1. Predictive factors for pleural drainage volume after uniportal video-assisted thoracic surgery lobectomy for non-small cell lung cancer: a single-institution retrospective study
- Author
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Suyan Tian, Jialin Li, Xinliang Gao, Wei Liu, and Mingbo Tang
- Subjects
medicine.medical_specialty ,Lung Neoplasms ,genetic structures ,medicine.medical_treatment ,VATS lobectomy ,lcsh:Surgery ,Pleural drainage volume ,030204 cardiovascular system & hematology ,lcsh:RC254-282 ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Non-small cell lung cancer ,Carcinoma, Non-Small-Cell Lung ,medicine ,Humans ,Uniportal VATS lobectomy ,Lung cancer ,Pneumonectomy ,Aged ,Retrospective Studies ,Univariate analysis ,Ejection fraction ,business.industry ,Thoracic Surgery, Video-Assisted ,Research ,Retrospective cohort study ,Stroke Volume ,lcsh:RD1-811 ,medicine.disease ,Prognosis ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Surgery ,Chest tube ,030228 respiratory system ,Oncology ,Cardiothoracic surgery ,Drainage ,business ,Body mass index ,Predictive factors - Abstract
Objective To identify the predictive factors associated with pleural drainage volume (PDV) after uniportal video-assisted thoracic surgery (VATS) lobectomy for non-small cell lung cancer (NSCLC). Methods A total of 440 consecutive NSCLC patients who underwent uniportal VATS lobectomy were enrolled in this study between November 2016 and July 2019. Thirty-four parameters, including patients’ clinicopathological characteristics and other potential predictors were collected. Daily drainage volume was summed up as PDV. Univariate analysis and multivariate regression models were fitted to identify independent predictive factors for PDV. Results The median PDV was 840 ml during the median drainage duration of 4 days. A strong correlation was observed between PDV and drainage duration (correlation coefficient = 0.936). On univariate analysis, age, forced expiratory volume in 1 s % predicted (FEV1%), left ventricular ejection fraction (LVEF), operation time, serum total protein (TP), and body mass index (BMI) showed a significant correlation with PDV (P value, < 0.001, < 0.001, 0.003, 0.008, 0.028, and 0.045, respectively). Patients with smoking history (P = 0.030) or who underwent lower lobectomy (P = 0.015) showed significantly increased PDV than never smokers or those who underwent upper or middle lobectomy, respectively. On multivariate regression analysis, older age (P< 0.001), lower FEV1% (P< 0.001), lower LVEF (P = 0.011), lower TP (P = 0.013), and lower lobectomy (P = 0.016) were independent predictors of increased PDV. Conclusions Predictive factors of PDV can be identified. Based on these predictors, patients can be treated with tailored individualized safe chest tube management.
- Published
- 2020