1. Lifespan-extending property of 6-shogaol from Zingiber officinale Roscoe in Caenorhabditis elegans
- Author
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Yeong Jee Kim, Su Jin Kim, Dae Keun Kim, In Hyun Hwang, Jun Hyeong Kim, Yun Jeong Noh, and Eun Byeol Lee
- Subjects
0301 basic medicine ,Aging ,Transgene ,Longevity ,ved/biology.organism_classification_rank.species ,Catechols ,Ginger ,Biology ,Antioxidants ,Green fluorescent protein ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Stress, Physiological ,Drug Discovery ,Animals ,Enzyme inducer ,Caenorhabditis elegans ,Model organism ,Molecular Structure ,Mechanism (biology) ,ved/biology ,Organic Chemistry ,Shogaol ,biology.organism_classification ,Cell biology ,030104 developmental biology ,chemistry ,030220 oncology & carcinogenesis ,Models, Animal ,biology.protein ,Molecular Medicine ,Zingiber officinale - Abstract
Aging is a key risk factor for many diseases, understanding the mechanism of which is becoming more important for drug development given the fast-growing aging population. In the course of our continued efforts to discover anti-aging natural products, the active constituent 6-shogaol was isolated from Zingiber officinale Roscoe. The chemical structure of 6-shogaol was identified by comparison of its NMR data with literature values. The lifespan-extending effect of 6-shogaol was observed in a dose-dependent manner in Caenorhabditis elegans that has been widely used as a model organism for human aging studies. Mechanism of such action was investigated using C. elegans models, suggesting that 6-shogaol is capable of increasing stress tolerances via enzyme induction. The proposed mechanism was further supported by observation of the increase in SOD and HSP expressions upon treatment with 6-shogaol in transgenic strains of C. elegans which contain GFP-based reporters. In addition, the mechanism was elaborated by confirming that the effect observed for 6-shogaol is independent from other aging-related factors that are known to affect the aging process of C. elegans.
- Published
- 2018