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Anti-tuberculosis activity and its structure-activity relationship (SAR) studies of oxadiazole derivatives: A key review
- Source :
- European journal of medicinal chemistry. 209
- Publication Year :
- 2020
-
Abstract
- With the increasing number of cases of inactive and drug-resistance tuberculosis, there is an urgent need to develop new potent molecules set for fighting this brutal disease. Medicinal chemistry concerns the discovery, the development, the identification, and the interpretation of the mode of action of biologically active compounds at the molecular level. Molecules bearing oxadiazoles are one such class that could be considered to satisfy this need. Oxadiazole regioisomers have been investigated in drug discovery programs for their capacity to go about as powerful linkers and as pharmacophoric highlights. Oxadiazoles can go about as bioisosteric substitutions for the hydrazide moiety which can be found in first-line anti-TB drugs, and some have been likewise answered to cooperate with more current anti-TB targets. This present review summarizes the current innovations of oxadiazole-based derivatives with potential antituberculosis activity and bacteria discussing various aspects of structure-activity relationship (SAR).
- Subjects :
- Models, Molecular
Antitubercular Agents
Oxadiazole
Hydrazide
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
Structure-Activity Relationship
Molecular level
Anti tuberculosis
Drug Discovery
Structure–activity relationship
Moiety
Animals
Humans
Tuberculosis
030304 developmental biology
Pharmacology
0303 health sciences
Oxadiazoles
010405 organic chemistry
Drug discovery
Organic Chemistry
Biological activity
General Medicine
Mycobacterium tuberculosis
Combinatorial chemistry
0104 chemical sciences
chemistry
Subjects
Details
- ISSN :
- 17683254
- Volume :
- 209
- Database :
- OpenAIRE
- Journal :
- European journal of medicinal chemistry
- Accession number :
- edsair.doi.dedup.....355050f177c18845baafb4b495a27122