1. The clinical and immunomodulatory effects of green soybean extracts
- Author
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Shinjiro Imai, Mamoru Isemura, Tsutomu Nakayama, Yuki Katayanagi, Ryuta Fukutomi, Kyoko Taguchi, Kensuke Yasui, and Hiroyuki Ikemoto
- Subjects
Adult ,Guinea Pigs ,Pilot Projects ,Mucous membrane of nose ,Pharmacology ,Biology ,Immunoglobulin E ,Analytical Chemistry ,Guinea pig ,Mice ,Animals ,Humans ,Immunologic Factors ,Secretion ,B-cell activating factor ,B-Lymphocytes ,Mice, Inbred BALB C ,Plant Extracts ,Rhinitis, Allergic, Seasonal ,Cedar pollinosis ,General Medicine ,Real-time polymerase chain reaction ,Seeds ,Glycine ,Immunology ,biology.protein ,Pollen ,Female ,Soybeans ,Food Science - Abstract
The present study was performed to investigate the immune-modulating activities of extracts from green soybean (Glycine max) in a 2,4-toluene diisocyanate (TDI)-inducing guinea pig rhinitis model and a human trial study for allergic rhinitis. Hot water extracts of green soybean were chosen for animal experimentation on the basis of their ability to regulate the production of B cell-activating factor of the TNF family and a proliferation-inducing ligand in mouse spleen cells. Green soybean extracts significantly decreased the levels of ovalubumin (OVA)-specific IgE in mice and significantly suppressed the TDI-induced nasal mucosa secretion. An open-label human pilot study was performed on 16 subjects, using Japanese cedar pollinosis. The symptom scores for Japanese cedar pollinosis were better in the long-term green soybean extracts intake group than in the withdrawal short-term intake group. Green soybean extracts had great potential as an orally active immune modulator for the treatment of various allergic diseases.
- Published
- 2013