with measurements for other young T Tauri stars and provides an important contribution to the existing sample given it is the only known developed planetary system hosted by a young classical T Tauri star. Moreover, we potentially identify an interesting and suggestive trend when plotting the effective temperature and the mean magnetic field strength of T Tauri stars. While a larger sample is needed for confirmation, this trend appears only for a subset of the sample, which may have implications regarding the magnetic field generation., Comment: 21 pages, 10 figures; Accepted by ApJ

Published
2019
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81. A remark on the enumeration of rooted labeled trees

Author

Sokal, Alan D.

Subjects
Mathematics - Combinatorics, 05A15 (Primary), 05A10, 05A19, 05C05 (Secondary)
Abstract

Two decades ago, Chauve, Dulucq and Guibert showed that the number of rooted trees on the vertex set $[n+1]$ in which exactly $k$ children of the root are lower-numbered than the root is $\binom{n}{k} \, n^{n-k}$. Here I give a simpler proof of this result., Comment: LaTex2e, 9 pages. Version 2 contains a Note Added with a quick and elegant proof due to Jiang Zeng. To be published in Discrete Mathematics

Published
2019
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82. Chemical Abundances Of Open Clusters From High-Resolution Infrared Spectra. II. NGC 752

Author

Topcu, G. Böcek, Afsar, M., Sneden, C., Pilachowski, C. A., Denissenkov, P. A., VandenBerg, D. A., Wright, D., Mace, G. N., Jaffe, D. T., Strickland, E., Kim, H., and Sokal, K. R.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

We present a detailed near-infrared chemical abundance analysis of 10 red giant members of the Galactic open cluster NGC 752. High-resolution (R$\simeq$45000) near-infrared spectral data were gathered with the Immersion Grating Infrared Spectrograph (IGRINS), providing simultaneous coverage of the complete H and K bands. We derived the abundances of H-burning (C, N, O), $\alpha$ (Mg, Si, S, Ca), light odd-Z (Na, Al, P, K), Fe-group (Sc, Ti, Cr, Fe, Co, Ni) and neutron-capture (Ce, Nd, Yb) elements. We report the abundances of S, P, K, Ce, and Yb in NGC 752 for the first time. Our analysis yields solar metallicity and solar abundance ratios for almost all of the elements heavier than the CNO group in NGC 752. O and N abundances were measured from a number of OH and CN features in the $H$ band, and C abundances were determined mainly from CO molecular lines in the K band. High excitation \ion{C}{i} lines present in both near-infrared and optical spectra were also included in the C abundance determinations. Carbon isotopic ratios were derived from the R-branch band heads of first overtone (2-0) and (3$-$1) $^{12}$CO and (2-0) $^{13}$CO lines near 23440 \AA and (3-1) $^{13}$CO lines at about 23730 \AA. The CNO abundances and $^{12}$C/$^{13}$C ratios are all consistent with our giants having completed "first dredge-up" envelope mixing of CN-cyle products. We independently assessed NGC 752 stellar membership from Gaia astrometry, leading to a new color-magnitude diagram for this cluster. Applications of Victoria isochrones and MESA models to these data yield an updated NGC 752 cluster age (1.52 Gyr) and evolutionary stage indications for the program stars. The photometric evidence and spectroscopic light element abundances all suggest that the most, perhaps all of the program stars are members of the helium-burning red clump in this cluster., Comment: 16 pages, 11 figures

Published
2019
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88. Investigating Student Teaching Directors' Definitions of 'Teacher' and Paradigms of Disability in Canadian Teacher Education Programs

Author

Sokal, Laura, Woloshyn, Debra, and Wilson, Alina

Abstract

Directors of Student Teaching from teacher preparation programs across Canada were surveyed and then interviewed in follow-up focus groups to determine the opportunities and barriers they perceived during processes of placing pre-service teachers with disabilities into practicum settings. These data are interrogated within three theoretical frameworks about disability--the medical model, the social model, and the critical disability theory--to determine whether decision-making by Directors of Student Teaching reflects a predominant paradigm of disability. Deconstructions of the current concept of "teacher" are presented with reference to these three paradigms of disability.

Published
2022
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89. Demoralization as a Form of Teacher Burnout

Author

Sokal, Laura and Eblie Trudel, Lesley

Abstract

Over fifty years of research investigating teacher burnout has resulted in a well-accepted model of burnout that involves three dimensions: exhaustion, depersonalization, and loss of accomplishment. Recently, a new cause of teacher attrition has been proposed called "demoralization," on the argument that demoralization is a distinct phenomenon from burnout. In light of new research methodologies that allow for examination of unique pathways or "profiles" of teacher burnout, we explore the question, providing an analysis that suggests instead that depersonalization can be fairly represented as one profile of burnout.

Published
2022

91. Acute effects of insulin and insulin‐induced hypoglycaemia on carotid body chemoreceptor activity and cardiorespiratory responses in dogs

Author

Santhosh M. Baby, Faisal Zaidi, Gerald E. Hunsberger, David Sokal, Isha Gupta, Silvia V. Conde, Daniel Chew, Kristen Rall, and Robert W. Coatney

Subjects
carotid body, carotid body chemoreceptors, dogs, hypoglycaemia, insulin, sodium cyanide, Physiology, QP1-981
Abstract

Abstract The carotid body chemoreceptors (CBC) play an important role in the adaptive counter‐regulatory response to hypoglycaemia by evoking the CBC‐mediated sympathetic neuronal system to restore normoglycaemia. Ex vivo studies have shown varied responses of insulin‐induced hypoglycaemia on CBC function, and several in vivo studies have indirectly established the role of CBCs in restoring normoglycaemia in both animals and humans. However, a direct effect of insulin and/or insulin‐induced hypoglycaemia on CBC activity is not established in animal models. Therefore, the aim of this study was to evaluate in vivo effects of insulin and insulin‐induced hypoglycaemia on CBC activity and cardiorespiration in a preclinical large animal model. The carotid sinus nerve (CSN) activity and cardiorespiratory responses to sodium cyanide (NaCN; 25 µg/kg) were compared before (euglycaemic) and after (hypoglycaemic) intracarotid administration of insulin (12.5–100 µU/dogs) in beagle dogs. Insulin administration increased CSN activity and minute ventilation (V̇E) with significant (P

Published
2023
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92. The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation

Author

Marino Caruso, Sébastien Meurant, Damien Detraux, Amandine Mathieu, Manon Gilson, Marc Dieu, Antoine Fattaccioli, Catherine Demazy, Mustapha Najimi, Etienne Sokal, Thierry Arnould, Catherine Verfaillie, Denis L.J. Lafontaine, and Patricia Renard

Subjects
stem cells, hepatocyte differentiation, translational regulation, TOP mRNA, iPSC, polysome profiling, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

Summary: Translational regulation is of paramount importance for proteome remodeling during stem cell differentiation at both the global and the transcript-specific levels. In this study, we characterized translational remodeling during hepatogenic differentiation of induced pluripotent stem cells (iPSCs) by polysome profiling. We demonstrate that protein synthesis increases during exit from pluripotency and is then globally repressed during later steps of hepatogenic maturation. This global downregulation of translation is accompanied by a decrease in the abundance of protein components of the translation machinery, which involves a global reduction in translational efficiency of terminal oligopyrimidine tract (TOP) mRNA encoding translation-related factors. Despite global translational repression during hepatogenic differentiation, key hepatogenic genes remain efficiently translated, and the translation of several transcripts involved in hepatospecific functions and metabolic maturation is even induced. We conclude that, during hepatogenic differentiation, a global decrease in protein synthesis is accompanied by a specific translational rewiring of hepatospecific transcripts.

Published
2023
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93. SARS-CoV-2 Omicron BA.1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals

Author

Sokal, Aurélien, Barba-Spaeth, Giovanna, Hunault, Lise, Fernández, Ignacio, Broketa, Matteo, Meola, Annalisa, Fourati, Slim, Azzaoui, Imane, Vandenberghe, Alexis, Lagouge-Roussey, Pauline, Broutin, Manon, Roeser, Anais, Bouvier-Alias, Magali, Crickx, Etienne, Languille, Laetitia, Fournier, Morgane, Michel, Marc, Godeau, Bertrand, Gallien, Sébastien, Melica, Giovanna, Nguyen, Yann, Canoui-Poitrine, Florence, Pirenne, France, Megret, Jérôme, Pawlotsky, Jean-Michel, Fillatreau, Simon, Reynaud, Claude-Agnès, Weill, Jean-Claude, Rey, Félix A., Bruhns, Pierre, Mahévas, Matthieu, and Chappert, Pascal

Published
2023
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94. Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry

Author

Abban, Dzifa Wosornu, Abdul, Nasser, Abud, Atilio Marcelo, Adams, Fran, Addala, Srinivas, Adragão, Pedro, Ageno, Walter, Aggarwal, Rajesh, Agosti, Sergio, Agostoni, Piergiuseppe, Aguilar, Francisco, Linares, Julio Aguilar, Aguinaga, Luis, Ahmed, Jameel, Aiello, Allessandro, Ainsworth, Paul, Aiub, Jorge Roberto, Al-Dallow, Raed, Alderson, Lisa, Aldrete Velasco, Jorge Antonio, Alexopoulos, Dimitrios, Manterola, Fernando Alfonso, Aliyar, Pareed, Alonso, David, Alves da Costa, Fernando Augusto, Amado, José, Amara, Walid, Amelot, Mathieu, Amjadi, Nima, Ammirati, Fabrizio, Andrade, Marianna, Andrawis, Nabil, Annoni, Giorgio, Ansalone, Gerardo, Ariani, M.Kevin, Arias, Juan Carlos, Armero, Sébastien, Arora, Chander, Aslam, Muhammad Shakil, Asselman, M., Audouin, Philippe, Augenbraun, Charles, Aydin, S., Ayryanova, Ivaneta, Aziz, Emad, Backes, Luciano Marcelo, Badings, E., Bagni, Ermentina, Baker, Seth H., Bala, Richard, Baldi, Antonio, Bando, Shigenobu, Banerjee, Subhash, Bank, Alan, Esquivias, Gonzalo Barón, Barr, Craig, Bartlett, Maria, Kes, Vanja Basic, Baula, Giovanni, Behrens, Steffen, Bell, Alan, Benedetti, Raffaella, Mazuecos, Juan Benezet, Benhalima, Bouziane, Bergler-Klein, Jutta, Berneau, Jean-Baptiste, Bernstein, Richard A., Berrospi, Percy, Berti, Sergio, Berz, Andrea, Best, Elizabeth, Bettencourt, Paulo, Betzu, Robert, Bhagwat, Ravi, Bhatta, Luna, Biscione, Francesco, Bisignani, Giovanni, Black, Toby, Bloch, Michael J., Bloom, Stephen, Blumberg, Edwin, Bo, Mario, Bøhmer, Ellen, Bollmann, Andreas, Bongiorni, Maria Grazia, Boriani, Giuseppe, Boswijk, D.J., Bott, Jochen, Bottacchi, Edo, Kalan, Marica Bracic, Bradman, Drew, Brautigam, Donald, Breton, Nicolas, Brouwers, P.J.A.M., Browne, Kevin, Cortada, Jordi Bruguera, Bruni, A., Brunschwig, Claude, Buathier, Hervé, Buhl, Aurélie, Bullinga, John, Cabrera, Jose Walter, Caccavo, Alberto, Cai, Shanglang, Caine, Sarah, Calò, Leonardo, Calvi, Valeria, Sánchez, Mauricio Camarillo, Candeias, Rui, Capuano, Vincenzo, Capucci, Alessandro, Caputo, Ronald, Rizo, Tatiana Cárdenas, Cardona, Francisco, Carlos da Costa Darrieux, Francisco, Duarte Vera, Yan Carlos, Carolei, Antonio, Carreño, Susana, Carvalho, Paula, Cary, Susanna, Casu, Gavino, Cavallini, Claudio, Cayla, Guillaume, Celentano, Aldo, Cha, Tae-Joon, Cha, Kwang Soo, Chae, Jei Keon, Chalamidas, Kathrine, Challappa, Krishnan, Chand, Sunil Prakash, Chandrashekar, Harinath, Chartier, Ludovic, Chatterjee, Kausik, Chavez Ayala, Carlos Antero, Cheema, Aamir, Cheema, Amjad, Chen, Lin, Chen, Shih-Ann, Chen, Jyh Hong, Chiang, Fu-Tien, Chiarella, Francesco, Chih-Chan, Lin, Cho, Yong Keun, Choi, Jong-Il, Choi, Dong Ju, Chouinard, Guy, Hoi-Fan Chow, Danny, Chrysos, Dimitrios, Chumakova, Galina, José Roberto, Eduardo Julián, Valenzuela, Chuquiure, Nica, Nicoleta Cindea, Cislowski, David J., Clay, Anthony, Clifford, Piers, Cohen, Andrew, Cohen, Michael, Cohen, Serge, Colivicchi, Furio, Collins, Ronan, Colonna, Paolo, Compton, Steve, Connolly, Derek, Conti, Alberto, Buenostro, Gabriel Contreras, Coodley, Gregg, Cooper, Martin, Coronel, Julian, Corso, Giovanni, Sales, Juan Cosín, Cottin, Yves, Covalesky, John, Cracan, Aurel, Crea, Filippo, Crean, Peter, Crenshaw, James, Cullen, Tina, Darius, Harald, Dary, Patrick, Dascotte, Olivier, Dauber, Ira, Davalos, Vicente, Davies, Ruth, Davis, Gershan, Davy, Jean-Marc, Dayer, Mark, De Biasio, Marzia, De Bonis, Silvana, De Caterina, Raffaele, De Franceschi, Teresiano, de Groot, J.R., De Horta, José, De La Briolle, Axel, Topete, Gilberto de la Pena, Vicenzo de Paola, Angelo Amato, de Souza, Weimar, de Veer, A., De Wolf, Luc, Decoulx, Eric, Deepak, Sasalu, Defaye, Pascal, Del-Carpio Munoz, Freddy, Brkljacic, Diana Delic, Deumite, N. Joseph, Di Legge, Silvia, Diemberger, Igor, Dietz, Denise, Dionísio, Pedro, Dong, Qiang, Rossi dos Santos, Fabio, Dotcheva, Elena, Doukky, Rami, D'Souza, Anthony, Dubrey, Simon, Ducrocq, Xavier, Dupljakov, Dmitry, Duque, Mauricio, Dutta, Dipankar, Duvilla, Nathalie, Duygun, A., Dziewas, Rainer, Eaton, Charles B., Eaves, William, Ebels-Tuinbeek; Clifford Ehrlich, L.A., Eichinger-Hasenauer, Sabine, Eisenberg, Steven J., El Jabali, Adnan, El Shahawy, Mahfouz, Hernandes, Mauro Esteves, Izal, Ana Etxeberria, Evonich, Rudolph, III, Evseeva, Oksana, Ezhov, Andrey, Fahmy, Raed, Fang, Quan, Farsad, Ramin, Fauchier, Laurent, Favale, Stefano, Fayard, Maxime, Fedele, Jose Luis, Fedele, Francesco, Fedorishina, Olga, Fera, Steven R., Gomes Ferreira, Luis Gustavo, Ferreira, Jorge, Ferri, Claudio, Ferrier, Anna, Ferro, Hugo, Finsen, Alexandra, First, Brian, Fischer, Stuart, Fonseca, Catarina, Almeida, Luísa Fonseca, Forman, Steven, Frandsen, Brad, French, William, Friedman, Keith, Friese, Athena, Fruntelata, Ana Gabriela, Fujii, Shigeru, Fumagalli, Stefano, Fundamenski, Marta, Furukawa, Yutaka, Gabelmann, Matthias, Gabra, Nashwa, Gadsbøll, Niels, Galinier, Michel, Gammelgaard, Anders, Ganeshkumar, Priya, Gans, Christopher, Quintana, Antonio Garcia, Gartenlaub, Olivier, Gaspardone, Achille, Genz, Conrad, Georger, Frédéric, Georges, Jean-Louis, Georgeson, Steven, Giedrimas, Evaldas, Gierba, Mariusz, Ortega, Ignacio Gil, Gillespie, Eve, Giniger, Alberto, Giudici, Michael C., Gkotsis, Alexandros, Glotzer, Taya V., Gmehling, Joachim, Gniot, Jacek, Goethals, Peter, Goldbarg, Seth, Goldberg, Ronald, Goldmann, Britta, Golitsyn, Sergey, Gómez, Silvia, Mesa, Juan Gomez, Gonzalez, Vicente Bertomeu, Gonzalez Hermosillo, Jesus Antonio, González López, Víctor Manuel, Gorka, Hervé, Gornick, Charles, Gorog, Diana, Gottipaty, Venkat, Goube, Pascal, Goudevenos, Ioannis, Graham, Brett, Greer, G. Stephen, Gremmler, Uwe, Grena, Paul G., Grond, Martin, Gronda, Edoardo, Grönefeld, Gerian, Gu, Xiang, Torres Torres, Ivett Guadalupe, Guardigli, Gabriele, Guevara, Carolina, Guignier, Alexandre, Gulizia, Michele, Gumbley, Michael, Günther, Albrecht, Ha, Andrew, Hahalis, Georgios, Hakas, Joseph, Hall, Christian, Han, Bing, Han, Seongwook, Hargrove, Joe, Hargroves, David, Harris, Kenneth B., Haruna, Tetsuya, Hayek, Emil, Healey, Jeff, Hearne, Steven, Heffernan, Michael, Heggelund, Geir, Heijmeriks, J.A., Hemels, Maarten, Hendriks, I., Henein, Sam, Her, Sung-Ho, Hermany, Paul, Hernández Del Río, Jorge Eduardo, Higashino, Yorihiko, Hill, Michael, Hisadome, Tetsuo, Hishida, Eiji, Hoffer, Etienne, Hoghton, Matthew, Hong, Kui, Hong, Suk keun, Horbach, Stevie, Horiuchi, Masataka, Hou, Yinglong, Hsing, Jeff, Huang, Chi-Hung, Huckins, David, Hughes, kathy, Huizinga, A., Hulsman, E.L., Hung, Kuo-Chun, Hwang, Gyo-Seung, Ikpoh, Margaret, Imberti, Davide, Ince, Hüseyin, Indolfi, Ciro, Inoue, Shujiro, Irles, Didier, Iseki, Harukazu, Israel, C. Noah, Iteld, Bruce, Iyer, Venkat, Jackson-Voyzey, Ewart, Jaffrani, Naseem, Jäger, Frank, James, Martin, Jang, Sung-Won, Jaramillo, Nicolas, Jarmukli, Nabil, Jeanfreau, Robert J., Jenkins, Ronald D., Sánchez, Carlos Jerjes, Jimenez, Javier, Jobe, Robert, Joen-Jakobsen, Tomas, Jones, Nicholas, Moura Jorge, Jose Carlos, Jouve, Bernard, Jung, Byung Chun, Jung, Kyung Tae, Jung, Werner, Kachkovskiy, Mikhail, Kafkala, Krystallenia, Kalinina, Larisa, Kallmünzer, Bernd, Kamali, Farzan, Kamo, Takehiro, Kampus, Priit, Kashou, Hisham, Kastrup, Andreas, Katsivas, Apostolos, Kaufman, Elizabeth, Kawai, Kazuya, Kawajiri, Kenji, Kazmierski, John F., Keeling, P., Kerr Saraiva, José Francisco, Ketova, Galina, Khaira, Ajit Singh, Khripun, Aleksey, Kim, Doo-Il, Kim, Young Hoon, Kim, Nam Ho, Kim, Dae Kyeong, Kim, Jeong Su, Kim, June Soo, Kim, Ki Seok, Kim, Jin bae, Kinova, Elena, Klein, Alexander, Kmetzo, James J., Kneller, G. Larsen, Knezevic, Aleksandar, Angela Koh, Su Mei, Koide, Shunichi, Kollias, Anastasios, Kooistra, J.A., Koons, Jay, Koschutnik, Martin, Kostis, William J., Kovacic, Dragan, Kowalczyk, Jacek, Koziolova, Natalya, Kraft, Peter, Kragten, Johannes A., Krantz, Mori, Krause, Lars, Krenning, B.J., Krikke, F., Kromhout, Z., Krysiak, Waldemar, Kumar, Priya, Kümler, Thomas, Kuniss, Malte, Kuo, Jen-Yuan, Küppers, Achim, Karla Kurrelmeyer, Kwak, Choong Hwan, Laboulle, Bénédicte, Labovitz, Arthur, Lai, Wen Ter, Lam, Andy, Lam, Yat Yin, Zanetti, Fernando Lanas, Landau, Charles, Landini, Giancarlo, Figueiredo, Estêvão Lanna, Larsen, Torben, Lavandier, Karine, LeBlanc, Jessica, Lee, Moon Hyoung, Lee, Chang-Hoon, Lehman, John, Leitão, Ana, Lellouche, Nicolas, Lelonek, Malgorzata, Lenarczyk, Radoslaw, Lenderink, T., González, Salvador León, Leong-Sit, Peter, Leschke, Matthias, Ley, Nicolas, Li, Zhanquan, Li, Xiaodong, Li, Weihua, Li, Xiaoming, Lichy, Christhoh, Lieber, Ira, Limon Rodriguez, Ramon Horacio, Lin, Hailong, Lip, Gregory Y.H., Liu, Feng, Liu, Hengliang, Esperon, Guillermo Llamas, Navarro, Nassip Llerena, Lo, Eric, Lokshyn, Sergiy, López, Amador, López-Sendón, José Luís, Lorga Filho, Adalberto Menezes, Lorraine, Richard S., Luengas, Carlos Alberto, Luke, Robert, Luo, Ming, Lupovitch, Steven, Lyrer, Philippe, Ma, Changsheng, Ma, Genshan, Madariaga, Irene, Maeno, Koji, Magnin, Dominique, Maid, Gustavo, Mainigi, Sumeet K., Makaritsis, Konstantinos, Malhotra, Rohit, Manning, Rickey, Manolis, Athanasios, Manrique Hurtado, Helard Andres, Mantas, Ioannis, Jattin, Fernando Manzur, Maqueda, Vicky, Marchionni, Niccolo, Ortuno, Francisco Marin, Santana, Antonio Martín, Martinez, Jorge, Maskova, Petra, Hernandez, Norberto Matadamas, Matsuda, Katsuhiro, Maurer, Tillmann, Mauro, Ciro, May, Erik, Mayer, Nolan, McClure, John, McCormack, Terry, McGarity, William, McIntyre, Hugh, McLaurin, Brent, Medina Palomino, Feliz Alvaro, Melandri, Francesco, Meno, Hiroshi, Menzies, Dhananjai, Mercader, Marco, Meyer, Christian, Meyer, Beat J., Miarka, Jacek, Mibach, Frank, Michalski, Dominik, Michel, Patrik, Chreih, Rami Mihail, Mikdadi, Ghiath, Mikus, Milan, Milicic, Davor, Militaru, Constantin, Minaie, Sedi, Minescu, Bogdan, Mintale, Iveta, Mirault, Tristan, Mirro, Michael J., Mistry, Dinesh, Miu, Nicoleta Violeta, Miyamoto, Naomasa, Moccetti, Tiziano, Mohammed, Akber, Nor, Azlisham Mohd, Mollerus, Michael, Molon, Giulio, Mondillo, Sergio, Moniz, Patrícia, Mont, Lluis, Montagud, Vicente, Montaña, Oscar, Monti, Cristina, Moretti, Luciano, Mori, Kiyoo, Moriarty, Andrew, Morka, Jacek, Moschini, Luigi, Moschos, Nikitas, Mügge, Andreas, Mulhearn, Thomas J., Muresan, Carmen, Muriago, Michela, Musial, Wlodzimierz, Musser, Carl W., Musumeci, Francesco, Nageh, Thuraia, Nakagawa, Hidemitsu, Nakamura, Yuichiro, Nakayama, Toru, Nam, Gi-Byoung, Nanna, Michele, Natarajan, Indira, Nayak, Hemal M., Naydenov, Stefan, Nazlić, Jurica, Cristian Nechita, Alexandru, Nechvatal, Libor, Negron, Sandra Adela, Neiman, James, Neuenschwander, Fernando Carvalho, Neves, David, Neykova, Anna, Miguel, Ricardo Nicolás, Nijmeh, George, Nizov, Alexey, Campos, Rodrigo Noronha, Nossan, Janko, Novikova, Tatiana, Nowalany-Kozielska, Ewa, Nsah, Emmanuel, Nunez Fragoso, Juan Carlos, Nurgalieva, Svetlana, Nuyens, Dieter, Nyvad, Ole, Odin de Los Rios Ibarra, Manuel, O'Donnell, Philip, O'Donnell, Martin, Oh, Seil, Oh, Yong Seog, Oh, Dongjin, O'Hara, Gilles, Oikonomou, Kostas, Olivares, Claudia, Oliver, Richard, Ruiz, Rafael Olvera, Olympios, Christoforos, omaszuk-Kazberuk, Anna, Asensi, Joaquín Osca, Jose, eena Padayattil, Padilla Padilla, Francisco Gerardo, Rios, Victoria Padilla, Pajes, Giuseppe, Pandey, Shekhar, Paparella, Gaetano, Paris, F., Park, Hyung Wook, Park, Jong Sung, Parthenakis, Fragkiskos, Passamonti, Enrico, Patel, Rajesh J., Patel, Jaydutt, Patel, Mehool, Patrick, Janice, Jimenez, Ricardo Pavón, Paz, Analía, Pengo, Vittorio, Pentz, William, Pérez, Beatriz, Pérez Ríos, Alma Minerva, Pérez-Cabezas, Alejandro, Perlman, Richard, Persic, Viktor, Perticone, Francesco, Peters, Terri K., Petkar, Sanjiv, Pezo, Luis Felipe, Pflücke, Christian, Pham, David N., Phillips, Roland T., Phlaum, Stephen, Pieters, Denis, Pineau, Julien, Pinter, Arnold, Pinto, Fausto, Pisters, R., Pivac, Nediljko, Pocanic, Darko, Podoleanu, Cristian, Politano, Alessandro, Poljakovic, Zdravka, Pollock, Stewart, Garcéa, Jose Polo, Poppert, Holger, Porcu, Maurizio, Reino, Antonio Pose, Prasad, Neeraj, Précoma, Dalton Bertolim, Prelle, Alessandro, Prodafikas, John, Protasov, Konstantin, Pye, Maurice, Qiu, Zhaohui, Quedillac, Jean-Michel, Raev, Dimitar, Raffo Grado, Carlos Antonio, Rahimi, Sidiqullah, Raisaro, Arturo, Rama, Bhola, Ramos, Ricardo, Ranieri, Maria, Raposo, Nuno, Rashba, Eric, Rauch-Kroehnert, Ursula, Reddy, Ramakota, Renda, Giulia, Reza, Shabbir, Ria, Luigi, Richter, Dimitrios, Rickli, Hans, Rieker, Werner, Vera, Tomas Ripolil, Ritt, Luiz Eduardo, Roberts, Douglas, Briones, Ignacio Rodriguez, Rodriguez Escudero, Aldo Edwin, Pascual, Carlos Rodríguez, Roman, Mark, Romeo, Francesco, Ronner, E., Roux, Jean-Francois, Rozkova, Nadezda, Rubacek, Miroslav, Rubalcava, Frank, Russo, Andrea M., Rutgers, Matthieu Pierre, Rybak, Karin, Said, Samir, Sakamoto, Tamotsu, Salacata, Abraham, Salem, Adrien, Bodes, Rafael Salguero, Saltzman, Marco A., Salvioni, Alessandro, Vallejo, Gregorio Sanchez, Fernández, Marcelo Sanmartín, Saporito, Wladmir Faustino, Sarikonda, Kesari, Sasaoka, Taishi, Sati, Hamdi, Savelieva, Irina, Scala, Pierre-Jean, Schellinger, Peter, Scherr, Carlos, Schmitz, Lisa, Schmitz, Karl-Heinz, Schmitz, Bettina, Schnabel, Teresa, Schnupp, Steffen, Schoeniger, Peter, Schön, Norbert, Schwimmbeck, Peter, Seamark, Clare, Searles, Greg, Seidl, Karl-Heinz, Seidman, Barry, Sek, Jaroslaw, Sekaran, Lakshmanan, Serrati, Carlo, Shah, Neerav, Shah, Vinay, Shah, Anil, Shah, Shujahat, Sharma, Vijay Kumar, Shaw, Louise, Sheikh, Khalid H., Shimizu, Naruhito, Shimomura, Hideki, Shin, Dong-Gu, Shin, Eun-Seok, Shite, Junya, Sibilio, Gerolamo, Silver, Frank, Sime, Iveta, Simmers, Tim A., Singh, Narendra, Siostrzonek, Peter, Smadja, Didier, Smith, David W., Snitman, Marcelo, Filho, Dario Sobral, Soda, Hassan, Sofley, Carl, Sokal, Adam, Oi Yan, Yannie Soo, Sotolongo, Rodolfo, Ferreira de Souza, Olga, Sparby, Jon Arne, Spinar, Jindrich, Sprigings, David, Spyropoulos, Alex C., Stakos, Dimitrios, Steinwender, Clemens, Stergiou, Georgios, Stiell, Ian, Stoddard, Marcus, Stoikov, Anastas, Streb, Witold, Styliadis, Ioannis, Su, Guohai, Su, Xi, Sudnik, Wanda, Sukles, Kai, Sun, Xiaofei, Swart, H., Szavits-Nossan, Janko, Taggeselle, Jens, Takagi, Yuichiro, Singh Takhar, Amrit Pal, Tamm, Angelika, Tanaka, Katsumi, Tanawuttiwat, Tanyanan, Tang, Sherman, Tang, Aylmer, Tarsi, Giovanni, Tassinari, Tiziana, Tayal, Ashis, Tayebjee, Muzahir, Berg, J.M. ten, Tesloianu, Dan, The, Salem H.K., Thomas, Dierk, Timsit, Serge, Tobaru, Tetsuya, Tomasik, Andrzej R., Torosoff, Mikhail, Touze, Emmanuel, Trendafilova, Elina, Tsai, W. Kevin, Tse, Hung Fat, Tsutsui, Hiroshi, Tu, Tian Ming, Tuininga, Ype, Turakhia, Minang, Turk, Samir, Turner, Wayne, Tveit, Arnljot, Tytus, Richard, Valadão, C., van Bergen, P.F.M.M., van de Borne, Philippe, van den Berg, B.J., van der Zwaan, C., Van Eck, M., Vanacker, Peter, Vasilev, Dimo, Vasilikos, Vasileios, Vasilyev, Maxim, Veerareddy, Srikar, Miño; Asok Venkataraman, Mario Vega, Verdecchia, Paolo, Versaci, Francesco, Vester, Ernst Günter, Vial, Hubert, Victory, Jason, Villamil, Alejandro, Vincent, Marc, Vlastaris, Anthony, Dahl, Jürgen vom, Vora, Kishor, Vranian, Robert B., Wakefield, Paul, Wang, Ningfu, Wang, Mingsheng, Wang, Xinhua, Wang, Feng, Wang, Tian, Warner, Alberta L., Watanabe, Kouki, Wei, Jeanne, Weimar, Christian, Weiner, Stanislav, Weinrich, Renate, Wen, Ming-Shien, Wiemer, Marcus, Wiggers, Preben, Wilke, Andreas, Williams, David, Williams, Marcus L., Witzenbichler, Bernhard, Wong, Brian, Lawrence Wong, Ka Sing, Wozakowska-Kaplon, Beata, Wu, Shulin, Wu, Richard C., Wunderlich, Silke, Wyatt, Nell, Wylie, John (Jack), Xu, Yong, Xu, Xiangdong, Yamanoue, Hiroki, Yamashita, Takeshi, Bryan Yan, Ping Yen, Yang, Tianlun, Yao, Jing, Yeh, Kuo-Ho, Yin, Wei Hsian, Yotov, Yoto, Zahn, Ralf, Zarich, Stuart, Zenin, Sergei, Zeuthen, Elisabeth Louise, Zhang, Huanyi, Zhang, Donghui, Zhang, Xingwei, Zhang, Ping, Zhang, Jun, Zhao, Shui Ping, Zhao, Yujie, Zhao, Zhichen, Zheng, Yang, Zhou, Jing, Zimmermann, Sergio, Zini, Andrea, Zizzo, Steven, Zong, Wenxia, Zukerman, L. Steven, Romiti, Giulio Francesco, Corica, Bernadette, Proietti, Marco, Mei, Davide Antonio, Frydenlund, Juliane, Bisson, Arnaud, Olshansky, Brian, Chan, Yi-Hsin, Huisman, Menno V., and Chao, Tze-Fan

Published
2023
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95. Interim results from an ongoing, open-label, single-arm trial of odevixibat in progressive familial intrahepatic cholestasis

Author

Thompson, Richard J., Artan, Reha, Baumann, Ulrich, Calvo, Pier Luigi, Czubkowski, Piotr, Dalgic, Buket, D’Antiga, Lorenzo, Di Giorgio, Angelo, Durmaz, Özlem, Gonzalès, Emmanuel, Grammatikopoulos, Tassos, Gupte, Girish, Hardikar, Winita, Houwen, Roderick H.J., Kamath, Binita M., Karpen, Saul J., Lacaille, Florence, Lachaux, Alain, Lainka, Elke, Loomes, Kathleen M., Mack, Cara L., Mattsson, Jan P., McKiernan, Patrick, Ni, Quanhong, Özen, Hasan, Rajwal, Sanjay R., Roquelaure, Bertrand, Shteyer, Eyal, Sokal, Etienne, Sokol, Ronald J., Soufi, Nisreen, Sturm, Ekkehard, Tessier, Mary Elizabeth, van der Woerd, Wendy L., Verkade, Henkjan J., Vittorio, Jennifer M., Wallefors, Terese, Warholic, Natalie, Yu, Qifeng, Horn, Patrick, and Kjems, Lise

Published
2023
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97. Barriers and Facilitators to Promoting Oral Health Literacy and Patient Communication among Dental Providers in California.

Author

Tseng, Winston, Pleasants, Elizabeth, Ivey, Susan L, Sokal-Gutierrez, Karen, Kumar, Jayanth, Hoeft, Kristin S, Horowitz, Alice M, Ramos-Gomez, Francisco, Sodhi, Miku, Liu, Jessica, and Neuhauser, Linda

Subjects
dental providers, health literacy, oral health, oral health literacy, provider-patient communication, Toxicology
Abstract

Studies demonstrate that dental providers value effective provider-patient communication but use few recommended communication techniques. This study explored perspectives of California dental providers and oral health literacy experts in the United States on use of communication techniques. We conducted a qualitative key informant interview study with 50 participants between November 2019 and March 2020, including 44 dental providers (dentists, hygienists, and assistants) in public or private practice in California and 6 oral health literacy (OHL) experts. We undertook thematic analysis of interview transcripts and descriptive statistics about interviewees from pre-surveys. Dental providers reported frequently speaking slowly, and using simple language and models/radiographs to communicate with patients, while infrequently using interpretation/translation, illustrations, teach-back, or motivational interviewing. Providers reported using only 6 of the 18 American Medical Association's (AMA) recommended communication techniques and only 3 of the 7 AMA's basic communication techniques. A majority of providers indicated using one of five oral health assessment and educational strategies. Key barriers to effective communication included limited time, financial incentives promoting treatment over prevention, lack of OHL training, limited plain-language patient education materials, and patients with low OHL knowledge. Dental organizations should prioritize supporting dental providers in effective patient communication practices. Standardizing OHL continuing education, creating an evidence-based OHL toolkit for dental teams, ensuring accessible interpretation/translation services, and incentivizing dental providers to deliver education could improve oral health literacy and outcomes.

Published
2020

99. Assessment of Bioavailability Parameters of Mono- and Bistriazole Derivatives of Propynoylbetulin

Author

Monika Kadela-Tomanek, Arkadiusz Sokal, Klaudia Stocerz, Ewa Bębenek, Elwira Chrobak, and Paweł Olczyk

Subjects
betulin, triazole, lipophilicity, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

Bioavailability describes the properties that determine the passage of a compound through biological barriers. In many cases, bioavailability depends on the lipophilicity of the compound. In this study, the lipophilicity as well as other bioavailability properties of the mono- and bistriazole derivatives of betulin are presented. The lipophilicity was determined using RP-TLC and theoretical methods. The experimental lipophilicity of mono- and bistriazole derivatives is in the range from 4.39 to 7.85 and from 3.75 to 8.83, respectively. The lipophilicity of mono- and bistriazoles is similar, and the logPTLC depends on the type of substituent at the triazole ring. The introduction of a substituent with oxygen and nitrogen atoms decreases lipophilicity. Comparing the experimental and theoretical lipophilicity shows that the milogP and XLOGP3 programs best reproduce the experimental values. The in silico-determined pharmacokinetic parameters show that monotriazole derivatives could be used as oral drugs while bistriazoles show low availability after oral administration. Triazoles could be used as transdermal drugs. The analysis of in silico bioavailability parameters shows that the type of substituent at the triazole ring influences the pharmacokinetic properties, while the number of triazole rings slightly affects the bioavailability properties of the compound.

Published
2024
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100. Studies on the Aptasensor Miniaturization for Electrochemical Detection of Lead Ions

Author

Marta Jarczewska, Marta Sokal, Marcin Olszewski, and Elzbieta Malinowska

Subjects
miniaturized electrodes, aptamers, redox indicators, voltammetry, Biotechnology, TP248.13-248.65
Abstract

Lead poses severe effects on living organisms, and since Pb2+ ions tend to accumulate in different organs, it is crucial to monitor Pb2+ concentration in samples such as water and soil. One of the approaches is the utilization of biosensors combined with aptamer-based layers for the electrochemical detection of lead ions. Herein, we present the studies of applying miniaturized screen-printed transducers as solid surfaces to fabricate aptamer layers. As the research is the direct continuation of our previous studies regarding the use of gold disk electrodes, the working parameters of elaborated aptasensors were defined, including the range of linear response (10–100 nM), selectivity as well as stability, regeneration, and feasibility of application for the analysis of real samples. This was achieved using voltammetric techniques including cyclic and square-wave voltammetry in the presence of methylene blue redox indicator.

Published
2024
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