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A study conducted at the University of Sydney explored the potential of delivering Lacticaseibacillus rhamnosus GG (LGG) into the lungs for treating bacterial pulmonary infections through nebulization. The research compared the efficiency of a vibrating-mesh nebulizer (VMN) and a jet nebulizer (JN) in nebulizing LGG suspended in different liquid media. The study found that the nebulization efficiency of LGG depended on the nebulizer type and the liquid medium of the probiotic suspension. [Extracted from the article]

Researchers from Certara UK Ltd. have developed a physiologically based pharmacokinetic (PBPK) model to evaluate the use of 4b-hydroxycholesterol (4b-OHC) as a biomarker for hepatic CYP3A activity. The model successfully simulated plasma 4b-OHC levels in different populations and captured changes in levels due to CYP3A inducers like rifampicin. This study offers a quantitative modeling framework for assessing drug-drug interaction risks related to hepatic CYP3A induction. [Extracted from the article]

A study conducted at the University of Genova focused on developing a multilayer film for the treatment of oral mucosa lesions. The film included a soluble eggshell membrane fraction and showed promising results in promoting wound healing and releasing antimicrobial substances. The research aimed to improve patients' quality of life by accelerating the recovery process and reducing the risk of bacterial infections. The findings suggest that the formulated trilayer films have properties that make them potentially suitable for protecting oral lesions and aiding in rapid healing. [Extracted from the article]

Researchers from Beijing University of Chinese Medicine have published a report on the use of numerical simulation technology in advancing drug preparation. The study highlights the application scenarios and examples of mechanistic modeling in pharmacy research, emphasizing the concept of quality by design. The research concludes that numerical simulation saves experimental cost and time, speeding up the experimental process and guiding formulation with the help of mechanistic models. This study provides valuable insights for drug researchers looking to optimize preparation parameters and predict potential quality problems in drug products. [Extracted from the article]

A new report presents fresh data on pharmaceutics, specifically focusing on the development of robust human liver microsomal stability prediction models. The researchers discuss the challenges of pharmacokinetic issues in drug discovery and the need for high-throughput in vitro assays to evaluate the pharmacokinetic profiles of compounds. They describe the development of an in silico model for predicting human liver microsomal stability using experimental datasets and achieved model accuracies exceeding 80%. The best model, along with a subset of the dataset, has been made publicly accessible for the benefit of the drug discovery community. This research is the largest open-source model of its kind and the first to leverage cross-species data. [Extracted from the article]

A new study conducted by Lek Pharmaceuticals d.d. in Ljubljana, Slovenia, explores the use of matrixing designs in stability studies for parenteral medications. Matrixing designs offer an alternative approach to traditional stability testing by testing only a fraction of samples at each time point. The study focused on three parenteral medications and found that degradation products varied among the products and that a reduction of two time points per batch was the most appropriate approach. This research contributes to the understanding of utilizing reduced matrixing designs in stability studies, which can help reduce costs and time while maintaining precision and reliability. [Extracted from the article]

Researchers from the National and Kapodistrian University of Athens have developed a methodology to estimate population pharmacokinetic (PK) parameters from patients' reported aggregate concentration-time data. The method was applied to the data of gevokizumab, a monoclonal antibody, using a second-generation minimal physiologically based pharmacokinetic (mPBPK) model. The analysis was performed using R software and Bayesian priors were applied to the parameters. The researchers concluded that this method could be used for other drugs with different PK models and when multiple aggregate datasets need to be combined for a meta-analysis. [Extracted from the article]

Researchers from Shanghai Jiao Tong University School of Medicine have conducted a study on the pharmacokinetics and pharmacodynamics of remimazolam, a benzodiazepine used for sedation and anesthesia. The study aimed to establish a population model to optimize dosing regimens for sedation therapy. Data was collected from a clinical pharmacology study involving healthy Chinese volunteers, and a population PK/PD model was developed. The researchers also created a web-based dashboard to provide individualized dosing regimens. The study concluded that the established model could be used to optimize individual dosing regimens for remimazolam. [Extracted from the article]

A recent study conducted at Hannover Medical School in Germany explored the use of a molded round window niche implant (RNI) as a delivery system for dexamethasone (DEX) in cochlear implant (CI) surgery. The researchers found that the RNI containing 10% DEX had anti-inflammatory properties and beneficial effects on hearing preservation at high frequencies. The study involved guinea pigs as a CI-trauma model and evaluated the drug release, auditory response, impedance measurement, micro-computed tomography imaging, and histology. The findings suggest that the RNI could be a promising approach for preserving residual hearing after CI surgery. [Extracted from the article]

Researchers from Universidade Estadual do Centro-Oeste in Guarapuava, Brazil have developed and characterized hydrogels and films based on cationic guar gum (CGG) for wound healing. The hydrogels showed adequate viscosity and spreadability for wound coverage, but their bioadhesive strength was reduced on injured skin. In contrast, the films maintained consistent bioadhesive strength regardless of skin condition and demonstrated superior antioxidant potential compared to the hydrogels. The films also showed biocompatibility, cell proliferation, and potential wound healing, making them promising for advanced wound treatment. [Extracted from the article]

A recent report from the Hebrew University of Jerusalem discusses the effects of simulated microgravity on the cellular uptake of small molecules. The study found that exposure to simulated microgravity led to an increase in the cellular uptake of efflux transporter substrates, while a glucose transporter substrate showed a decrease. Additionally, the study found that the cellular emission of molecules larger than ~3000 g/mol was reduced in simulated microgravity. The researchers suggest that short-term exposure to simulated microgravity could have differential effects on drug distribution across membranes, and longer exposure during spaceflight may have distinct effects on the cellular uptake of small molecules. [Extracted from the article]

A recent article published in Pharmaceutics discusses the applications of amphiphilic copolymers (ACs) in drug release systems for skin treatment. ACs are versatile systems that can form nanomaterials such as micelles, vesicles, nanocapsules, and nanogels. These materials have been extensively studied for their ability to enhance the solubility and permeation of poorly water-soluble drugs into skin tissue, making them useful for treating skin diseases, including cancer and infections caused by bacteria, fungi, and viruses. The article provides a comprehensive analysis of the effects of ACs on various skin diseases and highlights their potential as alternative treatments. [Extracted from the article]

Researchers from Cardinal Stefan Wyszynski University in Warsaw, Poland have conducted a study on the complexation of folic acid (FA) and its structural analog methotrexate (MTX) with cyclodextrins. The researchers found that the addition of simple sugars, such as D-glucose, D-galactose, and D-mannose, to cyclodextrins can enhance the complexation of FA and MTX. The study utilized experimental and theoretical methods to prove the complexation, and the results showed that the addition of a glucose subunit significantly increased the association constant for both FA and MTX. The research provides new insights into the field of pharmaceutics and may have implications for drug development. [Extracted from the article]

A recent study conducted at the University of Blida 1 in Algeria has explored the development of inclusion complexes of niflumic acid (NA) with 2-hydroxypropyl-b-cyclodextrin (2HP-b-CD) to address the drug's poor solubility and low bioavailability. The study investigated the effect of converting NA to its sodium salt (NAs) and adding hydroxypropyl methylcellulose (HPMC) on complex formation. The results showed that the NAs-2HP-b-CD-HPMC complex exhibited the highest drug-cyclodextrin interactions, improved solubility, and dissolution profiles. This complex has the potential to enhance the therapeutic effectiveness of NA and minimize side effects. [Extracted from the article]

Researchers at the University of Bonn in Germany have developed a method for analyzing the penetration depth and kinetics of drugs in the cornea. The study used a semiquantitative imaging method and a quantitative corneal depth-cut technique to assess the penetration of fluorescein sodium in sheep corneas. The researchers found that both methods effectively demonstrated the concentration- and time-dependent depth of penetration. The study also validated the traceability of kinetic processes using polysorbate 80 as a penetration enhancer and detected the retention of larger structures in the lacrimal layer. [Extracted from the article]

A recent study conducted by researchers at the Institute of Gene Biology in Moscow, Russia, focuses on the development of modular nanotransporters (MNTs) for targeted cancer treatment. The study explores the optimization of MNT design by creating smaller-sized MNTs with truncated carrier modules. The researchers found that these new MNTs demonstrated high affinity for target receptors and exhibited endosomolytic activity. Additionally, the study revealed that the N-terminal part of the carrier module showed promising results in terms of binding to Keap1 and enhancing the photodynamic efficacy of the attached photosensitizer. This research provides valuable insights into the potential of MNTs for targeted intracellular drug delivery. [Extracted from the article]

A recent report from University Hospital in Angers, France discusses the potential use of 3,4-Methylenedioxymethamphetamine (MDMA) in treating post-traumatic stress disorders (PTSD) and substance use disorders. The research highlights the importance of pharmacogenomics in guiding MDMA treatment by identifying individuals with genetic predispositions that affect their response to the drug. The study emphasizes the need for large-scale pharmacogenomics studies to optimize the therapeutic use of MDMA and minimize its risks. Further research is required to investigate the genetic variants and genes involved in MDMA metabolism and pharmacodynamics. [Extracted from the article]

A recent study conducted by researchers at the State University of Londrina in Brazil has found that geraniol, a natural compound, can enhance the effectiveness of fluconazole, an antifungal drug, against Candida tropicalis, a pathogenic yeast. Candida tropicalis is known to cause a range of infections, from superficial to life-threatening. The study found that geraniol exhibited a time-dependent fungicidal effect on the yeast cells, inhibited the adhesion of the cells, and caused morphological and ultrastructural alterations in biofilms. The combination of geraniol and fluconazole showed promise in controlling azole-resistant Candida tropicalis infections without causing toxicity. [Extracted from the article]

A recent study conducted by researchers at the University of Parma in Italy compared the characteristics of Ryaltris, a nasal spray for allergies, with other commercially available anti-allergic nasal sprays. The study found that Ryaltris had a higher viscosity and slower flow compared to other products, suggesting potential advantages in terms of clinical behavior. The researchers used innovative characterization methods, including dissolution tests and intranasal deposition profiles, to differentiate between the different products and gain a clear understanding of their behavior. This research provides valuable insights into the efficacy of nasal suspensions containing corticosteroids. [Extracted from the article]

Researchers from Public Assistance - Paris Hospitals (AP-HP) have conducted a study on the pharmaceutics of the antiviral drug Doravirine (DOR). The study aimed to assess the impact of a change in packaging on the drug's key attributes, such as assay, impurity profile, and dissolution. The researchers characterized the potential degradation products of DOR and conducted a toxicological assessment. The study concluded that the formation of DOR's degradation products should be a primary focus when considering repackaging. For more information, readers can refer to the article "Physicochemical Stability of Doravirine (Pifeltro(R)): Characterization of Main Degradation Products and Assessment of Stability of Tablets Repackaged in Single-Dose Unit Containers" published in the journal Pharmaceutics. [Extracted from the article]

Researchers at Jinan University in Guangzhou, China have published a report on pharmaceutics, focusing on the measurement of drug release kinetics. The study aimed to develop a method for real-time visualization and quantification of drug release from microspheres in vitro. The researchers used fluorescence imaging with the FRET system to monitor drug release and found a correlation between fluorescence alterations and drug release profiles. This research has implications for enhancing therapeutic effectiveness and minimizing side effects. [Extracted from the article]

A study conducted by researchers at the University of Limerick in Ireland explores the effects of atomisation gas flow rate on the properties and bioactivity of particles used in pulmonary inhalation of biotherapeutics. The study aims to develop techniques that engineer particles to specific target profiles while minimizing protein denaturation. The results show that optimizing the interplay between atomisation gas flow rate and excipient concentration can produce free-flowing powder with retained bioactivity approaching 100%, low moisture content, and small particle size. This research provides valuable insights for the design of protein-specific spray-drying parameters for inhalable biotherapeutics. [Extracted from the article]

A recent study conducted at the University of Greifswald in Germany focused on the development of long-lasting mucoadhesive oral dosage forms for the treatment of esophageal diseases. The researchers utilized the EsoCap device for targeted local application of films in the esophagus. They also explored different formulation strategies, such as varying film thicknesses and polymer grades, to increase the retention time of the films. The study highlights the importance of biorelevant test systems and the potential of viscous saliva formulations in extending the mucosal contact time. For more information, the full research article can be accessed through the provided link. [Extracted from the article]

A recent study conducted by researchers at the University of Banja Luka in Bosnia and Herzegovina focused on the design of novel TRPA1 agonists, which are compounds that can activate TRPA1 channels in the body. The researchers aimed to investigate the role of TRPA1 channels in carvacrol-induced vasodilation and design new compounds based on carvacrol's structure with improved activities. Through in vitro and in silico studies, the researchers found that carvacrol-induced vasodilation is partly mediated by the activation of TRPA1 channels. They also identified a specific compound, D27, as the best candidate for further synthesis and experimental evaluation. This research has implications for the treatment of hypertension and the development of new vasodilator drugs. [Extracted from the article]

Researchers from the Petru Poni Institute of Macromolecular Chemistry in Iasi, Romania have developed a method for creating pharmaceutical formulations of the antibiotic enrofloxacin (ENR) using polymer-free electrospinning. ENR is commonly used in veterinary medicine but has limited water solubility and low bioavailability. The researchers used custom-prepared cyclodextrin-oligolactide (CDLA) derivatives to improve the solubility of ENR and incorporated significant amounts of the antibiotic into CDLA nanofibrous webs. The formulations were found to have antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, and the presence of CDLA did not inhibit the antibacterial activity of ENR. Further development of these formulations is recommended. [Extracted from the article]

A recent study conducted by researchers at Teva Pharmaceutical Industries Ltd. explores the development and therapeutic application of long-acting injectable products for chronic or long-term treatments. The study focuses on TV-46000, a subcutaneous injectable formulation of risperidone used to treat schizophrenia in adults. The researchers used physiologically-based pharmacokinetic modeling and in vitro-in vivo correlation to predict the pharmacokinetic profile of TV-46000 in humans. The results suggest that the release profile of TV-46000 is species-dependent and cannot be directly extrapolated from dog to human. The study concludes that this alternative approach combining modeling methods is valuable for complex injectable formulations where traditional methods are not applicable. [Extracted from the article]

A recent report published by AbbVie Deutschland GmbH & Co. KG discusses the challenges of developing drugs with complex chemical structures, known as 'beyond rule of five' (bRo5) compounds. These compounds often have difficult physicochemical properties, making it challenging to measure their permeability using the Caco-2 assay. The researchers implemented a novel assay that improved the measurement of permeability for bRo5 compounds, achieving comparable performance to the standard assay for predicting human absorption. This optimized equilibrated Caco-2 assay provides a high-throughput method for measuring cellular permeability in the bRo5 chemical space. [Extracted from the article]

Researchers at the State University of Campinas (UNICAMP) in Brazil have developed a versatile nanostructured lipid carrier (NLC) for the incorporation and stability of the anesthetic drug butamben. NLCs are composed of liquid lipids, solid lipids, and surfactants, allowing for the encapsulation of lipophilic drugs. The researchers optimized the surfactant system and found that stable NLCs were obtained using specific surfactants. The study also found that the addition of a hydrophilic excipient helped in stabilizing the system and decreasing particle size. The research concluded that while some NLC formulations showed phase separation or precipitation, they could be freeze-dried to avoid these issues in an aqueous medium. [Extracted from the article]

Researchers at the University of Szeged in Hungary have published a new report on pharmaceutics. The study focuses on the discovery of new bioactive compounds in the African plant Centrapalus pauciflorus, which has traditionally been used in medicine for chest pain and stomach aches. The researchers isolated three new meroterpenoids from the plant, as well as a known compound. These compounds showed moderate but selective activity against certain cancer cell lines. The findings suggest that these compounds could be potential targets for the development of new drugs. [Extracted from the article]

A study conducted by researchers at China Pharmaceutical University has developed a new method for delivering small interfering RNA (siRNA) therapeutics to cancer cells. The researchers created a family of ferrocenyl amphiphilic dendrimers (Fc-AmDs) that respond to high levels of reactive oxygen species (ROS) in cancer cells. One specific dendrimer, Fc-C [ [8] ] -AmD 8A, demonstrated optimal siRNA delivery and gene silencing. This research represents a novel on-demand delivery system for cancer cell-specific siRNA delivery and opens new possibilities for designing self-assembly nanosystems for drug delivery. [Extracted from the article]

A recent study conducted by the University of Torino in Italy has found that essential oils, when used in combination with traditional antifungal agents, show promise in fighting resistant clinical isolates of Candida auris, a pathogen that has become a global health concern. The study found that certain essential oils, such as thyme, cinnamon, geranium, clove bud, lemongrass, and mentha of Pancalieri, were effective in preventing the growth of C. auris. Additionally, combinations of these essential oils with antifungal drugs, such as micafungin, fluconazole, and 5-flucytosine, showed synergistic effects against the pathogen. These findings suggest that these essential oil combinations could potentially be used as a therapeutic alternative to reduce the dose of individual components and limit side effects, offering a potential solution to the challenge of resistance in C. auris infections. [Extracted from the article]

A recent study conducted by researchers at the University of Bisha explores the use of microneedles for drug delivery, diagnostics, and cosmetic treatments. The study focuses on the design and manufacture of customized microneedle arrays using laser ablation. The researchers found that the laser pulse width and interval significantly affect the diameter and height of the microneedles. This research lays the groundwork for the development of customized microneedles for therapeutic applications such as dermal sensors, drug delivery, and vaccine delivery. [Extracted from the article]

A recent study conducted by researchers at the Federal University of Bahia in Brazil explored the pharmacokinetics and lung penetration of a compound called 6-methoxyseselin, derived from Zanthoxylum tingoassuiba. The compound demonstrated various therapeutic properties, including antiasthmatic effects. The study involved administering the compound through inhalation and intravenous routes in mice, and the results showed favorable pharmacokinetic profiles and high lung penetration factors. This research suggests that 6-methoxyseselin has potential for further drug development as a new anti-asthmatic medication. [Extracted from the article]

A recent study conducted by researchers at the University of Pittsburgh explores the use of polymeric microparticles (MPs) as a potential solution to the limitations of standard pharmaceuticals and their delivery methods. The study focuses on identifying critical processing parameters in the manufacturing process of double-emulsion poly(lactic-co-glycolic) acid MPs and their impact on various quality attributes. The results highlight the importance of understanding the manufacturing and characterization of these MPs, which could enhance their translation into clinical applications. This research provides valuable insights for the development of new drug delivery systems. [Extracted from the article]

A recent study conducted by Guizhou Medical University in China investigated the effect of the pharmaceutical excipient PEG400 on the pharmacokinetics of baicalin, a compound found in traditional Chinese medicine. The study found that PEG400 influenced the concentration of baicalin in hepatocytes and increased its bioavailability. Additionally, PEG400 had an inhibitory effect on the efflux transporters involved in the metabolism of baicalin in the liver. These findings suggest that PEG400 can improve the effectiveness of baicalin by affecting its transporters. [Extracted from the article]

A recent study conducted by the Food and Drug Administration (FDA) has focused on improving the quality assessment of pharmaceuticals in the United States. The FDA's Center for Drug Evaluation and Research (CDER) has implemented a network of regulatory innovations to enhance the submission, assessment, and lifecycle management of pharmaceutical quality information. These innovations include the development of tools such as the Knowledge-Aided Assessment and Structured Application (KASA), a new common technical document for quality, and the Quality Surveillance Dashboard (QSD). The goal of these efforts is to ensure the availability of high-quality medicines for patients in the United States. [Extracted from the article]

Researchers from the University of Porto in Portugal have conducted a study to assess the biocompatibility of poly(amido amine) (PAMAM), a dendrimer used for drug delivery. They used a zebrafish larvae model to evaluate the impact of a systemic injection of PEG-PAMAM-Rhodamine conjugates on survival, animal development, inflammation, and neurotoxicity. The study found that the highest tested concentration of PEG-PAMAM-Rhodamine had significant toxicological effects, while a lower concentration was deemed safe. The researchers concluded that the study provides valuable information for future use of PEG-PAMAM-Rhodamine in theragnostics and establishes new methodologies for toxicology studies using other nanosystems for systemic delivery. [Extracted from the article]

A recent study conducted in Weifang, China, investigated the effects of targeted drug therapy on renal injury caused by unilateral ureteral obstruction (UUO) in rats. The researchers found that UUO rats experienced declined renal function, renal tubular injury, increased inflammatory response, and oxidative stress, along with aggravated cellular senescence. However, after treatment with the anti-senescence drug ABT263, the rats showed a lower number of senescent cells, reduced renal tubular injury and apoptosis, enhanced proliferation, reduced oxidative stress and inflammation, improved renal function, and inhibited fibrosis. This study highlights the critical role of cellular senescence in the transformation of acute injury into chronic fibrosis. [Extracted from the article]

A recent study conducted by researchers at the University of Maribor in Slovenia has developed an in vitro human liver model for toxicity assessment. The researchers aimed to address the lack of translational potential in existing in vitro toxicological models, which hinders their application in clinical settings. The model consisted of four different types of primary liver cells and was cultured in various combinations to resemble the liver microenvironment. The researchers observed similar biomarker values to those measured in clinical diagnostics when the model was exposed to certain drugs. Additionally, they found that Kupffer and LSEC cells may be suitable candidates for identifying clinical diagnostic markers of liver function. This study provides valuable insights into the development of more effective in vitro models for toxicity assessment. [Extracted from the article]

A recent study from the University of Muenster in Germany examines the use of electronic tongues (e-tongues) in pharmaceutical drug development. The researchers critically evaluate the performance of e-tongues in assessing peroral formulations with bitter active pharmaceutical ingredients. They review the literature from the past decade to determine if e-tongues meet expectations and have the potential to become a standard tool in drug development. The study finds reliable protocols for the qualified performance of e-tongue instruments, taste-masking assessments, and the evaluation of bitterness under certain circumstances. For more information, readers can access the full article through the provided link. [Extracted from the article]

A study conducted by Egis Pharmaceuticals Plc. in Budapest, Hungary focuses on the development of an Analytical Target Profile (ATP) and the selection of in vitro release test (IVRT) technology for diclofenac sodium topical hydrogel and cream. The study compares four different IVRT apparatuses and investigates their performance characteristics. The research concludes that the best apparatus for developing IVRT quality control tests in both cases was USP II with an immersion cell. This information is available in the journal article "An Analytical Target Profile for the Development of an In Vitro Release Test Method and Apparatus Selection in the Case of Semisolid Topical Formulations" published in Pharmaceutics. [Extracted from the article]

A recent article from the Department of Life discusses the use of brain organoids in drug testing and modeling neurological diseases. The researchers highlight the urgent need for new therapeutic approaches for neurological disorders, which are a leading cause of death and disability worldwide. Brain organoids, which can reproduce different brain regions and maturation stages, have shown promise in drug screening and disease modeling. The article explores the advantages, challenges, and limitations of using organoids in this context, as well as potential future directions for improving the drug-screening process. [Extracted from the article]

A new study from Universite Paris Cite highlights the potential of three-dimensional printing (3DP) technology in the pharmaceutical industry, particularly for pediatric drug development. The researchers emphasize that 3DP offers advantages such as personalized medicines, faster manufacturing timelines, and on-demand drugs in hospitals and pharmacies. The article focuses on extrusion-based 3D printing technology and its benefits for pediatric pharmaceutical formulations. The study concludes that 3DP has shown great promise in pharmaceuticals and summarizes the discoveries made in this field. [Extracted from the article]

A recent study conducted by researchers at North-West University in Potchefstroom, South Africa, explores the use of fixed-dose combination (FDC) therapy in the treatment of chronic conditions. The study highlights the advantages and limitations of FDC formulations and discusses the design features of commercially available FDC products. The researchers also identify research gaps and provide guidance for formulation scientists in developing new FDC products. The study emphasizes the importance of patient adherence to polytherapy and offers insights into improving treatment outcomes. [Extracted from the article]

A recent report from the University of Pecs discusses the importance of flow properties in the processing of drug dosage forms. The researchers aimed to refine the analysis and methods for measuring flowability by combining empirical observations and chaos theory in a dynamic time-dependent model. The study found that sphericity and particle size are the most significant factors influencing the flowability of pharmaceutical preparations. The integration of chaos theory and empirical observations provides a comprehensive understanding of particle flow behavior, which is crucial for optimizing manufacturing processes. [Extracted from the article]

Researchers from the University of Messina in Italy have developed a liquid formulation using rutin/sulfobutylether-b-cyclodextrin (RTN/SBE-b-CD) as a potential treatment for ocular infections. The formulation was found to have high water solubility, allowing for the dissolution of the solid complex within 30 minutes. In vitro testing showed that the formulation had significant antibacterial and antibiofilm activity against Staphylococcus aureus and Pseudomonas aeruginosa strains. This research suggests that RTN/SBE-b-CD could be a promising therapeutic option for ocular infections. [Extracted from the article]

A recent study conducted by researchers at the Lithuanian University of Health Sciences explores the use of retroviruses as a potential delivery system for drugs. The researchers suggest that the use of virus-like particles based on retroviruses could help overcome the problem of non-specific drug targeting and produce more precise therapeutic effects. They highlight PEG10, a retrotransposon-derived gene, as a promising candidate for drug formulations due to its lower immunogenicity. The study concludes that utilizing existing knowledge in this area could lead to the development of suitable drug formulations for individual diseases. [Extracted from the article]