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Polyvalent DNA prime and envelope protein boost HIV-1 vaccine elicits humoral and cellular responses and controls plasma viremia in rhesus macaques following rectal challenge with an R5 SHIV isolate
- Source :
- Journal of medical primatology. 34(5-6)
- Publication Year :
- 2005
-
Abstract
- Immunization of macaques with multivalent DNA encoding gp120 genes from HIV-1 subtypes A, B, C and E and a gag gene followed by boosting with homologous gp120 proteins elicited strong anti-gp120 antibodies capable of neutralizing homologous and to a lesser degree heterologous HIV-1 isolates. Both Env- and Gag-specific cell mediated immune (CMI) responses were detected in the immunized animals. Following rectal challenge with an SHIV isolate encoding HIV-1(Ba-L)env, plasma viremia in the infected immunized animals was significantly lower than that observed in the naïve animals. Further, one of six immunized animals was completely protected whereas all six naïve animals were infected. These results demonstrate that a vaccine based on priming with a polyvalent DNA vaccine from multiple HIV-1 subtypes followed by boosting with homologous Env proteins elicits anti-HIV-1 immune responses capable of controlling rectal transmission of SHIV(Ba-L).
- Subjects :
- viruses
Simian Acquired Immunodeficiency Syndrome
Heterologous
Priming (immunology)
Viremia
Enzyme-Linked Immunosorbent Assay
Biology
HIV Envelope Protein gp120
Antibodies, Viral
Monocytes
Article
DNA vaccination
Interferon-gamma
Immune system
Neutralization Tests
medicine
Animals
Neutralizing antibody
AIDS Vaccines
General Veterinary
Monkey Diseases
Lentiviruses, Primate
virus diseases
Group-specific antigen
medicine.disease
Virology
Genes, gag
Macaca mulatta
Immunology
biology.protein
HIV-1
Animal Science and Zoology
Antibody
Subjects
Details
- ISSN :
- 00472565
- Volume :
- 34
- Issue :
- 5-6
- Database :
- OpenAIRE
- Journal :
- Journal of medical primatology
- Accession number :
- edsair.doi.dedup.....a72f90a2b1ad57764dcae985537d6138