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A study conducted at the University of Siena in Italy focused on Anti-Synthetase Syndrome (ASS), a rare autoimmune disease. The research evaluated the efficacy and safety of a treatment regimen involving glucocorticoids and immunosuppressants, with prednisone tapering. The study recommended early use of rituximab (RTX) for arthritis and suggested it as a pivotal treatment for Interstitial Lung Disease (ILD) as well. The findings raise questions about maintenance therapy and treatment-free remission in ASS patients. [Extracted from the article]

Researchers at the University of Siena in Italy conducted a study on a 47-year-old man with a history of drug and alcohol abuse who presented with double vision and postural instability. The patient was found to have a compound heterozygous FOLR1 gene variation associated with adult-onset paucisymptomatic leukoencephalopathy and cerebral folate deficiency. Despite stable clinical and MRI features over a two-year period, the study highlights the importance of considering cerebral folate deficiency in adult patients with stable diffuse MRI white matter changes. [Extracted from the article]

A recent study conducted by the University of Siena in Italy utilized inductively coupled plasma mass spectrometry (ICP-MS) to analyze trace and ultratrace elements in Sangiovese grapes from the Chianti region. The research aimed to determine the geographical origin of the grapes by measuring elemental content in vineyard soil, leaves, and grapes. The study successfully developed a multivariate model using selected elements to differentiate between samples from different zones in the Chianti area, even in regions located in close proximity. This peer-reviewed research contributes to the growing interest in certifying the origin of agricultural goods to combat counterfeiting and ensure consumer protection. [Extracted from the article]

A study conducted at the University of Siena in Italy focused on the use of all-femtosecond laser-cut corneal allogenic intracorneal ring segments (AFXL CAIRSs) in clinical medicine. The research involved a pilot ex vivo study using human donor eye-bank corneas and the first clinical cases in Italy. The study found that pre-implantation crosslinking of the segments improved tissue stiffness and grip, leading to positive outcomes in patients' visual acuity and corneal thickness. The research concluded that functional data and corneal thickness significantly improved without adverse events, suggesting promise for this method in standardization. [Extracted from the article]

Researchers from the University of Siena conducted a study on the use of social media by caregivers of individuals with Autism Spectrum Disorder (ASD) during the COVID-19 pandemic. The study found that while social media did not fully address the difficulties faced by individuals with ASD, caregivers dealing with high levels of anxiety perceived it as more useful. The research suggests the need for further exploration on how to effectively implement social media for individuals with ASD. [Extracted from the article]

A study conducted in Siena, Italy, focused on the trend of emergency department visits for bronchiolitis in children from 2018 to 2023. The research found that children under 1 year old with respiratory distress symptoms were more likely to access the emergency department. The study concluded that integrating hospital services and community medicine protocols could help reduce unnecessary visits to the emergency department for mild cases of bronchiolitis. [Extracted from the article]

A recent study from the University of Siena in Italy focused on post-bariatric thigh lift procedures, highlighting the challenges and technical considerations involved in this type of surgery. The research emphasized the importance of individualized treatment plans for patients based on their specific needs. The study also discussed the effectiveness of liposuction-assisted inner thigh lift with combined horizontal-vertical scars and skin-only excision for most patients, while acknowledging that some cases may require more invasive strategies. The research suggests that artificial intelligence may play a growing role in post-bariatric thigh lift procedures in the future. [Extracted from the article]

Researchers at the University of Siena in Italy have developed a web-based international registry dedicated to atypical pigmented skin lesions of the face, focusing on lentigo. The registry includes clinical and dermoscopic data on various types of lesions, such as lentigo maligna and melanoma, and aims to aid in the diagnosis and prevention of skin conditions. This research provides valuable data for the development of diagnostic support tools to assist dermatologists in identifying challenging cases of atypical pigmented facial lesions. [Extracted from the article]

A study conducted at the University of Siena in Italy compared two methods of detecting KL-6 in patients with interstitial lung diseases (ILD). The research found that there was diagnostic agreement between the two methods for both bronchoalveolar lavage (BAL) and serum samples. The study concluded that the findings provide further knowledge on KL-6 expression in different ILDs, suggesting its potential utility in the differential diagnosis of these conditions. [Extracted from the article]

A report from Siena University Hospital discusses new findings on porokeratosis, a rare skin condition that can be misdiagnosed with other skin conditions. The study utilized line-field confocal optical coherence tomography (LC-OCT) to differentiate between porokeratosis variants and mimicker conditions. The research found that LC-OCT provided accurate imaging up to a depth of 500 μm, aiding in the noninvasive diagnosis of porokeratosis variants. The study highlights the potential of LC-OCT in assisting with rapid and accurate diagnosis, potentially avoiding the need for incisional biopsies in uncertain cases. [Extracted from the article]

A study conducted at University Hospital in Siena, Italy, explored the feasibility of using a wearable sensor device to monitor the vitals of patients with Rett syndrome, a rare neurodevelopmental disorder primarily affecting females. The study found that sleep is disturbed in individuals with Rett syndrome and that they experience autonomic nervous system dysfunction, exercise fatigue, and an increased risk of sudden death. The researchers discovered that heart rate and heart rate variability could serve as objective markers of fatigue, illness severity, and disease progression in Rett syndrome. This study highlights the potential for continuous non-invasive home monitoring to improve the understanding and management of Rett syndrome. [Extracted from the article]

A recent study conducted by researchers at the University of Siena in Italy explored the relationship between Familial Mediterranean Fever (FMF) and the risk of cancer development. FMF is a severe systemic inflammatory condition that affects the innate immune system. The study found that FMF patients had a reduced risk of developing malignant neoplasms compared to patients with fibromyalgia, Still's disease, and Behçet's disease. However, when cancer did occur in FMF patients, it was more frequent in those with a severe disease phenotype and colchicine-resistant disease. The study identified several clinical variables associated with cancer development in FMF patients, including age at disease onset, number of attacks per year, and the use of certain medications. [Extracted from the article]

A recent study conducted by the University of Siena in Italy examined the frequency of awake bruxism behaviors in a group of undergraduate dentistry students and its correlation with anxiety and depression. The study used a smartphone-based ecological momentary assessment to evaluate the frequency of five oral behaviors associated with bruxism. The results showed that individuals with anxiety and depression traits had a significantly higher frequency of these behaviors compared to those without. The study suggests that psychological factors play a significant role in awake bruxism behaviors. [Extracted from the article]

A recent study conducted by researchers at the University of Siena in Italy explores the impact of different agricultural practices on soil communities in vineyards. The study highlights the importance of viticulture in the Mediterranean region and its potential effects on soil ecosystems. The researchers specifically focus on the effects of conventional and organic viticulture practices on soil mesofauna, emphasizing the need to understand how organic practices contribute to maintaining soil functionality and biodiversity. This research provides valuable insights for the development of environmentally sustainable viticulture practices. [Extracted from the article]

A recent study from the Cardiovascular Department in Siena, Italy challenges the traditional paradigm of assessing myocardial viability in patients with ischaemic left ventricular dysfunction (ILVD). While previous retrospective studies supported the idea that improved function after revascularization leads to better health outcomes, data from prospective trials have diverged from this hypothesis. The researchers argue for a more comprehensive approach that takes into account the complex pathophysiology of ILVD and the beneficial effects of revascularization in preventing myocardial infarction and ventricular arrhythmias. This research has been peer-reviewed and published in the European Heart Journal Supplements. [Extracted from the article]

A study conducted by the University of Siena in Italy aimed to evaluate the association between environmental risk factors and the presence of caries in pediatric patients. The study included 118 pediatric patients and investigated lifestyle habits through questionnaires. The results confirmed the role of nutritional habits in caries development, particularly in deciduous teeth. The researchers concluded that further clinical studies are needed to improve the quality of questionnaires and evaluate the cause/effect relationship between environmental risk factors and caries. [Extracted from the article]

A recent study conducted by researchers at the University of Siena in Italy explored the effects of repetitive transcranial magnetic stimulation (rTMS) on patients with sensorineural hearing loss (SHL). The study found that rTMS treatment over the auditory cortex improved speech intelligibility and pure tone reception skills in SHL patients. The effects of the treatment were observed immediately after the treatment and continued to be present one week later. This research suggests that rTMS may be a promising intervention for individuals with SHL to enhance their speech perception abilities. [Extracted from the article]

Researchers from the University of Siena in Italy have developed a novel bioresponsive self-immolative spacer for the controlled release of various compounds, including thiols, phenols, amines, sulfonamides, and amides. The spacer is based on the structure of (5-nitro-2-pyrrolyl)methanol (NPYM-OH) and has three sites for bioconjugation. The release of the compounds was achieved through selective reduction of the nitro group. The researchers also created a hypoxia-activated prodrug derived from an HDAC inhibitor that showed activity in cancer cells under hypoxic conditions. This research was supported by PNRR Tuscany Health Ecosystem - Ecosistemi dell'innovazione. [Extracted from the article]

Researchers from the Department of Pediatrics in Siena, Italy conducted a study to assess the prevalence of ankyloglossia (a condition where the lingual frenulum interferes with tongue functionality) among healthy newborns and its correlation with breastfeeding difficulties. The study included 190 infants, of which 11.05% had a high MLFPI score (indicating ankyloglossia). The data showed that a high MLFPI score was associated with breastfeeding difficulties at one and six months. The study suggests that in cases of ankyloglossia, referral to experienced personnel for support or surgical evaluation may be necessary. The rate of surgical removal of the frenulum was low in the cohort studied. [Extracted from the article]

A recent report from the University of Siena in Italy provides new insights into the survival rate and complications of zygomatic implant placement. The study conducted a systematic review and meta-analysis of clinical studies on four surgical techniques for zygomatic implant placement. The results showed that zygomatic implant placement is a reliable technique for the rehabilitation of severely atrophic maxillae, regardless of the surgical technique used. However, accurate case and surgical protocol selection are crucial to reduce postoperative complications. [Extracted from the article]

A new report from researchers in Siena, Italy discusses the increasing incidence of gastro-entero-pancreatic neuroendocrine tumors and the recommended approach for treatment. The study focuses on the occurrence of gallbladder lithiasis and its complications in patients who underwent surgery for neuroendocrine tumors and received long-term somatostatin analogues. The researchers found that somatostatin analogues may influence gallbladder motility and lead to the development of gallstones. They suggest that prophylactic cholecystectomy during upfront surgery for neuroendocrine tumors could prevent emergency cholecystectomy for gallstone complications. This research has been peer-reviewed. [Extracted from the article]

A recent study conducted by researchers at the University of Siena in Italy explores the use of radiology in paleoanthropological analyses to diagnose hereditary hemoglobinopathies, such as b-thalassemia, in sub-adult individuals found in archaeological contexts. The study focused on a sample from an early medieval site affected by malaria, and the researchers used macroscopic paleopathological analysis and CT analysis of the ribs to confirm the presence of b-thalassemia. Additionally, dental micro-CT revealed a direct relationship between the degrees of anemia and dentinogenesis defects, providing a new approach for diagnosing b-thalassemia in archaeological contexts. This research contributes to our understanding of the natural history of the disease and offers a valuable tool for differential diagnoses. [Extracted from the article]

Researchers at the University of Siena in Italy have conducted a study on the role of the Nlrp1 inflammasome in skin cancer and inflammatory skin diseases. Inflammasomes are protein complexes that protect against pathogens and initiate inflammation. The Nlrp1 inflammasome, in particular, has been associated with various skin disorders and conditions, including rare monogenic skin disorders and autoimmune diseases such as vitiligo, psoriasis, and atopic dermatitis. The researchers aim to shed light on the implications of dysregulation of the Nlrp1 inflammasome in skin diseases and explore its potential as a therapeutic target. This research has been peer-reviewed. [Extracted from the article]

A report from the University of Siena in Italy provides new insights into lymphedema, a condition that affects millions of people worldwide as a side effect of oncological treatments. The report focuses on the structure of lymphatic collecting vessels and the histopathological changes that occur in lymphedema. The researchers highlight the importance of using functional vessels for surgical techniques aimed at treating lymphedema. They also note that different types of vessels may coexist in the same patient, with the distal part of the limb containing less affected vessels that are more likely to perform efficient lymphatic-venular anastomosis. This research has been peer-reviewed and is available for further exploration. [Extracted from the article]

New research from the University of Siena in Italy has found that age at diagnosis is a prognostic factor for differentiated thyroid carcinoma (DTC) patients classified as low and intermediate risk. The study retrospectively evaluated 863 DTC patients and found that older age at diagnosis was associated with a higher rate of structural disease, recurrent disease, and death in the intermediate-risk group. The research suggests that age at diagnosis can help predict individual outcomes in intermediate-risk DTC patients, allowing for tailored management. This study has been peer-reviewed and published in The Journal of Clinical Endocrinology & Metabolism. [Extracted from the article]

A recent study conducted by GlaxoSmithKline plc in Siena, Italy, explores the development of a single-dose vaccine for Group B Streptococcus, a bacterial infection that poses a risk to neonates. The researchers focused on the capsular polysaccharide, a key antigen that can elicit protective antibodies when conjugated to carrier proteins. They successfully optimized self-assembling virus-like particles conjugated to Group B Streptococcus capsular polysaccharides, which demonstrated strong immune responses in mice after just one immunization. This pre-clinical study provides proof of concept for a potential single-dose vaccine. [Extracted from the article]

Keywords: Siena; Italy; Europe; Medical Devices and Surgical Technology; Health and Medicine; Mental Health; Psychiatric; Psychiatry; Surgery EN Siena Italy Europe Medical Devices and Surgical Technology Health and Medicine Mental Health Psychiatric Psychiatry Surgery 1305 1305 1 11/06/23 20231110 NES 231110 2023 NOV 12 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- A new study on Medical Devices and Surgical Technology is now available. Siena, Italy, Europe, Medical Devices and Surgical Technology, Health and Medicine, Mental Health, Psychiatric, Psychiatry, Surgery. [Extracted from the article]

Keywords for this news article include: Siena, Italy, Europe, Sustainability Research, Sustainable Food and Agriculture, University of Siena. Keywords: Siena; Italy; Europe; Sustainability Research; Sustainable Food and Agriculture EN Siena Italy Europe Sustainability Research Sustainable Food and Agriculture 249 249 1 11/06/23 20231109 NES 231109 2023 NOV 9 (NewsRx) -- By a News Reporter-Staff News Editor at Food Weekly News -- Fresh data on Sustainability Research - Sustainable Food and Agriculture are presented in a new report. [Extracted from the article]

Siena, Italy, Europe, Antifungals, Antiinfectives, Drugs and Therapies, Health and Medicine Keywords: Siena; Italy; Europe; Antifungals; Antiinfectives; Drugs and Therapies; Health and Medicine EN Siena Italy Europe Antifungals Antiinfectives Drugs and Therapies Health and Medicine 1416 1416 1 10/30/23 20231103 NES 231103 2023 NOV 3 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Letter on the CDC & FDA -- Investigators discuss new findings in Drugs and Therapies - Antiinfectives. [Extracted from the article]

Siena, Italy, Europe, Diet and Nutrition, Health and Medicine, Mediterranean Diet, Mouth Diseases and Conditions, Periodontal Diseases and Conditions, Periodontitis Keywords: Siena; Italy; Europe; Diet and Nutrition; Health and Medicine; Mediterranean Diet; Mouth Diseases and Conditions; Periodontal Diseases and Conditions; Periodontitis EN Siena Italy Europe Diet and Nutrition Health and Medicine Mediterranean Diet Mouth Diseases and Conditions Periodontal Diseases and Conditions Periodontitis 3749 3749 1 10/30/23 20231103 NES 231103 2023 NOV 3 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Periodontal Diseases and Conditions - Periodontitis have been published. [Extracted from the article]

Keywords for this news article include: Siena, Italy, Europe, Arrhythmia, Cardiac Arrhythmias, Cardiology, Cytokines, Health and Medicine, Heart Disorders and Diseases, Intercellular Signaling Peptides and Proteins, Risk and Prevention, University of Siena. Keywords: Siena; Italy; Europe; Arrhythmia; Cardiac Arrhythmias; Cardiology; Cytokines; Health and Medicine; Heart Disorders and Diseases; Intercellular Signaling Peptides and Proteins; Risk and Prevention EN Siena Italy Europe Arrhythmia Cardiac Arrhythmias Cardiology Cytokines Health and Medicine Heart Disorders and Diseases Intercellular Signaling Peptides and Proteins Risk and Prevention 387 387 1 10/03/23 20231003 NES 231003 2023 OCT 2 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- A new study on Heart Disorders and Diseases - Cardiac Arrhythmias is now available. Siena, Italy, Europe, Arrhythmia, Cardiac Arrhythmias, Cardiology, Cytokines, Health and Medicine, Heart Disorders and Diseases, Intercellular Signaling Peptides and Proteins, Risk and Prevention. [Extracted from the article]

Keywords: Siena; Italy; Europe; Health and Medicine; Ischemia; Surgery; Thrombectomy; Vascular Diseases and Conditions EN Siena Italy Europe Health and Medicine Ischemia Surgery Thrombectomy Vascular Diseases and Conditions 881 881 1 09/04/23 20230908 NES 230908 2023 SEP 10 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Current study results on Vascular Diseases and Conditions - Ischemia have been published. Siena, Italy, Europe, Health and Medicine, Ischemia, Surgery, Thrombectomy, Vascular Diseases and Conditions. [Extracted from the article]

Siena, Italy, Europe, Obesity Fitness and Wellness, Cardiology, Cardiovascular, Diagnosis, Diagnostic Techniques and Procedures, Doppler Echocardiography, Echocardiography, Health and Medicine, Therapy Keywords: Siena; Italy; Europe; Obesity Fitness and Wellness; Cardiology; Cardiovascular; Diagnosis; Diagnostic Techniques and Procedures; Doppler Echocardiography; Echocardiography; Health and Medicine; Therapy EN Siena Italy Europe Obesity Fitness and Wellness Cardiology Cardiovascular Diagnosis Diagnostic Techniques and Procedures Doppler Echocardiography Echocardiography Health and Medicine Therapy 417 417 1 06/26/23 20230630 NES 230630 2023 JUN 26 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- Data detailed on Obesity, Fitness and Wellness have been presented. [Extracted from the article]