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Differentiation-associated alteration in sensitivity to apoptosis induced by (-)-epigallocatechin-3-O-gallate in HL-60 cells
- Source :
- Biomedical Research. 30:201-206
- Publication Year :
- 2009
- Publisher :
- Biomedical Research Press, 2009.
-
Abstract
- Green tea and its constituent (-)-epigallocatechin-3-O-gallate (EGCG) are known to have apoptosis-inducing activity on tumor cells including human leukemia HL-60 cells, providing an explanation for their anti-cancer effects. In the present study, we compared the sensitivity of undifferentiated cells and differentiated HL-60 cells with normal-like phenotypic characters. HL-60 cells treated with three differentiating agents were found to be resistant to EGCG-mediated apoptosis as compared with undifferentiated cells. Gene and protein expression of 67 kDa laminin receptor was down-regulated in differentiated HL-60 cells, suggesting its contribution to the difference in sensitivity in view of the fact that the receptor is a target of EGCG's action to induce apoptosis. The finding supports the view that EGCG induces apoptosis preferentially in cancer cells as compared with normal counterparts.
- Subjects :
- Cellular differentiation
Apoptosis
HL-60 Cells
Biology
Epigallocatechin gallate
complex mixtures
Antioxidants
Catechin
General Biochemistry, Genetics and Molecular Biology
Receptors, Laminin
chemistry.chemical_compound
Humans
Receptor
Tea
Gene Expression Regulation, Leukemic
food and beverages
Cell Differentiation
General Medicine
Green tea
Molecular biology
Phenotype
67 kDa Laminin Receptor
chemistry
Biochemistry
Cancer cell
Subjects
Details
- ISSN :
- 1880313X and 03886107
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Biomedical Research
- Accession number :
- edsair.doi.dedup.....0c6cdc7fe74317bd5484c7ef8adbcb20