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A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies
- Source :
- Trends in pharmacological sciences. 20(11)
- Publication Year :
- 1999
-
Abstract
- Peptidyl toxins are used extensively to determine the pharmacology of ion channels. Four families of peptides have been purified from scorpion venom. In this article, the classification of K + -channel-blocking peptides belonging to family 2 peptides and comprising 30–40 amino acids linked by three or four disulfide bridges, will be discussed. Evidence is provided for the existence of 12 molecular subfamilies, named α-KTx1–12, containing 49 different peptides. Because of the pharmacological divergence of these peptides, the principle of classification was based on a primary sequence alignment, combined with maximum parsimony and Neighbour-Joining analysis.
- Subjects :
- Pharmacology
chemistry.chemical_classification
Scorpion toxin
Potassium Channels
biology
Mesobuthus martensii
Molecular Sequence Data
Scorpion Venoms
Venom
Peptide
Toxicology
biology.organism_classification
Maurotoxin
chemistry
Biochemistry
Terminology as Topic
Potassium Channel Blockers
Amino Acid Sequence
Peptides
Peptide sequence
Mesobuthus eupeus
Subjects
Details
- ISSN :
- 01656147
- Volume :
- 20
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Trends in pharmacological sciences
- Accession number :
- edsair.doi.dedup.....78776dfd1b8a832d0cd8984ac802a0dd