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Characterization of a SHIV162P3 variant evolved in an infected rhesus macaque with persistent plasma viremia
- Source :
- Virus research. 151(2)
- Publication Year :
- 2009
-
Abstract
- Typically plasma viremia is controlled in macaques challenged with R5 tropic SHIV162P3 during the chronic phase of infection. However, in a few infected animals it sustains for a prolonged period. Persistent plasma viremia in two such macaques led to a rapid decline of CD4+ T-cells in blood leading to the induction of AIDS. A viral variant from one of these animals showed sensitivity to soluble CD4 and maraviroc similar to the challenge virus. However, it exhibited reduced sensitivity to anti-gp120 antibody b12 and to sera from SHIV162P3-infected macaques or HIV-1-infected humans. Molecular sequencing of the env gene from this virus revealed multiple mutations clustering on the V1 domain of gp120. These results demonstrate that evolution of the envelope in SHIV-infected macaques may lead to the emergence of a viral variant with altered immunological characteristics.
- Subjects :
- Male
Cancer Research
Anti-HIV Agents
viruses
Period (gene)
Mutation, Missense
Simian Acquired Immunodeficiency Syndrome
Viremia
HIV Antibodies
Virus
Maraviroc
chemistry.chemical_compound
Plasma
Cyclohexanes
Virology
medicine
Animals
Neutralizing antibody
Gene
biology
virus diseases
Gene Products, env
Sequence Analysis, DNA
Triazoles
biology.organism_classification
medicine.disease
Antibodies, Neutralizing
Macaca mulatta
CD4 Lymphocyte Count
Rhesus macaque
Infectious Diseases
chemistry
Amino Acid Substitution
Immunology
biology.protein
Simian Immunodeficiency Virus
Antibody
Subjects
Details
- ISSN :
- 18727492
- Volume :
- 151
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Virus research
- Accession number :
- edsair.doi.dedup.....97ba76cd012130fcd1cee325b5bdfee7