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Acyl-CoA: Cholesterol acyltransferase inhibitors fromIlex macropoda
Acyl-CoA: Cholesterol acyltransferase inhibitors fromIlex macropoda
- Source :
- Archives of Pharmacal Research. 29:191-194
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- Twigs from Ilex macropoda were extracted with MeOH, and the concentrated extracts were partitioned with CH2Cl2, EtOAc, n-BuOH, and H2O. Repeated column chromatography of the CH2Cl2 fraction ultimately resulted in the isolation of two compounds, via activity-guided fractionation, using ACAT inhibitory activity measurements. According to the physico-chemical data, the chemical structures of these isolated compounds were identified as lupeol (1) and betulin (2). Compounds 1 and 2 were shown to inhibit the activity of hACAT-1 and hACAT-2 in a dose-dependent manner, and compounds 1 and 2 inhibited hACAT-1 with IC50 values of 48 and 83 microM, respectively.
- Subjects :
- Ilex macropoda
Sterol O-acyltransferase
Fractionation
Ilex
chemistry.chemical_compound
Column chromatography
Drug Discovery
Ic50 values
Animals
Humans
Enzyme Inhibitors
Lupeol
Betulin
Molecular Structure
integumentary system
biology
Plant Extracts
Anticholesteremic Agents
Organic Chemistry
Triterpenes
Biochemistry
chemistry
Enzyme inhibitor
biology.protein
Molecular Medicine
Pentacyclic Triterpenes
Sterol O-Acyltransferase
Subjects
Details
- ISSN :
- 19763786 and 02536269
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Archives of Pharmacal Research
- Accession number :
- edsair.doi.dedup.....4e4d4465537184fc1ab1e59e0511d66e
- Full Text :
- https://doi.org/10.1007/bf02969391