51. Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates
- Author
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Sallie R. Permar, Anthony L. DeVico, Suefen Kwa, Mario Roederer, Robert Howington, Song Ding, M. Juliana McElrath, Bette T. Korber, Ryan Duffy, Roger Le Grand, George N. Pavlakis, Susan W. Barnett, Ranajit Pal, Sanjay Phogat, Haesun Park, Robert A. Seder, Genevieve G. Fouda, Georgia D. Tomaras, Shanmugalakshmi Sadagopal, Louis J. Picker, Mariano Esteban, Xiaoying Shen, Rama Rao Amara, Giuseppe Pantaleo, Robin J. Shattock, Barbara K. Felber, Otto O. Yang, David C. Montefiori, Diane L. Bolton, Alethea Cope, and Kirchhoff, F
- Subjects
and promotion of well-being ,viruses ,Human immunodeficiency virus (HIV) ,medicine.disease_cause ,Antibodies, Viral ,Medical and Health Sciences ,Immunoglobulin G ,Epitope ,Epitopes ,Viral Envelope Proteins ,Antibody Specificity ,Viral ,biology ,Simian immunodeficiency virus ,virus diseases ,Biological Sciences ,humanities ,Specific antibody ,Infectious Diseases ,3.4 Vaccines ,HIV/AIDS ,Simian Immunodeficiency Virus ,Antibody ,Infection ,Biotechnology ,Primates ,Immunology ,Microbiology ,Antibodies ,Vaccine Related ,Antigen ,Species Specificity ,Virology ,Vaccines and Antiviral Agents ,medicine ,Animals ,Vaccine Related (AIDS) ,Linear epitope ,Agricultural and Veterinary Sciences ,Prevention ,Prevention of disease and conditions ,Microarray Analysis ,Good Health and Well Being ,Insect Science ,biology.protein ,HIV-1 ,Immunization - Abstract
To evaluate antibody specificities induced by simian immunodeficiency virus (SIV) versus human immunodeficiency virus type 1 (HIV-1) envelope antigens in nonhuman primate (NHP), we profiled binding antibody responses to linear epitopes in NHP studies with HIV-1 or SIV immunogens. We found that, overall, HIV-1 Env IgG responses were dominated by V3, with the notable exception of the responses to the vaccine strain A244 Env that were dominated by V2, whereas the anti-SIVmac239 Env responses were dominated by V2 regardless of the vaccine regimen.
- Published
- 2015