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A ferroptosis-related gene signature predicts overall survival in patients with lung adenocarcinoma
- Source :
- Future oncology (London, England). 17(12)
- Publication Year :
- 2021
-
Abstract
- Aims: To elucidate the association between ferroptosis-related genes and prognosis in patients with lung adenocarcinoma (LUAD). Materials & methods: A ferroptosis-related gene signature was made by lasso regression analysis through the LUAD datasets of the Cancer Genome Atlas. The prognostic value of the multigene signature was externally validated in the GSE72094 dataset from the Gene Expression Omnibus database. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analysis were used to explore underlying mechanisms. Results & conclusion: We established a novel ferroptosis-related gene signature for overall survival in LUAD that was predictive in both the training and validation cohorts. Immune-related pathways were significantly enriched, and immune status differed between the high- and low-risk groups. Targeting ferroptosis is a potential therapeutic option in LUAD. These results still need to be confirmed by more studies.
- Subjects :
- 0301 basic medicine
Adult
Male
Cancer Research
Lung Neoplasms
Datasets as Topic
Adenocarcinoma of Lung
Computational biology
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Overall survival
Biomarkers, Tumor
Medicine
Ferroptosis
Humans
In patient
KEGG
Gene
Aged
Aged, 80 and over
Lung
business.industry
Gene Expression Profiling
General Medicine
Gene signature
Middle Aged
medicine.disease
Prognosis
Gene Expression Regulation, Neoplastic
030104 developmental biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Adenocarcinoma
Female
business
Transcriptome
Subjects
Details
- ISSN :
- 17448301
- Volume :
- 17
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Future oncology (London, England)
- Accession number :
- edsair.doi.dedup.....bf2dd799cd9698b0c46e4c0e2bd473c4