1. Green synthesis, Characterization and In vitro Biological Studies of Quercetin complexes with Zn (II) Acetate and N^N Moiety
- Author
-
Om Prakash Tiwari, Kavindra Nath Tiwari, Tanu Srivastava, Angaraj Singh, Pradeep Kumar, S. K. Mishra, Amit Singh, Jitendra Kumar, and Ashutosh Dwivedi
- Subjects
Biological studies ,010405 organic chemistry ,DPPH ,Solid-state ,010402 general chemistry ,01 natural sciences ,In vitro ,0104 chemical sciences ,chemistry.chemical_compound ,Minimum inhibitory concentration ,chemistry ,Moiety ,heterocyclic compounds ,Pharmacology (medical) ,Quercetin ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Nuclear chemistry - Abstract
Green synthesis of two coordination complexes of zinc acetate with N^N moiety on quercetin, which is a flavonoid is carried out. The complexes were obtained in high yields (> 97%) by grinding methods without the involvement of any solvent. Neither catalyst nor any additives were needed to perform the reactions. It was characterized by FT-IR, UV-Vis, NMR, HRMS, and elemental analysis. Antioxidant activity was done through the DPPH method which was compared with ascorbic acid and ligand (Quercetin). The study reveals that Complex 1 (IC50 163.093µg/ml) has significant free radical scavenging activity as compared to complex 2 (IC50 258.683µg/ml). Biological activity was performed against microbes (E. coli and S. aureus). MIC value of complex 1 (15.50µg/ml E. coli, 7.18µg/ml S. aureus) was found more significant as compared to complex 2 (22.51µg/ml E. coli, 18.62µg/ml S. aureus) and quercetin.
- Published
- 2021