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Acyl-CoA: Cholesterol acyltransferase inhibitors fromIlex macropoda

Acyl-CoA: Cholesterol acyltransferase inhibitors fromIlex macropoda

Authors :
Sung-Hoon Kim
Kyung-Ran Im
Nam-In Baek
Byoung-Mog Kwon
Dae Keun Kim
Tae-Sook Jeong
Source :
Archives of Pharmacal Research. 29:191-194
Publication Year :
2006
Publisher :
Springer Science and Business Media LLC, 2006.

Abstract

Twigs from Ilex macropoda were extracted with MeOH, and the concentrated extracts were partitioned with CH2Cl2, EtOAc, n-BuOH, and H2O. Repeated column chromatography of the CH2Cl2 fraction ultimately resulted in the isolation of two compounds, via activity-guided fractionation, using ACAT inhibitory activity measurements. According to the physico-chemical data, the chemical structures of these isolated compounds were identified as lupeol (1) and betulin (2). Compounds 1 and 2 were shown to inhibit the activity of hACAT-1 and hACAT-2 in a dose-dependent manner, and compounds 1 and 2 inhibited hACAT-1 with IC50 values of 48 and 83 microM, respectively.

Details

ISSN :
19763786 and 02536269
Volume :
29
Database :
OpenAIRE
Journal :
Archives of Pharmacal Research
Accession number :
edsair.doi.dedup.....4e4d4465537184fc1ab1e59e0511d66e
Full Text :
https://doi.org/10.1007/bf02969391