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51. Cover Feature: Synthesis of Cyclen‐Functionalized Ethenylene‐Based Periodic Mesoporous Organosilica Nanoparticles and Metal‐Ion Adsorption Studies (ChemNanoMat 11/2020)

Author: Laurence Raehm, Roser Pleixats, Jean-Olivier Durand, Hao Li, Gulaim A. Seisenbaeva, Ani Vardanyan, and Clarence Charnay
Subjects: Materials science, Renewable Energy, Sustainability and the Environment, Energy Engineering and Power Technology, Nanoparticle, Metal adsorption, Biomaterials, chemistry.chemical_compound, Mesoporous organosilica, Cyclen, chemistry, Chemical engineering, Metal ion adsorption, Feature synthesis, Materials Chemistry, Cover (algebra)
Published: 2020

52. Hollow Organosilica Nanoparticles for Drug Delivery

Author: Christophe Nguyen, Saher Rahmani, Jelena Budimir, Alia Akrout, Morgane Daurat, Clarence Charnay, Magali Gary-Bobo, Dina Aggad, Laurence Raehm, Anastasia Godefroy, Hanene Largot, Jean-Olivier Durand, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Nanomedsyn
Subjects: Nanoparticle, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Gemcitabine Hydrochloride, medicine, [CHIM]Chemical Sciences, Microemulsion, skin and connective tissue diseases, Chemistry, digestive, oral, and skin physiology, technology, industry, and agriculture, General Chemistry, 021001 nanoscience & nanotechnology, Uniform size, Gemcitabine, 0104 chemical sciences, Methotrexate, MCF-7 breast cancer cells, Organosilica Nanoparticles, Drug delivery, Breast cancer cells, 0210 nano-technology, medicine.drug, Nuclear chemistry
Abstract: International audience; The sol‐gel synthesis of hollow organosilica nanoparticles incorporating amino groups with uniform size are described. These nanoparticles were successfully prepared via a microemulsion method. Then, the hollow nanoparticles were loaded with gemcitabine hydrochloride or methotrexate and studied in MCF‐7 breast cancer cells.
Published: 2018

53. Biosafety of Mesoporous Silica Nanoparticles

Author: Magali Gary-Bobo, Yannick Guari, Jean Charles Gaillard, Joël Chopineau, Jean-Marie Devoisselle, Jean Armengaud, Morgane Daurat, Marcel Garcia, Afitz Da Silva, Jeff L. Nyalosaso, Cédric Pisani, Marie Maynadier, Estelle Rascol, Odette Prat, Clarence Charnay, Christophe Dorandeu, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2), Génétique et Amélioration des Fruits et Légumes (GAFL), Institut National de la Recherche Agronomique (INRA), Institut de Chimie de Clermont-Ferrand - Clermont Auvergne (ICCF), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Sigma CLERMONT (Sigma CLERMONT), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Innovations technologiques pour la Détection et le Diagnostic (LI2D), Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Médicaments et Technologies pour la Santé (MTS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1), Centre de Biochimie Structurale [Montpellier] (CBS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Larionova, Joulia, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Médicaments et Technologies pour la Santé (MTS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), NanoMedSyn (NMS), Université de Nîmes (UNIMES), French National Research Agency (BioSiPharm project) : ANR-13-NANO-0007, Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Sigma CLERMONT (Sigma CLERMONT)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Chimie et Biologie des Membranes et des Nanoobjets (CBMN), Université Sciences et Technologies - Bordeaux 1-École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), and NanoMedSyn
Subjects: safety, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Biomedical Engineering, Nanoparticle, Bioengineering, Protein Corona, Context (language use), Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biochemistry, lcsh:Technology, Biomaterials, Biosafety, protein corona, [CHIM]Chemical Sciences, [CHIM.COOR]Chemical Sciences/Coordination chemistry, mesoporous silica, ComputingMilieux_MISCELLANEOUS, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, [CHIM.MATE] Chemical Sciences/Material chemistry, Chemistry, lcsh:T, [CHIM.MATE]Chemical Sciences/Material chemistry, Mesoporous silica, [CHIM.COOR] Chemical Sciences/Coordination chemistry, 021001 nanoscience & nanotechnology, adverse outcome pathways, 3. Good health, 0104 chemical sciences, internalization, nanoparticles, Drug delivery, Perspective, Molecular Medicine, Nanomedicine, 0210 nano-technology, Biotechnology, Potential toxicity
Abstract: International audience; Careful analysis of any new nanomedicine device or disposal should be undertaken to comprehensively characterize the new product before application, so that any unintended side effect is minimized. Because of the increasing number of nanotechnology-based drugs, we can anticipate that regulatory authorities might adapt the approval process for nanomedicine products due to safety concerns, e.g., request a more rigorous testing of the potential toxicity of nanoparticles (NPs). Currently, the use of mesoporous silica nanoparticles (MSN) as drug delivery systems is challenged by a lack of data on the toxicological profile of coated or non-coated MSN. In this context, we have carried out an extensive study documenting the influence of different functionalized MSN on the cellular internalization and in vivo behaviour. In this article, a synthesis of these works is reviewed and the perspectives are drawn. The use of magnetic MSN (Fe3O4@MSN) allows an efficient separation of coated NPs from cell cultures with a simple magnet, leading to results regarding corona formation without experimental bias. Our interest is focused on the mechanism of interaction with model membranes, the adsorption of proteins in biological fluids, the quantification of uptake, and the effect of such NPs on the transcriptomic profile of hepatic cells that are known to be readily concerned by NPs' uptake in vivo, especially in the case of an intravenous injection.
Published: 2018

54. Porous Porphyrin-Based Organosilica Nanoparticles for NIR Two-Photon Photodynamic Therapy and Gene Delivery in Zebrafish

Author: Nadir Bettache, Jonas G. Croissant, Vincent Chaleix, Michel Wong Chi Man, Mireille Rossel, Xavier Cattoën, Karen Tresfield, Niveen M. Khashab, Danielle Laurencin, Sébastien Richeter, Rachid Sougrat, Sébastien Clément, Jean-Olivier Durand, Chiara Mauriello Jimenez, Dina Aggad, Magali Gary-Bobo, Nicolas Cubedo, Erwan Oliviero, Marcel Garcia, Vincent Sol, Shahad Alsaiari, Marie Maynadier, Laurence Raehm, Manuel A. Roldan-Gutierrez, Clarence Charnay, Dorothée Berthomieu, Dalaver H. Anjum, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), King Abdullah University of Science and Technology (KAUST), KAUST Catalysis Center (KCC), King Abdullah University of Sciences & Technologie, Optique et Matériaux (OPTIMA ), Institut Néel (NEEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), NanoMedSyn, Laboratoire de Chimie des Substances Naturelles (LCSN), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Dynamique moléculaire des interactions membranaires (DMIM), and Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 2 - Sciences et Techniques (UM2)
Subjects: Materials science, medicine.medical_treatment, Confocal, Nanoparticle, Photodynamic therapy, Nanotechnology, 02 engineering and technology, Gene delivery, 010402 general chemistry, 01 natural sciences, Biomaterials, chemistry.chemical_compound, Two-photon excitation microscopy, Electrochemistry, medicine, Zebrafish, Multiphoton imaging, ComputingMilieux_MISCELLANEOUS, biology, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, biology.organism_classification, Porphyrin, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, chemistry, 0210 nano-technology
Abstract: C.M.J. and D.A. contributed equally to this work. The grant “Chercheur d'Avenir Languedoc-Roussillon” attributed to M.G.-B. and the ANR nanoptPDT are gratefully acknowledged. The authors thank L. Lichon for technical assistance. DFT calculations were performed using HPC resources from the CINES (projects x2016087394 and x2015087394), and from the CALMIP (Grant 2016-[P16042]). The authors thank MRI (Montpellier RIO Imaging platform) for confocal and multiphoton imaging facilities.
Published: 2018

55. Mechanochemistry for 'no solvent, no base, no waste' preparation of Hydantoin-based Active Pharmaceutical Ingredients: Nitrofurantoin and Dantrolene

Author: Francesco Delogu, Ivan Halasz, Andrea Porcheddu, Evelina Colacino, Julien Fullenwarth, Clarence Charnay, Ruben Guerra, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze Chimiche e Geologiche Centro Grandi Strumenti and INSTM unit, Università di Cagliari, Rudjer Boskovic Institute [Zagreb], Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Dipartimento di Ingegneria Meccanica, and Universita degli Studi di Cagliari [Cagliari]
Subjects: Base (chemistry), Hydantoin, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Related derivatives, 010402 general chemistry, 01 natural sciences, Physical Chemistry, Dantrolene, chemistry.chemical_compound, NATURAL SCIENCES, Mechanochemistry, medicine, [CHIM]Chemical Sciences, Environmental Chemistry, Organic chemistry, Active ingredient, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Organic Chemistry, Pollution, dantrolene, nitrofurantoin, green-metrics, solvent-free, mechanochemcal, 0104 chemical sciences, Solvent, Nitrofurantoin, medicine.drug
Abstract: The eco-compatible, energy-efficient, low environmental impact, gram scale, mechanochemical preparation of marketed drugs such as Nitrofurantoin (Furantin©, antibacterial agent), Dantrolene (Dantrium©, a muscle relaxant also used for prevention of malignant hyperthermia) and their structurally related derivatives, is herein reported. The solvent-, base- and waste-free stoichiometric ball-milling of 1-amino-hydantoin chlorohydrate and various aldehydes led to the more stable E-regioisomers selectively, in high yield and pure form without post-reaction work-up. Not a drop of organic solvent was used for the entire process and hydrazones were stable in the presence of water and gaseous HCl, formed during the synthesis. Comparative mechanochemical experiments were performed using diverse milling devices and jar materials, the Active Pharmaceutical Ingredients were analyzed by PXRD and green metrics are calculated.
Published: 2018

56. Biocompatibility assessment of functionalized magnetic mesoporous silica nanoparticles in human HepaRG cells

Author: Christophe Dorandeu, Jean-Marie Devoisselle, Joël Chopineau, Clarence Charnay, Yannick Guari, Estelle Rascol, Odette Prat, Cédric Pisani, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Chimie moléculaire et organisation du solide (CMOS), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Université de Nîmes (UNIMES), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: 0301 basic medicine, Materials science, Biocompatibility, Cell Survival, Surface Properties, Biomedical Engineering, Biocompatible Materials, 02 engineering and technology, Pharmacology, Toxicology, 03 medical and health sciences, Microscopy, Electron, Transmission, Cell Line, Tumor, PEG ratio, Materials Testing, Humans, MTT assay, [CHIM.COOR]Chemical Sciences/Coordination chemistry, Particle Size, Magnetite Nanoparticles, ComputingMilieux_MISCELLANEOUS, Drug Carriers, Dose-Response Relationship, Drug, Gene Expression Profiling, Mesoporous silica, 021001 nanoscience & nanotechnology, Silicon Dioxide, Lipids, 030104 developmental biology, Drug delivery, Biophysics, Nanocarriers, 0210 nano-technology, Toxicogenomics, Drug carrier, Transcriptome, Porosity, Nanomedicine, particle characterization, whole-gene expression, adverse outcome pathway, hepatic cholestasis , nanobiosafety
Abstract: Magnetic mesoporous silica nanoparticles (M-MSNs) are a promising class of nanoparticles for drug delivery. However, a deep understanding of the toxicological mechanisms of action of these nanocarriers is essential, especially in the liver. The potential toxicity on HepaRG cells of pristine, pegylated (PEG), and lipid (DMPC) M-MSNs were compared. Based on MTT assay and real-time cell impedance, none of these NPs presented an extensive toxicity on hepatic cells. However, we observed by transmission electron microscopy (TEM) that the DMPC and pristine M-MSNs were greatly internalized. In comparison, PEG M-MSNs showed a slower cellular uptake. Whole gene expression profiling revealed the M-MSNs molecular modes of action in a time-and dose-dependent manner. The lowest dose tested (1.6 µg/cm²) induced no molecular effect and was defined as ‘No Observed Transcriptional Effect level’. The dose 16 µg/cm² revealed nascent but transient effects. At the highest dose (80 µg/cm²), adverse effects have clearly arisen and increased over time. The limit of biocompatibility for HepaRG cells could be set at 16 µg/cm² for these NPs. Thanks to a comparative pathway-driven analysis, we highlighted the sequence of events that leads to the disruption of hepatobiliary system, elicited by the three types of M-MSNs, at the highest dose. The Adverse Outcome Pathway of hepatic cholestasis was implicated. Toxicogenomics applied to cell cultures is an effective tool to characterize and compare the modes of action of many substances. We propose this strategy as an asset for upstream selection of the safest nanocarriers in the framework of regulation for nanobiosafety
Published: 2017

57. Biocompatible Periodic Mesoporous Ionosilica Nanoparticles with Ammonium Walls: Application to Drug Delivery

Author: Morgane Daurat, Anastasia Godefroy, Dina Aggad, Afitz Da Silva, Magali Gary-Bobo, Philippe Dieudonné, Peter Hesemann, Jean-Olivier Durand, Roza Bouchal, Leïla Lesaffre, Clarence Charnay, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), NanoMedSyn, Laboratoire Charles Coulomb (L2C), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, Silicon dioxide, Nanoparticle, Nanotechnology, 02 engineering and technology, 010402 general chemistry, periodic mesoporous organosilica, 01 natural sciences, chemistry.chemical_compound, Drug Delivery Systems, Specific surface area, anion exchange, Ammonium Compounds, General Materials Science, Ammonium, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Silicon Dioxide, 0104 chemical sciences, Mesoporous organosilica, ionosilica, chemistry, Drug delivery, drug delivery, nanoparticles, Particle size, 0210 nano-technology, Mesoporous material, Porosity
Abstract: International audience; Periodic mesoporous ionosilica nanoparticles with ammonium wallswere synthesized exclusively from a trisilylated ammonium precursor. The nanoparticlesdisplay a uniform particle size, together with a high specific surface area and anordered hexagonal pore architecture. Completely biocompatible in vitro and in vivo,the nanoparticles are efficiently endocytosed by RAW 264.7 macrophages and used ascarrier vehicles for anionic drugs. Diclofenac-loaded ionosilica nanoparticles are veryefficient in inhibiting lipopolysaccharides-induced inflammation.
Published: 2017

58. Experimental separation steps influence the protein content of corona around mesoporous silica nanoparticles

Author: Jean Armengaud, Odette Prat, Christophe Dorandeu, Clarence Charnay, Yannick Guari, Jean-Marie Devoisselle, Jean-Charles Gaillard, Cédric Pisani, Joël Chopineau, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Université de Nîmes (UNIMES), Laboratoire Innovations technologiques pour la Détection et le Diagnostic (LI2D), Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Médicaments et Technologies pour la Santé (MTS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: endocrine system, Materials science, Silicon dioxide, Analytical chemistry, Nanoparticle, Protein Corona, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, Magnetization, Tandem Mass Spectrometry, Humans, General Materials Science, Centrifugation, [CHIM.COOR]Chemical Sciences/Coordination chemistry, ComputingMilieux_MISCELLANEOUS, Proteins, Mesoporous silica, Silicon Dioxide, 021001 nanoscience & nanotechnology, Corona, 0104 chemical sciences, chemistry, Chemical engineering, Nanoparticles, Nanocarriers, 0210 nano-technology, Chromatography, Liquid
Abstract: In order to direct nanocarriers to their targets efficiently, we have to understand the interactions occurring at the nano-bio interface between nanocarriers and human proteins, which forms the layer called the corona. However, experiments aiming to identify and quantify the proteins in the corona, especially critical steps in the separation of nanoparticles from biological media may affect the corona composition. Here, we used nano-LC MS/MS to compare the protein corona contents obtained after using two different separation methods. We showed that applying centrifugation versus magnetization to isolate nanoparticles surrounded by a corona resulted in protein loss and a reshuffling of their respective abundances.
Published: 2017

59. Biological Fate of Fe3O4 Core-Shell Mesoporous Silica Nanoparticles Depending on Particle Surface Chemistry

Author: Jean-Marie Devoisselle, Wei Liu, Joséphine Lai-Kee-Him, Yannick Guari, Mélanie Auffan, Afitz Da Silva, Magali Gary-Bobo, Estelle Rascol, Morgane Daurat, Patrick Bron, Bernard Angeletti, Clarence Charnay, Marie Maynadier, Christophe Dorandeu, Joël Chopineau, Marcel Garcia, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), NanoMedSyn (NMS), Centre de Biochimie Structurale [Montpellier] (CBS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Nîmes (UNIMES), Institut Charles Gerhardt, Université Montpellier 2 - Sciences et Techniques ( UM2 ), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] ( IBMM ), Ecole Nationale Supérieure de Chimie de Montpellier ( ENSCM ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier ( ICGM ICMMM ), Université Montpellier 1 ( UM1 ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Ecole Nationale Supérieure de Chimie de Montpellier ( ENSCM ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de recherche en cancérologie de Montpellier ( IRCM ), Université Montpellier 1 ( UM1 ) -CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Centre de Biochimie Structurale [Montpellier] ( CBS ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Interactions cellulaires et moléculaires ( ICM ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -IFR140-Centre National de la Recherche Scientifique ( CNRS ), Centre européen de recherche et d'enseignement de géosciences de l'environnement ( CEREGE ), Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Collège de France ( CdF ) -Institut National de la Recherche Agronomique ( INRA ) -Institut national des sciences de l'Univers ( INSU - CNRS ), School of Computer [Chine], National University of Defense Technology [Changsha], Chimie moléculaire et organisation du solide ( CMOS ), Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), NanoMedSyn, Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), and Beaussier, Catherine
Subjects: safety, General Chemical Engineering, Nanoparticle, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Nanotechnology, nanoparticles, surface coating, cell-membrane interactions, biodistribution, 02 engineering and technology, Polyethylene glycol, 010402 general chemistry, 01 natural sciences, Article, Cell membrane, chemistry.chemical_compound, PEG ratio, medicine, General Materials Science, [INFO.INFO-BT]Computer Science [cs]/Biotechnology, Lipid bilayer, Chemistry, technology, industry, and agriculture, Mesoporous silica, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Surface coating, [INFO.INFO-BT] Computer Science [cs]/Biotechnology, medicine.anatomical_structure, Membrane, Chemical engineering, [SDU.STU] Sciences of the Universe [physics]/Earth Sciences, 0210 nano-technology, [ INFO.INFO-BT ] Computer Science [cs]/Biotechnology
Abstract: International audience; The biological fate of nanoparticles (NPs) for biomedical applications is highly dependent of their size and charge, their aggregation state and their surface chemistry. The chemical composition of the NPs surface influences their stability in biological fluids, their interaction with proteins, and their attraction to the cell membranes. In this work, core-shell magnetic mesoporous silica nanoparticles (Fe 3 O 4 @MSN), that are considered as potential theranostic candidates, are coated with polyethylene glycol (PEG) or 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayer. Their biological fate is studied in comparison to the native NPs. The physicochemical properties of these three types of NPs and their suspension behavior in different media are investigated. The attraction to a membrane model is also evaluated using a supported lipid bilayer. The surface composition of NPs strongly influences their dispersion in biological fluids mimics, protein binding and their interaction with cell membrane. While none of these types of NPs is found to be toxic on mice four days after intravenous injection of a dose of 40 mg kg 1 of NPs, their surface coating nature influences the in vivo biodistribution. Importantly, NP coated with DMPC exhibit a strong accumulation in liver and a very low accumulation in lung in comparison with nude or PEG ones.
Published: 2017

60. The timeline of corona formation around silica nanocarriers highlights the role of the protein interactome

Author: Jean-Marie Devoisselle, Jeff L. Nyalosaso, Cédric Pisani, Yannick Guari, Michael Odorico, Odette Prat, Joël Chopineau, Jean Armengaud, Jean-Charles Gaillard, Clarence Charnay, Génétique et Amélioration des Fruits et Légumes (GAFL), Institut National de la Recherche Agronomique (INRA), Laboratoire Innovations technologiques pour la Détection et le Diagnostic (LI2D), Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Médicaments et Technologies pour la Santé (MTS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Etude de la Matière en Mode Environnemental (L2ME), Institut de Chimie Séparative de Marcoule (ICSM - UMR 5257), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Clermont-Ferrand (ICCF), SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de Nîmes (UNIMES), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), ANR-13-NANO-0007,BioSiPharm,Sécurité biologique des nanoparticules de silice mésoporeuse selon leur recouvrement de surface et mise en place de standards d'évaluation(2013), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Médicaments et Technologies pour la Santé (MTS), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay
Subjects: Serum, endocrine system, Materials science, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Systems biology, Protein Corona, Nanotechnology, 02 engineering and technology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 010402 general chemistry, Proteomics, 01 natural sciences, Interactome, Biological fluids, Animals, Humans, [CHIM]Chemical Sciences, [CHIM.COOR]Chemical Sciences/Coordination chemistry, General Materials Science, Protein Interaction Maps, ComputingMilieux_MISCELLANEOUS, Systems Biology, [CHIM.MATE]Chemical Sciences/Material chemistry, Mesoporous silica, Silicon Dioxide, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Nanoparticles, Cattle, Adsorption, Nanocarriers, 0210 nano-technology, Protein network
Abstract: International audience; Magnetic mesoporous silica nanoparticles (M-MSNs) represent promising targeting tools for theranostics. Engineering the interaction of nanoparticles (NPs) with biological systems requires an understanding of protein corona formation around the nanoparticles as this drives the biological fate of nanocarriers. We investigated the behavior of proteins in contact with M-MSNs by high-throughput comparative proteomics, using human and bovine sera as biological fluids, in order to assess the adsorption dynamics of proteins in these media. Using system biology tools, and especially protein-protein interaction databases, we demonstrated how the protein network builds up within the corona over the course of the experiment. Based on these results, we introduce and discuss the role of the "corona interactome" as an important factor influencing protein corona evolution. The concept of the "corona interactome" is an original methodology which could be generalized to all NP candidates. Based on this, pre-coating nanocarriers with specific proteins presenting minimal interactions with opsonins might provide them with properties such as stealth.
Published: 2017

61. Preparation and characterization of gold nanoparticles and nanowires loaded into rod-shaped silica by a one-step procedure

Author: Clarence Charnay, Elimame Elaloui, Sana Kachbouri, Najib Mnasri, Jerzy Zajac, Jeff L. Nyalosaso, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Material Environment and Energy Laboratory (UR14ES26), Science Faculty of Gafsa, Gafsa University, Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2), Institut de Chimie de Clermont-Ferrand - Clermont Auvergne (ICCF), Sigma CLERMONT (Sigma CLERMONT)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Faculté des Sciences de Gafsa, Université de Gafsa, and Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, Inorganic chemistry, Nanowire, Nanoparticle, 02 engineering and technology, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, 010402 general chemistry, 01 natural sciences, Physisorption, X-ray photoelectron spectroscopy, Gold carbene complex, [CHIM]Chemical Sciences, General Materials Science, Metallic nanowire, ComputingMilieux_MISCELLANEOUS, Rod-like mesoporous silica, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, Mesoporous silica, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Colloidal gold, Micellar solubilization, 0210 nano-technology, Mesoporous material, Dispersion (chemistry)
Abstract: International audience; Rod-shaped mesoporous silica nanoparticles (RMSN) with built-in gold nanoparticles or thin gold nanowires in the pore channels were in situ synthesized via a one-step procedure. The insertion of a hydrophobic gold precursor into the mesopores of RMSN was reached through a micellar solubilization mechanism and gold nanoparticles were achieved through a thermal reduction. The resulting RMSN and Au-RMSN samples were characterized by using X-ray diffraction, transmission and scanning microscopies (TEM and SEM), X-ray photoelectron spectroscopy (XPS), nitrogen physisorption and solid-state Nuclear Magnetic Resonance (NMR). The interaction of Au precursor (a carbene complex) with the thiol group at the silica surface was identified and found to play a crucial role in the dispersion of the uniform metal nanoparticles at the internal surface of RMSN. Moreover, TEM micrographs revealed the absence of large gold particles outside the mesopore network. The shape of Au nanoparticles and their loading amount in the mesoporous silica could be easily tuned by altering the concentration of gold precursor.
Published: 2017

62. Front Cover: Organosilica Nanoparticles for Gemcitabine Monophosphate Delivery in Cancer Cells (ChemNanoMat 7/2019)

Author: Saher Rahmani, Clarence Charnay, Yannick Guari, Laurence Raehm, Morgane Daurat, Magali Gary-Bobo, Christophe Nguyen, Peter Hesemann, Roza Bouchal, Jelena Budimir, Alia Akrout, Nadir Bettache, Jean-Olivier Durand, Sébastien Richeter, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: Renewable Energy, Sustainability and the Environment, Chemistry, Energy Engineering and Power Technology, Nanoparticle, Cancer, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, medicine.disease, 01 natural sciences, Gemcitabine, 0104 chemical sciences, Biomaterials, Front cover, Cancer cell, Drug delivery, Materials Chemistry, Cancer research, medicine, [CHIM]Chemical Sciences, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS, medicine.drug
Abstract: International audience
Published: 2019

63. In vitro lipid peroxidation of intestinal bile salt-based nanoemulsions: Potential role of antioxidants

Author: Sylvie Avallone, Clarence Charnay, Julie Courraud, Jean-Paul Cristol, Jacques Berger, Nutrition et Alimentation des Populations aux Suds (NutriPass), Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Département de Biochimie, Centre Hospitalier Universitaire de Montpellier, and Université Montpellier 1 (UM1)
Subjects: Antioxidant, micelles, medicine.medical_treatment, alpha-Tocopherol, Amidines, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, digestion, medicine.disease_cause, Models, Biological, 01 natural sciences, Biochemistry, Antioxidants, Bile Acids and Salts, Lipid peroxidation, AAPH, 03 medical and health sciences, chemistry.chemical_compound, detergent, medicine, Tocopherol, Intestinal Mucosa, Sodium dodecyl sulfate, Carotenoid, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, 010401 analytical chemistry, carotenoids, Fatty acid, General Medicine, Oxidants, beta Carotene, tocopherol, Nanostructures, 3. Good health, 0104 chemical sciences, Oxidative Stress, postprandial oxidative stress, chemistry, Emulsions, Lipid Peroxidation, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Oxidative stress, Hemin
Abstract: Over the last decades, oxidative stress has been described as a deleterious phenomenon contributing to numerous noncommunicable diseases such as cardiovascular disease, diabetes, and cancers. As many authors ascribed the healthy effect of fruit and vegetable consumption mainly to their antioxidant contents, it has been hypothesized that their protection could occur from the gut. Therefore, the aim of this study was to develop an original and physiological model of nanoemulsions to study lipid peroxidation within the intestine and to assess the properties of potential antioxidants in this setting. Several nanoemulsions were compared in terms of physical characteristics and reactivity to 2,2'-azobis-(2-amidinopropane) hydrochloride (AAPH)-induced oxidation. Formulations included different types of lipids, a detergent (a conjugated bile salt or sodium dodecyl sulfate) and, finally, lipophilic antioxidants. Hemin and myoglobin were also tested as relevant potential oxidants. Fatty acid (FA) peroxidation was monitored by gas chromatography while malondialdehyde and antioxidant contents were measured by HPLC. Investigated nanoemulsions were composed of spherical or cylindrical mixed micelles, the latter being the least resistant to oxidation. In the experimental conditions, AAPH was the only efficient oxidant. Alpha-tocopherol and lutein significantly slowed FA degradation from 4 to 1 mu M, respectively. On the contrary, beta-carotene did not show any protective capacity at 4 mu M. In conclusion, the tested nanoemulsions were appropriate to assess antioxidant capacity during the intestinal phase of digestion.
Published: 2013

64. Synthesis, decoration, and cellular effects of magnetic mesoporous silica nanoparticles

Author: C. Pisani, Magali Gary-Bobo, Patrick Bron, Yannick Guari, Christophe Dorandeu, Marie Maynadier, J. Lai Kee Him, Clarence Charnay, Joël Chopineau, Jeff L. Nyalosaso, Jean-Marie Devoisselle, Xavier Dumail, Estelle Rascol, Odette Prat, Marcel Garcia, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), NanoMedSyn, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Centre de Biochimie Structurale [Montpellier] (CBS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université de Nîmes (UNIMES), ANR-13-NANO-0007,BioSiPharm,Sécurité biologique des nanoparticules de silice mésoporeuse selon leur recouvrement de surface et mise en place de standards d'évaluation(2013), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Interactions cellulaires et moléculaires (ICM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) (BIAM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), NanoMedSyn (NMS), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDV.BIO]Life Sciences [q-bio]/Biotechnology, General Chemical Engineering, media_common.quotation_subject, Dispersity, Nanoparticle, Nanotechnology, 02 engineering and technology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 010402 general chemistry, 01 natural sciences, Nanomaterials, PEG ratio, [CHIM]Chemical Sciences, [CHIM.COOR]Chemical Sciences/Coordination chemistry, Lipid bilayer, Internalization, ComputingMilieux_MISCELLANEOUS, media_common, Low toxicity, Chemistry, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, Mesoporous silica, 021001 nanoscience & nanotechnology, 0104 chemical sciences, [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology, 0210 nano-technology
Abstract: Mesoporous Silica Nanoparticles (MSN) are now considered as multifunctional platforms for pharmaceutical development. The goal of this study was to optimize a synthesis procedure to obtain reproducible monodisperse magnetic core@shell Fe3O4@MSN with different coatings and study their uptake by cells. 100 nm core@shell nanoparticles with a unique 18 nm magnetic core were synthesized and covered with PEG groups or coated with a lipid bilayer in a controlled manner and their cellular fate was investigated. Both PEG and lipidic coated nanoparticles exhibit a low toxicity when incubated with Hep-G2 cells compared to pristine ones. Furthermore, the different real-time impedance cellular profiles that were observed and the particles uptake by the cells investigated by TEM suggest different internalization mechanisms or uptake kinetics depending on MSN coverage. This study is a first essential step to ensuring the preparation of well-defined nanomaterials for medical applications; it is considered as a crucial step to be able to perform detailed research about cellular trafficking and signaling pathways.
Published: 2016

65. Functionalized Mesoporous Silica Nanoparticle with Antioxidants as a New Carrier That Generates Lower Oxidative Stress Impact on Cells

Author: Saher Rahmani, Jean-Olivier Durand, Patrick Balaguer, Clarence Charnay, Eric Badia, Jean-Paul Cristol, Abdelhay Boulahtouf, Raymond Ebabe Elle, Marion Morena, Luc P. R. Bidel, Céline Lauret, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Département de biochimie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, INRA Montpellier, Institut National de la Recherche Agronomique (INRA), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Amélioration génétique et adaptation des plantes méditerranéennes et tropicales (UMR AGAP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), MORNET, Dominique, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Antioxidant, Cell Survival, NF-E2-Related Factor 2, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Catechols, Pharmaceutical Science, 02 engineering and technology, medicine.disease_cause, Polymerase Chain Reaction, Antioxidants, Nrf2, catechol antioxidant, 03 medical and health sciences, Rutin, chemistry.chemical_compound, Caco-2 cell line, Cell Line, Tumor, Drug Discovery, medicine, Humans, antioxidative response, Chemistry, Transfection, 021001 nanoscience & nanotechnology, Silicon Dioxide, Hydroquinones, [SDV] Life Sciences [q-bio], HaCaT, Oxidative Stress, 030104 developmental biology, medicine.anatomical_structure, Biochemistry, Cell culture, HaCaT cell line, Biophysics, mesoporous silica nanoparticle, Molecular Medicine, Nanoparticles, Quercetin, Caco-2 Cells, 0210 nano-technology, Keratinocyte, Oxidative stress
Abstract: UMR AGAP équipe DAAV Diversité, adaptation et amélioration de la vigne; International audience; Mesoporous silica nanoparticles (MSNs) were covalently coated with antioxidant molecules, namely, caffeic acid (MSN-CAF) or rutin (MSN-RUT), in order to diminish the impact of oxidative stress induced after transfection into cells, thus generating safer carriers used for either drug delivery or other applications. Two cellular models involved in the entry of NPs in the body were used for this purpose: the intestinal Caco-2 and the epidermal HaCaT cell lines. Rutin gave the best results in terms of antioxidant capacities preservation during coupling procedures, cellular toxicity alleviation, and decrease of ROS level after 24 h incubation of cells with grafted nanoparticles. These protective effects of rutin were found more pronounced in HaCaT than in Caco-2 cells, indicating some cellular specificity toward defense against oxidative stress. In order to gain more insight about the Nrf2 response, a stable transfected HaCaT cell line bearing repeats of the antioxidant response element (ARE) in front of a luciferase reporter gene was generated. In this cell line, both tBHQ and quercetin (Nrf2 agonists), but not rutin, were able to induce, in a dose-dependent fashion, the luciferase response. Interestingly, at high concentration, MSN-RUT was able to induce a strong Nrf2 protective response in HaCaT cells, accompanied by a comparable induction of HO-1 mRNA. The level of these responses was again less important in Caco-2 cells. To conclude, in keratinocyte cell line, the coupling of rutin to silica nanoparticles was beneficial in term of ROS reduction, cellular viability, and protective effects mediated through the activation of the Nrf2 antioxidant pathway.
Published: 2016

66. One Step Synthesis of Gold-Loaded Radial Mesoporous Silica Nanospheres and Supported Lipid Bilayer Functionalization: Towards Bio-Multifunctional Sensors

Author: Alain Brisson, Clarence Charnay, Sisareuth Tan, Joël Chopineau, Remi Veneziano, Jean-Marie Devoisselle, Gaelle Derrien, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Chimie et Biologie des Membranes et des Nanoobjets (CBMN), Université de Bordeaux (UB)-École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université de Nîmes (UNIMES)
Subjects: Materials science, Surface Properties, Lipid Bilayers, supported lipid bilayers, Metal Nanoparticles, Nanoparticle, Nanotechnology, Biosensing Techniques, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biomaterials, gold insertion, radial porosity, Microscopy, Electron, Transmission, nanoporous silica sphere, Dynamic light scattering, Zeta potential, Animals, Receptors, Growth Factor, General Materials Science, Surface charge, Particle Size, Lipid bilayer, Cryoelectron Microscopy, Serum Albumin, Bovine, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry, Mesoporous silica, Silicon Dioxide, 021001 nanoscience & nanotechnology, protein adsorption, 0104 chemical sciences, Microscopy, Electron, Scanning, Cattle, Adsorption, Gold, Particle size, 0210 nano-technology, Nanospheres, Biotechnology, Protein adsorption
Abstract: International audience; A simple synthetic route is developed to achieve gold functionalized radial mesoporous silica nanoparticles (Au-MsNP) synthesized by a one step procedure fully compatible with basic conditions required for the preparation of monodispersed nanospheres. In a second step, Au-MsNP particles have been coated with phospholipid bilayers in order to design an advanced biofunctional platform with the gold metallic nanoparticles previously grown into the pore channels and responsible for a plasmonic activity relevant for biosensing. The size of Au-MsNP is checked by dynamic light scattering while zeta potential measurements reflect their surface charge. The particle morphology is characterized by transmission and scanning electron microscopy and the Si/Au ratios are obtained from energy dispersive X-ray analysis. The textural properties of Au-MsNP, specific surface area and pore size, are determined from N2 adsorption. The supported bilayers are achieved from vesicles of different phospholipids incubated with Au-MsNP particles. The coating efficiency is investigated by zeta potential and cryo- transmission electron microscopy. The plasmonic activities of bare Au-MsNP particles and coated lipid bilayer Au-MsNP platform are evidenced for two model systems: direct adsorption of bovine serum albumin and molecular recognition events between avidin molecules and biotin receptors integrated in the supported lipid bilayer.
Published: 2012

67. Ring-Closing Metathesis in Aqueous Micellar Medium

Author: Lionel Laville, Jean Martinez, Evelina Colacino, Clarence Charnay, Frédéric Lamaty, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)
Subjects: Magnetic Resonance Spectroscopy, chemistry.chemical_element, Alkenes, 010402 general chemistry, Metathesis, Heterogeneous catalysis, 01 natural sciences, Ruthenium, Catalysis, Surface-Active Agents, chemistry.chemical_compound, Ring-closing metathesis, Organometallic Compounds, Organic chemistry, Micelles, ComputingMilieux_MISCELLANEOUS, Aqueous solution, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Cationic polymerization, Water, [CHIM.CATA]Chemical Sciences/Catalysis, General Chemistry, Combinatorial chemistry, 0104 chemical sciences, Malonate, chemistry, Cyclization
Abstract: Underwater exploration: The ring-closing metathesis of N,N-diallyltosylamine (DATs) and diallyldiethyl malonate has been studied in aqueous micellar medium, at room temperature, in the presence of four different gemini cationic surfactants and various ruthenium catalysts. For the first time, the adsorption mechanisms and the reaction steps involved in this heterogeneous catalytic process were elucidated.
Published: 2011

68. Regeneration of spent bleaching earth by treatment with cethyltrimethylammonium bromide for application in elimination of acid dye

Author: Mohand Said Ouali, L.C. de Ménorval, Mohamed Mana, Jerzy Zajac, Clarence Charnay, Laboratoire de Valorisation des Materiaux, Université de Mostaganem, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: General Chemical Engineering, Kinetics, Intercalation (chemistry), Inorganic chemistry, 02 engineering and technology, 010501 environmental sciences, 01 natural sciences, Isotherms, Industrial and Manufacturing Engineering, chemistry.chemical_compound, Acid dye, Bromide, Environmental Chemistry, Organoclay, 0105 earth and related environmental sciences, Aqueous solution, Sorption, Spent bleaching earth, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry, 021001 nanoscience & nanotechnology, 6. Clean water, chemistry, Bentonite, 0210 nano-technology
Abstract: International audience; A spent bleaching earth from an edible oil refinery has been treated with an aqueous cetyltrimethylammonium bromide solution in order to remove the edible oil impregnating the solid material and to intercalate the ammonium cation in the interlayer space of the bentonite. The obtained material was characterized by XRD and TGA-DSC and the results were compared with that of a virgin bleaching earth. The prepared organophilic bentonite was used to remove the dye acid black 10B from the aqueous solution. The removal study included the sorption isotherms, kinetics, pH and temperature effect. The maximum removal capacity obtained (100 mg g−1) was better than those of some non conventional sorbents.
Published: 2011

69. Photodynamic Therapy: Porous Porphyrin-Based Organosilica Nanoparticles for NIR Two-Photon Photodynamic Therapy and Gene Delivery in Zebrafish (Adv. Funct. Mater. 21/2018)

Author: Marcel Garcia, Nicolas Cubedo, Rachid Sougrat, Vincent Sol, Jean-Olivier Durand, Erwan Oliviero, Magali Gary-Bobo, Vincent Chaleix, Danielle Laurencin, Mireille Rossel, Karen Tresfield, Niveen M. Khashab, Xavier Cattoën, Nadir Bettache, Dorothée Berthomieu, Sébastien Clément, Chiara Mauriello Jimenez, Manuel A. Roldan-Gutierrez, Sébastien Richeter, Dina Aggad, Jonas G. Croissant, Michel Wong Chi Man, Marie Maynadier, Laurence Raehm, Dalaver H. Anjum, Shahad Alsaiari, and Clarence Charnay
Subjects: Materials science, biology, medicine.medical_treatment, Nanoparticle, Photodynamic therapy, 02 engineering and technology, Gene delivery, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, biology.organism_classification, 01 natural sciences, Porphyrin, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, Biomaterials, chemistry.chemical_compound, Two-photon excitation microscopy, chemistry, Electrochemistry, Zebrafish embryo, medicine, Biophysics, 0210 nano-technology, Zebrafish
Published: 2018

70. Competitive interactions between components in surfactant–cosurfactant–additive systems

Author: Clarence Charnay, Jerzy Zajac, Louis-Charles de Ménorval, Radhouane Chaghi, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: Magnetic Resonance Spectroscopy, Surface Properties, Inorganic chemistry, 02 engineering and technology, n-heptanoic acid, 010402 general chemistry, 01 natural sciences, Micelle, Biomaterials, Surface-Active Agents, chemistry.chemical_compound, Colloid and Surface Chemistry, Phenols, Pulmonary surfactant, Competitive interactions, Organic chemistry, Phenol, Conductimetry, 1H NMR spectroscopy, Micelles, 1-heptanol, Molality, Aqueous solution, Cetrimonium, Chemistry, Hexadecyltrimethylammonium bromide, Heptanoic acid, Aqueous two-phase system, [CHIM.MATE]Chemical Sciences/Material chemistry, Reference Standards, 021001 nanoscience & nanotechnology, Titration calorimetry, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Heptanoic Acids, Cetrimonium Compounds, Titration, Micellar solubilization, 0210 nano-technology, Heptanol
Abstract: International audience; Complex interactions of phenol (PhOH), heptanol (HeOH) and heptanoic acid (HeOIC) with micellar aggregates of hexadecyltrimethylammonium bromide (HTAB) in aqueous solutions at surfactant concentrations close to the CMC, HeOH or HeOIC content of 0.5 mmol kg_1, and phenol molality of 1, 5, or 10 mmol kg_1 have been investigated at 303 K by means of 1H NMR spectroscopy, titration calorimetry and solution conductimetry. The analysis of the composition-dependence of the 1Hchemical shifts assigned to selected protons in the surfactant and additive units revealed the location of PhOH both within the hydrophobic micelle core and in the vicinity of the quaternary ammonium groups, the phenol penetration being somewhat deeper in the presence of HeOIC. The phenomenon was globally more exothermic with increasing extent of PhOH solubilization and it was accompanied by a gradual decrease in the positive entropy of micellization. The solubilization was competitive for high phenol contents in the aqueous phase, with some HeOH and HeOIC units being displaced progressively towards the aqueous phase.
Published: 2010

71. Nonionic polyoxazoline surfactants based on renewable source: Synthesis, surface and bulk properties

Author: Vincent Lapinte, Chloe Giardi, Jean Jacques Robin, Clarence Charnay, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), and AIME
Subjects: Polymers and Plastics, General Chemical Engineering, self-organisation, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biochemistry, Micelle, Surface tension, Amphiphile, Polymer chemistry, Materials Chemistry, Environmental Chemistry, nonionic surfactant, lipopolymer, chemistry.chemical_classification, Castor oil, Chemistry, Cationic polymerization, General Chemistry, Polymer, 021001 nanoscience & nanotechnology, 0104 chemical sciences, polyoxazoline, End-group, [CHIM.POLY]Chemical Sciences/Polymers, Chemical engineering, Polymerization, Critical micelle concentration, 0210 nano-technology
Abstract: International audience; The synthesis of amphiphilic lipid-polyoxazoline based on copolymers (CO-POxn) with narrow distribution has been achieved via cationic ring-opening polymerization of 2-methyl-2-oxazoline (MOx). Lipid-macroinitiator (COTs) was obtained from commercial castor oil (CO), widely renewable agricultural resource. CO-POxn with various length segments were synthesized from a macroinitiator COTs in order to investigate the effect of the length of the hydrophilic segment on the solution behavior of the nonionic polymer surfactants CO-POxn. The results showed that the critical micelle concentration rised with the increase of POx content and inversely surface tension decreased. The average size of aggregates of these structures suggested the formation of vesicles or nonspherical micelles. Star-shaped morphology of CO-POxn in solid state has also been observed using environmental scanning electron microscopy (ESEM). Addionally energy dispersive X-ray (EDX) analysis demonstrated the presence of POx block in the concentric stripes of the texture.
Published: 2009

72. ChemInform Abstract: Microwave-Ultrasound Simultaneous Irradiation: A Hybrid Technology Applied to Ring Closing Metathesis

Author: Marilena Radoiu, F. De Angelis, Jean Martinez, Clarence Charnay, Frédéric Lamaty, M. Sacco, and Evelina Colacino
Subjects: Sonotrode, Coaxial cable, business.industry, Chemistry, General Medicine, Metathesis, law.invention, Semiconductor, Ring-closing metathesis, law, Salt metathesis reaction, Optoelectronics, Irradiation, business, Microwave
Abstract: A new hybrid microwave (MW) and ultrasound (US)-assisted reactor concept was investigated. The 2.45 GHz microwaves were delivered by a semiconductor generator via a coaxial cable to a monomode Transverse Electric (TE) microwave resonant cavity within which the reactor was placed; the US (25 kHz) were delivered at the bottom of the TE cavity via a novel designed sonotrode consisting of a detachable metallic plate-probe (indirect sonication). The semiconductor microwave generator helped to optimize the absorbed energy via its automatic frequency tuning function. The dual MW/US device allowed the use of both technologies separately or in a simultaneous combined manner. The ring-closing metathesis of diethyl diallyl malonate in glycerol micellar conditions was studied as an example using this novel hybrid technology. The results were compared with those obtained when microwaves or ultrasound were applied individually. Various benzylidene-, indenylidene- and Hoveyda–Grubbs-type catalysts were screened. The novel reactor for combined MW/US irradiation showed beneficial effects on the outcome of the reaction.
Published: 2015

73. One-Pot Construction of Multipodal Hybrid Periodic Mesoporous Organosilica Nanoparticles with Crystal-Like Architectures

Author: Laurence Raehm, Jonas G. Croissant, Xavier Cattoën, Jean-Olivier Durand, Clarence Charnay, Michel Wong Chi Man, Philippe Dieudonné, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Optique et Matériaux (OPTIMA), Institut Néel (NEEL), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), Laboratoire Charles Coulomb (L2C), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), ANR mechanano, and ANR-10-NANO-0022,MECHANANO,Nanomachines mécanisées pour l'activation à deux photons(2010)
Subjects: Crystal, Mesoporous organosilica, Materials science, Chemical engineering, Mechanics of Materials, Mechanical Engineering, Nanoparticle, General Materials Science, [CHIM.MATE]Chemical Sciences/Material chemistry, ComputingMilieux_MISCELLANEOUS, Sol-gel
Abstract: The design of hybrid multipodal PMO (mp-PMO) nanoparticles with crystal-like architectures elaborated in a one-pot, two-step process, involving the preparation of a benzene-based spherical PMO core followed by the formation of ethylene-based rod-shaped PMO pods on these cores is described.
Published: 2015

74. Conductivity and Dielectric Relaxation in Crosslinked PVA by Oxalic and Citric Acids

Author: R. Pedicini, Alessandra Carbone, Mourad Arous, Arbi Fattoum, and Clarence Charnay
Subjects: Arrhenius equation, Materials science, Polymers and Plastics, Analytical chemistry, macromolecular substances, Activation energy, Dielectric, Conductivity, symbols.namesake, Electrical resistivity and conductivity, Materials Chemistry, symbols, Relaxation (physics), Glass transition, Polarization (electrochemistry)
Abstract: In this work we investigated polyvinyl alcohol films which we crosslinked at various crosslinking degrees by oxalic and citric acids for the fuel cell applications. We studied the effects of the crosslinking on structure, thermal properties, electric conductivity and dielectric relaxations. The glass transition temperature is increased indicating the lowering of the local mobility of the polymer chains. X-ray diffraction showed the presence of non-dissociated acid phases in dried samples. The Dc conductivity increases by increasing both the relative humidity and the temperature obeying to an Arrhenius law with activation energy compatible with proton conductivity type. The Ac conductivity studied between 10−1 Hz and 1 MHz showed a power law response in the high frequency range. This behavior characterizes the charge transport in disordered materials. At low frequencies the Ac conductivity is governed by the electrode/sample interface polarization. The use of the dielectric permittivity indicates the presence of a relaxation process attributed to electrode/sample interface polarization and another relaxation process attributed to alpha relaxation of the polyvinyl alcohol chains.
Published: 2015

75. Microwave-ultrasound simultaneous irradiation: a hybrid technology applied to ring closing metathesis

Author: Marilena Radoiu, Evelina Colacino, Jean Martinez, F. De Angelis, M. Sacco, Frédéric Lamaty, Clarence Charnay, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi dell'Aquila = University of L'Aquila (UNIVAQ), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), SAIREM, Erasmus Placement Program, Università de L'Aquila – Italy, SAIREM Neyron France, REUS Contes France, European Project: 39631,ERASMUS, Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Dipartimento di Scienze Fisiche e Chimiche, Università dell'Aquila e Consorzio (INCA), Università degli Studi dell'Aquila (UNIVAQ), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: Sonotrode, Materials science, business.industry, Coaxial cable, [CHIM.ORGA]Chemical Sciences/Organic chemistry, General Chemical Engineering, Sonication, General Chemistry, Metathesis, 7. Clean energy, law.invention, Ring-closing metathesis, Semiconductor, law, Optoelectronics, Irradiation, business, Microwave
Abstract: International audience; A new hybrid microwave (MW) and ultrasound (US)-assisted reactor concept was investigated. The 2.45 GHz microwaves were delivered by a semiconductor generator via a coaxial cable to a monomode Transverse Electric (TE) microwave resonant cavity within which the reactor was placed; the US (25 kHz) were delivered at the bottom of the TE cavity via a novel designed sonotrode consisting of a detachable metallic plate-probe (indirect sonication). The semiconductor microwave generator helped to optimize the absorbed energy via its automatic frequency tuning function. The dual MW/US device allowed the use of both technologies separately or in a simultaneous combined manner. The ring-closing metathesis of diethyl diallyl malonate in glycerol micellar conditions was studied as an example using this novel hybrid technology. The results were compared with those obtained when microwaves or ultrasound were applied individually. Various benzylidene-, indenylidene- and Hoveyda–Grubbs-type catalysts were screened. The novel reactor for combined MW/US irradiation showed beneficial effects on the outcome of the reaction.
Published: 2015

76. Copper-Containing Rod-Shaped Nanosized Silica Particles for Microwave-Assisted Synthesis of Triazoles in Aqueous Solution

Author: Jerzy Zajac, Jeff L. Nyalosaso, Frédéric Lamaty, Jean Martinez, Evelina Colacino, Clarence Charnay, Najib Mnasri, Gaelle Derrien, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Université de Gafsa, Institut de Chimie de Clermont-Ferrand (ICCF), SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), and Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM)
Subjects: Heterogeneous catalysis, Aqueous solution, Materials science, Renewable Energy, Sustainability and the Environment, Click chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, General Chemical Engineering, Inorganic chemistry, Nanoparticle, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, Mesoporous silica, Catalysis, Environmental Chemistry, Surface modification, Nanoparticles, Micellar solubilization, Dispersion (chemistry), Mesoporous material, Microwaves, Multicomponent reactions (MCR)
Abstract: International audience; Cu-doped rod-shaped mesoporous silica nanoparticles (Cu-RMSN) were synthesized by a new one-step approach based on in situ functionalization procedure referring to the phenomenon of micellar solubilization. SEM and TEM studies revealed the rod-like morphology of uniformly sized particles with longitudinal mesopore channels. The BET specific surface areas were near 500 m2 g–1 and the average pore diameter varied from 3 to 3.6 nm. The composite Cu-RMSN proved to be an efficient heterogeneous catalyst for a microwave-assisted three-component 1,3-dipolar cycloaddition reaction in aqueous solution. The one-pot preparation of 1,4-dibustituted-1,2,3-triazole derivatives was straightforward and high yielding, due to the high copper dispersion at the pore surface resulting in the high accessibility of the active sites. The efficiency of the catalyst was also demonstrated upon recycling, making such synthesis a truly green process with marked step and solvent economy and important waste reduction.
Published: 2015

77. Microcalorimetric studies of cationic gemini surfactant with a hydrophilic spacer group

Author: A. Bendjeriou, Gaelle Derrien, P. Hartmann, S. Partyka, Clarence Charnay, Laboratoire des Agrégats Moléculaires et Matériaux Inorganiques (LAMMI), and Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 2 - Sciences et Techniques (UM2)
Subjects: Isothermal microcalorimetry, Thermodynamics of micellization, Inorganic chemistry, Enthalpy, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Micelle, chemistry.chemical_compound, Pulmonary surfactant, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Polymer chemistry, Physical and Theoretical Chemistry, Instrumentation, Ethylene oxide, Chemistry, Cationic polymerization, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Gemini surfactants, 0104 chemical sciences, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Microcalorimetry, Critical micelle concentration, 0210 nano-technology
Abstract: International audience; The aim of this work is to investigate the micellization thermodynamics for gemini surfactants with a hydrophilic spacer group, i.e. Br− n-C12H25N+Me2single bondCH2(CH2OCH2)xCH2N+Me2single bondn-C12H25 Br−, referred to as 12-EOx-12, where x = 1, 3, 6, 7. These oligooxaalkanediyl-α,ω-bis(dimethyldodecylammonium bromide) dimeric surfactants were synthesized by a two step reaction. Their physicochemical properties in aqueous solutions have been studied by microcalorimetry at 298 K, electrical conductivity and surface tension measurements. The critical micellar concentration (cmc) and the head-group area (a0) per molecule at the air–water interface increase with increasing number of oxide ethylene moieties in the spacer and, consequently, with the enhanced hydrophilic character of the molecule. The calorimetric studies of the self-assembly process confirm this trend, since the exothermic values of the differential enthalpy of micellization (ΔmicH°) decrease as the ethylene oxide moieties are lengthened. Moreover, the values of the free energy and entropy of micellization indicate an entropy driven phenomenon for all surfactants. These results are compared with those obtained for gemini cationic surfactants with a hydrophobic spacer and the differences observed are discussed in terms of the hydrophilic head-group conformation in the micelle.
Published: 2005

78. Reduced Symmetry Metallodielectric Nanoparticles: Chemical Synthesis and Plasmonic Properties

Author: R. Kelley Bradley, Corey Radloff, Naomi J. Halas, Allen Lee, Clarence Charnay, Shi-Qing Man, and Cristin E. Moran
Subjects: Nanostructure, Materials science, Materials Chemistry, Shell (structure), Finite-difference time-domain method, Nanoparticle, Nanotechnology, Physical and Theoretical Chemistry, Polarization (electrochemistry), Ray, Nanoscopic scale, Plasmon, Surfaces, Coatings and Films
Abstract: We report a general chemical strategy for producing reduced-symmetry metallodielectric nanoparticles, nanocups, and nanocaps that combines nanoscale masking techniques and nanoparticle-seeded electroless plating. Using this approach, silica nanoparticles with a gold cup-shaped shell and, alternatively, a gold cap, are obtained. The plasmon response of both nanostructures is a sensitive function of orientation of the nanostructure with respect to the direction and polarization of incident light. This orientation dependence is examined experimentally by studying the extinction spectra of oriented nanocups and nanocaps on transparent substrates, and is also evaluated theoretically using a three-dimensional finite difference time domain (FDTD) method.
Published: 2003

79. Polymer Adsorption Effects on Structure and Rheological Properties of Concentrated Suspensions of Talc Particles

Author: Serge Lagerge and Clarence Charnay
Subjects: Chromatography, Polymers and Plastics, Chemistry, Polymer adsorption, Talc, Dispersant, Polyelectrolyte, Surfaces, Coatings and Films, Suspension (chemistry), Adsorption, Rheology, Chemical engineering, medicine, Physical and Theoretical Chemistry, Dispersion (chemistry), medicine.drug
Abstract: The adsorption of a polyacrylate sodium salt (PANa) onto talc and its influence on the dispersion of the particles is investigated both in dilute suspensions (adsorption isotherm, ion titration, and electrophoretic mobility) and in concentrated dispersions (rheology). The adsorption of negatively charged dispersant on the negative surface of talc remains possible through a charge compensation effect of PANa with Ca2+ ions originating from the dissolution of carbonated impurities in the talc samples. It is evident that the prevailing mechanism of adsorption involves a bridging process through Ca2+ cations between the negatively charged surface and the negative macromolecule. The adsorption analysis of the PANa is then correlated with the rheological behavior of the concentrated suspensions of talc particles. Evolution of the viscosity of the suspensions suggested the polymer was able to improve the dispersion of solid particles in concentrated suspension. In another part, the influence of associat...
Published: 2003

80. Inside Cover: Engineered Au Core@Prussian Blue Analogous Shell Nanoheterostructures: Their Magnetic and Optical Properties (Chem. Eur. J. 31/2017)

Author: Yannick Guari, Clarence Charnay, Marc Georg Willinger, Jérôme Long, Guillaume Maurin-Pasturel, Alexander A. Trifonov, Christian Guérin, Maria A. Palacios, and Joulia Larionova
Subjects: Prussian blue, 010405 organic chemistry, Chemistry, Organic Chemistry, Shell (structure), Nanotechnology, General Chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, Core (optical fiber), chemistry.chemical_compound, Crystallography, Cover (algebra)
Published: 2017

81. Synthesis of novel multi-cationic PEG-based ionic liquids

Author: Clarence Charnay, Anissa Bendjeriou, Evelina Colacino, Jean Martinez, Frédéric Lamaty, Najib Mnasri, Martina Maya Cecchini, Francesco De Angelis, Università degli Studi dell'Aquila = University of L'Aquila (UNIVAQ), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Grant Pôle Chimie Balard (Montpellier - France), Università de l'Aquila (Italy), European Project: 39631,ERASMUS, Dipartimento di Scienze Fisiche e Chimiche, Università dell'Aquila e Consorzio (INCA), Università degli Studi dell'Aquila (UNIVAQ), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: Materials Chemistry2506 Metals and Alloys, liquids, synthesis, Ionic bonding, Catalysis, ionic, ILPEGs, chemistry.chemical_compound, PEG-based, thermophysical, Polymer chemistry, Amphiphile, PEG ratio, Materials Chemistry, Thermal stability, hydrophobic, Methylene, Chemistry (all), novel, poly(ethylene glycol), Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Cationic polymerization, General Chemistry, multi-cationic, Ionic liquid, tri-cationic, Ethylene glycol
Abstract: International audience; The syntheses of ten novel mono-, di- or tri-cationic poly(ethylene glycol)-based ionic liquids (ILPEGs), incorporating tetra-substituted ammonium cations, are described. The poly(ethylene glycol) chains could be bridged or not and bore the cation. In the di-cationic ILPEG family, hydrophobic poly(methylene) or amphipathic poly(oxyethylene) spacers, with various lengths, were designed to connect the polar heads, while in the tri-cationic ILPEG family, the spacer was constituted by substituted diamines. The thermophysical properties such as viscosity or thermal stability were also investigated.
Published: 2014

82. Versatile heavy metals removal via magnetic mesoporous nanocontainers

Author: Jérôme Long, Jonas G. Croissant, Laurence Raehm, Makhlouf Boufatit, Soroya Dib, J.O. Durand, Siham Chelouaou, F. Sadi-Hassaine, Clarence Charnay, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: Materials science, [CHIM.ORGA]Chemical Sciences/Organic chemistry, General Chemical Engineering, Metal ions in aqueous solution, Inorganic chemistry, Iron oxide, Magnetic separation, 02 engineering and technology, General Chemistry, Mesoporous silica, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, Adsorption, chemistry, Surface modification, 0210 nano-technology, Porosity, Mesoporous material, ComputingMilieux_MISCELLANEOUS
Abstract: Versatile heavy metal ions removal is performed via iron oxide core mesoporous silica shell nanocontainers functionalized with diethylene triamine pentaacetic acid. Magnetic separation from aqueous media is obtained for a dozen of the most toxic heavy metal ions with remarkable efficiencies. Furthermore, this study demonstrates enhancement of the adsorption capacities with the combination of porous and surface functionalization of the nanocontainers.
Published: 2014

83. Micelles into Glycerol Solvent: Overcoming Side Reactions of Glycerol

Author: Martina Sacco, Jean Martinez, Abdellah Hamel, Clarence Charnay, Najib Mnasri, Frédéric Lamaty, Francesco De Angelis, Evelina Colacino, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Department of Chemistry, Université Badji Mokhtar - Annaba [Annaba] (UBMA), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell'Aquila (UNIVAQ), PENNAKEM (Renewable Resource Chemistry, U.S.A.), and Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Glycerol, General Chemical Engineering, Micellar catalysis, Critical micellar concentration, Metathesis, 7. Clean energy, Micelle, Catalysis, chemistry.chemical_compound, Ring-closing metathesis, Gemini surfactants, Organic chemistry, Environmental Chemistry, Chemical Engineering (all), Renewable Energy, Microwaves, ComputingMilieux_MISCELLANEOUS, Chemistry (all), Renewable Energy, Sustainability and the Environment, Sustainability and the Environment, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Cationic polymerization, General Chemistry, 6. Clean water, Solvent, chemistry, 13. Climate action, Critical micelle concentration
Abstract: The ring-closing metathesis (RCM) of diethyl diallylmalonate in glycerol micellar conditions was studied using microwave irradiation. The micellization of different cationic surfactants in glycerol was first investigated. The results show the superiority of micellar catalysis in glycerol for a RCM reaction compared to glycerol alone, limiting byproduct formation. In comparison with the classical solution syntheses, the method here described allows safer reaction conditions, less hazardous chemical syntheses, and use of renewable feedstocks. The practical workup, separation, and purification operations minimize the use of materials.
Published: 2014

84. ChemInform Abstract: Poly(ethylene glycol)-Based Ionic Liquids: Properties and Uses as Alternative Solvents in Organic Synthesis and Catalysis

Author: Frédéric Lamaty, Evelina Colacino, Jean Martinez, Clarence Charnay, Francesco De Angelis, and Martina Maya Cecchini
Subjects: chemistry.chemical_compound, chemistry, Rheology, Chemical engineering, Organocatalysis, Ionic liquid, Organic synthesis, General Medicine, Biodegradation, Glass transition, Ethylene glycol, Catalysis
Abstract: PEG-based ionic liquids are a new appealing group of solvents making the link between two distinct but very similar fluids: ionic liquids and poly(ethylene glycol)s. They find applications across a range of innumerable disciplines in science, technology, and engineering. In the last years, the possibility to use these as alternative solvents for organic synthesis and catalysis has been increasingly explored. This Review highlights strategies for their synthesis, their physical properties (critical point, glass transition temperature, density, rheological properties), and their application in reactions catalyzed by metals (such as Pd, Cu, W, or Rh) or as organic solvent (for example for multicomponent reactions, organocatalysis, CO2 transformation) with special emphasis on their toxicity, environmental impact, and biodegradability. These aspects, very often neglected, need to be considered in addition to the green criteria usually considered to establish ecofriendly processes.
Published: 2014

85. Improved gene transfer with histidine-functionalized mesoporous silica nanoparticles

Author: David Brevet, Jean-Olivier Durand, Ouahiba Hocine, Anthony Delalande, Chantal Pichon, Laurence Raehm, Patrick Midoux, Clarence Charnay, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Centre de biophysique moléculaire (CBM), and Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
Subjects: animal structures, media_common.quotation_subject, Genetic Vectors, Pharmaceutical Science, Nanoparticle, Cytomegalovirus, Transfection, Achilles Tendon, Mice, In vivo, Luciferases, Firefly, Animals, Humans, Electrophoretic mobility shift assay, Histidine, Internalization, ComputingMilieux_MISCELLANEOUS, media_common, Drug Carriers, Propylamines, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Chemistry, Gene Transfer Techniques, DNA, Mesoporous silica, Silanes, Silicon Dioxide, 3. Good health, HEK293 Cells, Biochemistry, Biophysics, Degradation (geology), Nanoparticles, sense organs, Plasmids
Abstract: Mesoporous silica nanoparticles (MSN) were functionalized with aminopropyltriethoxysilane (MSN-NH2) then L-histidine (MSN-His) for pDNA delivery in cells and in vivo. The complexation of pDNA with MSN-NH2 and MSN-His was first studied with gel shift assay. pDNA complexed with MSN-His was better protected from DNase degradation than with MSN-NH2. An improvement of the transfection efficiency in cells was observed with MSN-His/pDNA compared to MSN-NH2/pDNA, which could be explained by a better internalization of MSN-His. The improvement of the transfection efficiency with MSN-His was also observed for gene transfer in Achilles tendons in vivo.
Published: 2014

86. Silver nanoparticle-containing submicron-in-size mesoporous silica-based systems for iodine entrapment and immobilization from gas phase

Author: Jerzy Zajac, Elimame Elaloui, Louis-Charles de Ménorval, Najib Mnasri, Younes Moussaoui, Clarence Charnay, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: Materials science, Sintering, 02 engineering and technology, General Chemistry, Mesoporous silica, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Silver nanoparticle, 0104 chemical sciences, law.invention, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Adsorption, Chemical engineering, Mechanics of Materials, law, Particle, Organic chemistry, General Materials Science, Calcination, Particle size, 0210 nano-technology, Mesoporous material, ComputingMilieux_MISCELLANEOUS
Abstract: Submicron-in-size silica particles with controllable morphology, particle size and mesoporosity, have been prepared under basic conditions making use of cationic alkyltrimethylammonium surfactants (C n TAB, n = 12,16,18) as porogens. Gaseous nitrogen adsorption, XRD and TEM experiments revealed quasi-spherical homodispersed objects possessing regular mesopores of the MCM-41 type; lengthening of the hydrophobic tail of the template resulted in smaller particles with greater intraparticle pores. The aggregation and sintering of individual silica particles during the calcination step led to the formation of particle clusters comprising interparticle voids, as evidenced by the 129 Xe NMR and TEM studies. The calcined particles were subsequently loaded with metallic silver. The measurements of iodine adsorption onto Ag-functionalized materials from the gas phase were supplemented by XRD, SEM/EDX, and TGA/DTA studies. It was demonstrated that the functionalized silica retained much gaseous iodine in an irreversible manner, mainly as an ‘interfacial’ AgI. The best compromise between the textural parameters and the post-synthesis functionalization was obtained for the large-pore silica templated with C 18 TAB. Indications about the presence of silver metal nanoparticles, displaying certain heterogeneity in size and shape, within the pores of this sample were given based on the analysis of 129 Xe NMR spectra supplemented by UV–Visible absorption spectra and powder XRD patterns in the wide-angle region. The material can be recommended for the entrapment and immobilization of radioactive iodine in the nuclear industry since it guarantees that the adsorbed pollutant is primarily localized within the material pores and is thermally stable up to 800 K in air.
Published: 2014

87. Assessment of the Surface Heterogeneity of Talc Materials

Author: S. Partyka, Clarence Charnay, and Serge Lagerge
Subjects: Aqueous solution, Chemistry, Inorganic chemistry, Ionic bonding, Talc, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Biomaterials, Colloid and Surface Chemistry, Adsorption, Pulmonary surfactant, Phase (matter), medicine, Dispersion (chemistry), Protein adsorption, medicine.drug
Abstract: The hydrophobic and hydrophilic components of the surface of talc materials in aqueous solution were determined using ionic surfactants and their polar headgroup adsorption isotherms. The hydrophilic and hydrophobic surface areas are inferred from the amount of probe molecule adsorbed and the structure of the adsorbed layer. Natural dispersion of talc shows at 298 K a pH of 9.4 and the electrophoretic measurements indicate that the particles are negatively charged. The hydrophilic surface area is estimated from the adsorption of benzyltrimethylammonium ions (BTMA(+)) through electrostatic interactions as supported by the increase of divalent ions in the bulk phase and the decrease in the exothermic displacement enthalpy. It was also observed from the adsorption isotherm of benzene sulfonate anions that the density of positive surface sites is very low and is thus neglected. The adsorption of an anionic surfactant essentially occurs through dispersive interactions between the nonpolar organic tail of the molecule and the hydrophobic surface. Furthermore, some assumptions on the structure of dodecyl sulfate surfactant aggregates at the interface allow the hydrophobic part of the talc particles to be estimated. The cationic surfactant adsorption has been investigated and found to corroborate the hydrophilic and hydrophobic area values first obtained. Copyright 2001 Academic Press.
Published: 2001

88. Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers

Author: Jean-Olivier Durand, Marie Maynadier, Laurence Raehm, Jeffrey I. Zink, Jeff L. Nyalosaso, Mireille Blanchard-Desce, Magali Gary-Bobo, Marcel Garcia, Audrey Gallud, Olivier Mongin, Jie Lu, Harmel Peindy N'Dongo, Nathalie Cheminet, Derrick Tarn, Clarence Charnay, Françoise Serein-Spirau, Thibaut Jarrosson, Tania M. Guardado-Alvarez, Jonas G. Croissant, Gaelle Derrien, Fuyuhiko Tamanoi, Chemical and Biological Engineering [Albuquerque], The University of New Mexico [Albuquerque], Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Clermont-Ferrand - Clermont Auvergne (ICCF), Sigma CLERMONT (Sigma CLERMONT)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Synthèse et électrosynthèse organiques (SESO), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1), Department of Chemistry, Massachusetts Institute of Technology (MIT), Microbiology, Immunology and Molecular Genetics (UCLA), University of California [Los Angeles] (UCLA), University of California-University of California, Department of Chemistry and Biochemistry, Exotic Materials Institute, University of California, Los Angeles (UCLA), Department of Chemistry and Biochemistry, University of California Los Angeles, Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University of California (UC)-University of California (UC), ANR-10-NANO-0022,MECHANANO,Nanomachines mécanisées pour l'activation à deux photons(2010), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Institut des Sciences Chimiques de Rennes (ISCR), Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Rennes-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), Chimie et Photonique Moléculaires (CPM), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Centre National de la Recherche Scientifique (CNRS), Nyalosaso, Jeff, and NANOTECHNOLOGIES ET NANOSYSTEMES - Nanomachines mécanisées pour l'activation à deux photons - - MECHANANO2010 - ANR-10-NANO-0022 - P2N - VALID
Subjects: Fluorophore, Stereochemistry, [CHIM.THER] Chemical Sciences/Medicinal Chemistry, [SDV.CAN]Life Sciences [q-bio]/Cancer, 02 engineering and technology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, mesoporous materials, 010402 general chemistry, 01 natural sciences, Catalysis, Article, chemistry.chemical_compound, Drug Delivery Systems, Two-photon excitation microscopy, [SDV.CAN] Life Sciences [q-bio]/Cancer, Neoplasms, medicine, cancer, Humans, ComputingMilieux_MISCELLANEOUS, [CHIM.MATE] Chemical Sciences/Material chemistry, two-photon excitation, Chemistry, 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Cancer, General Chemistry, General Medicine, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, medicine.disease, [CHIM.ORGA] Chemical Sciences/Organic chemistry, 0104 chemical sciences, 3. Good health, Förster resonance energy transfer, azobenzene, Azobenzene, Drug delivery, Cancer cell, drug delivery, Biophysics, Nanoparticles, 0210 nano-technology, Azo Compounds, Camptothecin, medicine.drug
Abstract: International audience; A therapy of cancer cells: Two-photon-triggered camptothecin delivery (see picture) with nanoimpellers was studied in MCF-7 breast cancer cells. A fluorophore with a high two-photon absorption cross-section was first incorporated in the nanoimpellers. Fluorescence resonance energy transfer (FRET) from the fluorophore to the azobenzene moiety was demonstrated.
Published: 2013

89. Measurement of Uptake and Release Capacities of Mesoporous Silica Nanoparticles Enabled by Nanovalve Gates

Author: Zongxi Li, Angela A. Hwang, Jeff L. Nyalosaso, Gaelle Derrien, Jean Durand, Sui Yang, Clarence Charnay, Daniel P. Ferris, Jeffrey I. Zink, University of California [Los Angeles] (UCLA), University of California, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut de Chimie de Clermont-Ferrand - Clermont Auvergne (ICCF), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Sigma CLERMONT (Sigma CLERMONT), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2), Department of Chemistry and Biochemistry, University of California Los Angeles, and University of California-University of California
Subjects: Nanoparticle, Nanotechnology, [SDV.CAN]Life Sciences [q-bio]/Cancer, 02 engineering and technology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 010402 general chemistry, 01 natural sciences, Article, Silica nanoparticles, Biological stain, Specific surface area, Molecule, Physical and Theoretical Chemistry, ComputingMilieux_MISCELLANEOUS, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, Mesoporous silica, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, General Energy, Water soluble, Chemical engineering, 0210 nano-technology, Mesoporous material
Abstract: International audience; The uptake and release capacities of mesoporous silica particles are measured on nanovalve-gated stimulated release systems, using a water soluble biological stain, Hoechst 33342, as the cargo model. Five different types of mesoporous silica nanoparticles: 2D-hexagonal MCM-41, swollen pore MCM-41, rod-like MCM-41, hollow mesoporous nanoparticles and radial mesoporous nanoparticles are studied and compared. Solid silica nanoparticles are used as the control. Because of the presence of the nanovalves, the loaded and capped particles can be washed thoroughly without losing the content of the mesopores. The quantity of Hoechst 33342 molecules trapped within the nanoparticles and released upon opening the nanovalves are systematically studied for the first time. The loading conditions are optimized by varying the Hoechst concentration in the loading solutions. Surprisingly, increasing the Hoechst concentration in the loading solution does not always result in a larger amount of Hoechst being trapped and released. Among the five types of mesoporous silica nanoparticles, the radial mesoporous nanoparticles and the swollen pore MCM-41 particles show the highest and lowest release capacity, respectively. The uptake capacities is correlated with the specific surface area of the materials rather than their internal volume. The uptake and release behaviors are also affected by charge and spatial factors.
Published: 2013

90. Poly(ethylene glycol)-based ionic liquids: properties and uses as alternative solvents in organic synthesis and catalysis

Author: Evelina Colacino, Frédéric Lamaty, Francesco De Angelis, Clarence Charnay, Jean Martinez, Martina Maya Cecchini, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Dipartimento di Scienze Fisiche e Chimiche, Università dell'Aquila e Consorzio (INCA), Università degli Studi dell'Aquila (UNIVAQ), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: General Chemical Engineering, Ionic Liquids, Chemistry Techniques, Synthetic, 010402 general chemistry, 01 natural sciences, Catalysis, Polyethylene Glycols, chemistry.chemical_compound, Rheology, Environmental Chemistry, Organic chemistry, Animals, Humans, General Materials Science, heterocycles, poly(ethylene glycols), 010405 organic chemistry, multicomponent reactions, toxicity, [CHIM.CATA]Chemical Sciences/Catalysis, Biodegradation, 0104 chemical sciences, General Energy, ionic liquids, chemistry, Organocatalysis, Ionic liquid, Solvents, Organic synthesis, Glass transition, Ethylene glycol
Abstract: International audience; : PEG-based ionic liquids are a new appealing group of solvents making the link between two distinct but very similar fluids: ionic liquids and poly(ethylene glycol)s. They find applications across a range of innumerable disciplines in science, technology, and engineering. In the last years, the possibility to use these as alternative solvents for organic synthesis and catalysis has been increasingly explored. This Review highlights strategies for their synthesis, their physical properties (critical point, glass transition temperature, density, rheological properties), and their application in reactions catalyzed by metals (such as Pd, Cu, W, or Rh) or as organic solvent (for example for multicomponent reactions, organocatalysis, CO2 transformation) with special emphasis on their toxicity, environmental impact, and biodegradability. These aspects, very often neglected, need to be considered in addition to the green criteria usually considered to establish ecofriendly processes.
Published: 2013

91. Hydrophilization by coating of silylated polyoxazoline using sol-gel process

Author: Cédric Alexis, Jean-Jacques Robin, Clarence Charnay, Vincent Lapinte, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: Materials science, General Chemical Engineering, One-Step, 02 engineering and technology, engineering.material, Solid surface energy, 010402 general chemistry, 01 natural sciences, Hydrophilization, Contact angle, Hybrid coating, Coating, Polymer chemistry, Materials Chemistry, Sol-gel, chemistry.chemical_classification, Organic Chemistry, Cationic polymerization, Polymer, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Surfaces, Coatings and Films, [CHIM.POLY]Chemical Sciences/Polymers, Polymerization, chemistry, engineering, Polyoxazoline polymer, 0210 nano-technology
Abstract: International audience; Hybrid films prepared from TEOS and polyoxazolines (Si-POx-Si) crosslinking agents were coated on different substrates in order to modify their surface properties. The film cohesion and adhesion on sub- strates were expected through the hydrogen bonding of the polyoxazoline crosslinked network. Low molecular-weight ﰁ,ﰂ-unsaturated polyoxazolines (DA-PMOx)s were synthesized by a one step cationic ring-opening polymerization (CROP) of 2-methyl-2-oxazoline (MOx) with a good control over the molec- ular weight. Based on double thiol-ene coupling (d-TEC) a post-functionalization of DA-PMOx end chains gave in good yield polyoxazoline cross linker (Si-POx-Si). Glass and various polymer substrates (PP, PEI, POM, etc.) were spin coated by the organic-inorganic hybrid films through sol-gel process. AFM, SEM, visible reflectance spectroscopy and contact angle experiments allowed the full characterization of targeted surfaces and demonstrated the efficiency of the polyoxazoline coating.
Published: 2013

92. Corona interactome: A key for deciphering protein adsorption kinetics on silica nanocarriers surface

Author: Clarence Charnay, Odette Prat, Jeff L. Nyalosaso, Jean Armengaud, Jean-Charles Gaillard, Yannick Guari, Michael Odorico, Jean-Marie Devoisselle, Joël Chopineau, and Cédric Pisani
Subjects: Corona (optical phenomenon), Chemistry, Kinetics, Nanotechnology, General Medicine, Nanocarriers, Toxicology, Interactome, Protein adsorption
Published: 2016

93. Aluminium-derivatized silica monodisperse nanospheres by a one-step synthesis-functionalization method and application as acid catalysts in liquid phase

Author: Gaelle Derrien, Louis-Charles de Ménorval, Jeff L. Nyalosaso, Clarence Charnay, Jerzy Zajac, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut de Chimie de Clermont-Ferrand - Clermont Auvergne (ICCF), Sigma CLERMONT (Sigma CLERMONT)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)
Subjects: Materials science, Butanol, Dispersity, 02 engineering and technology, General Chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Catalysis, chemistry.chemical_compound, Chemical engineering, chemistry, Aluminosilicate, Materials Chemistry, Organic chemistry, Surface modification, Particle size, 0210 nano-technology, Porosity, Ethylene glycol, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; Aluminium-derivatized submicron-in-size silica spheres (Al-MSS), with controllable morphology, particle size, mesoporosity, and incorporation of an active phase at the internal surface, have been prepared by a one-step synthesis-functionalization method in view of potential applications in the liquid phase. Four Al-MSS samples were prepared with a molar Si/Al ratio in the initial gel of 44, 22, 11, and 7, and their properties were compared with those of a purely siliceous sample (MSS). Nitrogen adsorption, XRD, SEM and TEM studies revealed homodispersed particles with average diameters ranging between 350 and 520 nm and possessing radial porosity. BET specific surface areas were included between 900 and 1300 m2 g−1 and the average pore diameter varied from 3 to 3.4 nm. Surface reactivity and Al accessibility at the material surface were determined with measurements of two-cycle ammonia adsorption and EDX-based calculations. The best compromise between textural parameters, surface properties, and stoichiometric Al incorporation was achieved with Al-MSS-22. This sample was further characterized by 129Xe-NMR, 27Al-MAS-NMR, XPS, NH3-TPD and IR methods to confirm the high accessibility of its internal porous structure and the presence of weak Brønsted and strong Lewis acid sites on its surface. The catalytic behavior of Al-MSS-22 in the liquid phase was tested in esterification reactions of ethanoic acid with alcohols or polyols such as butanol, isoamyl alcohol, ethylene glycol, and glycerol. In the case of alcohols, the remarkable performance of this aluminosilicate was supported by conversion rates close to 100%, allowing the amount of the catalytic material to be significantly decreased compared with other systems already tested in the literature.
Published: 2012

94. ChemInform Abstract: Synthesis of a New Hydrophilic Poly(ethylene glycol)-ionic Liquid and Its Application in Peptide Synthesis

Author: Francisco Galindo, Jean Martinez, Frédéric Lamaty, Clarence Charnay, Pauline Petiot, Evelina Colacino, and Lucy Puttergill
Subjects: Solvent, chemistry.chemical_compound, Viscosity, chemistry, Ionic liquid, Polymer chemistry, Peptide synthesis, Thermal stability, Ammonium, General Medicine, Mass spectrometry, Ethylene glycol
Abstract: The synthesis of a new hydrophilic ammonium-based poly(ethylene glycol)-ionic liquid (PEG-IL) is reported; the structure was assigned by NMR (1H, 13C) and MALDI mass spectrometry. The viscosity and thermal stability were also studied, as well as its polarity. Its application as an alternative solvent in the synthesis of dipeptides under microwave irradiation is also described.
Published: 2011

95. Synthesis of a new hydrophilic poly(ethylene glycol)-ionic liquid and its application in peptide synthesis

Author: Jean Martinez, Lucy Puttergill, Francisco Galindo, Evelina Colacino, Pauline Petiot, Clarence Charnay, Frédéric Lamaty, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Departamento de Quimica Inorganica y Organica, and Universitat Jaume I
Subjects: Ionic Liquids, 010402 general chemistry, Mass spectrometry, 01 natural sciences, Catalysis, Polyethylene Glycols, chemistry.chemical_compound, Viscosity, Polymer chemistry, Materials Chemistry, Peptide synthesis, [CHIM]Chemical Sciences, Thermal stability, Ammonium, Microwaves, ComputingMilieux_MISCELLANEOUS, Molecular Structure, 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Metals and Alloys, Temperature, General Chemistry, Dipeptides, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Solvent, Quaternary Ammonium Compounds, chemistry, Ionic liquid, Ceramics and Composites, Ethylene glycol
Abstract: International audience; The synthesis of a new hydrophilic ammonium-based poly(ethylene glycol)-ionic liquid (PEG-IL) is reported; the structure was assigned by NMR (1H, 13C) and MALDI mass spectrometry. The viscosity and thermal stability were also studied, as well as its polarity. Its application as an alternative solvent in the synthesis of dipeptides under microwave irradiation is also described.
Published: 2010

96. Silicalites and Mesoporous Silica Nanoparticles for photodynamic therapy

Author: Pierre Couleaud, Sébastien Richeter, Alain Morère, Magali Gary-Bobo, Ouahiba Hocine, Monique Smaïhi, Simon Fontanel, Bernard Loock, Marie Maynadier, Laurence Raehm, Gaelle Derrien, Philippe Maillard, Céline Frochot, Jean-Olivier Durand, Clarence Charnay, Amar Sahmoune, David Brevet, Marcel Garcia, Conception, synthèse et vectorisation de biomolécules. (CSVB), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institut Européen des membranes (IEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Marie, Nathalie, Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: medicine.medical_treatment, Pharmaceutical Science, Nanoparticle, Mannose, Photodynamic therapy, Nanotechnology, Breast Neoplasms, Receptors, Cell Surface, 02 engineering and technology, 010402 general chemistry, Endocytosis, 01 natural sciences, chemistry.chemical_compound, Drug Delivery Systems, Cell Line, Tumor, medicine, Humans, Lectins, C-Type, Microparticle, ComputingMilieux_MISCELLANEOUS, Fluorescent Dyes, Microscopy, Confocal, Singlet Oxygen, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Silicates, [CHIM.MATE]Chemical Sciences/Material chemistry, Mesoporous silica, 021001 nanoscience & nanotechnology, Silicon Dioxide, [CHIM.ORGA] Chemical Sciences/Organic chemistry, 3. Good health, 0104 chemical sciences, Mannose-Binding Lectins, Photochemotherapy, Biophysics, Surface modification, Nanoparticles, Female, Fluorescein, 0210 nano-technology, Mesoporous material, Lysosomes, Mannose Receptor
Abstract: International audience; The synthesis of silicalites and Mesoporous Silica Nanoparticles (MSN), which covalently incorporate original water-soluble photosensitizers for PDT applications is described. PDT was performed on MDA-MB-231 breast cancer cells. All the nanoparticles showed significant cell death after irradiation, which was not correlated with 1O2 quantum yield of the nanoparticles. Other parameters are involved and in particular the surface and shape of the nanoparticles which influence the pathway of endocytosis. Functionalization with mannose was necessary to obtain the best results with PDT due to an active endocytosis of mannose-functionalized nanoparticles. The quantity of mannose on the surface should be carefully adjusted as a too high amount of mannose impairs the phototoxicity of the nanoparticles. Fluorescein was also encapsulated in MCM-41 type MSN in order to localize the nanoparticles in the organelles of the cells by confocal microscopy. The MSN were localized in lysosomes after active endocytosis by mannose receptors.
Published: 2010

97. Competitive solubilization of phenol by cationic surfactant micelles in the range of low additive and surfactant concentrations

Author: Jerzy Zajac, Clarence Charnay, Louis-Charles de Ménorval, Gaelle Derrien, Radhouane Chaghi, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: Aqueous solution, Butanol, Cationic polymerization, 02 engineering and technology, Surfaces and Interfaces, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Micelle, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Pulmonary surfactant, Critical micelle concentration, Electrochemistry, Organic chemistry, Phenol, General Materials Science, Titration, 0210 nano-technology, Spectroscopy, Nuclear chemistry
Abstract: International audience; Competitive interactions of phenol (PhOH) with micellar aggregates of hexadecyltrimethylammonium bromide (HTAB) against 1-butanol (BuOH) in aqueous solutions at surfactant concentrations close to the critical micelle concentration (CMC), BuOH concentration of 0.5 mmol kg-1, and phenol contents of 1, 5, or 10 mmol kg-1 have been investigated at 303 K by means of 1H NMR spectroscopy, titration calorimetry, and solution conductimetry. The solubilization loci for phenol were deduced from the composition-dependence of the 1H chemical shifts assigned to various protons in the surfactant and additive units. Since in pure HTAB solutions phenol is already in competition with Br-, addition of 1 mmol kg-1 NaBr to the system weakens the phenol competitiveness. The presence of butanol in the HTAB micelles causes phenol to penetrate deeper toward the hydrophobic micelle core. For higher phenol contents, the butanol molecules are constrained to remain in the bulk solution and are progressively replaced within the HTAB micelles by the aromatic units. The competitive character of phenol solubilization against butanol is well supported by changes in the thermodynamic parameters of HTAB micellization in the presence of both of the additives.
Published: 2009

98. Contribution of 1H NMR to the investigation of the adsorption of cationic Gemini surfactants with oligooxyethylene spacer group onto silica

Author: Marc Lindheimer, Clarence Charnay, Louis Charles de Ménorval, Gaelle Derrien, Anissa Bendjeriou-Sedjerari, Jerzy Zajac, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: Inorganic chemistry, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Micelle, Biomaterials, Surface tension, chemistry.chemical_compound, Colloid and Surface Chemistry, Adsorption, Pulmonary surfactant, Group (periodic table), Gemini surfactant, 1H NMR spectroscopy, Ethylene oxide, Chemistry, Cationic polymerization, Micellization, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Chemical engineering, Proton NMR, Interfacial aggregation, 0210 nano-technology
Abstract: 7 pages; International audience; The present study aims to investigate the behavior of a series of cationic Gemini surfactants with a hydrophilic spacer at liquid–gas and solid–liquid interfaces, with particular emphasis on the effect of spacer length. Gemini surfactants containing two quaternary ammonium groups bound by an ethylene oxide spacer chain, referred to as 12-EOx-12 with x=1,3,7 and 12 were synthesized. Surface tension measurements were used to show that the hydrophilic spacer with oxyethylene moieties was not fully extended at the air–water interface. With increasing the spacer group size, it became sufficiently flexible to adopt a particular conformation with a loop at the water side of the interface. A combined study by adsorption isotherm measurements and 1H NMR spectroscopy allowed a detailed description of the adsorption mechanism of these investigated 12-EOx-12 surfactants, with NMR providing more precise information on the conformation of hydrophilic spacer at the solid–liquid interface. Binding to the silica surface involved one cationic headgroup for the surfactants with a short spacer and the two headgroups for the ones with a long spacer. The number of charged surface sites was estimated by considering the dimeric surfactant as a “molecular ruler.” The small density of adsorption sites gave rise to the formation of pinned surface micelles.
Published: 2009

99. Interactions of phenol with cationic micelles of hexadecyltrimethylammonium bromide studied by titration calorimetry, conductimetry, and 1H NMR in the range of low additive and surfactant concentrations

Author: Radhouane Chaghi, Louis-Charles de Ménorval, Jerzy Zajac, Gaelle Derrien, Clarence Charnay, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: Enthalpy, Inorganic chemistry, 02 engineering and technology, Calorimetry, 010402 general chemistry, 01 natural sciences, Micelle, Biomaterials, chemistry.chemical_compound, Surface-Active Agents, Colloid and Surface Chemistry, Pulmonary surfactant, Phenol–micelle interactions, Organic chemistry, Phenol, Conductimetry, 1H NMR spectroscopy, Nuclear Magnetic Resonance, Biomolecular, Micelles, Aqueous solution, Hexadecyltrimethylammonium micelles, Chemistry, Cetrimonium, Electric Conductivity, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Titration calorimetry, Phenol solubilization loci, Solubility, Proton NMR, Cetrimonium Compounds, Thermodynamics, Titration, Protons, Micellar solubilization, 0210 nano-technology
Abstract: Interactions of phenol (PhOH) with micellar aggregates of hexadecyltrimethylammonium bromide (HTAB) in aqueous solutions at surfactant concentrations close to the CMC and phenol contents of 1, 5, or 10 mmol kg −1 have been investigated at 303 K by means of titration calorimetry, solution conductimetry, and 1 H NMR spectroscopy. Estimates of the main thermodynamic parameters related to HTAB micellization were made for PhOH/HTAB/H 2 O systems based on the specific conductivity measurements and calorimetric determination of the cumulative enthalpy of dilution as functions of the surfactant concentration at a fixed additive content. The combined analysis of the results obtained in H 2 O solutions pointed to the preferential location of PhOH in the outer micelle parts by an enthalpy-driven mechanism. Additional PhOH molecules were located increasingly deeper within the micelle core. The 1 H NMR study of PhOH solubilization by 1.5 mmol kg −1 HTAB solutions in D 2 O indicated that the two categories of the solubilization site became saturated with the solubilizate already at the lowest additive content. Dissimilar amounts of the solubilized material in H 2 O and D 2 O solutions were ascribed to the difference in the initial micelle structures formed in the two solvents, as inferred from calorimetry and 1 H NMR studies of the HTAB micellization in D 2 O and H 2 O.
Published: 2008

100. Copper-containing monodisperse mesoporous silica nanospheres by a smart one-step approach

Author: Jacques Rozière, Gaelle Derrien, Jerzy Zajac, Deborah J. Jones, and Clarence Charnay
Subjects: Materials science, Nitrogen, Dispersity, chemistry.chemical_element, One-Step, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Catalysis, Metal, Colloid, Materials Chemistry, Metals and Alloys, General Chemistry, Mesoporous silica, 021001 nanoscience & nanotechnology, Silicon Dioxide, Copper, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Mesoporous organosilica, chemistry, visual_art, Ceramics and Composites, visual_art.visual_art_medium, Adsorption, 0210 nano-technology, Dispersion (chemistry), Porosity, Nanospheres
Abstract: Copper-containing mesoporous silica spheres of size in the colloidal range with perfect conservation of pore-ordering, shape and monodispersity and high intra-pore metal dispersion were prepared via a new one-step synthesis and functionalisation route.
Published: 2008

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