1. Cardenolides from the stem bark of Salacia staudtiana.
- Author
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Kamtcha, Duplex Wetadieu, Tene, Mathieu, Bedane, Kibrom Gebreheiwot, Knauer, Lena, Strohmann, Carsten, Tane, Pierre, Kusari, Souvik, and Spiteller, Michael
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ANTI-infective agents , *BARK , *ESCHERICHIA coli , *MEDICINAL plants , *PSEUDOMONAS , *STAPHYLOCOCCUS aureus , *PLANT stems , *STEROIDS , *IN vitro studies - Abstract
Seven new cardenolides, staudtianoside A−F ( 1−6 ) and staudtianogenin A ( 8 ), were isolated along with six known compounds from the stem bark of the Cameroonian medicinal plant Salacia staudtiana Loes. ex Fritsch. The structures were elucidated by means of ESI-HRMS and NMR spectroscopic methods and by comparison with literature data. The relative configurations of the new compounds were determined by X-ray diffraction analysis, NOESY correlation and coupling constants. We evaluated the antibacterial efficacy of the isolated compounds against two commonly dispersed environmental strains of Escherichia coli and Bacillus subtilis , as well as against two human pathogenic clinical strains of Staphylococcus aureus and Pseudomonas aeruginosa . Compounds 1 , 2 and 8 exhibited marked antibacterial potencies against the clinically relevant P. aeruginosa that were comparable to the standard antibiotics. Compound 2 was also active against S. aureus and E. coli . Further, compounds 5 and 8 demonstrated efficacy against E. coli as well as B. subtilis . The structure-activity relationship of the tested compounds is discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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