Back to Search
Start Over
Effect of the ketogenic diet on glycemic control, insulin resistance, and lipid metabolism in patients with T2DM: a systematic review and meta-analysis
- Source :
- Nutrition & Diabetes
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background At present, the beneficial effect of the ketogenic diet (KD) on weight loss in obese patients is generally recognized. However, a systematic research on the role of KD in the improvement of glycemic and lipid metabolism of patients with diabetes is still found scarce. Methods This meta-study employed the meta-analysis model of random effects or of fixed effects to analyze the average difference before and after KD and the corresponding 95% CI, thereby evaluating the effect of KD on T2DM. Results After KD intervention, in terms of glycemic control, the level of fasting blood glucose decreased by 1.29 mmol/L (95% CI: −1.78 to −0.79) on average, and glycated hemoglobin A1c by 1.07 (95% CI: −1.37 to −0.78). As for lipid metabolism, triglyceride was decreased by 0.72 (95% CI: −1.01 to −0.43) on average, total cholesterol by 0.33 (95% CI: −0.66 to −0.01), and low-density lipoprotein by 0.05 (95% CI: −0.25 to −0.15); yet, high-density lipoprotein increased by 0.14 (95% CI: 0.03−0.25). In addition, patients’ weight decreased by 8.66 (95% CI: −11.40 to −5.92), waist circumference by 9.17 (95% CI: −10.67 to −7.66), and BMI by 3.13 (95% CI: −3.31 to −2.95). Conclusion KD not only has a therapeutic effect on glycemic and lipid control among patients with T2DM but also significantly contributes to their weight loss.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
030209 endocrinology & metabolism
Glycemic Control
Review Article
030204 cardiovascular system & hematology
Body Mass Index
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Insulin resistance
Weight loss
Diabetes mellitus
Internal medicine
Weight Loss
Internal Medicine
medicine
Humans
Triglycerides
Aged
Nutrition
Glycemic
Glycated Hemoglobin
Triglyceride
business.industry
Type 2 diabetes
Lipid metabolism
Middle Aged
Lipid Metabolism
medicine.disease
Lipids
Cholesterol
Endocrinology
Diabetes Mellitus, Type 2
chemistry
Female
Insulin Resistance
Waist Circumference
medicine.symptom
Diet, Ketogenic
business
Body mass index
Ketogenic diet
Subjects
Details
- ISSN :
- 20444052
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Nutrition & Diabetes
- Accession number :
- edsair.doi.dedup.....6707fe1d10c277895841e9185e935934