Inhibitory activity of 6-O-angeloylprenolin fromCentipeda minima on farnesyl protein transferase

Authors :: Jae Heon Yang
Jae Soon Eun
Jae Hyeok Lee
Byoung-Mog Kwon
Sung-Hoon Kim
Hyun Mi Oh
Dae Keun Kim
Nam-In Baek
Source :: Archives of Pharmacal Research. 29:64-66
Publication Year :: 2006
Publisher :: Springer Science and Business Media LLC, 2006.
Abstract: The methanolic extract of the aerial parts ofCentipeda minima was found to show inhibitory activity on farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of 6-O-angeloylprenolin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of 6-O-angeloylprenolin was 18.8 μM.

Subjects :: Farnesyl Protein Transferase
biology
Chemistry
Stereochemistry
6-O-angeloylprenolin
Organic Chemistry
Pharmacology toxicology
Fractionation
Inhibitory postsynaptic potential
Centipeda minima
Biochemistry
Enzyme inhibitor
Drug Discovery
biology.protein
Molecular Medicine
IC50

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