33 results on '"Guo, Xu"'
Search Results
2. Safety, Immunogenicity, and Effectiveness of Chinese-Made COVID-19 Vaccines in the Real World: An Interim Report of a Living Systematic Review.
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Qi, Yangyang, Zheng, Hui, Wang, Jinxia, Chen, Yani, Guo, Xu, Li, Zheng, Zhang, Wei, Zhou, Jiajia, Wang, Songmei, Lin, Boyi, Zhang, Lin, Yan, Tingting, Clemens, John, Xia, Jielai, An, Zhijie, Yin, Zundong, Wang, Xuanyi, and Feng, Zijian
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BOOSTER vaccines ,VACCINE effectiveness ,HUMORAL immunity ,VACCINE safety ,COVID-19 vaccines - Abstract
Background: Several COVID-19 vaccines were developed and approved in China. Of these, the BIBB-CorV and CoronaVac inactivated whole-virion vaccines were widely distributed in China and developing countries. However, the performance of the two vaccines in the real world has not been summarized. Methods: A living systematic review based on findings from ongoing post-licensure studies was conducted, applying standardized algorithms. Articles published between 1 May 2020 and 31 May 2022 in English and Chinese were searched for in Medline, Embase, WanFang Data, medRxiv, bioRxiv, arXiv, SSRN, and Research Square, using SARS-CoV-2, COVID-19, and vaccine as the MeSH terms. Studies with estimates of safety, immunogenicity, and effectiveness from receiving the BIBB-CorV or CoronaVac vaccine that met the predefined screening criteria underwent a full-text review. The Joanna Briggs Institute's Critical Appraisal Checklist and the Cochrane risk of bias were used for assessment of the quality. A random-effects meta-regression model was applied to identify the potential impact factors on the vaccines' effectiveness. Results: In total, 32578 articles were identified, of these, 770 studies underwent a full-text review. Eventually, 213 studies were included. The pooled occurrence of solicited and unsolicited adverse events after any dose of either vaccine varied between 10% and 40%. The top five commonly reported rare adverse events were immunization stress-related responses (211 cases, 50.0%), cutaneous responses (43 cases, 10.2%), acute neurological syndrome (39 cases, 9.2%), anaphylaxis (17 cases, 4.0%), and acute stroke (16 cases, 3.8%). The majority (83.3%) recovered or were relieved within several days. The peak neutralization titers against the ancestral strain was found within 1 month after the completion of the primary series of either vaccine, with a GMT (geometric mean titer) of 43.7 (95% CI: 23.2–82.4), followed by a dramatic decrease within 3 months. At Month 12, the GMT was 4.1 (95% CI: 3.8–4.4). Homologous boosting could restore humoral immunity, while heterologous boosting elicited around sixfold higher neutralization titers in comparison with homologous boosting. The effectiveness of receiving either vaccine against death and severe disease was around 85% for both shortly after the primary series. At Month 12, the protection against death did not decline, while the protection against severe disease decreased to ~75%. Conclusions: Both the BIBP-CorV and CoronaVac inactivated vaccines are safe. Sustained vaccine effectiveness against death was determined 12 months after the primary series, although protection against severe disease decreased slightly over time. A booster dose could strengthen the waning effectiveness; however, the duration of the incremental effectiveness and the additional benefit provided by a heterologous booster need to be studied. [ABSTRACT FROM AUTHOR]
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- 2024
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3. A meta-analysis of the accuracy of Xpert MTB/RIF in diagnosing intestinal tuberculosis.
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Ding, Yuan-Lin, Yan, Rui-Chao, Chen, Hao-Kai, and Guo, Xu-Guang
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MEDICAL information storage & retrieval systems ,RECEIVER operating characteristic curves ,META-analysis ,DESCRIPTIVE statistics ,SYSTEMATIC reviews ,MEDLINE ,ODDS ratio ,MEDICAL databases ,ONLINE information services ,DATA analysis software ,QUALITY assurance ,CONFIDENCE intervals ,MYCOBACTERIUM tuberculosis ,RIFAMPIN ,DRUG resistance ,SENSITIVITY & specificity (Statistics) - Abstract
Objective A detection method with high efficiency and accuracy is urgently needed in clinical work. The purpose of our study was to determine the diagnostic accuracy of the Xpert MTB/RIF assay for intestinal tuberculosis (ITB). Methods We searched PubMed and 4 other databases from their establishment to July 19, 2022, for published essays of diagnostic performance in which Xpert MTB/RIF was used to test patients with clinically suspected ITB. An assessment of the quality of the selected literature was conducted using QUADAS-2. We built forest plots by MetaDiSc software. Results The pooled Xpert MTB/RIF sensitivity was 48%, and the specificity was 99%. Moreover, the positive likelihood ratio for ITB diagnosis was 21.61. The negative likelihood ratio was 0.54. There were substantial variations between the study estimates of sensitivity (I
2 = 87.6%) and specificity (I2 = 82.4%). Conclusion Intestinal TB is detected with limited diagnostic sensitivity by Xpert MTB/RIF but with high specificity. An Xpert-positive result may facilitate the rapid identification of ITB cases. Nevertheless, a negative result has less certainty in excluding the disease. [ABSTRACT FROM AUTHOR]- Published
- 2024
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4. Optimal analgesic regimen for total shoulder arthroplasty: a randomized controlled trial and network meta-analysis.
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Li, Shiye, Chen, Wenjie, Feng, Liang'en, and Guo, Xu
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ONLINE information services ,MEDICAL databases ,DRUG efficacy ,META-analysis ,MEDICAL information storage & retrieval systems ,ANALGESICS ,SYSTEMATIC reviews ,BUPIVACAINE ,NERVE block ,TREATMENT effectiveness ,MEDLINE ,DATA analysis software ,TOTAL shoulder replacement ,POSTOPERATIVE pain - Abstract
Objective: Clinical approaches to analgesia following total shoulder arthroplasty include liposomal bupivacaine, local infiltration analgesia, single-shot interscalene block, and continuous interscalene block. However, the best method remains contentious. This study conducts a network meta-analysis comparing these four methods, aiming to identify the most effective analgesic approach. Methods: Randomized controlled trials on analgesic regimens for total shoulder arthroplasty were identified through searches of PUBMED, Cochrane Central Register of Controlled Trials, EMBASE, Web of Science, and Scopus databases, covering their inception through November 2023. Network meta-analysis was performed using STATA 15.1, and the Cochrane Handbook version 5.1.0 risk of bias tool was employed for quality assessment of the literature. Results: Twelve randomized controlled trials were included, comprising 1537 patients undergoing total shoulder arthroplasty. The interventions compared were ssISB, cISB, LIA, and LB. Regarding the quality of the literature, four studies were deemed low risk, one high risk, and seven moderate risk. The network meta-analysis revealed that in terms of VAS scores in the PACU, the ssISB group was the most effective, followed by cISB and LB, with LIA being the least effective. This pattern continued in VAS scores on the first and second postoperative days. Regarding morphine consumption, the cISB group showed the most significant reduction in the PACU and on the first postoperative day, while the LIA group performed best in total postoperative morphine consumption. The shortest average hospital stay was noted in the cISB group. Conclusion: The ssISB method excels in controlling early postoperative pain, particularly during the PACU stage and early postoperative period. Additionally, the cISB method is notable for reducing postoperative morphine consumption and shortening average hospital stays. While the LIA method ranks first in reducing total morphine consumption, it is weaker in pain control. The LB method is underwhelming across most assessment parameters. These findings underscore the importance of selecting appropriate analgesic strategies for different postoperative recovery phases and provide valuable insights for clinicians to optimize postoperative pain management. Furthermore, they suggest a need for future research to explore the specific application and effectiveness of these methods in varying clinical contexts. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Pooled analysis of T2 Candida for rapid diagnosis of candidiasis
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Tang, Dong-Lan, Chen, Xiao, Zhu, Chang-Guo, Li, Zhong-wei, Xia, Yong, and Guo, Xu-Guang
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- 2019
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6. Evaluation of RT-LAMP Assay for Rapid Detection of SARS-CoV-2.
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Li, Ya-Ping, Cao, Xun-Jie, Luo, Xin, Xie, Tian-Ao, Liu, Wan-Jun, Xie, Shi-Ming, Lin, Min, and Guo, Xu-Guang
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ONLINE information services ,MEDICAL databases ,COVID-19 ,MOLECULAR diagnosis ,META-analysis ,MEDICAL information storage & retrieval systems ,CONFIDENCE intervals ,SYSTEMATIC reviews ,COMMUNITY health services ,PRIMARY health care ,DESCRIPTIVE statistics ,COVID-19 testing ,SENSITIVITY & specificity (Statistics) ,MEDLINE ,DATA analysis software ,ODDS ratio ,LOGISTIC regression analysis ,NUCLEIC acid amplification techniques ,EARLY diagnosis - Abstract
Objective To evaluate the accuracy of the reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay for rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in community or primary-care settings. Method We systematically searched the Web of Science, Embase, PubMed, and Cochrane Library databases. We conducted quality evaluation using ReviewManager software (version 5.0). We then used MetaDisc software (version 1.4) and Stata software (version 12.0) to build forest plots, along with a Deeks funnel plot and a bivariate boxplot for analysis. Result Overall, the sensitivity, specificity, and diagnostic odds ratio were 0.79, 0.97, and 328.18, respectively. The sensitivity for the subgroup with RNA extraction appeared to be higher, at 0.88 (0.86–0.90), compared to the subgroup without RNA extraction, at 0.50 (0.45–0.55), with no significant difference in specificity. Conclusion RT-LAMP assay exhibited high specificity regarding current SARS-CoV-2 infection. However, its overall sensitivity was relatively moderate. Extracting RNA was found to be beneficial in improving sensitivity. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Evaluation of the efficiency and safety of combined chemotherapy and molecular-targeted therapy in the treatment of advanced gastric cancer: A protocol for systematic review and meta-analysis
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Zhan He and Jian-Guo Xu
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medicine.medical_specialty ,medicine.medical_treatment ,MEDLINE ,Cochrane Library ,meta ,chemotherapy ,law.invention ,Targeted therapy ,Randomized controlled trial ,Meta-Analysis as Topic ,law ,Stomach Neoplasms ,Study Protocol Systematic Review ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Molecular Targeted Therapy ,Intensive care medicine ,business.industry ,gastric cancer ,Cancer ,Combination chemotherapy ,General Medicine ,medicine.disease ,Radiation therapy ,Research Design ,Meta-analysis ,business ,molecular therapy ,Research Article ,Systematic Reviews as Topic - Abstract
Background: Gastric cancer is considered to be the sixth prevalent cancer and the third widespread trigger of cancer-associated deaths globally. One of the major method of treating this harmful condition is completely resecting the entire tumor. Standard treatment procedures, including radiotherapy, surgery, and chemotherapy are ineffective for patients with advanced gastric cancer (AGC), mainly because the predictions are deficient. Many studies have recently sought to examine the effect of combining chemotherapy and molecular-targeted therapy, supposing that such developments could become effective for treating AGC. Still, the advantages of combining chemotherapy plus molecular-targeted therapy to treat advanced gastric cancer appear to be unconvincing. Methods and analysis: We intend to perform an electronic search using information obtained from PubMed, EMBASE, Cochrane Library, ScienceDirect, Web of Science, China National Knowledge Infrastructure, and WanFang databases. Specifically, we will consider all randomized controlled trials published in English or Chinese, and focus only on those assessing the effectiveness and safety of a MIC of chemotherapy and molecular-targeted therapy to treat AGC. Furthermore, two independent authors will conduct data extraction as well as explore the risk of bias. Furthermore, we intend to use the odds ratio for dichotomous data, mean differences or standardized mean differences for continuous data, along with hazard ratio for time-to-event data, with 95% confidence intervals (CIs). Ethics and dissemination: Because of the nature of this study, we will not require ethical approval. Instead, we will report the review reported in a peer-reviewed journal.
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- 2021
8. A Meta-Analysis of Calcium Intake and Risk of Glioma.
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Guo, Xu and Piao, Haozhe
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ONLINE information services , *META-analysis , *MEDICAL information storage & retrieval systems , *CONFIDENCE intervals , *SYSTEMATIC reviews , *GLIOMAS , *DIETARY supplements , *RISK assessment , *DESCRIPTIVE statistics , *DIETARY calcium , *MEDLINE , *ODDS ratio , *DISEASE risk factors - Abstract
A meta-analysis was conducted to investigate the correlation between calcium intake and the risk of brain tumors (especially glioma). The PubMed, Web of Science, and Embase databases were searched for relevant papers on the association between calcium intake and glioma as of August 22, 2021. The odds ratio (OR) with a 95% confidence interval (CI) was calculated using a random-effects model. Egger's test was conducted to assess publication bias. The meta-analysis includes four studies. The meta-analysis showed that calcium intake and the risk of brain tumors have a significant negative relationship (OR = 0.28; 95% CI: 0.11 to 0.72; P = 0.008). Dose-response analysis showed that for every 100 mg/day increase in calcium intake, the risk of glioma decreased by 7% (OR = 0.93; 95% CI: 0.88 to 0.98). In addition, compared with humans without calcium intake, when calcium intake is 455 mg/day, 800 mg/day and 1000 mg/day, the risk of glioma is 0.65 (95% CI 0.43, 0.97), 0.55 (95% CI 0.37, 0.82) and 0.37 (95% CI 0.15, 0.86). There is a significant negative association between calcium intake and brain tumors (especially gliomas), but more high-quality studies are needed to verify these results. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Association of Rotavirus Vaccines With Reduction in Rotavirus Gastroenteritis in Children Younger Than 5 Years: A Systematic Review and Meta-analysis of Randomized Clinical Trials and Observational Studies
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Zi-Wei Sun, Hua-Guo Xu, Hemant Goyal, Hai-Ling Lu, Yu Fu, Rui-Xia Yang, and Ye Jiang
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Diarrhea ,Pediatrics ,medicine.medical_specialty ,medicine.disease_cause ,Rotavirus Infections ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,030225 pediatrics ,Rotavirus ,medicine ,Humans ,030212 general & internal medicine ,Adverse effect ,Original Investigation ,Randomized Controlled Trials as Topic ,business.industry ,Infant, Newborn ,Rotavirus Vaccines ,Infant ,Odds ratio ,Rotavirus vaccine ,Gastroenteritis ,Meta-analysis ,Relative risk ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Cohort ,business - Abstract
Importance Rotavirus vaccines have been introduced worldwide, and the clinical association of different rotavirus vaccines with reduction in rotavirus gastroenteritis (RVGE) after introduction are noteworthy. Objective To evaluate the comparative benefit, risk, and immunogenicity of different rotavirus vaccines by synthesizing randomized clinical trials (RCTs) and observational studies. Data Sources Relevant studies published in 4 databases: Embase, PubMed, the Cochrane Library, and Web of Science were searched until July 1, 2020, using search terms including “rotavirus” and “vaccin*.” Study Selection Randomized clinical trials and cohort and case-control studies involving more than 100 children younger than 5 years that reported the effectiveness, safety, or immunogenicity of rotavirus vaccines were included. Data Extraction and Synthesis A random-effects model was used to calculate relative risks (RRs), odds ratios (ORs), risk differences, and 95% CIs. Adjusted indirect treatment comparison was performed to assess the differences in the protection of Rotarix and RotaTeq. Main Outcomes and Measures The primary outcomes were RVGE, severe RVGE, and RVGE hospitalization. Safety-associated outcomes involved serious adverse events, intussusception, and mortality. Results A meta-analysis of 20 RCTs and 38 case-control studies revealed that Rotarix (RV1) significantly reduced RVGE (RR, 0.316 [95% CI, 0.224-0.345]) and RVGE hospitalization risk (OR, 0.347 [95% CI, 0.279-0.432]) among children fully vaccinated; RotaTeq (RV5) had similar outcomes (RVGE: RR, 0.350 [95% CI, 0.275-0.445]; RVGE hospitalization risk: OR, 0.272 [95% CI, 0.197-0.376]). Rotavirus vaccines also demonstrated higher protection against severe RVGE. Additionally, no significant differences in the protection of RV1 and RV5 against rotavirus disease were noted in adjusted indirect comparisons. Moderate associations were found between reduced RVGE risk and Rotavac (RR, 0.664 [95% CI, 0.548-0.804]), Rotasiil (RR, 0.705 [95% CI, 0.605-0.821]), and Lanzhou lamb rotavirus vaccine (RR, 0.407 [95% CI, 0.332-0.499]). All rotavirus vaccines demonstrated no risk of serious adverse events. A positive correlation was also found between immunogenicity and vaccine protection (eg, association of RVGE with RV1: coefficient, −1.599; adjustedR2, 99.7%). Conclusions and Relevance The high protection and low risk of serious adverse events for rotavirus vaccines in children who were fully vaccinated emphasized the importance of worldwide introduction of rotavirus vaccination. Similar protection provided by Rotarix and RotaTeq relieves the pressure of vaccines selection for health care authorities.
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- 2021
10. Efficacy and safety of surgical ablation concomitant to coronary artery bypass grafting for atrial fibrillation: a meta-analysis
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Wei Wang, Kang Yi, Jie Gao, Shao-E He, Xiao-Min Xu, Tao You, Jian-Guo Xu, Yu-Hu Ma, and Wen-Xin Wang
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medicine.medical_specialty ,Bypass grafting ,business.industry ,Atrial fibrillation ,medicine.disease ,medicine.anatomical_structure ,Meta-analysis ,Internal medicine ,Concomitant ,Cardiology ,Medicine ,business ,Surgical ablation ,Artery - Published
- 2021
11. Epidemiology estimates of hepatitis D in individuals co-infected with human immunodeficiency virus and hepatitis B virus, 2002-2018: A systematic review and meta-analysis
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Hemant Goyal, Dong-Ze Ji, Hai-Yan Chen, Wei-Dong Cao, Hua-Guo Xu, Pei-Chun Han, and Dan-Ting Shen
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HBsAg ,medicine.medical_specialty ,Hepatitis B virus ,viruses ,Population ,HIV Infections ,medicine.disease_cause ,Virus ,03 medical and health sciences ,0302 clinical medicine ,Seroepidemiologic Studies ,Virology ,Epidemiology ,medicine ,Prevalence ,Seroprevalence ,Humans ,030212 general & internal medicine ,education ,education.field_of_study ,Hepatology ,business.industry ,Coinfection ,virus diseases ,HIV ,biochemical phenomena, metabolism, and nutrition ,medicine.disease ,Hepatitis B ,Hepatitis D ,Infectious Diseases ,Meta-analysis ,030211 gastroenterology & hepatology ,Hepatitis Delta Virus ,business - Abstract
Hepatitis delta virus (HDV) is an obligate satellite of hepatitis B virus (HBV). HIV/HDV co-infection is associated with a high rate of hepatic decompensation events and death. We aimed to characterize the epidemiology of HDV infection in HIV/HBV co-infected individuals. We systematically searched PubMed, Embase, Cochrane Library, Web of Science, CINAHL and Scopus for studies published from Jan 1, 2002 until May 7, 2018 measuring prevalence of HDV among the HIV population. Pooled seroprevalence was calculated with the DerSimonian-Laird random-effects model. Our search returned 4624 records, 38 of which met the inclusion and exclusion criteria. These studies included data for 63 cohorts from 18 countries and regions. The overall HDV seroprevalence of HIV-infected individuals was 1.03% (95% CI 0.43 to 1.85) in 2002-2018 globally. Moreover, the estimated pooled HDV seroprevalence among the general population was 1.07% (95% CI 0.65-1.59) in 2002-2018, which was not significantly different from the HDV seroprevalence of individuals living with HIV (p=0.951). The overall HDV seroprevalence of the HBsAg positive population was 12.15% (95% CI 10.22-14.20), p=0.434 when compared with the corresponding data of HIV/HBV co-infected individuals. This meta-analysis suggested that there was no difference between the HDV seroprevalence in HIV-infected individuals and the general population.
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- 2021
12. Xpert MTB/RIF Assay for the Diagnosis of Lymph Node Tuberculosis in Children: A Systematic Review and Meta-Analysis.
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Chen, Hao-Kai, Liu, Rui-Si, Wang, Yi-Xuan, Quan, En-Xiang, Liu, Yuan-Hua, and Guo, Xu-Guang
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LYMPH nodes ,TUBERCULOSIS ,RECEIVER operating characteristic curves ,CHILD mortality ,ODDS ratio - Abstract
Background: Lymph node tuberculosis (LNTB) is the leading type of extrapulmonary tuberculosis (EPTB) causing death in children. The Xpert MTB/RIF assay is a novel rapid test for the diagnosis of LNTB. Although previous evidence suggests that Xpert is reliably accurate in diagnosing EPTB in children, information is lacking for the specific type of LNTB in children. The aim of this study was to systematically assess the accuracy and reliability of Xpert for the diagnosis of LNTB in children. Methods: We systematically searched four databases, Embase, Cochrane Library, PubMed, and Web of Science, which extracted relevant data according to predefined inclusion and exclusion criteria. The data were analyzed by meta-Disc 1.4 and Stata 12.0 software to determine sensitivity, specificity, diagnostic odds ratio (DOR), etc. Results: A total of 646 samples from 8 studies were included in the analysis. The pooled sensitivity, specificity, negative likelihood ratio (NLR), positive likelihood ratio (PLR,) and combined diagnostic odds ratio (DOR) of Xpert for all samples were 0.79 (95% CI 0.70, 0.87), 0.90 (95% CI 0.86, 0.92), 0.29 (95% CI 0.19, 0.43), 7.20 (95% CI 3.32, 15.60), and 37.56 (95% CI 13.04, 108.15), respectively. The area under the curve (AUC) of the summary receiver operating characteristic (sROC) curve was 0.9050. Conclusion: Overall, Xpert showed moderate sensitivity and high specificity compared with culture in the diagnosis of LNTB in children. In addition, after analyzing the combined diagnostic odds ratio and positive LR, our study showed that Xpert has excellent diagnostic accuracy. [ABSTRACT FROM AUTHOR]
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- 2022
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13. Association Between Rotavirus Vaccination and Risk of Intussusception Among Neonates and Infants: A Systematic Review and Meta-analysis
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Hai-Ling Lu, Hemant Goyal, Ying Ding, and Hua-Guo Xu
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Male ,Rotavirus ,safety ,Pediatrics ,medicine.medical_specialty ,Letter ,Cochrane Library ,Placebo ,Rotavirus Infections ,law.invention ,Randomized controlled trial ,law ,Risk Factors ,medicine ,Humans ,Randomized Controlled Trials as Topic ,intussusception ,business.industry ,Absolute risk reduction ,Infant, Newborn ,Rotavirus Vaccines ,Infant ,General Medicine ,Rotavirus vaccine ,Letter To The Editor ,Vaccination ,Meta-analysis ,Relative risk ,Female ,business - Abstract
Importance The conclusions from the multiple randomized clinical trials exploring the relationship between development of intussusception and rotavirus vaccination among neonates and infants have been controversial. Objective To evaluate the association between rotavirus vaccination and risk of intussusception. Data Sources For this systematic review and meta-analysis, PubMed, Web of Science, Cochrane library, and Embase databases were searched from January 1, 1999, through December 31, 2018, using no language restrictions. The search terms wererotavirusorRV(rotavirus vaccine) orHRV(human rotavirus vaccine),vaccin*, andintussusception. Study Selection Randomized clinical trials of neonates and infants that compared the risk of intussusception after the vaccination with a placebo group were included. Data Extraction and Synthesis A fixed-effects model was used to pool the data. Statistical heterogeneity was assessed with Q test andI2statistic; relative risk (RR), risk difference (RD), and 95% CIs were calculated using the Mantel-Haenszel method. Main Outcomes and Measures The main outcome was the diagnosis of intussusception in the analysis. The pooled and subtotal results of RR, RD, and 95% CI for the risk of intussusception were estimated at 31 days, 1 year, and 2 years after vaccination. Results A total of 25 randomized clinical trials including 200 594 participants (104 647 receiving vaccine and 95 947 receiving placebo) in 33 countries from 4 continents were included in this meta-analysis. Twenty cases of definite intussusception were diagnosed within 31 days after rotavirus vaccination, with 11 cases (55%) in the vaccine group and 9 cases (45%) in the placebo group (RD, 0.17 per 10 000 infants [95% CI, −1.16 to 1.50 per 10 000 infants],P = .80; RR, 1.14 [95% CI, 0.49 to 2.64],P = .77). Seventy-four cases were reported within 1 year, with 37 cases (50%) in the vaccine group and 37 cases (50%) in the placebo group (RD, −0.65 per 10 000 infants [95% CI, −2.68 to 1.39 per 10 000 infants],P = .53; RR, 0.84 [95% CI, 0.53 to 1.32],P = .45). Fifty-nine cases were reported within 2 years, with 29 cases (49%) in the vaccine group and 30 cases (51%) in the placebo group (RD, −0.48 per 10 000 infants [95% CI, −3.64 to 2.69 per 10 000 infants],P = .77; RR, 0.91 [95% CI, 0.55 to 1.52],P = .73). Conclusions and Relevance Results of this systematic review and meta-analysis suggest that monovalent, pentavalent, monovalent human-bovine, oral bovine pentavalent, and human neonatal rotavirus vaccination was not associated with an elevated risk of intussusception among neonates or infants.
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- 2019
14. Evaluation of the curative effects of Bailing capsules for treating chronic obstructive pulmonary disease
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Weili Chu, Yumiao Zhao, Long Zhang, Ai-Guo Xu, Qin-Fu Xu, Huang Lisha, Yanbing Sheng, and Jia Junli
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Protocol (science) ,medicine.medical_specialty ,COPD ,business.industry ,MEDLINE ,General Medicine ,Odds ratio ,Cochrane Library ,medicine.disease ,Confidence interval ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Meta-analysis ,medicine ,030212 general & internal medicine ,Intensive care medicine ,business ,Meta-Analysis as Topic - Abstract
Background The goal of the present study is to evaluate the efficacy and safety of Bailing capsules, which is a traditional Chinese drug that can improve lung functionality when used to treat chronic obstructive pulmonary disease (COPD) patients. Methods A comprehensive search will be performed on the following primary electronic databases: PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, and WanFang database. A search of secondary sources includes reference lists of included studies. Two pairs of review authors will screen and scrutinize selected articles. This study will analyze continuous data as mean differences and dichotomous data as odds ratios, both with 95% confidence intervals. A sensitivity analysis will also be conducted to evaluate the stableness of the outcomes. RevMan 5.3 software was adopted to accomplish all the statistical analysis. Results The results obtained in this research shall be published in a peer-reviewed journal. Conclusion Based on the interpretations of the results, useful conclusions will be presented. These conclusions will offer additional insights with useful evidence to assess whether it is viable to use Bailing capsules as an effective and safety treatment option for COPD. Ethics and dissemination The present work does not involve any humans or animals; therefore, ethical approval is not needed. Systematic review registration March 26, 2021.osf.io/kvgbu. (https://osf.io/kvgbu/).
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- 2021
15. Meta-analysis of risk factors associated with atherosclerosis in patients with Kawasaki disease
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Han Zhang, Min Huang, Lijian Xie, Tingting Xiao, Jie Shen, and Ming-Guo Xu
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Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Heart disease ,Comorbidity ,Mucocutaneous Lymph Node Syndrome ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,030225 pediatrics ,Internal medicine ,Pediatric surgery ,medicine ,Humans ,In patient ,Child ,Maternal and child health ,business.industry ,Atherosclerosis ,medicine.disease ,Survival Rate ,Cholesterol ,Increased risk ,Case-Control Studies ,Meta-analysis ,Pediatrics, Perinatology and Child Health ,Disease Progression ,Cardiology ,Female ,Kawasaki disease ,business ,Developed country - Abstract
Kawasaki disease (KD) has now become the leading cause of acquired heart disease among children in developed countries. This study investigated whether patients with KD have an increased risk of atherosclerosis.Electronic databases, including PubMed, Embase and Springer link, were searched through June 1, 2015, for eligible studies. Studies were included when they met the following criteria: 1) an observational study focusing on evaluating the risk factors for atherosclerosis in patients with KD; 2) KD was diagnosed clinically according to the Japan Kawasaki Disease Research Committee or American Heart Association's diagnostic criteria; 3) the study subjects were KD patients without coronary heart disease or related cardiovascular disease (KD group) and non-KD patients as control (control group), and 4) investigation of important atherosclerosis risk factors, total cholesterol (TC), low-density lipoprotein cholesterol (LDL), triglycerides (TG), systolic blood pressure (SBP), and flowmediated dilatation (FMD). The methodological quality of the included studies was evaluated using the Newcastle- Ottawa Scale. Mean difference (MD) and relative risk (RR) and corresponding 95% confidence intervals (CI) were used to calculate the pooled results.Sixteen studies were included with a total of 870 patients, including 421 KD patients and 449 non-KD controls. Differences in TG and SBP between KD patients and controls were not significant; in contrast, TC and LDL levels were significantly higher in KD patients than the controls, whereas FMD in the KD patients was significantly lower.KD patients may have an increased risk of developing atherosclerosis.
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- 2016
16. Diagnostic accuracy of coronary angiography using 64-slice computed tomography in coronary artery disease
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Qiuqin Xu, Yueyue Ding, Ming-Guo Xu, Haitao Lv, Ling Sun, Fu-bin Yang, Mao Sheng, and Wan-liang Guo
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medicine.medical_specialty ,Funnel plot ,lcsh:Medicine ,Coronary Artery Disease ,Coronary Angiography ,Sensitivity and Specificity ,Likelihood ratios in diagnostic testing ,Coronary artery disease ,Multidetector Computed Tomography ,medicine ,Humans ,Receiver operating characteristic ,medicine.diagnostic_test ,business.industry ,lcsh:R ,Coronary Stenosis ,Area under the curve ,General Medicine ,medicine.disease ,Confidence interval ,ROC Curve ,Meta-analysis ,Angiography ,Systematic Review ,Radiology ,business - Abstract
Objectives: To conduct a meta-analysis and investigate the diagnostic value of 64-slice computed tomography (CT) angiography for diagnosing coronary artery disease (CAD) in patients. Methods: A comprehensive literature search from March 2005 to August 2014 was performed on the following databases: Cochrane Library; Medline; EmBase; PubMed; and BioMed Central database. As a reference standard, studies that assessed 64-slice CT angiography in detecting coronary artery stenosis (CAS) with invasive coronary angiography were included. Coronary artery stenosis was defined as ≥50% diameter stenosis. Diagnostic value was determined by pooling sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) values at segment-level analysis. Diagnostic accuracy was undertaken using area under the curve (AUC) value and summary receiver operating characteristic (SROC) curves. Publication bias was examined by Deek’s funnel plot asymmetry test. Results: Eight studies were included in the analysis, enrolling a total of 579 patients (7,407 segment coronary vessels). At segment-level, pooled sensitivity value was 90% (95% confidence interval [CI]: 83-95%), specificity was 91% (95% CI: 61-98%), PLR value was 9.7 (95% CI: 1.8-53.3), and NLR value was 0.11 (95% CI: 0.05-0.22) for CAS. Optimal cut-off point of sensitivity was 90%, and specificity under the SROC curve was 91%. The AUC value was 0.94. Conclusion: The 64-slice CT angiography is a reliable tool for detection of CAD when using a cut-off of more than or equal to 50% diameter stenosis in elderly population. Saudi Med J 2015; Vol. 36 (10): 1156-1162 doi: 10.15537/smj.2015.10.12415
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- 2015
17. Pooled Analysis of the Accuracy of Xpert Ebola Assay for Diagnosing Ebola Virus Infection.
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Pan, Zhi-Yong, Wu, Yan-Jun, Zeng, Ye-Xian, Lin, Hao, Xie, Tian-Ao, Li, Ya-Ping, Liu, Ye-Ling, He, Zhi-Jian, and Guo, Xu-Guang
- Subjects
REVERSE transcriptase polymerase chain reaction ,ONLINE information services ,EBOLA virus disease ,META-analysis ,MEDICAL information storage & retrieval systems ,INFORMATION storage & retrieval systems ,MEDICAL databases ,SYSTEMATIC reviews ,EBOLA virus ,COMPARATIVE studies ,DESCRIPTIVE statistics ,GENETIC techniques ,POLYMERASE chain reaction ,MEDLINE ,DATA analysis software ,RECEIVER operating characteristic curves - Abstract
Background. West Africa has witnessed the unprecedented outbreak of Ebola virus disease (EVD). The Ebola virus (EBOV) can cause Ebola hemorrhagic fever, which is documented as the most deadly viral hemorrhagic fever in the world. RT-PCR had been suggested to be employed in the detection of Ebola virus; however, this method has high requirements for laboratory equipment and takes a long time to determine Ebola infection. Although Xpert Ebola is a fast and simple instrument for the detection of Ebola virus, its effect is still unclear. This study is aimed at evaluating the accuracy of Xpert Ebola in diagnosing Ebola virus infection. Methods. Using the keywords "Xpert" and "Ebola virus", relevant studies were retrieved from the database of PubMed, Embase, Web of Science, and Cochrane. RT-PCR was employed as a reference standard to evaluate whether the study is eligible to be included in the meta-analysis. Data from these included studies were extracted by two independent assessors and were then analyzed by the Meta-DiSc 1.4 software to produce the heterogeneity of sensitivity (SEN), specificity (SP), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic advantage ratio (DOR) of the study. The results of pooled analysis were plotted, together with the summary receiver operating characteristic (SROC) curve plotted by calculating the area under the curve (AUC). Generated pooled summary estimates (95% CIs) were calculated for the evaluation of the overall accuracy of this study. Results. Five fourfold tables were made from the four studies that were included in the meta-analysis. The pooled sensitivity of Xpert Ebola was 0.98 (95% confidence interval (CI) (0.95, 0.99)), and the pooled specificity was 0.98 (95% CI (0.97, 0.99)). The pooled values of positive likelihood ratio was 53.91 (95% CI (12.82, 226.79)), with negative likelihood ratio being 0.04 (95% CI (0.02, 0.08)) and diagnostic odds ratio being 2649.45 (95% CI (629.61, 11149.02)). The AUC was 0.9961. Conclusions. Compared with RT-PCR, Xpert Ebola has high sensitivity and specificity. Therefore, it is a valued alternative method for the clinical diagnosis of Ebola virus infection. However, the Xpert Ebola test is a qualitative test that does not provide quantitative testing of EBOV concentration. Whether it can completely replace other methods or not calls for further evidences. [ABSTRACT FROM AUTHOR]
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- 2021
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18. Diagnostic Accuracy of Bronchoalveolar Lavage Fluid Galactomannan for Invasive Aspergillosis.
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Cao, Xun-Jie, Li, Ya-Ping, Xie, Li-Min, Zhang, Hong-Lang, Qin, Yu-Shan, and Guo, Xu-Guang
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BRONCHOALVEOLAR lavage ,CONFIDENCE intervals ,META-analysis ,POLYSACCHARIDES ,PROBABILITY theory ,PULMONARY aspergillosis ,SYSTEMATIC reviews ,PREDICTIVE tests ,RECEIVER operating characteristic curves ,DESCRIPTIVE statistics - Abstract
Background. The pathogenesis of invasive aspergillosis (IA) is still unknown, but its progression is rapid and mortality rate remains high. Bronchoalveolar lavage fluid (BALF) galactomannan (GM) analysis has been used to diagnose IA. This study is aimed at making an accurate estimate of the whole accuracy of BALF-GM in diagnosing IA. Methods. After a systematic review of the study, a bivariate meta-analysis was used to summarize the specificity (SPE), the sensitivity (SEN), the positive likelihood ratios (PLR), and the negative likelihood ratios (NLR) of BALF-GM in diagnosing IA. The overall test performance was summarized using a layered summary receiver operating characteristic (SROC) curve. Subgroup analysis was performed to explore the heterogeneity between studies. Results. A total of 65 studies that are in line with the inclusion criteria were included. The summary estimates of BALF-GM analysis are divided into four categories. The first is the proven+probable vs. possible+no IA, with an SPE, 0.87 (95% CI, 0.85-0.98); SEN, 0.81 (95% CI, 0.76-0.84); PLR, 9.78 (5.78-16.56); and NLR, 0.20 (0.14-0.29). The AUC was 0.94. The BALF-GM test for proven+probable vs. no IA showed SPE, 0.88 (95% CI, 0.87-0.90); SEN, 0.82 (95% CI, 0.78-0.85); PLR, 6.56 (4.93-8.75); and NLR, 0.24 (0.17-0.33). The AUC was 0.93. The BALF-GM test for proven+probable+possible vs. no IA showed SPE, 0.82 (95% CI, 0.79-0.95); SEN, 0.59 (95% CI, 0.55-0.63); PLR, 3.60 (2.07-6.25); and NLR, 0.31 (0.15-0.61). The AUC was 0.86. The analyses for others showed SPE, 0.85 (95% CI, 0.83-0.87); SEN, 0.89 (95% CI, 0.86-0.91); PLR, 6.91 (4.67-10.22); and NLR, 0.18 (0.13-0.26). The AUC was 0.94. Conclusions. The findings of this BALF-GM test resulted in some impact on the diagnosis of IA. The BALF-GM assay is considered a method for diagnosing IA with high SEN and SPE. However, the patients' underlying diseases may affect the accuracy of diagnosis. When the cutoff is greater than 1, the sensitivity will be higher. [ABSTRACT FROM AUTHOR]
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- 2020
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19. Evaluation of the Diagnostic Efficacy of Xpert CT/NG for Chlamydia trachomatis and Neisseria gonorrhoeae.
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Xie, Tian-Ao, Liu, Ye-Ling, Meng, Rui-Chun, Liu, Xiao-Shan, Fang, Ke-Ying, Deng, Shu-Ting, Fan, Shu-Jin, Chen, Chu-Mao, Lin, Qin-Rong, He, Zhi-Jian, Li, Zhen-Xing, Ouyang, Shi, Zhu, Guo-Dong, Ji, Tian-Xing, Xia, Yong, Pan, Zhi-Yong, and Guo, Xu-Guang
- Subjects
CHLAMYDIA infection diagnosis ,COMPUTER software ,INFORMATION storage & retrieval systems ,MEDICAL databases ,MEDICAL information storage & retrieval systems ,MEDLINE ,META-analysis ,NEISSERIA infections ,ONLINE information services ,QUALITY assurance ,SYSTEMATIC reviews ,RECEIVER operating characteristic curves ,PUBLICATION bias ,DATA analysis software ,NUCLEIC acid amplification techniques - Abstract
Background. Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are widely spread across the world. Asymptomatic or inconspicuous CT/NG infections are difficult to diagnose and treat. Traditional methods have the disadvantages of low detection rate, inaccurate results, and long detection time. However, Xpert CT/NG makes up for the aforementioned shortcomings and has research value and popularization significance. Methods. PubMed, Embase, Cochrane Library, and Web of Science were systematically searched, and studies were screened using Xpert CT/NG for diagnosing CT/NG. QUADAS-2 was used to evaluate the quality of the eligible studies. Then, two groups of researchers independently extracted data from these studies. Meta-analyses of sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the area under the curve (AUC) of the summary receiver operating characteristic (SROC) curve were conducted using Meta-DiSc 1.4. Finally, Deek's funnel plots were made using Stata 12.0 to evaluate publication bias. Results. 14 studies were identified, and 46 fourfold tables were extracted in this meta-analysis. The pooled SEN, SPE, PLR, NLR, DOR, and AUC in diagnosing CT were 0.94 (95% confidence interval (CI): 0.93–0.95), 0.99 (95% CI: 0.99–1.00), 97.17 (95% CI: 56.76–166.32), 0.07 (95% CI: 0.04–0.12), 1857.25 (95% CI: 943.78–3654.86), and 0.9960, respectively. The pooled SEN, SPE, PLR, NLR, DOR, and AUC in diagnosing NG were 0.95 (95% CI: 0.93–0.96), 1.00 (95% CI: 1.00–1.00), 278.15 (95% CI: 152.41–507.63), 0.08 (95% CI: 0.06–0.12), 4290.70 (95% CI: 2161.78–8516.16), and 0.9980, respectively. Conclusions. Xpert CT/NG had high diagnostic sensitivity and specificity for CT and NG. However, more evidence is required to confirm that Xpert CT/NG might serve as the primary method for detecting CT and NG and even the gold standard for diagnosis in the future. [ABSTRACT FROM AUTHOR]
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- 2020
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20. Angiotensin receptor blockers and breast cancer risk: a meta-analysis
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Jun Wu, Yun-Feng Qian, and Wei-Guo Xu
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Oncology ,medicine.medical_specialty ,Breast Neoplasms ,Subgroup analysis ,Risk Assessment ,White People ,Angiotensin Receptor Antagonists ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Asian People ,Risk Factors ,Internal medicine ,Odds Ratio ,medicine ,Humans ,Aged ,Chi-Square Distribution ,business.industry ,General Medicine ,Odds ratio ,Middle Aged ,Protective Factors ,Prognosis ,medicine.disease ,Confidence interval ,030220 oncology & carcinogenesis ,Meta-analysis ,Female ,Risk assessment ,business ,Chi-squared distribution - Abstract
Introduction Some studies reported that angiotensin receptor blockers (ARBs) reduced the risk of breast cancer. However, other studies did not show similar results. Evidence acquisition The PubMed and EMBASE databases were searched. The strength of the association between ARBs and the risk of breast cancer was measured by odds ratio (OR) and 95% confidence interval (CI). Evidence synthesis Eight eligible studies with 1,994,880 individuals were considered for this meta-analysis. ARBs was not associated with the risk of breast cancer (OR=0.93; 95% CI: 0.81-1.06; I2=86%). In the subgroup analysis of race, a significantly decreased breast cancer risk were observed in Asians (OR=0.62; 95% CI: 0.53-0.73; I2=0%). However, a significantly increased breast cancer risk were observed in Caucasians (OR=1.08; 95% CI: 1.02-1.13; I2=28%). Conclusions This study provided evidence that ARBs was associated with decreased breast cancer in Asians and increased risk of breast cancer in Caucasians.
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- 2017
21. Comparison of Intramedullary Nail Versus Conventional Ilizarov Method for Lower Limb Lengthening: A Systematic Review and Meta-Analysis
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Wei-guo Xu
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Adult ,medicine.medical_specialty ,medicine.medical_treatment ,Ilizarov Technique ,Lower limb ,Bone Lengthening ,law.invention ,Intramedullary rod ,03 medical and health sciences ,External fixation ,0302 clinical medicine ,Postoperative Complications ,Randomized controlled trial ,Web of knowledge ,law ,Fracture Fixation ,medicine ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Review Articles ,Randomized Controlled Trials as Topic ,030222 orthopedics ,business.industry ,Retrospective cohort study ,Surgery ,Fracture Fixation, Intramedullary ,Leg Length Inequality ,Meta-analysis ,business - Abstract
The objective of this systematic review and meta‐analysis was to compare the lengthening and then nailing (LATN) technique to the conventional Ilizarov method for limb lengthening. A systemic search of potential relevant literature was performed in databases, including the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, and the ISI Web of Knowledge, from their inception to 22 May 2015 using medical subject heading (MeSH) terms “Ilizarov,” “bone lengthening,” or “intramedullary nail.” A total of 89 titles and abstracts were preliminarily reviewed, of which 4 studies eventually satisfied the eligibility criteria, consisting of one randomized controlled trial (RCT), two clinical controlled trials and one retrospective cohort study. A total of 354 limbs were included in the study, among which 183 were lengthened over an intramedullary nail, and 171 limbs were lengthened conventionally. The mean difference (MD) was −50.21 for the external fixation index between the two groups (95% CI, −51.83 to −48.59; P < 0.00001) with high heterogeneity (I (2) = 99%); no significant difference in length was gained (MD = −0.30, 95% CI = −0.72 to 0.12; P = 0.16) with high heterogeneity (I (2) = 80%); and there was high significant difference for the consolidation index (MD = −19.97; 95% CI, −21.59 to −18.35; P < 0.00001) with high heterogeneity (I (2) = 100%). The overall rate of complications was relatively low, and differed significantly between the two groups. Through this meta‐analysis, we find that LATN is superior to the conventional method in regards to the external fixation index and the consolidation index, which means that LATN is an effective technique that can decrease the time needed in external fixation.
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- 2017
22. The effect of prediabetes on hepatocellular carcinoma risk: a systematic review and meta-analysis
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Yun-Feng Qian, Jun Wu, and Wei-Guo Xu
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Male ,Risk ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Subgroup analysis ,Gastroenterology ,White People ,Cohort Studies ,Prediabetic State ,03 medical and health sciences ,0302 clinical medicine ,Sex Factors ,Asian People ,Internal medicine ,medicine ,Humans ,Prediabetes ,Risk factor ,business.industry ,Hazard ratio ,Liver Neoplasms ,General Medicine ,medicine.disease ,digestive system diseases ,Increased risk ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Meta-analysis ,Case-Control Studies ,030211 gastroenterology & hepatology ,Female ,business ,Cohort study - Abstract
INTRODUCTION Some studies suggested an increased risk of hepatocellular carcinoma (HCC) risk in subjects with prediabetes, whereas other studies have reported negative results. Therefore, we did this meta-analysis to assess the role of prediabetes on HCC risk. EVIDENCE ACQUISITION We searched studies from PubMed, Embase, and Web of Science databases. The strength of association between prediabetes and HCC risk was assessed by calculating hazard ratio (HR) with 95% CI. EVIDENCE SYNTHESIS A total of 8 cohort studies and 1 case-control study with 1384594 individuals were included. Patients with prediabetes showed an increased HCC risk (HR=1.21; 95% CI, 1.13-1.30; P
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- 2016
23. Evaluation of Lateral-Flow Assay for Rapid Detection of Influenza Virus.
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Han, Meng-Yi, Xie, Tian-Ao, Li, Jia-Xin, Chen, Hui-Jin, Yang, Xiao-Hui, and Guo, Xu-Guang
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INFLUENZA diagnosis ,CONFIDENCE intervals ,IMMUNOASSAY ,INFORMATION storage & retrieval systems ,MEDICAL databases ,MEDICAL information storage & retrieval systems ,MEDLINE ,META-analysis ,ONLINE information services ,ORTHOMYXOVIRUSES ,SYSTEMATIC reviews ,RECEIVER operating characteristic curves ,DATA analysis software ,DESCRIPTIVE statistics ,ODDS ratio - Abstract
Background. Influenza virus mainly causes acute respiratory infections in humans. However, the diagnosis of influenza is not accurate based on clinical evidence, as the symptoms of flu are similar to other respiratory virus. The lateral-flow assay is a rapid method to detect influenza virus. But the effectiveness of the technique in detecting flu viruses is unclear. Hence, a meta-analysis would be performed to evaluate the accuracy of LFA in detecting influenza virus. Methods. Relevant literature was searched out in PubMed, Embase, Web of Science, and Cochrane Library databases with the keywords "lateral flow assay" and "flu virus". By Meta-DiSc software, pooled sensitivity, pooled specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), summary receiver operating characteristic curve (SROC), and area under the curve (AUC) can be calculated. Results. This meta-analysis contains 13 studies and 24 data. The pooled sensitivity and specificity of the influenza virus detected by LFA were 0.84 (95% CI: 0.82-0.86) and 0.97 (95% CI: 0.97-0.98), respectively. The pooled values of PLR, NLR, DOR, and SROC were 32.68 (17.16-62.24), 0.17 (0.13-0.24), 334.07 (144.27-773.53), and 0.9877. No publication bias was found. Conclusions. LFA exhibited high sensitivity and specificity in diagnosing influenza virus. It is a valuable alternative method which can diagnose influenza virus quickly. However, more evidence is required to confirm whether LFA is comparable to traditional methods for detecting the virus. [ABSTRACT FROM AUTHOR]
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- 2020
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24. Post-diagnosis Soy Food Intake and Breast Cancer Survival: A Meta-analysis of Cohort Studies
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Yang Liu, Yue-Can Zeng, Rui Xing, Feng Chi, Zhao-Guo Xu, and Rong Wu
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Cancer Research ,medicine.medical_specialty ,Epidemiology ,Breast Neoplasms ,Subgroup analysis ,Gastroenterology ,Cohort Studies ,Breast cancer ,Internal medicine ,medicine ,Humans ,Survival rate ,Gynecology ,business.industry ,Public Health, Environmental and Occupational Health ,Soy Foods ,Cancer ,Prognosis ,medicine.disease ,ER Negative ,Survival Rate ,Oncology ,Meta-analysis ,Soy food ,Female ,business ,Cohort study - Abstract
Background and Objectives: Data on associations between soy food intake after cancer diagnosis with breast cancer survival are conflicting, so we conducted this meta-analysis for more accurate evaluation. Methods: Comprehensive searches were conducted to find cohort studies of the relationship between soy food intake after cancer diagnosis and breast cancer survival. Data were analyzed with comprehensive meta-analysis software. Results: Five cohort studies (11,206 patients) were included. Pooling all comparisons, soy food intake after diagnosis was associated with reduced mortality (HR 0.85, 95%CI 0.77 0.93) and recurrence (HR 0.79, 95%CI 0.72 0.87). Pooling the comparisons of highest vs. lowest dose, soy food intake after diagnosis was again associated with reduced mortality (HR 0.84, 95%CI 0.71 0.99) and recurrence (HR 0.74, 95%CI 0.64 0.85). Subgroup analysis of ER status showed that soy food intake was associated with reduced mortality in both ER negative (highest vs. lowest: HR 0.75, 95%CI 0.64 0.88) and ER positive patients (highest vs. lowest: HR 0.72, 95%CI 0.61 0.84), and both premenopausal (highest vs. lowest: HR 0.78, 95%CI 0.69 0.88) and postmenopausal patients (highest vs. lowest: HR 0.81, 95%CI 0.73 0.91). In additioin, soy food intake was associated with reduced recurrence in ER negative (highest vs. lowest: HR 0.64, 95%CI 0.44 0.94) and ER+/PR+ (highest vs. lowest: HR 0.65, 95%CI 0.49 0.86), and postmenopausal patients (highest vs. lowest: HR 0.67, 95%CI 0.56 0.80). Conclusion: Our metaanalysis showed that soy food intake might be associated with better survival, especially for ER negative, ER+/ PR+, and postmenopausal patients.
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- 2013
25. Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis.
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Hai-Yan Chen, Dan-Ting Shen, Dong-Ze Ji, Pei-Chun Han, Wei-Ming Zhang, Jian-Feng Ma, Wen-Sen Chen, Hemant Goya, Shiyang Pan, and Hua-Guo Xu
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HEPATITIS D virus ,HEPATITIS B vaccines ,META-analysis ,VIRUS diseases - Published
- 2019
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26. Stereotactic radiosurgery of brainstem cavernous malformations: a systematic review and meta-analysis
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Hui Sun, Jian-Guo Xu, Xin-Yu Lu, and Qiao-Yu Li
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Gamma-knife surgery ,Hemangioma, Cavernous, Central Nervous System ,business.industry ,medicine.medical_treatment ,MEDLINE ,Cavernous malformations ,medicine.disease ,Radiosurgery ,Stereotaxic Techniques ,Treatment Outcome ,Relative risk ,Meta-analysis ,Stereotaxic technique ,medicine ,Humans ,Brainstem ,Nuclear medicine ,business ,Brain Stem - Abstract
Object Over the last two decades, stereotactic radiosurgery (SRS) has arisen as a promising approach in the management of brainstem cavernous malformations (CMs). In the present study, the authors report a systematic review and meta-analysis of the available published data regarding the radiosurgical management of brainstem CMs. Methods To identify eligible studies, systematic searches for brainstem CMs treated with SRS were conducted in major scientific publication databases. The search yielded 5 studies, which were included in the meta-analysis. Data from 178 patients with brainstem CMs were extracted. Hemorrhage rates before and after SRS were calculated, a meta-analysis was performed, and the risk ratio (RR) was determined. Results Four studies showed a statically significant reduction in the annual hemorrhage rate after SRS. The overall RR was 0.161 (95% CI 0.052–0.493; p = 0.001), and 21 patients (11.8%) had transient or permanent neurological deficits. Conclusions The present meta-analysis for the radiosurgical management of brainstem CMs shows that SRS can decrease the rate of repeat hemorrhage and has a low rate of adverse effects compared with surgery. The authors suggest that SRS may be considered as an alternative treatment for brainstem CMs that are inoperable or have a high operative risk.
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- 2014
27. Effects of toremifene versus tamoxifen on breast cancer patients: a meta-analysis
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Yue-Can Zeng, Zhao-Guo Xu, Rui Xing, Yang Liu, Rong Wu, and Feng Chi
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Oncology ,medicine.medical_specialty ,Antineoplastic Agents, Hormonal ,Breast Neoplasms ,law.invention ,Breast cancer ,Randomized controlled trial ,Meta-Analysis as Topic ,law ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,Radiology, Nuclear Medicine and imaging ,Vaginal bleeding ,Toremifene ,Gynecology ,business.industry ,Cancer ,General Medicine ,medicine.disease ,Prognosis ,Tamoxifen ,Selective estrogen receptor modulator ,Meta-analysis ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
Toremifene and tamoxifen are both selective estrogen receptor modulators used in the treatment of breast cancer patients. Therefore, we carried out a meta-analysis to achieve a more precise evaluation of the effects of toremifene versus tamoxifen on breast cancer patients, including the efficacy and safety, and the effects on the uterus, lipids, and bone. Comprehensive literature searches were conducted using the electronic databases and reference lists to include randomized controlled trials (RCTs) that compared toremifene with tamoxifen for breast cancer patients. Two reviewers independently selected studies and abstracted data. Data were analyzed by Review Manager, version 5.0. Twenty-three trials (7242 patients) were included. For early stage breast cancer, toremifene was associated with higher 5-year survival rates (OR 1.25, 95 % CI 1.04, 1.50), more vaginal discharge (OR 1. 32, 95 % CI 1.01, 1.73), a greater decrease in serum triglyceride levels (SMD −1.01, 95 % CI −1.89, −0.14), a smaller decrease in LDL cholesterol levels (SMD 0.45, 95 % CI 0.07, 0.84) and in bone mineral density in Ward’s triangle (SMD −0.36, 95 % CI −0.71, −0.01), and a greater increase in HDL cholesterol levels (SMD 0.43, 95 % CI 0.08, 0.77) than tamoxifen. For advanced breast cancer patients, toremifene was associated with more vaginal bleeding (OR 0.45, 95 % CI 0.26, 0.80) and a greater decrease in serum triglyceride levels (SMD −1.15, 95 % CI −1.90, −0.39) than tamoxifen. Available evidence showed that toremifene could be an alternative option to tamoxifen for both early and advanced breast cancer patients. However, the methodological quality of the included studies was low. More rigorous RCTs are needed to confirm the results of this meta-analysis in the future.
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- 2012
28. Adiponectin polymorphisms and non-alcoholic fatty liver disease risk: A meta-analysis.
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Wang, Jun, Guo, Xu‐Feng, Yu, Shi‐Jie, Song, Jia, Zhang, Ji‐Xiang, Cao, Zhuo, Wang, Jing, Ji, Meng‐Yao, and Dong, Wei‐Guo
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- *
ADIPONECTIN , *ADIPOSE tissues , *RISK-return relationships , *FATTY liver , *PEPTIDE hormones - Abstract
Background and Aim The adiponectin polymorphism has been implicated in susceptibility to non-alcoholic fatty liver disease ( NAFLD), but the results remain inconclusive. The aim of this meta-analysis is to investigate the association between adiponectin polymorphisms and NAFLD risk. Methods All eligible case-control studies published up to September 2013 were identified by searching Pub Med, Web of Science, and CNKI. Effect sizes of odds ratio ( OR) and 95% confidence interval (95% CI) were calculated by using a fixed- or random-effect model. Results A total of 10 case-control studies were included; of those, there were nine studies (1223 cases and 1580 controls) for +45 T> G polymorphism, seven studies (876 cases and 989 controls) for +276 G> T polymorphism, and three studies (299 cases and 383 controls) for −11337 C> G polymorphism. Overall, a significantly increased risk was found for +45 T> G and −11377 C> G polymorphism (+45 T> G: OR = 1.45, 95% CI: 1.06-2.00 for recessive model, OR = 1.48, 95% CI: 1.07-2.06 for GG vs TT; −11377 C> G: OR = 1.52, 95% CI: 1.10-2.09 for dominant model, OR = 3.88, 95% CI: 1.29-11.68 for GG vs CC), while for +276 G> T polymorphism, we found a significantly decreased risk between them ( OR = 0.65, 95% CI: 0.45-0.94 for recessive model, OR = 0.58, 95% CI: 0.40-0.84 for TT vs GG). In subgroup analysis by ethnicity, significant association was detected among Asians for +276 G> T polymorphism, but not for +45 T> G polymorphism. Besides, none of the three adiponectin polymorphisms was associated with the serum adiponectin levels. Conclusion This meta-analysis suggests that adiponectin +45 T> G and −11377 C> G polymorphisms might be a risk factor for NAFLD, while +276 G> T polymorphism may be a protective factor for NAFLD among Asians. [ABSTRACT FROM AUTHOR]
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- 2014
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29. Meta-analysis of the clinical efficacy and safety of single versus dual plate in the treatment of comminuted distal femur fractures
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Guo-xu Zhang, Ji Li, Qi-jun Xie, Mei-ren Zhang, Kui Zhao, and Hai-yun Chen
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distal femur fracture ,double plate ,lateral locking plate ,medial plate ,meta-analysis ,Orthopedic surgery ,RD701-811 - Abstract
Objective: Through meta-analysis, this study aims to comprehensively evaluate the efficacy of single-plating and double-plating in the treatment of comminuted fractures of the distal femur. Methods: Computer searches of PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), VIP, and Wanfang digital journals were performed, and the timeframe for the searches was from the establishment of each database to July 2023 for each of the databases. Meta-analysis was performed using RevMan 5.4 software provided by the Cochrane Library, and the review process was registered in the PROSPERO database. Results: A total of ten studies were included for statistical analysis. One randomised controlled study and nine retrospective cohort studies with a total of 563 patients were included. The double-plate group was superior to the single-plate group in terms of knee mobility at 6 months postoperatively, overall postoperative complications, and the rate of healing of knee deformity. However, it increased the operation time and intraoperative bleeding, and the difference between the two groups was statistically significant (P < 0.05). There was no significant difference between the two groups in terms of excellent knee function rate, fracture healing time, plate fracture, postoperative infection, delayed fracture healing, and non-union (P ≥ 0.05). Conclusion: Double plate fixation for comminuted fractures of the distal femur can improve knee mobility at 6 months postoperatively, reduce overall postoperative complications, and decrease the incidence of malunion healing. However, it increases operative time and bleeding. Randomised studies are needed to provide strong evidence in the future.
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- 2024
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30. A meta-analysis of the efficacy of Roux-en-Y anastomosis and jejunal interposition after total gastrectomy
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Yu-hang Liu, Rui Meng, Bing Zhu, Qi-qi Zhan, Xin Yang, Guan-yi Ding, Chun-liang Jia, and Wei-guo Xu
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Alimentary tract reconstruction ,Jejunal interposition ,Meta-analysis ,Roux-en-Y ,Total gastrectomy ,Surgery ,RD1-811 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background To compare the clinical efficacy of two alimentary tract reconstruction methods—“P”-shape jejunal interposition (PJI) and Roux-en-Y anastomosis after total gastrectomy. Method The following search phrases were utilized to search PubMed, Cochrane Library, Embase, China Academic Journals Network Full-text Database (CNKI), and Wanfang Database as of April 2022: “gastrectomy,” “Roux-en-Y,” “interposition,” “total gastrectomy,” and “jejunal interposition.” Meta-analysis of the operation time, intraoperative blood loss, complication rate, and postoperative nutritional status of patients was performed using RevMan 5.4 software. Results A total of 24 studies and 1887 patients were included in the study. Among patients who received a total gastrectomy, the operation time in the PJI group was substantially longer than that in the Roux-en-Y group (WMD = 19.77, 95% CI: 5.84–33.70, P = 0.005). The incidence of postoperative reflux esophagitis in the PJI group was considerably reduced than that in the Roux-en-Y group (OR = 0.39, 95% CI: 0.28–0.56, P
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- 2023
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31. Systematic evaluation of line probe assays for the diagnosis of tuberculosis and drug-resistant tuberculosis.
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Lin, Min, Chen, Ying-Wen, Li, Yun-Ran, Long, Li-Jun, Qi, Le-Yao, Cui, Ting-Ting, Wu, Shao-Yong, Lin, Jia-Yuan, Wu, Tong, Yang, Yi-Chen, Yuan, Wei-Hua, Wu, Ge-Yuan, Lan, Qi-Wen, Liu, Jia-Qi, Li, Ya-Ping, Yu, Zi-Yuan, and Guo, Xu-Guang
- Subjects
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RIFAMPIN , *TUBERCULOSIS , *MULTIDRUG-resistant tuberculosis , *MYCOBACTERIUM tuberculosis , *PUBLICATION bias , *ODDS ratio , *CROSS-cultural studies , *CONFIDENCE intervals - Abstract
• Using LPAs in TB detection. • Using LPAs in Drug-resistant TB detection. • LPAs detect TB and Drug-resistant TB correctly. • LPAs is a good method for TB diagnosis. Line probe assays (LPAs) are PCR-based assays used for the rapid diagnosis of Mycobacterium tuberculosis (MTB) and drug-resistant tuberculosis (DR-TB). But studies on its performance are insufficient. Thus, in this study, we conducted a systematic review and meta-analysis to evaluate the effect of LPAs in the detection of MTB and drug-resistant TB in comparison with the traditional culture and DST methods. A systemic literature search was conducted on the Web of Science, Embase, PubMed, the Cochrane Library, Scopus, and OVID databases. All the included studies were classified according to different detecting objects. Sensitivity, specificity, Positive Likely Ratio (PLR), Negative Likely Ratio (NLR), Diagnostic Odds Ratio (DOR), corresponding 95% confidence interval, Area Under Curve (AUC), Deeks' funnel plot, and Bivariate Boxplot was used to do the evaluation. 147 studies included 491 datasets, with 182,448 samples, were incorporated into our analysis. The sensitivity (95% CI), specificity (95% CI), PLR, NLR, DOR and AUC for MTB were 0.89 (0.86 to 0.92), 0.94 (0.90 to 0.97), 15.70, 0.11, 139 and 0.96, respectively; for rifampicin-resistant TB were 0.96 (0.95 to 0.97), 0.99 (0.98 to 0.99), 82.9, 0.04, 1994 and 1.00, respectively; for isoniazid-resistant TB were 0.91 (0.89 to 0.93), 0.99 (0.98 to 0.99), 83.4, 0.09, (0.99 to 1.00), 195.7, 0.07, 2783 and 1.00, respectively; for Multi-drug resistant TB (MDR-TB) were 0.93 (0.90 to 0.95), 1.00 (0.99 to 1.00), 195.7, 0.07, 2783 and 1.00, respectively; for extensively drug-resistant TB (XDR-TB) were 0.60 (0.33 to 0.82), 1.00 (0.95 to 1.00), 291.3, 0.4, 726 and 0.95, respectively; for (second-line drug-resistant TB) SLID-TB were 0.83 (0.78 to 0.87), 0.98 (0.97 to 0.99), 44.6, 0.17, 262 and 0.98, respectively. Sensitivity in pre-extensively drug-resistant TB (Pre-XDR-TB) was 0.67, specificity was 0.91. No publication bias existed according to Deeks' funnel plot. High diagnosis performance was confirmed in LPAs for the diagnosis of MTB and drug-resistant TB. LPAs might be a good alternative to culture and DST in detecting MTB, RR-TB, INH-TB, XDR-TB, SLID-TB, and MDR-TB. While more studies were still needed to explore the diagnosis performance of LPAs for Pre-XDR TB. [ABSTRACT FROM AUTHOR]
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- 2022
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32. Impact of 3D Rigid Ring Annuloplasty for Tricuspid Regurgitation: A Systematic Review and Meta-Analysis
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Tao You, Yu-Hu Ma, Kang Yi, Jie Gao, Jian-Guo Xu, Xiao-Min Xu, Shao-E He, Wei Wang, and Meng Ji
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tricuspid regurgitation ,three-dimensional rigid ring ,tricuspid annuloplasty ,meta-analysis ,systematic review ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundTricuspid annuloplasty (TAP) is accepted as the standard technique for correcting tricuspid regurgitation (TR). We conducted the present study to provide an overview of the contemporary results of 3D rigid ring annuloplasty for TR.MethodsA systematic literature search was carried out in eight databases to collect all relevant studies on the three-dimensional (3D) rigid ring annuloplasty treatment of TR published before October 1, 2020. The main outcomes of interest were postoperative TR grade, perioperative mortality, and recurrent TR.ResultsA total of eight studies were included, all of which were retrospective observational studies. Rigid 3D rings were compared with flexible bands, and there was no difference in perioperative mortality [odds ratio (OR) = 1.02; 95% CI (0.52, 2.02); p = 0.95], late mortality [OR = 0.99; 95% CI (0.28, 3.50); p = 0.98], or recurrent TR [OR = 0.59; 95% CI (0.29, 1.21); p = 0.15]. The postoperative TR grade associated with 3D rigid rings was 0.12 lower [mean difference (MD) = −0.12; 95% CI (−0.22, −0.01); p = 0.03], which indicated that 3D rigid rings result in better postoperative outcomes than flexible bands. Compared with suture annuloplasty, the postoperative TR grade of the 3D rigid ring group was 0.51 lower [MD = −0.51; 95% CI (−0.59, −0.43); p < 0.05]. Within the 5 years of follow-up, patients who underwent 3D rigid ring annuloplasty had lower TR recurrence [OR = 0.26; 95% CI (0.13, 0.50); p < 0.05].ConclusionsCompared with suture annuloplasty, 3D rigid rings present early advantages. The 3D rigid rings provide an acceptable short-term effect similar to that of the flexible bands, and a significant difference between these approaches was not discovered. However, the conclusion was based on the limited, short-term data available at the time of the study. Further research on the long-term effects of 3D rigid ring annuloplasty for TR is clearly needed.Systematic Review Registrationhttps://inplasy.com/inplasy-2021-3-0105/, identifier: 202130105.
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- 2022
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33. The Diagnostic Accuracy of Xpert Xpress to SARS-CoV-2: A systematic review.
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Cao, Xun-Jie, Fang, Ke-Ying, Li, Ya-Ping, Zhou, Jie, and Guo, Xu-Guang
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SARS-CoV-2 , *MEDICAL screening , *SENSITIVITY & specificity (Statistics) , *COVID-19 , *DEATH rate , *META-analysis - Abstract
• The articles included in the analysis are comprehensive. • The analysis results show that Xpress Xpert has high diagnostic efficiency and short detection time, so we suggest that Xpress Xpert be used as the gold standard for SARS-COV-2 detection • The Xpress Xpert is fast, accurate, and low-cost, so it can be used for large large-scale screening. The SARS-CoV-2 infection rate, as well as mortality rate, is high. There is an urgent need for a high-throughput, accurate and reliable method of diagnosing COVID-19 pneumonia. We included references from databases, such as PubMed, Cochrane Library, Web of Science, and Embase, and extracted data. Then, MetaDisc and STATA were used to establish forest plots and funnel plots for meta-analysis. We collected 14 articles and performed a systematic review. The following results were obtained: sensitivity and specificity were 0.97 (0.96 to 0.98) and 0.97 (0.96 to 0.98) respectively; PLR and NLR were 24.51 (16.63–36.12) and 0.03 (0.01 to 0.10) respectively, DOR was 975.15 (430.11–2210.88), and AUC was 0.9926. When Xpress detects SARS-CoV-2 in different samples, the heterogeneity is small and the specificity and sensitivity are extremely high. We recommend the employment of Xpert Xpress analysis in rapid screening. [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
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