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Inhibitory activity of 6-O-angeloylprenolin fromCentipeda minima on farnesyl protein transferase
- Source :
- Archives of Pharmacal Research. 29:64-66
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- The methanolic extract of the aerial parts ofCentipeda minima was found to show inhibitory activity on farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of 6-O-angeloylprenolin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of 6-O-angeloylprenolin was 18.8 μM.
Details
- ISSN :
- 19763786 and 02536269
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Archives of Pharmacal Research
- Accession number :
- edsair.doi...........4becf088d397960b87002be4fea1608f