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Diagnostic accuracy of coronary angiography using 64-slice computed tomography in coronary artery disease
- Source :
- Saudi Medical Journal, Vol 36, Iss 10, Pp 1156-1162 (2015), Saudi Medical Journal
- Publication Year :
- 2015
- Publisher :
- Ministry of Defence and Aviation, 2015.
-
Abstract
- Objectives: To conduct a meta-analysis and investigate the diagnostic value of 64-slice computed tomography (CT) angiography for diagnosing coronary artery disease (CAD) in patients. Methods: A comprehensive literature search from March 2005 to August 2014 was performed on the following databases: Cochrane Library; Medline; EmBase; PubMed; and BioMed Central database. As a reference standard, studies that assessed 64-slice CT angiography in detecting coronary artery stenosis (CAS) with invasive coronary angiography were included. Coronary artery stenosis was defined as ≥50% diameter stenosis. Diagnostic value was determined by pooling sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) values at segment-level analysis. Diagnostic accuracy was undertaken using area under the curve (AUC) value and summary receiver operating characteristic (SROC) curves. Publication bias was examined by Deek’s funnel plot asymmetry test. Results: Eight studies were included in the analysis, enrolling a total of 579 patients (7,407 segment coronary vessels). At segment-level, pooled sensitivity value was 90% (95% confidence interval [CI]: 83-95%), specificity was 91% (95% CI: 61-98%), PLR value was 9.7 (95% CI: 1.8-53.3), and NLR value was 0.11 (95% CI: 0.05-0.22) for CAS. Optimal cut-off point of sensitivity was 90%, and specificity under the SROC curve was 91%. The AUC value was 0.94. Conclusion: The 64-slice CT angiography is a reliable tool for detection of CAD when using a cut-off of more than or equal to 50% diameter stenosis in elderly population. Saudi Med J 2015; Vol. 36 (10): 1156-1162 doi: 10.15537/smj.2015.10.12415
- Subjects :
- medicine.medical_specialty
Funnel plot
lcsh:Medicine
Coronary Artery Disease
Coronary Angiography
Sensitivity and Specificity
Likelihood ratios in diagnostic testing
Coronary artery disease
Multidetector Computed Tomography
medicine
Humans
Receiver operating characteristic
medicine.diagnostic_test
business.industry
lcsh:R
Coronary Stenosis
Area under the curve
General Medicine
medicine.disease
Confidence interval
ROC Curve
Meta-analysis
Angiography
Systematic Review
Radiology
business
Subjects
Details
- Language :
- English
- ISSN :
- 16583175 and 03795284
- Volume :
- 36
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Saudi Medical Journal
- Accession number :
- edsair.doi.dedup.....fbb49204e2ea28a5f71b479e50b412e3