1. Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2021.3
- Author
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Stephan Grissmer, Aguan D. Wei, Leonard K. Kaczmarek, Richard W. Aldrich, George A. Gutman, K. George Chandy, and Heike Wulff
- Subjects
Subfamily ,biology ,Chemistry ,Stereochemistry ,Sodium ,hERG ,biology.protein ,chemistry.chemical_element ,Calcium ,Potassium channel ,K channels - Abstract
Calcium- and sodium- activated potassium channels are members of the 6TM family of K channels which comprises the voltage-gated KV subfamilies, including the KCNQ subfamily, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 6 or 7TM) and the Ca2+- and Na+-activated SK subfamily (nomenclature as agreed by the NC-IUPHAR Subcommittee on Calcium- and sodium-activated potassium channels [125]). As for the 2TM family, the pore-forming a subunits form tetramers and heteromeric channels may be formed within subfamilies (e.g. KV1.1 with KV1.2; KCNQ2 with KCNQ3).
- Published
- 2021